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Entry version 109 (29 Sep 2021)
Sequence version 1 (05 Feb 2008)
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Protein
Submitted name:

Histone-lysine N-methyltransferase PRDM16

Gene

Prdm16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferaseARBA annotation, Transferase
Biological processTranscription, Transcription regulationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Histone-lysine N-methyltransferase PRDM16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prdm16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917923, Prdm16

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000039410

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2A931

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2A931

PRoteomics IDEntifications database

More...
PRIDEi
A2A931

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
351386

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039410, Expressed in pes and 270 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2A931, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini82 – 210SETInterPro annotationAdd BLAST129
Domaini229 – 259C2H2-typeInterPro annotationAdd BLAST31
Domaini281 – 308C2H2-typeInterPro annotationAdd BLAST28
Domaini309 – 336C2H2-typeInterPro annotationAdd BLAST28
Domaini337 – 365C2H2-typeInterPro annotationAdd BLAST29
Domaini366 – 393C2H2-typeInterPro annotationAdd BLAST28
Domaini394 – 421C2H2-typeInterPro annotationAdd BLAST28
Domaini423 – 450C2H2-typeInterPro annotationAdd BLAST28
Domaini950 – 977C2H2-typeInterPro annotationAdd BLAST28
Domaini978 – 1006C2H2-typeInterPro annotationAdd BLAST29
Domaini1007 – 1034C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 66DisorderedSequence analysisAdd BLAST66
Regioni591 – 657DisorderedSequence analysisAdd BLAST67
Regioni788 – 837DisorderedSequence analysisAdd BLAST50
Regioni1026 – 1064DisorderedSequence analysisAdd BLAST39
Regioni1083 – 1168DisorderedSequence analysisAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi602 – 625Polar residuesSequence analysisAdd BLAST24
Compositional biasi626 – 645Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi817 – 831Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1038 – 1059Polar residuesSequence analysisAdd BLAST22
Compositional biasi1115 – 1134Acidic residuesSequence analysisAdd BLAST20

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160951

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd19213, PR-SET_PRDM16, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR044410, PRDM16_PR-SET
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00317, SET, 1 hit
SM00355, ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A2A931-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSKARARKL AKSDGDVVNN MYEPDPDLLA GQSAEEETED GILSPIPMGP
60 70 80 90 100
PSPFPTSEDF TPKEGSPYEA PVYIPEDIPI PPDFELRESS IPGAGLGIWA
110 120 130 140 150
KRKMEIGERF GPYVVTPRAA LKEADFGWEM LTDTEVSSQE SCIKKISEDL
160 170 180 190 200
GSEKFCVDAN QAGSGSWLKY IRVACSCDDQ NLAMCQINEQ IYYKVIKDIE
210 220 230 240 250
PGEELLVHVK EGAYSLGVMA PSLDEDPTFR CDECDELFQC RLDLRRHKKY
260 270 280 290 300
ACSSAGAQLY EGLGEELKPE GLGVGSDGQA HECKDCERMF PNKYSLEQHM
310 320 330 340 350
IVHTEEREYK CDQCPKAFNW KSNLIRHQMS HDSGKRFECE NCVKVFTDPS
360 370 380 390 400
NLQRHIRSQH VGARAHACPD CGKTFATSSG LKQHKHIHST VKPFICEVCH
410 420 430 440 450
KSYTQFSNLC RHKRMHADCR TQIKCKDCGQ MFSTTSSLNK HRRFCEGKNH
460 470 480 490 500
YTPGSIFTPG LPLTPSPMMD KTKPSPTLNH GGLGFSEYFP SRPHPGSLPF
510 520 530 540 550
SAAPPAFPAL TPGFPGIFPP SLYPRPPLLP PTPLLKSPLN HAQDAKLPSP
560 570 580 590 600
LGNPALPLVS AVSNSSQGAT AATGSEEKFD GRLEDAYAEK VKNRSPDMSD
610 620 630 640 650
GSDFEDINTT TGTDLDTTTG TGSDLDSDLD SDRDKGKDKG KPVESKPEFG
660 670 680 690 700
GASVPPGAMN SVAEVPAFYS QHSFFPPPEE QLLTASGAAG DSIKAIASIA
710 720 730 740 750
EKYFGPGFMS MQEKKLGSLP YHSVFPFQFL PNFPHSLYPF TDRALAHNLL
760 770 780 790 800
VKAEPKSPRD ALKVGGPSAE CPFDLTTKPK EAKPALLAPK VPLIPSSGEE
810 820 830 840 850
QPLDLSIGSR ARASQNGGGR EPRKNHVYGE RKPGVSEGLP KVCPAQLPQQ
860 870 880 890 900
PSLHYAKPSP FFMDPIYRVE KRKVADPVGV LKEKYLRPSP LLFHPQMSAI
910 920 930 940 950
ETMTEKLESF AAMKADSGSS LQPLPHHPFN FRSPPPTLSD PILRKGKERY
960 970 980 990 1000
TCRYCGKIFP RSANLTRHLR THTGEQPYRC KYCDRSFSIS SNLQRHVRNI
1010 1020 1030 1040 1050
HNKEKPFKCH LCNRCFGQQT NLDRHLKKHE HEGAPVSQHS GVLTNHLGTS
1060 1070 1080 1090 1100
ASSPTSESDN HALLDEKEDS YFSEIRNFIA NSEMNQASTR MDKRPEIQDL
1110 1120 1130 1140 1150
DSNPPCPGSA SAKPEDVEEE EEEELEEEDD DSLAGKSQED TVSPTPEPQG
1160 1170 1180 1190 1200
VYEDEEDEEP PSLTMGFDHT RRCVEERGGG LLALEPTPTF GKGLDLRRAA
1210 1220 1230 1240 1250
EEAFEVKDVL NSTLDSEVLK QTLYRQAKNQ AYAMMLSLSE DTPLHAPSQS
1260 1270
SLDAWLNITG PSSESGAFNP INHL
Length:1,274
Mass (Da):140,730
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9039EC0F8EC748BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A935PRD16_MOUSE
Histone-lysine N-methyltransferase ...
Prdm16 Kiaa1675, Mel1
1,275Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A933A2A933_MOUSE
Histone-lysine N-methyltransferase ...
Prdm16
1,276Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A934A2A934_MOUSE
Histone-lysine N-methyltransferase ...
Prdm16
1,177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A930A2A930_MOUSE
Histone-lysine N-methyltransferase ...
Prdm16
1,257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A929A2A929_MOUSE
Histone-lysine N-methyltransferase ...
Prdm16
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001277955.1, NM_001291026.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000105637; ENSMUSP00000101262; ENSMUSG00000039410

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
70673

UCSC genome browser

More...
UCSCi
uc008wbv.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001277955.1, NM_001291026.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

jPOSTiA2A931
MaxQBiA2A931
PRIDEiA2A931
ProteomicsDBi351386

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26849, 232 antibodies

The DNASU plasmid repository

More...
DNASUi
70673

Genome annotation databases

EnsembliENSMUST00000105637; ENSMUSP00000101262; ENSMUSG00000039410
GeneIDi70673
UCSCiuc008wbv.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63976
MGIiMGI:1917923, Prdm16
VEuPathDBiHostDB:ENSMUSG00000039410

Phylogenomic databases

GeneTreeiENSGT00940000160951
OrthoDBi1318335at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
70673, 1 hit in 65 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Prdm16, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039410, Expressed in pes and 270 other tissues
ExpressionAtlasiA2A931, baseline and differential

Family and domain databases

CDDicd19213, PR-SET_PRDM16, 1 hit
InterProiView protein in InterPro
IPR044410, PRDM16_PR-SET
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00317, SET, 1 hit
SM00355, ZnF_C2H2, 10 hits
SUPFAMiSSF57667, SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 10 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2A931_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A931
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 29, 2021
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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