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Protein
Submitted name:

Histone-lysine N-methyltransferase EHMT2

Gene

EHMT2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Histone-lysine N-methyltransferase EHMT2Imported
Gene namesi
Name:EHMT2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204371.11
HGNCiHGNC:14129 EHMT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204371

PTM / Processingi

Proteomic databases

MaxQBiA2ABF9
PRIDEiA2ABF9

Expressioni

Gene expression databases

BgeeiENSG00000204371 Expressed in 207 organ(s), highest expression level in nucleus accumbens
ExpressionAtlasiA2ABF9 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiA2ABF9, 13 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini711 – 944ANK_REP_REGIONInterPro annotationAdd BLAST234
Repeati741 – 773ANKPROSITE-ProRule annotationAdd BLAST33
Repeati774 – 806ANKPROSITE-ProRule annotationAdd BLAST33
Repeati807 – 831ANKPROSITE-ProRule annotationAdd BLAST25
Repeati841 – 873ANKPROSITE-ProRule annotationAdd BLAST33
Repeati907 – 939ANKPROSITE-ProRule annotationAdd BLAST33
Domaini1029 – 1092Pre-SETInterPro annotationAdd BLAST64
Domaini1095 – 1212SETInterPro annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili341 – 387Sequence analysisAdd BLAST47

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1082 Eukaryota
COG0666 LUCA
COG2940 LUCA
GeneTreeiENSGT00780000121845
HOGENOMiHOG000231216
HOVERGENiHBG028394
OMAiSPPIPCV
OrthoDBiEOG091G00U6

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038034 EHMT2
IPR007728 Pre-SET_dom
IPR001214 SET_dom
PANTHERiPTHR22884:SF361 PTHR22884:SF361, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 3 hits
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50867 PRE_SET, 1 hit
PS50280 SET, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A2ABF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGLPRGRGL MRARGRGRAA PPGSRGRGRG GPHRGRGRPR SLLSLPRAQA
60 70 80 90 100
SWTPQLSTGL TSPPVPCLPS QGEAPAEMGA LLLEKETRGA TERVHGSLGD
110 120 130 140 150
TPRSEETLPK ATPDSLEPAG PSSPASVTVT VGDEGADTPV GATPLIGDES
160 170 180 190 200
ENLEGDGDLR GGRILLGHAT KSFPSSPSKG GSCPSRAKMS MTGAGKSPPS
210 220 230 240 250
VQSLAMRLLS MPGAQGAAAA GSEPPPATTS PEGQPKVHRA RKTMSKPGNG
260 270 280 290 300
QPPVPEKRPP EIQHFRMSDD VHSLGKVTSD LAKRRKLNSG GGLSEELGSA
310 320 330 340 350
RRSGEVTLTK GDPGSLEEWE TVVGDDFSLY YDSYSVDERV DSDSKSEVEA
360 370 380 390 400
LTEQLSEEEE EEEEEEEEEE EEEEEEEEEE DEESGNQSDR SGSSGRRKAK
410 420 430 440 450
KKWRKDSPWV KPSRKRRKRE PPRAKEPRGV NGVGSSGPSE YMEVPLGSLE
460 470 480 490 500
LPSEGTLSPN HAGVSNDTSS LETERGFEEL PLCSCRMEAP KIDRISERAG
510 520 530 540 550
HKCMATESVD GELSGCNAAI LKRETMRPSS RVALMVLCET HRARMVKHHC
560 570 580 590 600
CPGCGYFCTA GTFLECHPDF RVAHRFHKAC VSQLNGMVFC PHCGEDASEA
610 620 630 640 650
QEVTIPRGDG VTPPAGTAAP APPPLSQDVP GRADTSQPSA RMRGHGEPRR
660 670 680 690 700
PPCDPLADTI DSSGPSLTLP NGGCLSAVGL PLGPGREALE KALVIQESER
710 720 730 740 750
RKKLRFHPRQ LYLSVKQGEL QKVILMLLDN LDPNFQSDQQ SKRTPLHAAA
760 770 780 790 800
QKGSVEICHV LLQAGANINA VDKQQRTPLM EAVVNNHLEV ARYMVQRGGC
810 820 830 840 850
VYSKEEDGST CLHHAAKIGN LEMVSLLLST GQVDVNAQDS GGWTPIIWAA
860 870 880 890 900
EHKHIEVIRM LLTRGADVTL TDNEENICLH WASFTGSAAI AEVLLNARCD
910 920 930 940 950
LHAVNYHGDT PLHIAARESY HDCVLLFLSR GANPELRNKE GDTAWDLTPE
960 970 980 990 1000
RSDVWFALQL NRKLRLGVGN RAIRTEKIIC RDVARGYENV PIPCVNGVDG
1010 1020 1030 1040 1050
EPCPEDYKYI SENCETSTMN IDRNITHLQH CTCVDDCSSS NCLCGQLSIR
1060 1070 1080 1090 1100
CWYDKDGRLL QEFNKIEPPL IFECNQACSC WRNCKNRVVQ SGIKVRLQLY
1110 1120 1130 1140 1150
RTAKMGWGVR ALQTIPQGTF ICEYVGELIS DAEADVREDD SYLFDLDNKD
1160 1170 1180 1190 1200
GEVYCIDARY YGNISRFINH LCDPNIIPVR VFMLHQDLRF PRIAFFSSRD
1210 1220 1230 1240 1250
IRTGEELGFD YGDRFWDIKS KYFTCQCGSE KCKHSAEAIA LEQSRLARLD
1260
PHPELLPELG SLPPVNT
Length:1,267
Mass (Da):138,770
Last modified:February 20, 2007 - v1
Checksum:i663CB53F5CBA6B3D
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96KQ7EHMT2_HUMAN
Histone-lysine N-methyltransferase ...
EHMT2 BAT8, C6orf30, G9A, KMT1C, NG36
1,210Annotation score:
A2ABF8A2ABF8_HUMAN
Histone-lysine N-methyltransferase ...
EHMT2
1,233Annotation score:
A0A0G2JK64A0A0G2JK64_HUMAN
Histone-lysine N-methyltransferase ...
EHMT2
1,267Annotation score:
A0A0G2JRN8A0A0G2JRN8_HUMAN
Histone-lysine N-methyltransferase ...
EHMT2
922Annotation score:
A0A0G2JIS2A0A0G2JIS2_HUMAN
Histone-lysine N-methyltransferase ...
EHMT2
1,176Annotation score:
A0A0G2JRR0A0A0G2JRR0_HUMAN
Histone-lysine N-methyltransferase ...
EHMT2
888Annotation score:
A0A0G2JIR1A0A0G2JIR1_HUMAN
Histone-lysine N-methyltransferase ...
EHMT2
1,233Annotation score:
H0Y4K5H0Y4K5_HUMAN
Histone-lysine N-methyltransferase ...
EHMT2
298Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662834 Genomic DNA No translation available.
AL671762 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
CR388202 Genomic DNA No translation available.
CR388219 Genomic DNA No translation available.
RefSeqiXP_005248881.1, XM_005248824.3
UniGeneiHs.709218

Genome annotation databases

EnsembliENST00000395728; ENSP00000379078; ENSG00000204371
ENST00000400006; ENSP00000382886; ENSG00000206376
ENST00000420930; ENSP00000397323; ENSG00000227333
ENST00000436403; ENSP00000398286; ENSG00000236759
GeneIDi10919
UCSCiuc063niw.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662834 Genomic DNA No translation available.
AL671762 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
CR388202 Genomic DNA No translation available.
CR388219 Genomic DNA No translation available.
RefSeqiXP_005248881.1, XM_005248824.3
UniGeneiHs.709218

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2ABF9, 13 interactors

Proteomic databases

MaxQBiA2ABF9
PRIDEiA2ABF9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395728; ENSP00000379078; ENSG00000204371
ENST00000400006; ENSP00000382886; ENSG00000206376
ENST00000420930; ENSP00000397323; ENSG00000227333
ENST00000436403; ENSP00000398286; ENSG00000236759
GeneIDi10919
UCSCiuc063niw.1 human

Organism-specific databases

CTDi10919
EuPathDBiHostDB:ENSG00000204371.11
HGNCiHGNC:14129 EHMT2
OpenTargetsiENSG00000204371
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1082 Eukaryota
COG0666 LUCA
COG2940 LUCA
GeneTreeiENSGT00780000121845
HOGENOMiHOG000231216
HOVERGENiHBG028394
OMAiSPPIPCV
OrthoDBiEOG091G00U6

Miscellaneous databases

ChiTaRSiEHMT2 human
GenomeRNAii10919

Gene expression databases

BgeeiENSG00000204371 Expressed in 207 organ(s), highest expression level in nucleus accumbens
ExpressionAtlasiA2ABF9 baseline and differential

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038034 EHMT2
IPR007728 Pre-SET_dom
IPR001214 SET_dom
PANTHERiPTHR22884:SF361 PTHR22884:SF361, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 3 hits
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50867 PRE_SET, 1 hit
PS50280 SET, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2ABF9_HUMAN
AccessioniPrimary (citable) accession number: A2ABF9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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