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Entry version 109 (08 May 2019)
Sequence version 3 (10 Apr 2019)
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Protein

Obscurin

Gene

Obscn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (By similarity). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (PubMed:23392350). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 4-phosphate (PtdIns4P), phosphatidylinositol 5-phosphate (PtdIns5P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (By similarity).By similarity1 Publication
Isoform 2 and isoform 3: bind phosphatidylinositol bisphosphates (PIP2s) via their PH domains and negatively regulate the PI3K/AKT/mTOR signaling pathway, thus contributing to the regulation of cardiomyocyte size and adhesion.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei6924Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei6929Phosphatidylinositol 3,4-bisphosphateBy similarity1
Binding sitei7445ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei7535Proton acceptorBy similarity1
Binding sitei8619ATPPROSITE-ProRule annotation1
Active sitei8709Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi7422 – 7430ATPPROSITE-ProRule annotationBy similarity9
Nucleotide bindingi8596 – 8604ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Developmental protein, Kinase, Muscle protein, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation
LigandATP-binding, Lipid-binding, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Obscurin (EC:2.7.11.11 Publication)
Alternative name(s):
Obscurin-RhoGEF
Obscurin-myosin light chain kinase
Short name:
Obscurin-MLCK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ObscnImported
Synonyms:Gm878
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2681862 Obscn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002962961 – 8886ObscurinAdd BLAST8886

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 81PROSITE-ProRule annotationBy similarity
Disulfide bondi257 ↔ 309PROSITE-ProRule annotationBy similarity
Disulfide bondi352 ↔ 402PROSITE-ProRule annotationBy similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei393PhosphoserineCombined sources1
Disulfide bondi885 ↔ 935PROSITE-ProRule annotationBy similarity
Disulfide bondi977 ↔ 1027PROSITE-ProRule annotationBy similarity
Disulfide bondi1069 ↔ 1119PROSITE-ProRule annotationBy similarity
Disulfide bondi1161 ↔ 1211PROSITE-ProRule annotationBy similarity
Disulfide bondi1253 ↔ 1303PROSITE-ProRule annotationBy similarity
Disulfide bondi1345 ↔ 1395PROSITE-ProRule annotationBy similarity
Disulfide bondi1437 ↔ 1487PROSITE-ProRule annotationBy similarity
Disulfide bondi1529 ↔ 1579PROSITE-ProRule annotationBy similarity
Disulfide bondi1621 ↔ 1671PROSITE-ProRule annotationBy similarity
Disulfide bondi1713 ↔ 1763PROSITE-ProRule annotationBy similarity
Disulfide bondi1805 ↔ 1855PROSITE-ProRule annotationBy similarity
Disulfide bondi1897 ↔ 1947PROSITE-ProRule annotationBy similarity
Disulfide bondi1989 ↔ 2039PROSITE-ProRule annotationBy similarity
Disulfide bondi2081 ↔ 2131PROSITE-ProRule annotationBy similarity
Disulfide bondi2263 ↔ 2313PROSITE-ProRule annotationBy similarity
Disulfide bondi2620 ↔ 2669PROSITE-ProRule annotationBy similarity
Disulfide bondi2743 ↔ 2793PROSITE-ProRule annotationBy similarity
Disulfide bondi2922 ↔ 2972PROSITE-ProRule annotationBy similarity
Disulfide bondi3100 ↔ 3150PROSITE-ProRule annotationBy similarity
Disulfide bondi3280 ↔ 3330PROSITE-ProRule annotationBy similarity
Modified residuei3321PhosphoserineCombined sources1
Disulfide bondi3369 ↔ 3419PROSITE-ProRule annotationBy similarity
Disulfide bondi3549 ↔ 3599PROSITE-ProRule annotationBy similarity
Disulfide bondi3638 ↔ 3688PROSITE-ProRule annotationBy similarity
Modified residuei3802PhosphoserineCombined sources1
Disulfide bondi3815 ↔ 3864PROSITE-ProRule annotationBy similarity
Disulfide bondi3903 ↔ 3952PROSITE-ProRule annotationBy similarity
Disulfide bondi4064 ↔ 4113PROSITE-ProRule annotationBy similarity
Disulfide bondi4152 ↔ 4201PROSITE-ProRule annotationBy similarity
Disulfide bondi4240 ↔ 4289PROSITE-ProRule annotationBy similarity
Disulfide bondi4328 ↔ 4377PROSITE-ProRule annotationBy similarity
Disulfide bondi4416 ↔ 4465PROSITE-ProRule annotationBy similarity
Disulfide bondi4504 ↔ 4553PROSITE-ProRule annotationBy similarity
Disulfide bondi4592 ↔ 4641PROSITE-ProRule annotationBy similarity
Disulfide bondi4680 ↔ 4729PROSITE-ProRule annotationBy similarity
Disulfide bondi4768 ↔ 4817PROSITE-ProRule annotationBy similarity
Disulfide bondi4856 ↔ 4906PROSITE-ProRule annotationBy similarity
Disulfide bondi4945 ↔ 4995PROSITE-ProRule annotationBy similarity
Modified residuei4960PhosphoserineCombined sources1
Disulfide bondi5034 ↔ 5086PROSITE-ProRule annotationBy similarity
Disulfide bondi5590 ↔ 5643PROSITE-ProRule annotationBy similarity
Modified residuei5699PhosphoserineCombined sources1
Modified residuei5703PhosphothreonineCombined sources1
Modified residuei5706PhosphoserineCombined sources1
Modified residuei5737PhosphothreonineCombined sources1
Modified residuei5754PhosphoserineCombined sources1
Disulfide bondi5868 ↔ 5920PROSITE-ProRule annotationBy similarity
Disulfide bondi6098 ↔ 6150PROSITE-ProRule annotationBy similarity
Modified residuei6512PhosphoserineCombined sources1
Modified residuei6518PhosphothreonineCombined sources1
Modified residuei6520PhosphoserineCombined sources1
Modified residuei6522PhosphoserineCombined sources1
Disulfide bondi6984 ↔ 7036PROSITE-ProRule annotationBy similarity
Disulfide bondi7078 ↔ 7131PROSITE-ProRule annotationBy similarity
Modified residuei7779PhosphoserineBy similarity1
Modified residuei8161PhosphoserineBy similarity1
Disulfide bondi8401 ↔ 8453PROSITE-ProRule annotationBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated by protein kinase domain 1 and 2.1 Publication
Two small isoforms, one probably containing protein kinase domain 2 and a partial protein kinase domain 1 and one containing only protein kinase domain 2, are glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AAJ9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AAJ9

PeptideAtlas

More...
PeptideAtlasi
A2AAJ9

PRoteomics IDEntifications database

More...
PRIDEi
A2AAJ9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AAJ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AAJ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscles including flexor digitorum brevis (FDB), soleus and tibialis anterior muscles, and to a lesser extent in heart muscles (at protein level) (PubMed:23392350). Isoform 2 and isoform 3 are expressed in the myocardium (at protein level) (PubMed:28826662).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 2 and isoform 3 are expressed during late embryogenesis and throughout postnatal development in the myocardium (at protein level) (PubMed:28826662). Isoform 3 is the predominant form in mid-embryogenesis (E11), and moderately decreases postnatally and in adulthood (at protein level) (PubMed:28826662). Isoform 2 increases significantly as development progresses (at protein evel) (PubMed:28826662).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via protein kinase domain 1) with CDH2 and (via protein kinase domain 1) with ATP1B1 (PubMed:23392350). Isoform 2 is found in a complex with DSG2, DESM, GJA1, CDH2 and VCL (PubMed:28826662). Isoform 3 is found in a complex with DSG2, DESM, GJA1, CDH2, ANK3 and VCL (PubMed:28826662).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A2AAJ9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000038264

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AAJ9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 99Ig-like 1Sequence analysisAdd BLAST91
Domaini109 – 201Ig-like 2Sequence analysisAdd BLAST93
Domaini234 – 320Ig-like 3Sequence analysisAdd BLAST87
Domaini329 – 415Ig-like 4Sequence analysisAdd BLAST87
Domaini513 – 610Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini702 – 793Ig-like 5Sequence analysisAdd BLAST92
Domaini859 – 951Ig-like 6Sequence analysisAdd BLAST93
Domaini951 – 1043Ig-like 7Sequence analysisAdd BLAST93
Domaini1043 – 1135Ig-like 8Sequence analysisAdd BLAST93
Domaini1135 – 1227Ig-like 9Sequence analysisAdd BLAST93
Domaini1227 – 1319Ig-like 10Sequence analysisAdd BLAST93
Domaini1319 – 1407Ig-like 11Sequence analysisAdd BLAST89
Domaini1411 – 1503Ig-like 12Sequence analysisAdd BLAST93
Domaini1503 – 1595Ig-like 13Sequence analysisAdd BLAST93
Domaini1595 – 1687Ig-like 14Sequence analysisAdd BLAST93
Domaini1687 – 1779Ig-like 15Sequence analysisAdd BLAST93
Domaini1779 – 1871Ig-like 16Sequence analysisAdd BLAST93
Domaini1871 – 1963Ig-like 17Sequence analysisAdd BLAST93
Domaini1963 – 2051Ig-like 18Sequence analysisAdd BLAST89
Domaini2055 – 2147Ig-like 19Sequence analysisAdd BLAST93
Domaini2152 – 2241Ig-like 20Sequence analysisAdd BLAST90
Domaini2242 – 2325Ig-like 21Sequence analysisAdd BLAST84
Domaini2329 – 2415Ig-like 22Sequence analysisAdd BLAST87
Domaini2420 – 2504Ig-like 23Sequence analysisAdd BLAST85
Domaini2598 – 2681Ig-like 24Sequence analysisAdd BLAST84
Domaini2721 – 2812Ig-like 25Sequence analysisAdd BLAST92
Domaini2900 – 2984Ig-like 26Sequence analysisAdd BLAST85
Domaini3078 – 3162Ig-like 27Sequence analysisAdd BLAST85
Domaini3258 – 3342Ig-like 28Sequence analysisAdd BLAST85
Domaini3348 – 3431Ig-like 29Sequence analysisAdd BLAST84
Domaini3527 – 3610Ig-like 30Sequence analysisAdd BLAST84
Domaini3616 – 3700Ig-like 31Sequence analysisAdd BLAST85
Domaini3785 – 3876Ig-like 32Sequence analysisAdd BLAST92
Domaini3881 – 3964Ig-like 33Sequence analysisAdd BLAST84
Domaini4042 – 4125Ig-like 34Sequence analysisAdd BLAST84
Domaini4130 – 4213Ig-like 35Sequence analysisAdd BLAST84
Domaini4219 – 4301Ig-like 36Sequence analysisAdd BLAST83
Domaini4307 – 4389Ig-like 37Sequence analysisAdd BLAST83
Domaini4395 – 4477Ig-like 38Sequence analysisAdd BLAST83
Domaini4483 – 4565Ig-like 39Sequence analysisAdd BLAST83
Domaini4571 – 4653Ig-like 40Sequence analysisAdd BLAST83
Domaini4659 – 4741Ig-like 41Sequence analysisAdd BLAST83
Domaini4746 – 4829Ig-like 42Sequence analysisAdd BLAST84
Domaini4833 – 4916Ig-like 43Sequence analysisAdd BLAST84
Domaini4923 – 5007Ig-like 44Sequence analysisAdd BLAST85
Domaini5013 – 5105Ig-like 45Sequence analysisAdd BLAST93
Domaini5378 – 5464Ig-like 46Sequence analysisAdd BLAST87
Domaini5471 – 5569Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini5557 – 5659Ig-like 47Sequence analysisAdd BLAST103
Domaini5821 – 5850IQPROSITE-ProRule annotationAdd BLAST30
Domaini5847 – 5930Ig-like 48Sequence analysisAdd BLAST84
Domaini6077 – 6166Ig-like 49Sequence analysisAdd BLAST90
Domaini6209 – 6298Ig-like 50Sequence analysisAdd BLAST90
Domaini6320 – 6416Ig-like 51Sequence analysisAdd BLAST97
Domaini6549 – 6616SH3PROSITE-ProRule annotationAdd BLAST68
Domaini6642 – 6826DHPROSITE-ProRule annotationAdd BLAST185
Domaini6844 – 6953PHPROSITE-ProRule annotationAdd BLAST110
Domaini6963 – 7046Ig-like 52Sequence analysisAdd BLAST84
Domaini7057 – 7147Ig-like 53Sequence analysisAdd BLAST91
Domaini7306 – 7394Ig-like 54Sequence analysisAdd BLAST89
Domaini7416 – 7669Protein kinase 1PROSITE-ProRule annotationAdd BLAST254
Domaini8380 – 8464Ig-like 55Sequence analysisAdd BLAST85
Domaini8474 – 8566Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST93
Domaini8590 – 8842Protein kinase 2PROSITE-ProRule annotationAdd BLAST253

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115256

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2AAJ9

Database for complete collections of gene phylogenies

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PhylomeDBi
A2AAJ9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 3 hits
cd00160 RhoGEF, 1 hit
cd12025 SH3_Obscurin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 70 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000048 IQ_motif_EF-hand-BS
IPR011009 Kinase-like_dom_sf
IPR035526 Obscurin_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS

Pfam protein domain database

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Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 60 hits
PF00612 IQ, 1 hit
PF00069 Pkinase, 2 hits
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 64 hits
SM00408 IGc2, 58 hits
SM00406 IGv, 13 hits
SM00015 IQ, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00220 S_TKc, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 66 hits
SSF49265 SSF49265, 3 hits
SSF50044 SSF50044, 1 hit
SSF56112 SSF56112, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 56 hits
PS50096 IQ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Two additional small isoforms seem to exist.1 Publication

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AAJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MDHSFSGAPR FLTRPKAFVV SVGKDATLSC QIVGNPTPHV SWEKDRQPVE
60 70 80 90 100
AGARFRLAQD GDVYRLTILD LALGDSGQYV CRARNAIGEA FAAVGLRVDS
110 120 130 140 150
EGTCAEQAPH FLLRPTSIRV REGADATFRC RVGGSPQPAV SWSKDGRRLG
160 170 180 190 200
PPDAPHVRVE EHGESSALRI RSARPRDGGT YEVRAENPLG SASAAAALVV
210 220 230 240 250
DSDAEVAGPP GTSTATLLAH LQQRREAMRA EGIPPSPPGA GTRTCTVTEG
260 270 280 290 300
KHARLSCFVT GEPKPETVWK KDGQLVTEGR RHVVYEDEQE NFVLKILFCK
310 320 330 340 350
QSDRGLYTCT ASNLVGQTYS SVLVVVREPT VPFKKRLQDL EVREKESATF
360 370 380 390 400
QCEVAQPATE AAWFKEETRL WASAKYDIEE EGTERRLTVR NVSADDDAVY
410 420 430 440 450
ICETTEGSRT VAELSVQGNL TRKLPRKTAV RTGDTAIFWV ELAVPEGPVR
460 470 480 490 500
WLRNQEEMVA GGRVAITAEG TCHTLTIFQC TLEDMGEVAF VSGGCRTTTQ
510 520 530 540 550
FCVSAPRRPP LYPPADPVVK AKTESSVTLS WSAPPHGDRP VTIDGYVLEK
560 570 580 590 600
RKLGAYAWSR CHEAGWLATT EFTITGVAEE GDFQFRVSAI NHFGQGPYLE
610 620 630 640 650
FPGTMHLVPM LAVKTPLKAV EAVEGGEVTF SVDLTVASSG EWFLDGEALK
660 670 680 690 700
ASSIYVIRCD RTRHMLTIRE VPARLHGAQL KFVANGIETS IQMVVRAALG
710 720 730 740 750
LPSSKLPAAA AREVLAQLHE EAQLLAELSD QAAAVTWLKD GRELSLGPKY
760 770 780 790 800
EMQVSAGRRA LLVRDVAQDD AGLYECVSRG SRTAYQLLVQ DITDGYRDWG
810 820 830 840 850
PAGPQKHMCK CAGAKIARYL GSSCYRFLQY DKGVWHWLEA ALDTRQGKGT
860 870 880 890 900
SSCSLHEKPK LVFAKGQQAH SEVKAEAGNS ATLSCEVTQA QTEVTWFKDG
910 920 930 940 950
KKLSSSSKVR MEASGCSRRL VVQQAGKADA GEYSCEAGGQ KLSFRLDVAE
960 970 980 990 1000
PKLVFAKGQQ AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK
1010 1020 1030 1040 1050
VRMEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV AEPKMVFAKE
1060 1070 1080 1090 1100
QQARSEVKAE AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRMEASGC
1110 1120 1130 1140 1150
SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVTEPKLVFA KEQQARSEVK
1160 1170 1180 1190 1200
AEVGNSATLS CEVAQAQTEV TWFKDGKKLS SSSKVRMEAS GCSRRLVVQQ
1210 1220 1230 1240 1250
AGKADAGEYS CEAGGQKLSF RLDVAEPKLV FAKEQQARSE VKAEAGNSAT
1260 1270 1280 1290 1300
LSCEVAQAQT EVTWFKDGKK LSSSSKVRME ASGCSRRLVV QQAGKADAGE
1310 1320 1330 1340 1350
YSCEAGGQKL SFHLDVTEPK LVFAKEQQAH SEVKAEAGAS ATLSCEVAQA
1360 1370 1380 1390 1400
QTEVTWFKDG KKLSSSSKVR MEASGCSRRL VVQQAGKADA GEYSCEAEGQ
1410 1420 1430 1440 1450
KLSFRLDVAE PKLVFAKEQQ ARSEVKAEAG ASATLSCEVA QAQTEVTWFK
1460 1470 1480 1490 1500
DGKKLSSSSK VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV
1510 1520 1530 1540 1550
AEPKLVFAKE QQANSEVKAE AGASATLSCE VAQAQTEVTW FKDGKKLSSS
1560 1570 1580 1590 1600
SKVRVEASGC SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVAEPKLAFA
1610 1620 1630 1640 1650
KEQQAHSEVK AEAGASATLS CEVAQAQTEV TWFKDGKKLS SSSKVRVEAS
1660 1670 1680 1690 1700
GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF RLDVAEPKLA FAKEQQAHSE
1710 1720 1730 1740 1750
VKAEAGASAT LSCEVAQAQT EVTWFKDGKK LSSSSKVRVE ASGCSRRLVV
1760 1770 1780 1790 1800
QQAGKADAGE YSCEAGGQKL SFRLDVAEPK LAFAKEQQAH SEVKAEAGAS
1810 1820 1830 1840 1850
ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR VEASGCSRRL VVQQAGKADA
1860 1870 1880 1890 1900
GEYSCEAGGQ KLFFRLDVAE PKLMFAKEQQ AHSEVKAEAG ASATLSCEVA
1910 1920 1930 1940 1950
QAQTEVTWFK DGKKLSSSSK VRVEASGCSR RLVVQQAGKA DAGEYSCEAG
1960 1970 1980 1990 2000
GQKLSFRLDV AEPKLVFAKE QQAHSEVKAE AGASATLSCE VAQAQTEVTW
2010 2020 2030 2040 2050
FKDGKKLSSS SKVRVEASGC SRRLVVQQVG KADAGEYSCE ARGQKLSFRL
2060 2070 2080 2090 2100
DVADTRLMFA KEQQARTEVK AEAGNSATLS CEVAQAQTEV TWFKDGKKLS
2110 2120 2130 2140 2150
SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF RLDVAEAESQ
2160 2170 2180 2190 2200
IPERPSRREP LVVKEHETII LTATIAAPSV AAVTWLKDGV EIRRSKRHEA
2210 2220 2230 2240 2250
TSLGDTHTLT VRGAQVLDSA IYSCRVGKEG QDFPVQVEEV AAKFSKPLEP
2260 2270 2280 2290 2300
VEGELGGTVM LVCELSPEQA EVVWRCGNTQ LRPGKRFQMT SEGPRRTLTV
2310 2320 2330 2340 2350
SGLREDDAEE YVCESRDDRT SARLTVKVPR VVKFTSGLSA MVAEEGQEAT
2360 2370 2380 2390 2400
FQCVVSPSDA GVTWYKDGMQ LQPSEKFVMV ESGASRSLTI LGLTLEDAGQ
2410 2420 2430 2440 2450
VTVEAEGASS SAALRVREAP VLFKKKLEPQ TVEERTSVTL EVELTRPWPE
2460 2470 2480 2490 2500
VKWTRNAAVL TPSENVEIRA EGARHCLVLR SVGFADRGFF GCETPDDKTQ
2510 2520 2530 2540 2550
AKLNVEMRQV RLVRGLQEVE AKEQGTASMD VELSHAEVEG SWTRDGLRLQ
2560 2570 2580 2590 2600
PGPKCHLAVQ GPVHILTLSA LQPQDSGLVA FRAEGVHTSA RLIVTELPVS
2610 2620 2630 2640 2650
FTRVLQDVVA TQKEKVTLEC ELSRPVDVRW LKDGVELRAG KAIGIVAQGT
2660 2670 2680 2690 2700
CRSLVIYRCE TGDQGVYVCD ALDAQTSASL RVQGRTYTLI FRRVLAEDAG
2710 2720 2730 2740 2750
EVKFVAENAE SRAHLRVKEL PVTLLRPLRD KIAMEKHRGV LECQVSRASA
2760 2770 2780 2790 2800
QVRWFKGGVE LQSGPKYEVV SDGLYRKLVI NDVQPEDEDT YTCDAGNVKT
2810 2820 2830 2840 2850
SAQFFVEEQS ITIVRGLKDM TVMEPAPAWF ECETSIPSVR PPKWLLGKTV
2860 2870 2880 2890 2900
LQAGGNVGLE QDGTVHRLTL HKTCSTMTGP VHFTIGKSRS SAQLVVSDIP
2910 2920 2930 2940 2950
VVLTRPLEPK AGRELQSVVL SCDFRPAPKA VQWYKDDTPL SPSEKFKMAL
2960 2970 2980 2990 3000
EGQMAELRIL RLTPADAGVY RCQAGSAQSS AEVTVEAREV TVIQPLQDAE
3010 3020 3030 3040 3050
AMEEGRVCFS CELSHKDEDI EWSLNGTPLY NDSFHEISHE GCLHTLVLKS
3060 3070 3080 3090 3100
VRQADTGTVC ATSPKVSVSA RLVVKGKPVV FLKALDDVSA EERGTLTLQC
3110 3120 3130 3140 3150
EVSDPEARVV WRKDGVELGP SDKYDFLHKA GARGLTVHDL SHEDAGLYTC
3160 3170 3180 3190 3200
QVGSKETQSK VSVHDLHVGI TKRLKTVEVL EGESCSFECV LSHESPSDPA
3210 3220 3230 3240 3250
VWTVGGKTVG GSGHFHAVRQ GRKYTLTVKD AALSDAGEVV FSVLGLTSKA
3260 3270 3280 3290 3300
SLIIRERPVD ITKPLEDQRT TLGEDVMLSC ELSRAGTSVR WLKDGKAIRK
3310 3320 3330 3340 3350
SQKYDLLSEG TRAVLVVRKA SLKDSGEYTC ETEASKSTAK LCVEEKANRF
3360 3370 3380 3390 3400
TEELADLQVE EKGRAVFTCK TEHPASVVTW RKGLLELRAS GKHVPSQEGL
3410 3420 3430 3440 3450
TLKLTINALE RTDSDTYTCD IGQARTQARL LVHGQKVRVI EDLEDTAVQE
3460 3470 3480 3490 3500
GSSAKFCCRI APADYGPVHW FLDKTPLHSN ELNEITVQPG GYHVLTLRQL
3510 3520 3530 3540 3550
ALKDSGTVYF EAGDQRTSAA LRVTEKPSIF SRPLTDVTVT EGEDLTLVCE
3560 3570 3580 3590 3600
TTTVDSSVRW TKDGKTLRPS ARCQLSHEGC QAQLLITATT PQDGGRYKCE
3610 3620 3630 3640 3650
IGGASSSSIV RVHALPVRFR ESLKDVEVPE GKAATLRCVL SSVAAPVEWR
3660 3670 3680 3690 3700
HGDDVLKSSN KYSLRQEGAV LELVIRDLQP QDSGQYSCSF GDQTTSATLT
3710 3720 3730 3740 3750
VKTSSAQFVG KLRNKEATEG TTVTLRCELT KEAPVEWKKG TETLRNGDKY
3760 3770 3780 3790 3800
SLKQDGAVCE LQICSLLVAD AGEYSCVCGQ EKTSATLTVK ALLVHFVRRL
3810 3820 3830 3840 3850
RSKEATEGDT TTLQCELSKA APVEWRKGTE TLRDGDRYSL KQDGAVCELQ
3860 3870 3880 3890 3900
IRSLTIADAG EYLCTCGQEK TSATLTVRAL PAKFKDSLKN EEATEGTTAT
3910 3920 3930 3940 3950
LSCELSKAAP VTWKKGPKTL QSGDKYVLRQ DGAVCGLQIH GLTMADAGEY
3960 3970 3980 3990 4000
SCVCGQEKTS ATLTVRGLPA KFIEDLRSQE ATEGATAILR CELSKAAPVE
4010 4020 4030 4040 4050
WRKGSETLKD GDRYTLRQDG AVCELQIRGL AVVDTGTYSS LPTKFTEGLR
4060 4070 4080 4090 4100
NEEATEGTMA TLRCQMSKAA PVEWRKGSET LRDGDRYSLR QDGAMCELQI
4110 4120 4130 4140 4150
RGLTIEDSGE YTCVCGQEKT SATLSVKALP SRFIEDLRSQ EATEGTMATL
4160 4170 4180 4190 4200
RCQMSKTAPV EWKKGSETLR DGGRYSLRQD GPVCELQICD LAVEDAGEYS
4210 4220 4230 4240 4250
CVCGQEKTSA TLSIKALPPR FIEDLRSQEA TEGTMATLRC QMSKAAPVEW
4260 4270 4280 4290 4300
RKGSETLGDG GRYSLRQNGA VCELQIHDLA VEDTGEYSCV CGQEKTSATL
4310 4320 4330 4340 4350
NVKALPPRFI EDLRSQEATE GTMATLRCQM SKAAPVEWRK GSETLRDGGR
4360 4370 4380 4390 4400
YSLRQDGAVC ELQIHDLDVE DAGQYSCVCG QEKTSAVLTV DALPPKFTEG
4410 4420 4430 4440 4450
LKKEEATEGT MVTLRCQMSK EATVEWRKGA KTLSDGGRYS LRQDGAMCEL
4460 4470 4480 4490 4500
QICGLAVEDA GEYSCVCGQE KTSATLSVKA LPPRFIEDLR SQEATEGTMA
4510 4520 4530 4540 4550
TLRCQMSKAA PVEWRKGSET LRDGDRYSLR QDGAVCELQI RDLAVEDAGE
4560 4570 4580 4590 4600
YLCVCGQEKT SATLSVKALP PRFIEDLRSQ EATEGTMATL RCQMSKAAPV
4610 4620 4630 4640 4650
EWRKGSKTLR DGDRYSLRQD GAMCELQICD LAVEDTGDYS CVCGQEKTSA
4660 4670 4680 4690 4700
TLSVKALPPR FIEDLRSQEA REGTVATLRC RMSKAAPVEW RKGSETLKDG
4710 4720 4730 4740 4750
DRYSLRQEGN LCELQIRDLA VEDTEEYSCV CGQEKTSATL SVKALPAKFI
4760 4770 4780 4790 4800
EDLRSQEAPE SSTVTLRCKL SKKASVVWKK GSETLRNGAR YSLRQDGAVC
4810 4820 4830 4840 4850
ELEIRDLTVE DTGEYSCTCG QERTSATLSI MAPQVVFQQP LQNLQAEEGS
4860 4870 4880 4890 4900
MASLRCELSV PNAAMVWSKG GLELQGDTRR EARQQGCVAE LLLRDLRRED
4910 4920 4930 4940 4950
AGEYSCTCGS QTTSATLMVT AAPVRFLREL QAQDVDEGAT ARLRCELSRE
4960 4970 4980 4990 5000
AVSVEWRKGS LQLFPCAKYQ MVQEGTTAEL LVHGVEQEDA GEYTCDAGHT
5010 5020 5030 5040 5050
QSIARLSVRA PKPKFKTDLQ STEQEAGGTA RLCCQLSEAE PGTPVQWLKE
5060 5070 5080 5090 5100
GVELHVGSKY EMRRQGAVCE LLIHGLEAKD TGEYACLVGG QKTLASLRVK
5110 5120 5130 5140 5150
EPEVTIVRGL VDMEVQADED VEFTCKVSQA GATDVQWHLQ GLPLQSNEVT
5160 5170 5180 5190 5200
EVAVLADGCT HVLQLKGVTL EDAGTVSFHV GGLSSSAQLT VRVPEVTVLE
5210 5220 5230 5240 5250
PLKDVQLSEG QDAHFRCRLS RASGQEARWA LGGVPLQCNE MNDITVEQGT
5260 5270 5280 5290 5300
LYLLTLHKVT LEDAGTITLQ VGSCSSEAQL KVTAKNTVLR GLENVDALEG
5310 5320 5330 5340 5350
GEALFECQLS QPEVAAHTWL LDDEPVHTSE KVEVVYFENG LRHLLLLKNL
5360 5370 5380 5390 5400
KPQDSCRVTF LAGDVVTSAF LTVRGWRLEV LEPPHDASVK AGMQVRFTCI
5410 5420 5430 5440 5450
LSEAVPVGEA TWYINGAAIQ PDDTDWTVTT DGSHHALTLS NAQPQHAGEV
5460 5470 5480 5490 5500
TFAARDAVAS ARLSVLALPD PPEDAEVVGR SDHSVTLSWV APMSDGGGGL
5510 5520 5530 5540 5550
CGYRVEMKEA STGQWQLCHD LVPGPECVVD DLVPGKTYRF RVAAVGPAGA
5560 5570 5580 5590 5600
GEPVHLPQMV KIAPAPAPAP APAPAPAPET RQAVVGEDIC LELEVAADGG
5610 5620 5630 5640 5650
EVVWHKGTER IQPGGHFEVL SRGQRQMLVI KGFRTEDQGE YRCGPIQGLP
5660 5670 5680 5690 5700
SSGAATFNVV MTSGSGDEVP AQPSLPPEAA QEGDLHLLWE ALARKRRMSR
5710 5720 5730 5740 5750
EPTLDSISEL PEEDSRVQHL RQEAEETAPD LSEGYSTADE LARTGEADLS
5760 5770 5780 5790 5800
HTSSDDESRA GTPSLVTYLK KAGGPGISPL ASKHEAQVTT SVKPQKQQEP
5810 5820 5830 5840 5850
VVPTCPPPGD LSAADLMDPS LDKAAVKIQA AFKGYKVRKE MKQQEGPVFS
5860 5870 5880 5890 5900
RTFGDTEAQV GDVLRLECVL ATKTDMRACW LKDGIELTDG RHYHIDQLKD
5910 5920 5930 5940 5950
GTCSLLVTGL APTDSGRYTC QVSTKSGRVS HSACVVVSGT ESEAESSSGG
5960 5970 5980 5990 6000
ELDDAFRRAA RRLHRLFRTK SPAELSEEEL FLSADEGPGE PEEPADWQTY
6010 6020 6030 6040 6050
REDENFVCIR FESLAEARQA VTCFRNMFAT MGIGVEISLG EQGPRGVEMR
6060 6070 6080 6090 6100
IGKVAPTVTP AVPLAKTPGL QTSDAAPVFL TELQNQDVQD GYPMSFDCVV
6110 6120 6130 6140 6150
TGQPVPSVRW FKDGKLLEED DHYMINEDQQ GGHQLIITAV VPADMGVYRC
6160 6170 6180 6190 6200
LAENSMGVSS TKAELRVELT STDYDTAADA TETSSYFSAQ GYLSSREQEG
6210 6220 6230 6240 6250
TESDEGQLPQ VLEELKDLQV APGTRLAKFQ LKVKGYPAPK LYWFKDGQPL
6260 6270 6280 6290 6300
TTSDHIRMTD KKTLHTLEIV SVTREDSGQY AAYISNAVGA AYSSARLLVR
6310 6320 6330 6340 6350
GPSEPEEKPA SDVHERLVPP RILEKFTPKK VKRGSSITFS VKVEGHPAPS
6360 6370 6380 6390 6400
VHWLKEEAEK GVLWIGPDTP GYTMASSSKQ HSLVLLDVGR QHQGTYTCIA
6410 6420 6430 6440 6450
TNPAGQALCS ASLHISGLAK EEEQERVKEA LISSFLQGTS QAVSAQMSES
6460 6470 6480 6490 6500
AGFADLVGQS KGESLVAEEA HSHLSLAEVG TEEFLQKLTS QITEMVSAKI
6510 6520 6530 6540 6550
SQAKLQVPGG DSDEETKTPS ASPRHGRSRP SSSVQESSSE SEDGDSRGEI
6560 6570 6580 6590 6600
FDIYVVTADY LPLGAEQDAI ILREGQYVEV LDSAHPLRWL VRTKPTKSSP
6610 6620 6630 6640 6650
SRQGWVSPAY LDKRLKLSPE WGPTEAPEFP GEAVSEDEYR TRLSSVIQEL
6660 6670 6680 6690 6700
LSSEQAFVGE LQFLESHHMK HLERSPRVPA AVASQKTVIF RNVQDISHFH
6710 6720 6730 6740 6750
SSFLKELQGC GTDDDVAMCF IKNQEAFEKY LEFLVGRVQA ESVVVSTPVQ
6760 6770 6780 6790 6800
EFYKKYAEET LSAKDPTQPP PPPLQHYLEQ PVERVQKYQA LLKELIRNKA
6810 6820 6830 6840 6850
RNRQNCALLE QAYAVVSALP QRAENKLHVS LMENYPGTLE ALGEPIRQGH
6860 6870 6880 6890 6900
FIVWEGAPGA RMPWKGHNRH VFLFRNYLVI CKPRRDSRTD TFSYVFRNMM
6910 6920 6930 6940 6950
KLSSIDLNDQ VEGDDRAFEV WHEREDSVRK YLLQARTVII KNSWVKEICG
6960 6970 6980 6990 7000
IQQRLAQPVW RPPEFEEELA DCTAELGETV KLACRVTGTP KPIVSWYKDG
7010 7020 7030 7040 7050
KPVEVDPHHI LIEDPDGSCT LILDNLTGID SGQYMCFAAS AAGNASTLGK
7060 7070 7080 7090 7100
ILVQVPPRFV NKVRATPFVE GEDAQITCTV EGAPYPQIRW YKDGTLLAPG
7110 7120 7130 7140 7150
NRYRMLNEPR SGVLVLVIQA ASKEDLGHYE CELVNRLGST RGGGELYMQS
7160 7170 7180 7190 7200
PALRARDQHH REQIVAAVED TSVEGSAHSA QDGADQQAAS VLWRLLGSEA
7210 7220 7230 7240 7250
LGPSPGDLPN TRQSEPPAFE EAASQIPGAA SGTPEVSQPG THKGLEQETT
7260 7270 7280 7290 7300
SSGSQGWTVP IRVEGTAWPG AGTGQLLLDV HSQVIMETTQ RTYVCQAPDT
7310 7320 7330 7340 7350
GVTRAPSMQV TIEDVQVQVG DMAQFDAVIE GHPPPIVTWY KGSTQLTSSA
7360 7370 7380 7390 7400
RLSQRQDGTT YSLVLTDVAP HDAGVYTCVA NNAGGQVLCK AELLVHGGDK
7410 7420 7430 7440 7450
LDAENQVYRR KLHSFYDVQE EIGRGVFGFV KRVQHKGNKM FCAAKFIPLR
7460 7470 7480 7490 7500
SKTRAQAYQE RDILATLGHP LVTGLLDQFE TRKTLILILE LCSSEELLDR
7510 7520 7530 7540 7550
LFKKGVVTEA EVKVYIQQLV EGLHYLHSHG ILHLDIKPPN ILMVHPARED
7560 7570 7580 7590 7600
IKICDFGFAQ KITPSEPQYS KYGSPEFVSP EIIEQNPVSE GSDIWAMGVI
7610 7620 7630 7640 7650
SYLSLTCSSP FAGESDRATL LNVLEGRVSW SSPTAAHLSE DAKDFIKATL
7660 7670 7680 7690 7700
QRTPRARPST SQCLAHPWFL KSMPAEEAHF INTKQLKFLL ARSRWQRSLM
7710 7720 7730 7740 7750
SYKSILVMRS IPELLQGPPD SPSLGVARHL RGEASGASSS SSSSDNELAP
7760 7770 7780 7790 7800
FARAKSLPPS PVTHSPLLHP RGFLRPSASL PEETEASMPT ADAAVPASPQ
7810 7820 7830 7840 7850
SAGPPASPGC VPRHSVISSL FYQQAGEGAE RGNKTSGAKR HPARRRHLLK
7860 7870 7880 7890 7900
GGYIARALPG LREPLMEYSL LEEEAAREEQ ASLMTKTPSF ETALRLPSSS
7910 7920 7930 7940 7950
VREVPGRSHS LDNPPVTTGP SPEACKEQLL FPPSTGLTHE TTAKDRGHKE
7960 7970 7980 7990 8000
GFLQESVPFP PMSGDSRPGK QEGSSQDSCR GKPASSCHSE LGSGSQEGCG
8010 8020 8030 8040 8050
PPSSQSLGSL PPQSLKKELS TSCGPLFSEQ PQAAPFPTQV SPLLGSEKEP
8060 8070 8080 8090 8100
QDGSLSEGPV PVPSSSPGSA SQVDASLDTE GLSEAGDTCD FTPPPQRPQE
8110 8120 8130 8140 8150
QATTRKFSLE SRGGYAGVAG YGTFAFGGDA GGMLGQGPLW ARMAWAVSQS
8160 8170 8180 8190 8200
SEEQDEAATE SPQPLESLGP IAEASGVPLR TSPSLTPWEE VEQVSLVQIR
8210 8220 8230 8240 8250
DLSGDAEAAD TISLDISEVD PAYLNLSDLY DIKYLPFEFM IFRRVPKPIE
8260 8270 8280 8290 8300
QPESPGSETE AGQGLADFLE EAAWPWPGEL GLRAGLEITE EPEEPGDLEA
8310 8320 8330 8340 8350
LLGEAAVGRK RKWSPSRGLF QFPGRCLSGE EPVELGLRQR VKASMAHISR
8360 8370 8380 8390 8400
ILKGRPEGPE REGPPRKKAG LASFRLSGLK GRDQELSDEA VVLGQSVTLA
8410 8420 8430 8440 8450
CQVLAQPTAQ ATWSKDGVLL ESSGHLLISS TLKNFQLLTI LVVKEEDLGT
8460 8470 8480 8490 8500
YTCCVSNPLG TAVTTGVLRK AERPSSSPRP EVGELYKDAV LLVWKPVESC
8510 8520 8530 8540 8550
GPVTYIVQCC IEGGSWTTLA SDISDCCYLT GKLSRGGMYI FRTACVSKAG
8560 8570 8580 8590 8600
MGPYSSPSEQ VLLGGPNHLA SEEESSRGRP AQLLPSTKTF AFQMQIRRGR
8610 8620 8630 8640 8650
FSVVRQCREK ASGRALAAKI VPYQPEDKTA VLREYEALKR LHHPHLAQLH
8660 8670 8680 8690 8700
AAYLSPRHLV LILELCSGPE LLPSLAERES YSESDVKDYL WQMLSATQYL
8710 8720 8730 8740 8750
HAQHILHLDL RSENMMVTEY NLLKVIDLGN AQSLDQEKVP APENFKDYLE
8760 8770 8780 8790 8800
TMAPELLEGQ GAVPQTDIWA IGVTAFIMLS GEYPESSEGT RDLQKGLRKG
8810 8820 8830 8840 8850
LIRLSRCYAG LSGGAVAFLQ SSLCAQPWGR PCASTCLQCG WLTEEGPTGS
8860 8870 8880
RPTPVTFPTV RLRAFVRERE KRRALLYKKH NLAQVR
Length:8,886
Mass (Da):966,591
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AF41AB644D02324
GO
Isoform 21 Publication (identifier: A2AAJ9-2) [UniParc]FASTAAdd to basket
Also known as: obsc-401 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-6831: Missing.
     7170-7176: DTSVEGS → ERRPSPP
     7177-8886: Missing.

Note: Lacks the kinase domain. No experimental confirmation available.Curated
Show »
Length:345
Mass (Da):38,996
Checksum:iF2D211BB2E2FA006
GO
Isoform 31 Publication (identifier: A2AAJ9-3) [UniParc]FASTAAdd to basket
Also known as: obsc-801 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-6831: Missing.
     7170-7563: DTSVEGSAHS...CDFGFAQKIT → VTEQETKVPK...GGEAPGPSQG
     7564-8886: Missing.

Show »
Length:732
Mass (Da):80,562
Checksum:i1938AD06F62BCCE1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BX05H7BX05_MOUSE
Obscurin
Obscn
8,032Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TJX7F6TJX7_MOUSE
Obscurin
Obscn
2,553Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QQ96E9QQ96_MOUSE
Obscurin
Obscn
7,496Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6X8F4F6X8F4_MOUSE
Obscurin
Obscn
397Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YJE4Z4YJE4_MOUSE
Obscurin
Obscn
7,646Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9JIB2J9JIB2_MOUSE
Obscurin
Obscn
855Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6H1A0A1W2P6H1_MOUSE
Obscurin
Obscn
974Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7DCJ0F7DCJ0_MOUSE
Obscurin
Obscn
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH44882 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7655R → Q in AAT80900 (PubMed:15185077).Curated1
Sequence conflicti8513G → E in AAT80900 (PubMed:15185077).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0600931 – 6831Missing in isoform 3 and isoform 2. 1 PublicationAdd BLAST6831
Alternative sequenceiVSP_0600947170 – 7563DTSVE…AQKIT → VTEQETKVPKKTVIIEETIT TVVKSPRGRRQSPGKSPSRS PSRRSASPRRPGLLAPERLY PPGTSPSRRLEVEQGRKAPV PALYVTEAEVHAPASQSQPK WLEVEETIEVRVKKTGSRGA SPVREMTSRGEGILFTLPGG IPGRDPNANNSNNKSVYQEA RTWGPAVVHVGEPFIFQVDS VGNVDWVAASPEPEQVRASQ KEENTERQEGCSDGDENTFL MEEPQDTDSLQGRDPKILTH NGRVLTLADLEDYVPQEGET FGCGDSTPSTPDEPPCEVSV LQREISEPTVGQPVLLNVGR PPGTGATPSFFRPGSQVHSP ESVSFLLREAWSGPVSAAPW TSSFHTHVQSSVDGSHGSFK TEVSTQTVSFGAVGETVTLH IDPDGGEAPGPSQG in isoform 3. 1 PublicationAdd BLAST394
Alternative sequenceiVSP_0600957170 – 7176DTSVEGS → ERRPSPP in isoform 2. 1 Publication7
Alternative sequenceiVSP_0600967177 – 8886Missing in isoform 2. 1 PublicationAdd BLAST1710
Alternative sequenceiVSP_0600977564 – 8886Missing in isoform 3. 1 PublicationAdd BLAST1323

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL456158 Genomic DNA No translation available.
BC044882 mRNA Translation: AAH44882.2 Different initiation.
BC060226 mRNA No translation available.
AY603754 mRNA Translation: AAT80900.1

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL456158 Genomic DNA No translation available.
BC044882 mRNA Translation: AAH44882.2 Different initiation.
BC060226 mRNA No translation available.
AY603754 mRNA Translation: AAT80900.1

3D structure databases

SMRiA2AAJ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2AAJ9, 2 interactors
STRINGi10090.ENSMUSP00000038264

PTM databases

iPTMnetiA2AAJ9
PhosphoSitePlusiA2AAJ9

Proteomic databases

MaxQBiA2AAJ9
PaxDbiA2AAJ9
PeptideAtlasiA2AAJ9
PRIDEiA2AAJ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2681862 Obscn

Phylogenomic databases

HOGENOMiHOG000115256
InParanoidiA2AAJ9
PhylomeDBiA2AAJ9

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2AAJ9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd00063 FN3, 3 hits
cd00160 RhoGEF, 1 hit
cd12025 SH3_Obscurin_like, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 70 hits
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000048 IQ_motif_EF-hand-BS
IPR011009 Kinase-like_dom_sf
IPR035526 Obscurin_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 60 hits
PF00612 IQ, 1 hit
PF00069 Pkinase, 2 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 64 hits
SM00408 IGc2, 58 hits
SM00406 IGv, 13 hits
SM00015 IQ, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00220 S_TKc, 2 hits
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 66 hits
SSF49265 SSF49265, 3 hits
SSF50044 SSF50044, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 56 hits
PS50096 IQ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOBSCN_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AAJ9
Secondary accession number(s): A2AB85
, B2FDE7, Q695L2, Q811H7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: April 10, 2019
Last modified: May 8, 2019
This is version 109 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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