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Protein
Submitted name:

Ral guanine nucleotide dissociation stimulator-like 2

Gene

RGL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Ral guanine nucleotide dissociation stimulator-like 2Imported
Gene namesi
Name:RGL2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000237441.9
HGNCiHGNC:9769 RGL2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000237441

PTM / Processingi

Proteomic databases

PRIDEiA2AB89

Expressioni

Gene expression databases

BgeeiENSG00000237441 Expressed in 227 organ(s), highest expression level in pituitary gland
ExpressionAtlasiA2AB89 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 146N-terminal Ras-GEFInterPro annotationAdd BLAST59

Phylogenomic databases

eggNOGiENOG410ITRE Eukaryota
ENOG4110VI4 LUCA
GeneTreeiENSGT00910000143985
HOVERGENiHBG086443

Family and domain databases

CDDicd06224 REM, 1 hit
InterProiView protein in InterPro
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR030749 RGL2
PANTHERiPTHR23113 PTHR23113, 1 hit
PTHR23113:SF213 PTHR23113:SF213, 1 hit
PfamiView protein in Pfam
PF00618 RasGEF_N, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50212 RASGEF_NTER, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AB89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPRPLRLLL DTSPPGGVVL SSFRSRDPEE GGGPGGLVVG GGQEEEEEEE
60 70 80 90 100
EEAPVSVWDE EEDGAVFTVT SRQYRPLDPL VPMPPPRSSR RLRAGTLEAL
110 120 130 140
VRHLLDTRTS GTDVSFMSAF LATHRAFTST PALLGLMADR LEALES
Length:146
Mass (Da):15,827
Last modified:February 20, 2007 - v1
Checksum:iD9DF7FAC270AB410
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O15211RGL2_HUMAN
Ral guanine nucleotide dissociation...
RGL2 RAB2L
777Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei146Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662820 Genomic DNA No translation available.
AL662827 Genomic DNA No translation available.
BX000343 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CR759817 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000412959; ENSP00000387453; ENSG00000228736
ENST00000425946; ENSP00000392918; ENSG00000237441
ENST00000431976; ENSP00000398125; ENSG00000237825
ENST00000446570; ENSP00000412625; ENSG00000224841
ENST00000455072; ENSP00000397558; ENSG00000206282
UCSCiuc063nwd.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662820 Genomic DNA No translation available.
AL662827 Genomic DNA No translation available.
BX000343 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CR759817 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA2AB89

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412959; ENSP00000387453; ENSG00000228736
ENST00000425946; ENSP00000392918; ENSG00000237441
ENST00000431976; ENSP00000398125; ENSG00000237825
ENST00000446570; ENSP00000412625; ENSG00000224841
ENST00000455072; ENSP00000397558; ENSG00000206282
UCSCiuc063nwd.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000237441.9
HGNCiHGNC:9769 RGL2
OpenTargetsiENSG00000237441
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITRE Eukaryota
ENOG4110VI4 LUCA
GeneTreeiENSGT00910000143985
HOVERGENiHBG086443

Miscellaneous databases

ChiTaRSiRGL2 human

Gene expression databases

BgeeiENSG00000237441 Expressed in 227 organ(s), highest expression level in pituitary gland
ExpressionAtlasiA2AB89 baseline and differential

Family and domain databases

CDDicd06224 REM, 1 hit
InterProiView protein in InterPro
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR030749 RGL2
PANTHERiPTHR23113 PTHR23113, 1 hit
PTHR23113:SF213 PTHR23113:SF213, 1 hit
PfamiView protein in Pfam
PF00618 RasGEF_N, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50212 RASGEF_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2AB89_HUMAN
AccessioniPrimary (citable) accession number: A2AB89
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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