UniProtKB - A2A9I7 (DMRTB_MOUSE)
Protein
Doublesex- and mab-3-related transcription factor B1
Gene
Dmrtb1
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 7 – 54 | DMPROSITE-ProRule annotationAdd BLAST | 48 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- germ cell development Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- sex differentiation Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Doublesex- and mab-3-related transcription factor B1Alternative name(s): Doublesex- and mab-3-related transcription factor 6 |
Gene namesi | Name:Dmrtb1 Synonyms:Dmrt6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1927125, Dmrtb1 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000316013 | 1 – 359 | Doublesex- and mab-3-related transcription factor B1Add BLAST | 359 |
Proteomic databases
PaxDbi | A2A9I7 |
PeptideAtlasi | A2A9I7 |
PRIDEi | A2A9I7 |
ProteomicsDBi | 279440 |
PTM databases
PhosphoSitePlusi | A2A9I7 |
Expressioni
Tissue specificityi
Brain.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000028610, Expressed in testis and 115 other tissues |
ExpressionAtlasi | A2A9I7, baseline and differential |
Genevisiblei | A2A9I7, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000064220 |
Miscellaneous databases
RNActi | A2A9I7, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 69 – 325 | Pro-richAdd BLAST | 257 |
Sequence similaritiesi
Belongs to the DMRT family.Curated
Phylogenomic databases
eggNOGi | KOG3815, Eukaryota |
GeneTreei | ENSGT00940000161912 |
HOGENOMi | CLU_073336_0_0_1 |
InParanoidi | A2A9I7 |
OMAi | KQCLCEK |
OrthoDBi | 1042183at2759 |
PhylomeDBi | A2A9I7 |
TreeFami | TF317837 |
Family and domain databases
Gene3Di | 4.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR001275, DM_DNA-bd IPR036407, DM_DNA-bd_sf IPR026607, DMRT/dsx/mab-3 |
PANTHERi | PTHR12322, PTHR12322, 1 hit |
Pfami | View protein in Pfam PF00751, DM, 1 hit |
SMARTi | View protein in SMART SM00301, DM, 1 hit |
SUPFAMi | SSF82927, SSF82927, 1 hit |
PROSITEi | View protein in PROSITE PS40000, DM_1, 1 hit PS50809, DM_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A2A9I7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRAPKCSRC RNHGYLVPVK GHTGKCRWKQ CICDKCYLIT ERQKIMAAQK
60 70 80 90 100
VLRTQAAEEQ VATVGTQGPQ LPPRAPAAAA TALSSSICPL PRAVPGGVGP
110 120 130 140 150
GPTATCFLER PPQAPSPGPS TFQLGPSGRP GPSTFQPGPG APGGLRDRSS
160 170 180 190 200
AWLPQLMPQA PRPELCYPDQ HLPVRPVPVP GPVRPVPRLP FADYGHPLRF
210 220 230 240 250
KSDHVVGAGN PEREPFKQCP ACVPVSPYQS FPLSEGQDSS SALGVPQQRG
260 270 280 290 300
FRHVSCSPYH RSGLVSEPAR DLQPTYCSPP PPPPPPPPPP LPAPPPQPQQ
310 320 330 340 350
PHFLPPGYLS ALHFLPPPPP PPSPPSFSLT YDTDKENTND QDAEAPTEPS
QDSPQEQSN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1ASP8 | B1ASP8_MOUSE | Doublesex- and mab-3-related transc... | Dmrtb1 | 203 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL627259 Genomic DNA No translation available. AF542048 mRNA Translation: AAN77235.1 |
CCDSi | CCDS51254.1 |
RefSeqi | NP_063925.1, NM_019872.1 |
Genome annotation databases
Ensembli | ENSMUST00000069271; ENSMUSP00000064220; ENSMUSG00000028610 |
GeneIDi | 56296 |
KEGGi | mmu:56296 |
UCSCi | uc008tzy.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL627259 Genomic DNA No translation available. AF542048 mRNA Translation: AAN77235.1 |
CCDSi | CCDS51254.1 |
RefSeqi | NP_063925.1, NM_019872.1 |
3D structure databases
SMRi | A2A9I7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000064220 |
PTM databases
PhosphoSitePlusi | A2A9I7 |
Proteomic databases
PaxDbi | A2A9I7 |
PeptideAtlasi | A2A9I7 |
PRIDEi | A2A9I7 |
ProteomicsDBi | 279440 |
Protocols and materials databases
Antibodypediai | 19214, 92 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000069271; ENSMUSP00000064220; ENSMUSG00000028610 |
GeneIDi | 56296 |
KEGGi | mmu:56296 |
UCSCi | uc008tzy.2, mouse |
Organism-specific databases
CTDi | 63948 |
MGIi | MGI:1927125, Dmrtb1 |
Phylogenomic databases
eggNOGi | KOG3815, Eukaryota |
GeneTreei | ENSGT00940000161912 |
HOGENOMi | CLU_073336_0_0_1 |
InParanoidi | A2A9I7 |
OMAi | KQCLCEK |
OrthoDBi | 1042183at2759 |
PhylomeDBi | A2A9I7 |
TreeFami | TF317837 |
Miscellaneous databases
BioGRID-ORCSi | 56296, 4 hits in 53 CRISPR screens |
ChiTaRSi | Dmrtb1, mouse |
PROi | PR:A2A9I7 |
RNActi | A2A9I7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028610, Expressed in testis and 115 other tissues |
ExpressionAtlasi | A2A9I7, baseline and differential |
Genevisiblei | A2A9I7, MM |
Family and domain databases
Gene3Di | 4.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR001275, DM_DNA-bd IPR036407, DM_DNA-bd_sf IPR026607, DMRT/dsx/mab-3 |
PANTHERi | PTHR12322, PTHR12322, 1 hit |
Pfami | View protein in Pfam PF00751, DM, 1 hit |
SMARTi | View protein in SMART SM00301, DM, 1 hit |
SUPFAMi | SSF82927, SSF82927, 1 hit |
PROSITEi | View protein in PROSITE PS40000, DM_1, 1 hit PS50809, DM_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DMRTB_MOUSE | |
Accessioni | A2A9I7Primary (citable) accession number: A2A9I7 Secondary accession number(s): Q8CGW8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | February 20, 2007 | |
Last modified: | April 7, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families