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Entry version 85 (08 May 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Fanconi anemia core complex-associated protein 100

Gene

Faap100

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6783310 Fanconi Anemia Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fanconi anemia core complex-associated protein 100By similarity
Alternative name(s):
Fanconi anemia-associated protein of 100 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Faap100By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1919135 Faap100

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002891311 – 879Fanconi anemia core complex-associated protein 100Add BLAST879

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2ACJ2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2ACJ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2ACJ2

PRoteomics IDEntifications database

More...
PRIDEi
A2ACJ2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2ACJ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2ACJ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025384 Expressed in 197 organ(s), highest expression level in dorsal pancreas

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2ACJ2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and FAAP100. Forms a subcomplex with FANCB and FANCL (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
215005, 9 interactors

Protein interaction database and analysis system

More...
IntActi
A2ACJ2, 8 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000026448

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEYW Eukaryota
ENOG410YKI3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016682

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112640

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2ACJ2

KEGG Orthology (KO)

More...
KOi
K10993

Identification of Orthologs from Complete Genome Data

More...
OMAi
YLAGFCC

Database of Orthologous Groups

More...
OrthoDBi
129283at2759

TreeFam database of animal gene trees

More...
TreeFami
TF330817

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029251 Faap100

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15146 FANCAA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2ACJ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGASSRVHY LSDFCCPLGG RAAGKPFVLR HEAEVFLSTG REFVYVYDQE
60 70 80 90 100
GGLLTAVYQF PDQVWHLQLL AIRRALYVLC ARTGIYCLSL DSLDRSGSQA
110 120 130 140 150
CEDKEEAAPP YPVIHVDPDA CVLPDAALCA FTVLDDMLVT LAQGPTQWKM
160 170 180 190 200
QLFERPCAGE EPLPRGQIGE VELSTCTPPG GVPEKPAAPR FLPVLCCVFP
210 220 230 240 250
PDSRAPHGHP QGCGCFTLEE ALFGLLFGVD ATLLQSPVIL CGLPDGQLCC
260 270 280 290 300
VVLKALVTSG LAPGDPKVLV KILHHLEEPV IFIGALRAEP HEEEAAGELL
310 320 330 340 350
PGQHEHSDCL VALGHQGRTL AIKASWSESG NLVPELREYC LPGPVLCAAC
360 370 380 390 400
DRDGHVYHST PSDLCVVDLT RRDSPWNPEK PDGAIGGLPS VLCPASLNIC
410 420 430 440 450
SALALCVTAR APTGSTELLA LSSKGRLITC SLDLNSEAPV PAKMAMANAG
460 470 480 490 500
QKIKELLLDI GDVSERVSFL KKAVDQRNKA ITSLNEAMNV SCALLSHPEG
510 520 530 540 550
DRPIACTITT SWSRLELRDM LMATCTLENS SSFSLDQGWT LCIQVLTSSS
560 570 580 590 600
ALDLDGTGSA FTYTIPVDRL GPGSRREVTL PLGPSESGVL DLPVTMSCWL
610 620 630 640 650
FYSLREVVGA ALAPSDPLEA PYLEQFPLSL PKQEGVCLPL CKRTVDMLQC
660 670 680 690 700
LRFAGAATHP AQAPCMPGPA CEPVETFLKT CQAPGSEPTG AASLRAKYLP
710 720 730 740 750
PSTASIRVSA GLLRAALEDS HSGFHLCSAT LRWLLAENAA VDVVRAQTLS
760 770 780 790 800
SIQGIAPDGT DVNLTVHEVA VTDLSPAGPI QAVEIQVESS SLANMCRAHH
810 820 830 840 850
AIIRRIQTMV TEQAALGSSP PDLRMQYLQQ IHANHQELLR EVQALRDQLC
860 870
TEDELSSCST AQKLLHIYKQ LRNPSLVLL
Length:879
Mass (Da):94,281
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83F2DF42485E2F50
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34203 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH48376 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK148234 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti436S → P in AK148234 (PubMed:16141072).Curated1
Sequence conflicti856S → G in AK148234 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK148234 mRNA No translation available.
AL669855 Genomic DNA No translation available.
BC034203 mRNA Translation: AAH34203.1 Different initiation.
BC048376 mRNA Translation: AAH48376.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49004.1

NCBI Reference Sequences

More...
RefSeqi
NP_082256.2, NM_027980.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000026448; ENSMUSP00000026448; ENSMUSG00000025384

Database of genes from NCBI RefSeq genomes

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GeneIDi
71885

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:71885

UCSC genome browser

More...
UCSCi
uc007msm.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148234 mRNA No translation available.
AL669855 Genomic DNA No translation available.
BC034203 mRNA Translation: AAH34203.1 Different initiation.
BC048376 mRNA Translation: AAH48376.1 Different initiation.
CCDSiCCDS49004.1
RefSeqiNP_082256.2, NM_027980.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi215005, 9 interactors
IntActiA2ACJ2, 8 interactors
STRINGi10090.ENSMUSP00000026448

PTM databases

iPTMnetiA2ACJ2
PhosphoSitePlusiA2ACJ2

Proteomic databases

EPDiA2ACJ2
MaxQBiA2ACJ2
PaxDbiA2ACJ2
PRIDEiA2ACJ2

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
71885
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026448; ENSMUSP00000026448; ENSMUSG00000025384
GeneIDi71885
KEGGimmu:71885
UCSCiuc007msm.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80233
MGIiMGI:1919135 Faap100

Phylogenomic databases

eggNOGiENOG410IEYW Eukaryota
ENOG410YKI3 LUCA
GeneTreeiENSGT00390000016682
HOGENOMiHOG000112640
InParanoidiA2ACJ2
KOiK10993
OMAiYLAGFCC
OrthoDBi129283at2759
TreeFamiTF330817

Enzyme and pathway databases

ReactomeiR-MMU-6783310 Fanconi Anemia Pathway

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2ACJ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025384 Expressed in 197 organ(s), highest expression level in dorsal pancreas
GenevisibleiA2ACJ2 MM

Family and domain databases

InterProiView protein in InterPro
IPR029251 Faap100
PfamiView protein in Pfam
PF15146 FANCAA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFP100_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ACJ2
Secondary accession number(s): Q0P653, Q810W2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 20, 2007
Last modified: May 8, 2019
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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