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Protein
Submitted name:

Flotillin-1

Gene

FLOT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Flotillin-1Imported
Gene namesi
Name:FLOT1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137312.14
HGNCiHGNC:3757 FLOT1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137312

PTM / Processingi

Proteomic databases

MaxQBiA2AB12
PRIDEiA2AB12

Expressioni

Gene expression databases

BgeeiENSG00000137312 Expressed in 234 organ(s), highest expression level in frontal cortex
ExpressionAtlasiA2AB12 baseline and differential

Structurei

3D structure databases

SMRiA2AB12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 168PHBInterPro annotationAdd BLAST168

Phylogenomic databases

eggNOGiKOG2668 Eukaryota
COG2268 LUCA
GeneTreeiENSGT00560000077232
HOGENOMiHOG000240804
HOVERGENiHBG051628

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR027705 Flotillin_fam
PANTHERiPTHR13806 PTHR13806, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 20 potential isoforms that are computationally mapped.Show allAlign All

A2AB12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV
60 70 80 90 100
KSEKVYTRHG VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA
110 120 130 140 150
LETLEGHQRA IMAHMTVEEI YKDRQKFSEQ VFKVASSDLV NMGISVVSYT
160 170 180 190 200
LKDIHDDQDY LHSLGKARTA QVQKDARIGE AEAKRDAGIR EAKAKQEKVS
210 220 230
AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQAD
Length:235
Mass (Da):26,165
Last modified:February 20, 2007 - v1
Checksum:i35276E4B8A510B1E
GO

Computationally mapped potential isoform sequencesi

There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O75955FLOT1_HUMAN
Flotillin-1
FLOT1
427Annotation score:
A2AB09A2AB09_HUMAN
Flotillin-1
FLOT1
238Annotation score:
A0A140T9R1A0A140T9R1_HUMAN
Flotillin-1
FLOT1
357Annotation score:
A0A140T9X0A0A140T9X0_HUMAN
Flotillin-1
FLOT1
231Annotation score:
A0A140T9W4A0A140T9W4_HUMAN
Flotillin-1
FLOT1
186Annotation score:
A0A140T907A0A140T907_HUMAN
Flotillin-1
FLOT1
60Annotation score:
A2AB13A2AB13_HUMAN
Flotillin-1
FLOT1
185Annotation score:
A2AB10A2AB10_HUMAN
Flotillin-1
FLOT1
252Annotation score:
A2AB11A2AB11_HUMAN
Flotillin-1
FLOT1
192Annotation score:
A2ABJ5A2ABJ5_HUMAN
Flotillin-1
FLOT1
145Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei235Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662797 Genomic DNA No translation available.
AL662848 Genomic DNA No translation available.
AL845353 Genomic DNA No translation available.
BX248307 Genomic DNA No translation available.
CR936878 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000421565; ENSP00000390961; ENSG00000206379
ENST00000436197; ENSP00000395732; ENSG00000232280
ENST00000445383; ENSP00000403627; ENSG00000230143
ENST00000445853; ENSP00000398834; ENSG00000137312
ENST00000454773; ENSP00000413293; ENSG00000206480
UCSCiuc063muq.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662797 Genomic DNA No translation available.
AL662848 Genomic DNA No translation available.
AL845353 Genomic DNA No translation available.
BX248307 Genomic DNA No translation available.
CR936878 Genomic DNA No translation available.

3D structure databases

SMRiA2AB12
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA2AB12
PRIDEiA2AB12

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421565; ENSP00000390961; ENSG00000206379
ENST00000436197; ENSP00000395732; ENSG00000232280
ENST00000445383; ENSP00000403627; ENSG00000230143
ENST00000445853; ENSP00000398834; ENSG00000137312
ENST00000454773; ENSP00000413293; ENSG00000206480
UCSCiuc063muq.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000137312.14
HGNCiHGNC:3757 FLOT1
OpenTargetsiENSG00000137312
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2668 Eukaryota
COG2268 LUCA
GeneTreeiENSGT00560000077232
HOGENOMiHOG000240804
HOVERGENiHBG051628

Miscellaneous databases

ChiTaRSiFLOT1 human

Gene expression databases

BgeeiENSG00000137312 Expressed in 234 organ(s), highest expression level in frontal cortex
ExpressionAtlasiA2AB12 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR027705 Flotillin_fam
PANTHERiPTHR13806 PTHR13806, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2AB12_HUMAN
AccessioniPrimary (citable) accession number: A2AB12
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 10, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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