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Entry version 91 (16 Oct 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Protein transport protein Sec24A

Gene

Sec24a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transportSAAS annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein transport protein Sec24AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sec24aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924621 Sec24a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AA71

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AA71

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AA71

PeptideAtlas

More...
PeptideAtlasi
A2AA71

PRoteomics IDEntifications database

More...
PRIDEi
A2AA71

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A2AA71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036391 Expressed in 237 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AA71 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AA71

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini424 – 460zf-Sec23_Sec24InterPro annotationAdd BLAST37
Domaini497 – 735Sec23_trunkInterPro annotationAdd BLAST239
Domaini740 – 824Sec23_BSInterPro annotationAdd BLAST85
Domaini835 – 935Sec23_helicalInterPro annotationAdd BLAST101
Domaini962 – 1035Gelsolin-likeInterPro annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 260DisorderedSequence analysisAdd BLAST260
Regioni272 – 325DisorderedSequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 54PolarSequence analysisAdd BLAST38
Compositional biasi67 – 95PolarSequence analysisAdd BLAST29
Compositional biasi102 – 116Pro-richSequence analysisAdd BLAST15
Compositional biasi126 – 140Pro-richSequence analysisAdd BLAST15
Compositional biasi164 – 182PolarSequence analysisAdd BLAST19
Compositional biasi192 – 235Pro-richSequence analysisAdd BLAST44
Compositional biasi236 – 259PolarSequence analysisAdd BLAST24
Compositional biasi272 – 295PolarSequence analysisAdd BLAST24
Compositional biasi296 – 315Pro-richSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1985 Eukaryota
COG5028 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182924

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000196365

Identification of Orthologs from Complete Genome Data

More...
OMAi
VVQDQVI

Database of Orthologous Groups

More...
OrthoDBi
330236at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01479 Sec24-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.20.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR041742 Sec24-like_trunk_dom
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2AA71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQPRIPAAR GAAASLQAQN GAASASGSPY TNGPVHNTLM SPQVSSSQGY
60 70 80 90 100
DSQPPGSYPR PMPAKTLNPF SAQSNYGGSQ GSGQTLNSPL VTSGPVLPSL
110 120 130 140 150
HSGPVPRMPL PTSQNPAATP MPSGSFLPGA NPPPPLNWQY NYPSTGPQTN
160 170 180 190 200
HFPHVAPPTL PGNPNLTADH QYVSSGDPAL QTSFKKPGSA LPLQNPPLPP
210 220 230 240 250
TFQPGAPPGP PPAGGPPPSR GPAPQKTPPR AAPPPSFNSA VNQEGITSNA
260 270 280 290 300
NNGSTAAHNT YDEIEGGGFL ATPQLVNQNP KTSRSVGSAY PSLPPGYQNS
310 320 330 340 350
APPVAGMPPP SLSYPSGPQA FTQTPLGANH LTASMSGLSL HPEGLRVVNL
360 370 380 390 400
LQERNMLPST PLQPPVPNLL EDIQKLNCNP ELFRCTLTSV PQTQALLNKA
410 420 430 440 450
KLPLGLLLHP FKDLVLPVVT SSTIVRCRSC RTYINPFVNF LDQRRWKCNL
460 470 480 490 500
CYRVNDVPEE FMYNPLTRVY GEPHKRPEVQ NATIEFMAPS EYMLRPPQPP
510 520 530 540 550
VYLFVFDVSH NAIETGYLNS VCQSLLDNLD LLPGNTRTKI GFITFDSTIH
560 570 580 590 600
FYSLQEGLSQ PQMLIVSDID DVFIPMPENL LVNLNESKEL VQDLLKTLPQ
610 620 630 640 650
MFTKTLETQS ALGPALQAAF KLISPTGGRM SVFQTQLPTL GVGALKPREE
660 670 680 690 700
PNQRSSAKEI HLTPSTDFYK KLALDCSGQQ AAVDLFLLSG QYSDLASLGC
710 720 730 740 750
ISRYSAGSVY YYPSYHHQHN PVQVQKLQKE LHRYLTRKIG FEAVMRIRCT
760 770 780 790 800
KGLSIHTFHG NFFVRSTDLL SLPNVNPDAG YAVQMSVEES LTDTQLVSFQ
810 820 830 840 850
SALLYTSSKG ERRIRVHTLC LPVVSTLNEV FLGADVQAIS GLLANMAVDR
860 870 880 890 900
SVTASLSDAR DALVNAVIDS LSAYRSSVLS GQQPGLMVPF SLRLFPLFVL
910 920 930 940 950
ALLKQKSFQT GTSIRLDERI FAMCQVKSQP LVHLMLTTHP SLYRVDNLSD
960 970 980 990 1000
EGALNINDRT IPQPPILQLS VEKLSRDGAF LMDAGSLLML WVGRNCSQNF
1010 1020 1030 1040 1050
LSQVLGVQNY ASIPQTMTDL PELDTPESAR IAAFISWLRE QRPFFPVLYV
1060 1070 1080
IREESLMKAA FLQSLVEDRT ESALSYYEFL LHIQQQVNK
Length:1,089
Mass (Da):118,654
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i036F62E23DE3F526
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U2P1SC24A_MOUSE
Protein transport protein Sec24A
Sec24a
1,090Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AA72A2AA72_MOUSE
Protein transport protein Sec24A
Sec24a
591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL645602 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001277714.1, NM_001290785.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000038210; ENSMUSP00000044370; ENSMUSG00000036391

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
77371

UCSC genome browser

More...
UCSCi
uc007iuj.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645602 Genomic DNA No translation available.
RefSeqiNP_001277714.1, NM_001290785.1

3D structure databases

SMRiA2AA71
ModBaseiSearch...

PTM databases

SwissPalmiA2AA71

Proteomic databases

EPDiA2AA71
jPOSTiA2AA71
MaxQBiA2AA71
PeptideAtlasiA2AA71
PRIDEiA2AA71

Genome annotation databases

EnsembliENSMUST00000038210; ENSMUSP00000044370; ENSMUSG00000036391
GeneIDi77371
UCSCiuc007iuj.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10802
MGIiMGI:1924621 Sec24a

Phylogenomic databases

eggNOGiKOG1985 Eukaryota
COG5028 LUCA
GeneTreeiENSGT00950000182924
HOGENOMiHOG000196365
OMAiVVQDQVI
OrthoDBi330236at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sec24a mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036391 Expressed in 237 organ(s), highest expression level in liver
ExpressionAtlasiA2AA71 baseline and differential

Family and domain databases

CDDicd01479 Sec24-like, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR041742 Sec24-like_trunk_dom
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AA71_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AA71
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 16, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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