UniProtKB - A2A9Q2 (A2A9Q2_MOUSE)
Protein
Submitted name:
Nardilysin, N-arginine dibasic convertase, NRD convertase 1
Gene
Nrd1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: InterPro
- metallopeptidase activity Source: UniProtKB-KW
GO - Biological processi
- positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
- regulation of endopeptidase activity Source: Ensembl
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Ligand | ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Nardilysin, N-arginine dibasic convertase, NRD convertase 1Imported |
Gene namesi | Name:Nrd1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1201386, Nrd1 |
Subcellular locationi
Mitochondrion
- mitochondrion Source: Ensembl
PTM / Processingi
Proteomic databases
EPDi | A2A9Q2 |
jPOSTi | A2A9Q2 |
MaxQBi | A2A9Q2 |
PeptideAtlasi | A2A9Q2 |
PRIDEi | A2A9Q2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000053510, Expressed in testis and 309 other tissues |
ExpressionAtlasi | A2A9Q2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 287 – 415 | Peptidase_M16InterPro annotationAdd BLAST | 129 | |
Domaini | 442 – 625 | Peptidase_M16_CInterPro annotationAdd BLAST | 184 | |
Domaini | 632 – 913 | Peptidase_M16_MInterPro annotationAdd BLAST | 282 | |
Domaini | 918 – 1099 | Peptidase_M16_CInterPro annotationAdd BLAST | 182 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 49 – 103 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 130 – 218 | DisorderedSequence analysisAdd BLAST | 89 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 51 – 67 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 77 – 93 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 137 – 207 | AcidicSequence analysisAdd BLAST | 71 |
Phylogenomic databases
GeneTreei | ENSGT00940000155026 |
OrthoDBi | 1008844at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS IPR007863, Peptidase_M16_C IPR032632, Peptidase_M16_M |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 2 hits PF16187, Peptidase_M16_M, 1 hit |
SUPFAMi | SSF63411, SSF63411, 4 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A2A9Q2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRRVAVAAV CVTGRKLRCE AGRELTALGR IEARGLCEES SKPFPTLTMP
60 70 80 90 100
GRNKAKSTCS CPDLQPNGQD LGESGRLARL GADESEEEGR SFSNVGDPEI
110 120 130 140 150
IKSPSDPKQY RYIKLQNGLQ ALLISDLSNV EGKTGNATDE EEEEEEEEEE
160 170 180 190 200
EDDDDDDDDD DDDEDSGAEI QDDDEEGFDD EEEFDDDDDD EHDDDDLENE
210 220 230 240 250
ENELEELEER VEARKKTTEK QQSQNLFLLW SKLTDRLWFK SSYSKMSSTL
260 270 280 290 300
LVETRNLYGV VGAESRSAPV EHLAGWQVEE QQGETDTVLS AAALCVGVGS
310 320 330 340 350
FADPDDLPGL AHFLEHMVFM GSLKYPDENG FDAFLKKHGG SDNASTDCER
360 370 380 390 400
TVFQFDVQRK YFKEALDRWA QFFIHPLMIR DAIDREVEAV DSEYQLARPS
410 420 430 440 450
DANRKEMLFG SLARPGHPMG KFFWGNAETL KHEPKKNNID THARLREFWM
460 470 480 490 500
RYYSAHYMTL VVQSKETLDT LEKWVTEIFS QIPNNGLPKP NFSHLTDPFD
510 520 530 540 550
TPAFNKLYRV VPIRKIHALT ITWALPPQQQ HYRVKPLHYI SWLVGHEGKG
560 570 580 590 600
SILSYLRKKC WALALFGGNG ETGFEQNSTY SVFSISITLT DEGYEHFYEV
610 620 630 640 650
AHTVFQYLKM LQKLGPEKRV FEEIQKIEDN EFHYQEQTDP VEYVENMCEN
660 670 680 690 700
MQLYPRQDFL TGDQLLFEYK PEVIAEALNQ LVPQKANLVL LSGANEGRCD
710 720 730 740 750
LKEKWFGTQY SIEDIENSWT ELWKSNFDLN PDLHLPAENK YIATDFTLKA
760 770 780 790 800
FDCPETEYPA KIVNTAQGCL WYKKDNKFKI PKAYIRFHLI SPLIQKSAAN
810 820 830 840 850
VVLFDIFVNI LTHNLAEPAY EADVAQLEYK LVAGEHGLII RVKGFNHKLP
860 870 880 890 900
LLFQLIIDYL TEFSSTPAVF TMITEQLKKT YFNILIKPET LAKDVRLLIL
910 920 930 940 950
EYSRWSMIDK YQALMDGLSL DSLLNFVKDF KSQLFVEGLV QGNVTSTESM
960 970 980 990 1000
DFLKYVVDKL NFAPLEREMP VQFQVVELPS GHHLCKVRAL NKGDANSEVT
1010 1020 1030 1040 1050
VYYQSGTRSL REYTLMELLV MHMEEPCFDF LRTKQTLGYH VYPTCRNTSG
1060 1070 1080 1090 1100
ILGFSVTVGT QATKYNSETV DKKIEEFLSS FEEKIENLTE DAFNTQVTAL
1110 1120 1130 1140 1150
IKLKECEDTH LGEEVDRNWN EVVTQQYLFD RLAHEIEALK SFSKSDLVSW
1160 1170 1180 1190 1200
FKAHRGPGSK MLSVHVVGYG KYELEEDGAP FGEDSNSREG MQLTYLPPSP
1210 1220
VLAESTTPIT DIRAFTATLS LFPYHKIVK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8BHG1 | NRDC_MOUSE | Nardilysin | Nrdc Nrd1 | 1,161 | Annotation score: | ||
A6PWC3 | A6PWC3_MOUSE | Nardilysin, N-arginine dibasic conv... | Nrd1 | 1,117 | Annotation score: | ||
Q3V3G9 | Q3V3G9_MOUSE | Nardilysin, N-arginine dibasic conv... | Nrd1 | 395 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL627406 Genomic DNA No translation available. |
RefSeqi | NP_001334098.1, NM_001347169.1 |
Genome annotation databases
Ensembli | ENSMUST00000106644; ENSMUSP00000102255; ENSMUSG00000053510 |
GeneIDi | 230598 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL627406 Genomic DNA No translation available. |
RefSeqi | NP_001334098.1, NM_001347169.1 |
3D structure databases
SMRi | A2A9Q2 |
ModBasei | Search... |
Proteomic databases
EPDi | A2A9Q2 |
jPOSTi | A2A9Q2 |
MaxQBi | A2A9Q2 |
PeptideAtlasi | A2A9Q2 |
PRIDEi | A2A9Q2 |
Protocols and materials databases
Antibodypediai | 19043, 140 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000106644; ENSMUSP00000102255; ENSMUSG00000053510 |
GeneIDi | 230598 |
Organism-specific databases
CTDi | 230598 |
MGIi | MGI:1201386, Nrd1 |
Phylogenomic databases
GeneTreei | ENSGT00940000155026 |
OrthoDBi | 1008844at2759 |
Miscellaneous databases
BioGRID-ORCSi | 230598, 5 hits in 19 CRISPR screens |
ChiTaRSi | Nrd1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053510, Expressed in testis and 309 other tissues |
ExpressionAtlasi | A2A9Q2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS IPR007863, Peptidase_M16_C IPR032632, Peptidase_M16_M |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 2 hits PF16187, Peptidase_M16_M, 1 hit |
SUPFAMi | SSF63411, SSF63411, 4 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A2A9Q2_MOUSE | |
Accessioni | A2A9Q2Primary (citable) accession number: A2A9Q2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |