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Protein

Dynein intermediate chain 2, axonemal

Gene

Dnai2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the dynein complex of respiratory cilia.By similarity

GO - Molecular functioni

  • dynein heavy chain binding Source: GO_Central
  • dynein light chain binding Source: GO_Central
  • microtubule motor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein intermediate chain 2, axonemal
Alternative name(s):
Axonemal dynein intermediate chain 2
Gene namesi
Name:Dnai2
Synonyms:Dnaic2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2685574 Dnaic2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003658161 – 623Dynein intermediate chain 2, axonemalAdd BLAST623

Proteomic databases

MaxQBiA2AC93
PaxDbiA2AC93
PRIDEiA2AC93

PTM databases

iPTMnetiA2AC93
PhosphoSitePlusiA2AC93

Expressioni

Tissue specificityi

Predominantly expressed in ovary, testis and lung.1 Publication

Developmental stagei

In ovaries, it is detected at high levels in vivo on day 10, with a subsequent decrease on days 15 and 20, in adult and old ovaries. Weakly expressed on day 5.1 Publication

Gene expression databases

BgeeiENSMUSG00000034706 Expressed in 87 organ(s), highest expression level in testis
ExpressionAtlasiA2AC93 baseline and differential
GenevisibleiA2AC93 MM

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains (Probable). Interacts with DNAAF2 (PubMed:19052621). Interacts with PIH1D3 (PubMed:24421334). Interacts with HEATR2; probably involved in outer arm dynein assembly (By similarity).By similarityCurated2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Dnaaf2Q8BPI12EBI-15744757,EBI-15744709

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-59778N
IntActiA2AC93, 1 interactor
STRINGi10090.ENSMUSP00000065787

Structurei

3D structure databases

ProteinModelPortaliA2AC93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati214 – 254WD 1Add BLAST41
Repeati261 – 302WD 2Add BLAST42
Repeati362 – 401WD 3Add BLAST40
Repeati405 – 445WD 4Add BLAST41
Repeati450 – 489WD 5Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi501 – 619Glu-richAdd BLAST119

Sequence similaritiesi

Belongs to the dynein intermediate chain family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IU37 Eukaryota
ENOG410XTD6 LUCA
GeneTreeiENSGT00930000150974
HOGENOMiHOG000259651
HOVERGENiHBG013035
InParanoidiA2AC93
KOiK11143
OMAiLIGGCYN
OrthoDBiEOG091G06TY
PhylomeDBiA2AC93
TreeFamiTF300553

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294 WD_REPEATS_REGION, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AC93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIVYVYLKK RSEFGKQCNF SDRQAELNID ILPNPELAAL YVERNPVDTG
60 70 80 90 100
IQCSASMSEH EANTERFEME SCGVNHVEGG WPKDVNPQEL EQTIRFRKKV
110 120 130 140 150
EKDENYINAV MQLGSIMEHC IKQNNAIDIY EEYFDDEEAV EVTEEAPSAK
160 170 180 190 200
TINVFRDPQE IKRTATHLSW HPDGNRKLAV AYSCLKFQRA PMSMNYDSYI
210 220 230 240 250
WDLENPNRPE IALKPLSPLV TLEYNPKDSH VLLGGCYNGQ IACWDTRKGS
260 270 280 290 300
LVAELSTIEF SHRDPVYGTI WLQSKTGTEC FSASTDGQVM WWDIRKISEP
310 320 330 340 350
IEVVIMDISR KEQLENALGA ISLEFESTLP TKFMVGTEQG IVISCNRKAK
360 370 380 390 400
TQAEKIVCTF YGHHGPIYAL QRNPFYPKNF LTVGDWTARI WSEDSRESSI
410 420 430 440 450
MWTKYHMAYL SDGAWSPVRP AVFFTTKMDG TLDIWDLVFK QCDPALSLKV
460 470 480 490 500
CDDPLFCLRV QDNGCLIACG SELGTTTLLE VSSSLSTLQR NEKNIASSIF
510 520 530 540 550
ERETRREKIL EARHREMRLK EKGKVEGKED DQKEEEAALD LDELVGKAEE
560 570 580 590 600
EFFEVIFSEL KRKEAEALKK KPKPRKKSSV KVEAEEEVEE NVGEEEEAGG
610 620
IIGIDAVEDM SEEAGEEQED VPT
Length:623
Mass (Da):70,968
Last modified:March 3, 2009 - v2
Checksum:iA31B5EF749EF7FF4
GO
Isoform 2 (identifier: A2AC93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-461: Missing.

Show »
Length:611
Mass (Da):69,578
Checksum:iA852565A51265DDA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GML5R4GML5_MOUSE
Dynein, axonemal, intermediate chai...
Dnaic2
562Annotation score:

Sequence cautioni

The sequence CAM19252 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036542450 – 461Missing in isoform 2. CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF565270 mRNA Translation: ABU62629.1
AL663079 Genomic DNA Translation: CAM19252.1 Sequence problems.
AL663079 Genomic DNA Translation: CAM19253.1
CH466558 Genomic DNA Translation: EDL34441.1
CCDSiCCDS36366.1 [A2AC93-1]
RefSeqiNP_001030050.2, NM_001034878.2 [A2AC93-1]
XP_006533723.1, XM_006533660.2 [A2AC93-1]
XP_006533724.1, XM_006533661.1 [A2AC93-1]
XP_006533725.1, XM_006533662.3 [A2AC93-1]
UniGeneiMm.212764

Genome annotation databases

EnsembliENSMUST00000069325; ENSMUSP00000065787; ENSMUSG00000034706 [A2AC93-1]
ENSMUST00000092469; ENSMUSP00000090126; ENSMUSG00000034706 [A2AC93-1]
GeneIDi432611
KEGGimmu:432611
UCSCiuc007mfn.1 mouse [A2AC93-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF565270 mRNA Translation: ABU62629.1
AL663079 Genomic DNA Translation: CAM19252.1 Sequence problems.
AL663079 Genomic DNA Translation: CAM19253.1
CH466558 Genomic DNA Translation: EDL34441.1
CCDSiCCDS36366.1 [A2AC93-1]
RefSeqiNP_001030050.2, NM_001034878.2 [A2AC93-1]
XP_006533723.1, XM_006533660.2 [A2AC93-1]
XP_006533724.1, XM_006533661.1 [A2AC93-1]
XP_006533725.1, XM_006533662.3 [A2AC93-1]
UniGeneiMm.212764

3D structure databases

ProteinModelPortaliA2AC93
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59778N
IntActiA2AC93, 1 interactor
STRINGi10090.ENSMUSP00000065787

PTM databases

iPTMnetiA2AC93
PhosphoSitePlusiA2AC93

Proteomic databases

MaxQBiA2AC93
PaxDbiA2AC93
PRIDEiA2AC93

Protocols and materials databases

DNASUi432611
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069325; ENSMUSP00000065787; ENSMUSG00000034706 [A2AC93-1]
ENSMUST00000092469; ENSMUSP00000090126; ENSMUSG00000034706 [A2AC93-1]
GeneIDi432611
KEGGimmu:432611
UCSCiuc007mfn.1 mouse [A2AC93-1]

Organism-specific databases

CTDi432611
MGIiMGI:2685574 Dnaic2

Phylogenomic databases

eggNOGiENOG410IU37 Eukaryota
ENOG410XTD6 LUCA
GeneTreeiENSGT00930000150974
HOGENOMiHOG000259651
HOVERGENiHBG013035
InParanoidiA2AC93
KOiK11143
OMAiLIGGCYN
OrthoDBiEOG091G06TY
PhylomeDBiA2AC93
TreeFamiTF300553

Miscellaneous databases

PROiPR:A2AC93
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034706 Expressed in 87 organ(s), highest expression level in testis
ExpressionAtlasiA2AC93 baseline and differential
GenevisibleiA2AC93 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDNAI2_MOUSE
AccessioniPrimary (citable) accession number: A2AC93
Secondary accession number(s): A2AC94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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