SH3 and PX domain-containing protein 2B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion."
    Hishida T., Eguchi T., Osada S., Nishizuka M., Imagawa M.
    FEBS J. 275:5576-5588(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DOMAIN.
• phosphatidylinositol-3-phosphate binding Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion."
    Hishida T., Eguchi T., Osada S., Nishizuka M., Imagawa M.
    FEBS J. 275:5576-5588(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DOMAIN.
• phosphatidylinositol-4-phosphate binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion."
    Hishida T., Eguchi T., Osada S., Nishizuka M., Imagawa M.
    FEBS J. 275:5576-5588(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DOMAIN.
• phosphatidylinositol-5-phosphate binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion."
    Hishida T., Eguchi T., Osada S., Nishizuka M., Imagawa M.
    FEBS J. 275:5576-5588(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DOMAIN.
• phosphatidylinositol binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• SH2 domain binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion."
    Hishida T., Eguchi T., Osada S., Nishizuka M., Imagawa M.
    FEBS J. 275:5576-5588(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DOMAIN.
• superoxide-generating NADPH oxidase activator activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adipose tissue development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome."
    Iqbal Z., Cejudo-Martin P., de Brouwer A., van der Zwaag B., Ruiz-Lozano P., Scimia M.C., Lindsey J.D., Weinreb R., Albrecht B., Megarbane A., Alanay Y., Ben-Neriah Z., Amenduni M., Artuso R., Veltman J.A., van Beusekom E., Oudakker A., Millan J.L.

    , Hennekam R., Hamel B., Courtneidge S.A., van Bokhoven H.
    Am. J. Hum. Genet. 86:254-261(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
• bone development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome."
    Iqbal Z., Cejudo-Martin P., de Brouwer A., van der Zwaag B., Ruiz-Lozano P., Scimia M.C., Lindsey J.D., Weinreb R., Albrecht B., Megarbane A., Alanay Y., Ben-Neriah Z., Amenduni M., Artuso R., Veltman J.A., van Beusekom E., Oudakker A., Millan J.L.

    , Hennekam R., Hamel B., Courtneidge S.A., van Bokhoven H.
    Am. J. Hum. Genet. 86:254-261(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
• cranial skeletal system development Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages."
    Dulk M., Kudlik G., Fekete A., Ernszt D., Kvell K., Pongracz J.E., Mero B.L., Szeder B., Radnai L., Geiszt M., Csecsy D.E., Kovacs T., Uher F., Lanyi A., Vas V., Buday L.
    Sci Rep 6:34280-34280(2016) [PubMed] [Europe PMC] [Abstract]
• extracellular matrix disassembly Source: MGI
• eye development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome."
    Iqbal Z., Cejudo-Martin P., de Brouwer A., van der Zwaag B., Ruiz-Lozano P., Scimia M.C., Lindsey J.D., Weinreb R., Albrecht B., Megarbane A., Alanay Y., Ben-Neriah Z., Amenduni M., Artuso R., Veltman J.A., van Beusekom E., Oudakker A., Millan J.L.

    , Hennekam R., Hamel B., Courtneidge S.A., van Bokhoven H.
    Am. J. Hum. Genet. 86:254-261(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
• heart development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome."
    Iqbal Z., Cejudo-Martin P., de Brouwer A., van der Zwaag B., Ruiz-Lozano P., Scimia M.C., Lindsey J.D., Weinreb R., Albrecht B., Megarbane A., Alanay Y., Ben-Neriah Z., Amenduni M., Artuso R., Veltman J.A., van Beusekom E., Oudakker A., Millan J.L.

    , Hennekam R., Hamel B., Courtneidge S.A., van Bokhoven H.
    Am. J. Hum. Genet. 86:254-261(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
• osteoblast fate commitment Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages."
    Dulk M., Kudlik G., Fekete A., Ernszt D., Kvell K., Pongracz J.E., Mero B.L., Szeder B., Radnai L., Geiszt M., Csecsy D.E., Kovacs T., Uher F., Lanyi A., Vas V., Buday L.
    Sci Rep 6:34280-34280(2016) [PubMed] [Europe PMC] [Abstract]
• podosome assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.8

    "The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation."
    Buschman M.D., Bromann P.A., Cejudo-Martin P., Wen F., Pass I., Courtneidge S.A.
    Mol. Biol. Cell 20:1302-1311(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION AT TYR-25, MUTAGENESIS OF TYR-25; TYR-373 AND TYR-508, SUBCELLULAR LOCATION.
• positive regulation of adipose tissue development Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages."
    Dulk M., Kudlik G., Fekete A., Ernszt D., Kvell K., Pongracz J.E., Mero B.L., Szeder B., Radnai L., Geiszt M., Csecsy D.E., Kovacs T., Uher F., Lanyi A., Vas V., Buday L.
    Sci Rep 6:34280-34280(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fat cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.1

    "A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion."
    Hishida T., Eguchi T., Osada S., Nishizuka M., Imagawa M.
    FEBS J. 275:5576-5588(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DOMAIN.
  • "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages."
    Dulk M., Kudlik G., Fekete A., Ernszt D., Kvell K., Pongracz J.E., Mero B.L., Szeder B., Radnai L., Geiszt M., Csecsy D.E., Kovacs T., Uher F., Lanyi A., Vas V., Buday L.
    Sci Rep 6:34280-34280(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages."
    Dulk M., Kudlik G., Fekete A., Ernszt D., Kvell K., Pongracz J.E., Mero B.L., Szeder B., Radnai L., Geiszt M., Csecsy D.E., Kovacs T., Uher F., Lanyi A., Vas V., Buday L.
    Sci Rep 6:34280-34280(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of multicellular organism growth Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages."
    Dulk M., Kudlik G., Fekete A., Ernszt D., Kvell K., Pongracz J.E., Mero B.L., Szeder B., Radnai L., Geiszt M., Csecsy D.E., Kovacs T., Uher F., Lanyi A., Vas V., Buday L.
    Sci Rep 6:34280-34280(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of stress fiber assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages."
    Dulk M., Kudlik G., Fekete A., Ernszt D., Kvell K., Pongracz J.E., Mero B.L., Szeder B., Radnai L., Geiszt M., Csecsy D.E., Kovacs T., Uher F., Lanyi A., Vas V., Buday L.
    Sci Rep 6:34280-34280(2016) [PubMed] [Europe PMC] [Abstract]
• protein localization to membrane Source: UniProtKB
• regulation of brood size Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages."
    Dulk M., Kudlik G., Fekete A., Ernszt D., Kvell K., Pongracz J.E., Mero B.L., Szeder B., Radnai L., Geiszt M., Csecsy D.E., Kovacs T., Uher F., Lanyi A., Vas V., Buday L.
    Sci Rep 6:34280-34280(2016) [PubMed] [Europe PMC] [Abstract]
• skeletal system development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome."
    Iqbal Z., Cejudo-Martin P., de Brouwer A., van der Zwaag B., Ruiz-Lozano P., Scimia M.C., Lindsey J.D., Weinreb R., Albrecht B., Megarbane A., Alanay Y., Ben-Neriah Z., Amenduni M., Artuso R., Veltman J.A., van Beusekom E., Oudakker A., Millan J.L.

    , Hennekam R., Hamel B., Courtneidge S.A., van Bokhoven H.
    Am. J. Hum. Genet. 86:254-261(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
• skeletal system morphogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages."
    Dulk M., Kudlik G., Fekete A., Ernszt D., Kvell K., Pongracz J.E., Mero B.L., Szeder B., Radnai L., Geiszt M., Csecsy D.E., Kovacs T., Uher F., Lanyi A., Vas V., Buday L.
    Sci Rep 6:34280-34280(2016) [PubMed] [Europe PMC] [Abstract]
• superoxide metabolic process Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• SH2 domain binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion."
    Hishida T., Eguchi T., Osada S., Nishizuka M., Imagawa M.
    FEBS J. 275:5576-5588(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DOMAIN.

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPPRRSIVEV KVLDVQKRRV PNKHYVYIIR VTWSSGATEA IYRRYSKFFD 
        60         70         80         90        100
LQMQMLDKFP MEGGQKDPKQ RIIPFLPGKI LFRRSHIRDV AVKRLIPIDE 
       110        120        130        140        150
YCKALIQLPP YISQCDEVLQ FFETRPEDLN PPKEEHIGKK KSGNDPTSVD 
       160        170        180        190        200
PMVLEQYVVV ADYQKQESSE ISLSVGQVVD IIEKNESGWW FVSTAEEQGW 
       210        220        230        240        250
VPATCLEGQD GVQDEFSLQP EEEEKYTVIY PYTARDQDEM NLERGAVVEV 
       260        270        280        290        300
VQKNLEGWWK IRYQGKEGWA PASYLKKNSG EPLPPKLGPS SPAHSGALDL 
       310        320        330        340        350
DGVSRHQNAM GREKELLNNQ RDGRFEGRLV PDGDVKQRSP KMRQRPPPRR 
       360        370        380        390        400
DMTIPRGLNL PKPPIPPQVE EEYYTIAEFQ TTIPDGISFQ AGLKVEVIEK 
       410        420        430        440        450
SLSGWWYIQM EDKEGWAPAT FIDKYKKTSS ASRPNFLAPL PHEMTQLRLG 
       460        470        480        490        500
DAAATENNTG PEAVGPSRPL PEAPHGAVDS GMLWSKDWKG GKEAPRKASS 
       510        520        530        540        550
DLSASTGYEE ISDPTQEEKP SLPPRKESII KSEEELLERE RQKMEPLRGS 
       560        570        580        590        600
SPKPPGMILP MIPAKHAPLA RDSRKPEPKL DKSKFPLRND MGLECGHKVL 
       610        620        630        640        650
AKEVKKPNLR PISRSKAELS EEKVDPTSQN LFMKSRPQVR PKPTPSPKTE 
       660        670        680        690        700
PAQSEDHVDI YNLRSKLRPA KSQEKALLDG ESHHAAGSHD TALSRSFLPG 
       710        720        730        740        750
EGPGHGQDRS GRQDGLSPKE TPCRAPPRPA KTTDPGPKNV PVPVQEATLQ 
       760        770        780        790        800
QRPVVPPRRP PPPKKTSSSP LSCRPLPEVR GAQREESRVA PAAGRALLVP 
       810        820        830        840        850
PKAKPFLSNS SVGQDDMRGK GGLGPRVTGK VGETREKAAS FLNADGPKDS 
       860        870        880        890        900
LYVAVANFEG DEDTSSFQEG TVFEVREKNS SGWWFCQVLS GAPSWEGWIP 

SNYLRKKP                                               

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot