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Protein
Submitted name:

Connector enhancer of kinase suppressor of Ras 1

Gene

Cnksr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5674135 MAP2K and MAPK activation

Names & Taxonomyi

Protein namesi
Submitted name:
Connector enhancer of kinase suppressor of Ras 1Imported
Gene namesi
Name:Cnksr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2670958 Cnksr1

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiA2A9K7
PaxDbiA2A9K7
PRIDEiA2A9K7

Expressioni

Gene expression databases

BgeeiENSMUSG00000028841 Expressed in 111 organ(s), highest expression level in gastrocnemius
GenevisibleiA2A9K7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030645

Structurei

3D structure databases

ProteinModelPortaliA2A9K7
SMRiA2A9K7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 70SAMInterPro annotationAdd BLAST64
Domaini78 – 164CRICInterPro annotationAdd BLAST87
Domaini226 – 276PDZInterPro annotationAdd BLAST51
Domaini387 – 486PHInterPro annotationAdd BLAST100

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili603 – 623Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1738 Eukaryota
ENOG41104C7 LUCA
GeneTreeiENSGT00390000017199
HOGENOMiHOG000231154
HOVERGENiHBG051039
InParanoidiA2A9K7
OMAiCFEDWEL
OrthoDBiEOG091G037J
PhylomeDBiA2A9K7
TreeFamiTF326495

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR017874 CRIC_domain
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF10534 CRIC_ras_sig, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51290 CRIC, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

A2A9K7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPVEAWTPG KVAAWLRGLD DALQDYPFED WQLPGKYLLQ LCPQSLEALT
60 70 80 90 100
VWPLGHQELI LDGVEQLRAL GSNLQTENLQ SLAQGLLERT QAFQSLVQGS
110 120 130 140 150
LGNCAETPAD VLKAAVELVR EAHALLSWLN GYLFSHLNDF SACQEIGVLC
160 170 180 190 200
GELGQVLQED CPEAEKERNI LRICSHVAGI CHNILSCSPE ELLEQKAVLE
210 220 230 240 250
SVQVDDPSGL EIHTTSNCLH FVSRVGVQAA TSSQILPGDE IVQVNEQVVV
260 270 280 290 300
GWSHKNMLRE LLREPAKVSL VLKKIPVPET PSQTSLDSPH LLSQSLPLNP
310 320 330 340 350
PSPRVPSEGL LADGTPGPSP AWTDSTSFDA QSPPTPPGPP GVLPEETAEP
360 370 380 390 400
LESSGHPDKS PILGRKKSKG IATRLSRRRV SCRELGLPDC DGWLLLRKVP
410 420 430 440 450
GGFMGPRWRR CWFVLKGHTL YWYRQPQDEK AEGLINLSNY SLESGHDQKK
460 470 480 490 500
KYVFQLTHDV YKPFIFAAET LSDLSKWVRH LITCISKYQA QGRAPSSARE
510 520 530 540 550
EDCYSETEAE DPDEEAGSRS ASPGPAQAWS DTSPVASPLQ SPRTSFNSSP
560 570 580 590 600
DSSDRALEGM VQGLRQGGVS LLGQPQPLTH EQWRSSFMRR NRDPHLNERA
610 620 630 640 650
HRIRALQSTL KAKLQELQAL EEVLGDPELT SAKFRQWKEQ NQELYSEGLR
660 670 680 690 700
TWGGTWAQTS SSDPNSDSRA HSPQPLPFDP EEPSQLFPLT PENSRQPPDL
Length:700
Mass (Da):77,485
Last modified:February 20, 2007 - v1
Checksum:iD1CF3F78EBA978CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627314 Genomic DNA No translation available.
RefSeqiNP_001074516.1, NM_001081047.1
UniGeneiMm.331958

Genome annotation databases

EnsembliENSMUST00000030645; ENSMUSP00000030645; ENSMUSG00000028841
GeneIDi194231
KEGGimmu:194231
UCSCiuc008vei.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627314 Genomic DNA No translation available.
RefSeqiNP_001074516.1, NM_001081047.1
UniGeneiMm.331958

3D structure databases

ProteinModelPortaliA2A9K7
SMRiA2A9K7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030645

Proteomic databases

MaxQBiA2A9K7
PaxDbiA2A9K7
PRIDEiA2A9K7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030645; ENSMUSP00000030645; ENSMUSG00000028841
GeneIDi194231
KEGGimmu:194231
UCSCiuc008vei.1 mouse

Organism-specific databases

CTDi10256
MGIiMGI:2670958 Cnksr1

Phylogenomic databases

eggNOGiKOG1738 Eukaryota
ENOG41104C7 LUCA
GeneTreeiENSGT00390000017199
HOGENOMiHOG000231154
HOVERGENiHBG051039
InParanoidiA2A9K7
OMAiCFEDWEL
OrthoDBiEOG091G037J
PhylomeDBiA2A9K7
TreeFamiTF326495

Enzyme and pathway databases

ReactomeiR-MMU-5674135 MAP2K and MAPK activation

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028841 Expressed in 111 organ(s), highest expression level in gastrocnemius
GenevisibleiA2A9K7 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR017874 CRIC_domain
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF10534 CRIC_ras_sig, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51290 CRIC, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2A9K7_MOUSE
AccessioniPrimary (citable) accession number: A2A9K7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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