Histone-lysine N-methyltransferase EHMT2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: Ensembl
• histone methyltransferase activity (H3-K27 specific) Source: Ensembl
• histone methyltransferase activity (H3-K9 specific) Source: Ensembl
• p53 binding Source: InterPro
• promoter-specific chromatin binding Source: Ensembl
• RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• behavioral response to cocaine Source: Ensembl
• cellular response to cocaine Source: Ensembl
• DNA methylation on cytosine within a CG sequence Source: Ensembl
• fertilization Source: Ensembl
• long-term memory Source: Ensembl
• negative regulation of autophagosome assembly Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• neuron fate specification Source: Ensembl
• organ growth Source: Ensembl
• phenotypic switching Source: Ensembl
• regulation of DNA methylation Source: Ensembl
• regulation of DNA replication Source: Ensembl
• regulation of histone H3-K4 methylation Source: Ensembl
• regulation of histone H3-K9 methylation Source: Ensembl
• response to ethanol Source: Ensembl
• response to fungicide Source: Ensembl
• response to nutrient levels Source: Ensembl
• spermatid development Source: Ensembl
• synaptonemal complex assembly Source: Ensembl

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: Ensembl
• p53 binding Source: InterPro

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MRGLPRGRGL MRARGRGRAA PPGSRGRGRG GPHRGRGRPR SLLSLPRAQA 
        60         70         80         90        100
SWTPQLSTGL TSPPVPCLPS QGEAPAEMGA LLLEKETRGA TERVHGSLGD 
       110        120        130        140        150
TPRSEETLPK ATPDSLEPAG PSSPASVTVT VGDEGADTPV GATPLIGDES 
       160        170        180        190        200
ENLEGDGDLR GGRILLGHAT KSFPSSPSKG GSCPSRAKMS MTGAGKSPPS 
       210        220        230        240        250
VQSLAMRLLS MPGAQGAAAA GSEPPPATTS PEGQPKVHRA RKTMSKPGNG 
       260        270        280        290        300
QPPVPEKRPP EIQHFRMSDD VHSLGKVTSD LAKRRKLNSG GGLSEELGSA 
       310        320        330        340        350
RRSGEVTLTK GDPGSLEEWE TVVGDDFSLY YDSYSVDERV DSDSKSEVEA 
       360        370        380        390        400
LTEQLSEEEE EEEEEEEEEE EEEEEEEEEE DEESGNQSDR SGSSGRRKAK 
       410        420        430        440        450
KKWRKDSPWV KPSRKRRKRE PPRAKEPRGV SNDTSSLETE RGFEELPLCS 
       460        470        480        490        500
CRMEAPKIDR ISERAGHKCM ATESVDGELS GCNAAILKRE TMRPSSRVAL 
       510        520        530        540        550
MVLCETHRAR MVKHHCCPGC GYFCTAGTFL ECHPDFRVAH RFHKACVSQL 
       560        570        580        590        600
NGMVFCPHCG EDASEAQEVT IPRGDGVTPP AGTAAPAPPP LSQDVPGRAD 
       610        620        630        640        650
TSQPSARMRG HGEPRRPPCD PLADTIDSSG PSLTLPNGGC LSAVGLPLGP 
       660        670        680        690        700
GREALEKALV IQESERRKKL RFHPRQLYLS VKQGELQKVI LMLLDNLDPN 
       710        720        730        740        750
FQSDQQSKRT PLHAAAQKGS VEICHVLLQA GANINAVDKQ QRTPLMEAVV 
       760        770        780        790        800
NNHLEVARYM VQRGGCVYSK EEDGSTCLHH AAKIGNLEMV SLLLSTGQVD 
       810        820        830        840        850
VNAQDSGGWT PIIWAAEHKH IEVIRMLLTR GADVTLTDNE ENICLHWASF 
       860        870        880        890        900
TGSAAIAEVL LNARCDLHAV NYHGDTPLHI AARESYHDCV LLFLSRGANP 
       910        920        930        940        950
ELRNKEGDTA WDLTPERSDV WFALQLNRKL RLGVGNRAIR TEKIICRDVA 
       960        970        980        990       1000
RGYENVPIPC VNGVDGEPCP EDYKYISENC ETSTMNIDRN ITHLQHCTCV 
      1010       1020       1030       1040       1050
DDCSSSNCLC GQLSIRCWYD KDGRLLQEFN KIEPPLIFEC NQACSCWRNC 
      1060       1070       1080       1090       1100
KNRVVQSGIK VRLQLYRTAK MGWGVRALQT IPQGTFICEY VGELISDAEA 
      1110       1120       1130       1140       1150
DVREDDSYLF DLDNKDGEVY CIDARYYGNI SRFINHLCDP NIIPVRVFML 
      1160       1170       1180       1190       1200
HQDLRFPRIA FFSSRDIRTG EELGFDYGDR FWDIKSKYFT CQCGSEKCKH 
      1210       1220       1230 
SAEAIALEQS RLARLDPHPE LLPELGSLPP VNT                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ