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UniProtKB - A2ABF8 (A2ABF8_HUMAN)
Protein
Submitted name:
Histone-lysine N-methyltransferase EHMT2
Gene
EHMT2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- histone-lysine N-methyltransferase activity Source: InterPro
- p53 binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- chromatin organization Source: UniProt
Names & Taxonomyi
Protein namesi | Submitted name: Histone-lysine N-methyltransferase EHMT2 |
Gene namesi | Name:EHMT2 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14129, EHMT2 |
VEuPathDBi | HostDB:ENSG00000204371 |
Subcellular locationi
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
ChromosomeARBA annotation, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000204371, Expressed in subventricular zone (inner) (primate) and 221 other tissues |
Interactioni
GO - Molecular functioni
- p53 binding Source: InterPro
Protein-protein interaction databases
IntActi | A2ABF8, 1 interactor |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 707 – 739 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 740 – 772 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 773 – 797 | ANKPROSITE-ProRule annotationAdd BLAST | 25 | |
Repeati | 807 – 839 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 873 – 905 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 995 – 1058 | Pre-SETInterPro annotationAdd BLAST | 64 | |
Domaini | 1061 – 1178 | SETInterPro annotationAdd BLAST | 118 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 319 | DisorderedSequence analysisAdd BLAST | 319 | |
Regioni | 337 – 439 | DisorderedSequence analysisAdd BLAST | 103 | |
Regioni | 571 – 631 | DisorderedSequence analysisAdd BLAST | 61 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 46 – 65 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 171 – 185 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 259 – 283 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 337 – 352 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 353 – 385 | Acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 395 – 422 | Basic residuesSequence analysisAdd BLAST | 28 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000159459 |
HOGENOMi | CLU_005790_0_0_1 |
OrthoDBi | 753093at2759 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.170.270.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR043550, EHMT1/EHMT2 IPR038034, EHMT2 IPR007728, Pre-SET_dom IPR001214, SET_dom IPR046341, SET_dom_sf |
PANTHERi | PTHR46307, PTHR46307, 2 hits PTHR46307:SF1, PTHR46307:SF1, 2 hits |
Pfami | View protein in Pfam PF12796, Ank_2, 3 hits PF05033, Pre-SET, 1 hit PF00856, SET, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00468, PreSET, 1 hit SM00317, SET, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF82199, SSF82199, 1 hit |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 5 hits PS50867, PRE_SET, 1 hit PS50280, SET, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
A2ABF8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGLPRGRGL MRARGRGRAA PPGSRGRGRG GPHRGRGRPR SLLSLPRAQA
60 70 80 90 100
SWTPQLSTGL TSPPVPCLPS QGEAPAEMGA LLLEKETRGA TERVHGSLGD
110 120 130 140 150
TPRSEETLPK ATPDSLEPAG PSSPASVTVT VGDEGADTPV GATPLIGDES
160 170 180 190 200
ENLEGDGDLR GGRILLGHAT KSFPSSPSKG GSCPSRAKMS MTGAGKSPPS
210 220 230 240 250
VQSLAMRLLS MPGAQGAAAA GSEPPPATTS PEGQPKVHRA RKTMSKPGNG
260 270 280 290 300
QPPVPEKRPP EIQHFRMSDD VHSLGKVTSD LAKRRKLNSG GGLSEELGSA
310 320 330 340 350
RRSGEVTLTK GDPGSLEEWE TVVGDDFSLY YDSYSVDERV DSDSKSEVEA
360 370 380 390 400
LTEQLSEEEE EEEEEEEEEE EEEEEEEEEE DEESGNQSDR SGSSGRRKAK
410 420 430 440 450
KKWRKDSPWV KPSRKRRKRE PPRAKEPRGV SNDTSSLETE RGFEELPLCS
460 470 480 490 500
CRMEAPKIDR ISERAGHKCM ATESVDGELS GCNAAILKRE TMRPSSRVAL
510 520 530 540 550
MVLCETHRAR MVKHHCCPGC GYFCTAGTFL ECHPDFRVAH RFHKACVSQL
560 570 580 590 600
NGMVFCPHCG EDASEAQEVT IPRGDGVTPP AGTAAPAPPP LSQDVPGRAD
610 620 630 640 650
TSQPSARMRG HGEPRRPPCD PLADTIDSSG PSLTLPNGGC LSAVGLPLGP
660 670 680 690 700
GREALEKALV IQESERRKKL RFHPRQLYLS VKQGELQKVI LMLLDNLDPN
710 720 730 740 750
FQSDQQSKRT PLHAAAQKGS VEICHVLLQA GANINAVDKQ QRTPLMEAVV
760 770 780 790 800
NNHLEVARYM VQRGGCVYSK EEDGSTCLHH AAKIGNLEMV SLLLSTGQVD
810 820 830 840 850
VNAQDSGGWT PIIWAAEHKH IEVIRMLLTR GADVTLTDNE ENICLHWASF
860 870 880 890 900
TGSAAIAEVL LNARCDLHAV NYHGDTPLHI AARESYHDCV LLFLSRGANP
910 920 930 940 950
ELRNKEGDTA WDLTPERSDV WFALQLNRKL RLGVGNRAIR TEKIICRDVA
960 970 980 990 1000
RGYENVPIPC VNGVDGEPCP EDYKYISENC ETSTMNIDRN ITHLQHCTCV
1010 1020 1030 1040 1050
DDCSSSNCLC GQLSIRCWYD KDGRLLQEFN KIEPPLIFEC NQACSCWRNC
1060 1070 1080 1090 1100
KNRVVQSGIK VRLQLYRTAK MGWGVRALQT IPQGTFICEY VGELISDAEA
1110 1120 1130 1140 1150
DVREDDSYLF DLDNKDGEVY CIDARYYGNI SRFINHLCDP NIIPVRVFML
1160 1170 1180 1190 1200
HQDLRFPRIA FFSSRDIRTG EELGFDYGDR FWDIKSKYFT CQCGSEKCKH
1210 1220 1230
SAEAIALEQS RLARLDPHPE LLPELGSLPP VNT
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ96KQ7 | EHMT2_HUMAN | Histone-lysine N-methyltransferase ... | EHMT2 BAT8, C6orf30, G9A, KMT1C, NG36 | 1,210 | Annotation score: | ||
A2ABF9 | A2ABF9_HUMAN | Histone-lysine N-methyltransferase ... | EHMT2 | 1,267 | Annotation score: | ||
A0A0G2JIS2 | A0A0G2JIS2_HUMAN | Histone-lysine N-methyltransferase ... | EHMT2 | 1,176 | Annotation score: | ||
A0A0G2JK64 | A0A0G2JK64_HUMAN | Histone-lysine N-methyltransferase ... | EHMT2 | 1,267 | Annotation score: | ||
A0A0G2JIR1 | A0A0G2JIR1_HUMAN | Histone-lysine N-methyltransferase ... | EHMT2 | 1,233 | Annotation score: | ||
A0A0G2JRN8 | A0A0G2JRN8_HUMAN | Histone-lysine N-methyltransferase ... | EHMT2 | 922 | Annotation score: | ||
A0A0G2JRR0 | A0A0G2JRR0_HUMAN | Histone-lysine N-methyltransferase ... | EHMT2 | 888 | Annotation score: | ||
H0Y4K5 | H0Y4K5_HUMAN | Histone-lysine N-methyltransferase ... | EHMT2 | 298 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL662834 Genomic DNA No translation available. AL671762 Genomic DNA No translation available. AL844853 Genomic DNA No translation available. CR388202 Genomic DNA No translation available. CR388219 Genomic DNA No translation available. |
RefSeqi | NP_001276342.1, NM_001289413.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL662834 Genomic DNA No translation available. AL671762 Genomic DNA No translation available. AL844853 Genomic DNA No translation available. CR388202 Genomic DNA No translation available. CR388219 Genomic DNA No translation available. |
RefSeqi | NP_001276342.1, NM_001289413.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A2ABF8, 1 interactor |
Proteomic databases
ProteomicsDBi | 358 |
Protocols and materials databases
Antibodypediai | 27888, 359 antibodies from 39 providers |
DNASUi | 10919 |
Genome annotation databases
Organism-specific databases
CTDi | 10919 |
HGNCi | HGNC:14129, EHMT2 |
OpenTargetsi | ENSG00000204371 |
VEuPathDBi | HostDB:ENSG00000204371 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159459 |
HOGENOMi | CLU_005790_0_0_1 |
OrthoDBi | 753093at2759 |
Miscellaneous databases
BioGRID-ORCSi | 10919, 101 hits in 1100 CRISPR screens |
ChiTaRSi | EHMT2, human |
GenomeRNAii | 10919 |
Gene expression databases
Bgeei | ENSG00000204371, Expressed in subventricular zone (inner) (primate) and 221 other tissues |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.170.270.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR043550, EHMT1/EHMT2 IPR038034, EHMT2 IPR007728, Pre-SET_dom IPR001214, SET_dom IPR046341, SET_dom_sf |
PANTHERi | PTHR46307, PTHR46307, 2 hits PTHR46307:SF1, PTHR46307:SF1, 2 hits |
Pfami | View protein in Pfam PF12796, Ank_2, 3 hits PF05033, Pre-SET, 1 hit PF00856, SET, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00468, PreSET, 1 hit SM00317, SET, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF82199, SSF82199, 1 hit |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 5 hits PS50867, PRE_SET, 1 hit PS50280, SET, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2ABF8_HUMAN | |
Accessioni | A2ABF8Primary (citable) accession number: A2ABF8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | May 25, 2022 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |