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Entry version 109 (02 Dec 2020)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Nardilysin, N-arginine dibasic convertase, NRD convertase 1

Gene

Nrd1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, MetalloproteaseARBA annotation, Protease
LigandZincARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nardilysin, N-arginine dibasic convertase, NRD convertase 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nrd1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1201386, Nrd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2A9Q2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2A9Q2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2A9Q2

PeptideAtlas

More...
PeptideAtlasi
A2A9Q2

PRoteomics IDEntifications database

More...
PRIDEi
A2A9Q2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000053510, Expressed in testis and 309 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2A9Q2, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2A9Q2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini287 – 415Peptidase_M16InterPro annotationAdd BLAST129
Domaini442 – 625Peptidase_M16_CInterPro annotationAdd BLAST184
Domaini632 – 913Peptidase_M16_MInterPro annotationAdd BLAST282
Domaini918 – 1099Peptidase_M16_CInterPro annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni49 – 103DisorderedSequence analysisAdd BLAST55
Regioni130 – 218DisorderedSequence analysisAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 67PolarSequence analysisAdd BLAST17
Compositional biasi77 – 93PolyampholyteSequence analysisAdd BLAST17
Compositional biasi137 – 207AcidicSequence analysisAdd BLAST71

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155026

Database of Orthologous Groups

More...
OrthoDBi
1008844at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011249, Metalloenz_LuxS/M16
IPR011765, Pept_M16_N
IPR001431, Pept_M16_Zn_BS
IPR007863, Peptidase_M16_C
IPR032632, Peptidase_M16_M

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00675, Peptidase_M16, 1 hit
PF05193, Peptidase_M16_C, 2 hits
PF16187, Peptidase_M16_M, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63411, SSF63411, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00143, INSULINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A2A9Q2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRRVAVAAV CVTGRKLRCE AGRELTALGR IEARGLCEES SKPFPTLTMP
60 70 80 90 100
GRNKAKSTCS CPDLQPNGQD LGESGRLARL GADESEEEGR SFSNVGDPEI
110 120 130 140 150
IKSPSDPKQY RYIKLQNGLQ ALLISDLSNV EGKTGNATDE EEEEEEEEEE
160 170 180 190 200
EDDDDDDDDD DDDEDSGAEI QDDDEEGFDD EEEFDDDDDD EHDDDDLENE
210 220 230 240 250
ENELEELEER VEARKKTTEK QQSQNLFLLW SKLTDRLWFK SSYSKMSSTL
260 270 280 290 300
LVETRNLYGV VGAESRSAPV EHLAGWQVEE QQGETDTVLS AAALCVGVGS
310 320 330 340 350
FADPDDLPGL AHFLEHMVFM GSLKYPDENG FDAFLKKHGG SDNASTDCER
360 370 380 390 400
TVFQFDVQRK YFKEALDRWA QFFIHPLMIR DAIDREVEAV DSEYQLARPS
410 420 430 440 450
DANRKEMLFG SLARPGHPMG KFFWGNAETL KHEPKKNNID THARLREFWM
460 470 480 490 500
RYYSAHYMTL VVQSKETLDT LEKWVTEIFS QIPNNGLPKP NFSHLTDPFD
510 520 530 540 550
TPAFNKLYRV VPIRKIHALT ITWALPPQQQ HYRVKPLHYI SWLVGHEGKG
560 570 580 590 600
SILSYLRKKC WALALFGGNG ETGFEQNSTY SVFSISITLT DEGYEHFYEV
610 620 630 640 650
AHTVFQYLKM LQKLGPEKRV FEEIQKIEDN EFHYQEQTDP VEYVENMCEN
660 670 680 690 700
MQLYPRQDFL TGDQLLFEYK PEVIAEALNQ LVPQKANLVL LSGANEGRCD
710 720 730 740 750
LKEKWFGTQY SIEDIENSWT ELWKSNFDLN PDLHLPAENK YIATDFTLKA
760 770 780 790 800
FDCPETEYPA KIVNTAQGCL WYKKDNKFKI PKAYIRFHLI SPLIQKSAAN
810 820 830 840 850
VVLFDIFVNI LTHNLAEPAY EADVAQLEYK LVAGEHGLII RVKGFNHKLP
860 870 880 890 900
LLFQLIIDYL TEFSSTPAVF TMITEQLKKT YFNILIKPET LAKDVRLLIL
910 920 930 940 950
EYSRWSMIDK YQALMDGLSL DSLLNFVKDF KSQLFVEGLV QGNVTSTESM
960 970 980 990 1000
DFLKYVVDKL NFAPLEREMP VQFQVVELPS GHHLCKVRAL NKGDANSEVT
1010 1020 1030 1040 1050
VYYQSGTRSL REYTLMELLV MHMEEPCFDF LRTKQTLGYH VYPTCRNTSG
1060 1070 1080 1090 1100
ILGFSVTVGT QATKYNSETV DKKIEEFLSS FEEKIENLTE DAFNTQVTAL
1110 1120 1130 1140 1150
IKLKECEDTH LGEEVDRNWN EVVTQQYLFD RLAHEIEALK SFSKSDLVSW
1160 1170 1180 1190 1200
FKAHRGPGSK MLSVHVVGYG KYELEEDGAP FGEDSNSREG MQLTYLPPSP
1210 1220
VLAESTTPIT DIRAFTATLS LFPYHKIVK
Length:1,229
Mass (Da):140,620
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD048A7F5AF5AEEEA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BHG1NRDC_MOUSE
Nardilysin
Nrdc Nrd1
1,161Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PWC3A6PWC3_MOUSE
Nardilysin, N-arginine dibasic conv...
Nrd1
1,117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3V3G9Q3V3G9_MOUSE
Nardilysin, N-arginine dibasic conv...
Nrd1
395Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL627406 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001334098.1, NM_001347169.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000106644; ENSMUSP00000102255; ENSMUSG00000053510

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
230598

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627406 Genomic DNA No translation available.
RefSeqiNP_001334098.1, NM_001347169.1

3D structure databases

SMRiA2A9Q2
ModBaseiSearch...

Proteomic databases

EPDiA2A9Q2
jPOSTiA2A9Q2
MaxQBiA2A9Q2
PeptideAtlasiA2A9Q2
PRIDEiA2A9Q2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
19043, 140 antibodies

Genome annotation databases

EnsembliENSMUST00000106644; ENSMUSP00000102255; ENSMUSG00000053510
GeneIDi230598

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
230598
MGIiMGI:1201386, Nrd1

Phylogenomic databases

GeneTreeiENSGT00940000155026
OrthoDBi1008844at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
230598, 5 hits in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nrd1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000053510, Expressed in testis and 309 other tissues
ExpressionAtlasiA2A9Q2, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011249, Metalloenz_LuxS/M16
IPR011765, Pept_M16_N
IPR001431, Pept_M16_Zn_BS
IPR007863, Peptidase_M16_C
IPR032632, Peptidase_M16_M
PfamiView protein in Pfam
PF00675, Peptidase_M16, 1 hit
PF05193, Peptidase_M16_C, 2 hits
PF16187, Peptidase_M16_M, 1 hit
SUPFAMiSSF63411, SSF63411, 4 hits
PROSITEiView protein in PROSITE
PS00143, INSULINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2A9Q2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A9Q2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: December 2, 2020
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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