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Protein
Submitted name:

Chymotrypsin-like elastase family, member 3A

Gene

Cela3a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS01.930

Names & Taxonomyi

Protein namesi
Submitted name:
Chymotrypsin-like elastase family, member 3AImported
Submitted name:
Elastase 3, pancreaticImported
Gene namesi
Name:Cela3aImported
Synonyms:Ela3Imported
ORF Names:mCG_120450Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3651647 Cela3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501508600917 – 283Sequence analysisAdd BLAST267

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000078520 Expressed in 4 organ(s), highest expression level in colon

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024200

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 281Peptidase S1InterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
HOVERGENiHBG013304
OMAiTAGHCIW
OrthoDBiEOG091G0DF7
TreeFamiTF330455

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

A2A9U8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRLLSSLLL VALASGCGQP SHNPSSRVVN GEEAVPHSWP WQVSLQYEMG
60 70 80 90 100
GSFHHTCGGS LITPDWVLTA GHCIMPYLNY RVVLGEHEHG VEEGSEQVIP
110 120 130 140 150
INAGELFVHP KWNSECVNCG NNIALVKLSR SAQLGDAVQL ACLPPAGEIL
160 170 180 190 200
PNGAPCYISG WGRLSTNGPL PTKLQQALLP VVDYEHCSRW DWWGHYVKRT
210 220 230 240 250
MVCAGGYIQA HSLSSDTHQP RLLSPLQGDS GGPLNCPADN GTWQVHGIAS
260 270 280
FVSPSGCNTL KKPTMFTRVS AFIDWIEETI ANN
Length:283
Mass (Da):30,712
Last modified:February 20, 2007 - v1
Checksum:i669BCAAE92A34487
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645468 Genomic DNA No translation available.
CH466552 Genomic DNA Translation: EDL29918.1
RefSeqiNP_001119790.1, NM_001126318.1
UniGeneiMm.297477
Mm.475541

Genome annotation databases

EnsembliENSMUST00000024200; ENSMUSP00000024200; ENSMUSG00000078520
GeneIDi242711
KEGGimmu:242711
UCSCiuc012dnj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645468 Genomic DNA No translation available.
CH466552 Genomic DNA Translation: EDL29918.1
RefSeqiNP_001119790.1, NM_001126318.1
UniGeneiMm.297477
Mm.475541

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024200

Protein family/group databases

MEROPSiS01.930

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024200; ENSMUSP00000024200; ENSMUSG00000078520
GeneIDi242711
KEGGimmu:242711
UCSCiuc012dnj.1 mouse

Organism-specific databases

CTDi10136
MGIiMGI:3651647 Cela3a

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
HOVERGENiHBG013304
OMAiTAGHCIW
OrthoDBiEOG091G0DF7
TreeFamiTF330455

Miscellaneous databases

ChiTaRSiCela3b mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078520 Expressed in 4 organ(s), highest expression level in colon

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2A9U8_MOUSE
AccessioniPrimary (citable) accession number: A2A9U8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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