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UniProtKB - A2A8V8 (A2A8V8_MOUSE)

Entry version 106 (25 May 2022)
Sequence version 1 (20 Feb 2007)
Previous versions | rss
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Protein
Submitted name:

Serine/arginine repetitive matrix protein 1

Gene

Srrm1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Serine/arginine repetitive matrix protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Srrm1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1858303, Srrm1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000028809

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A2A8V8

MaxQB - The MaxQuant DataBase

More...MaxQBi		A2A8V8

PeptideAtlas

More...PeptideAtlasi		A2A8V8

PRoteomics IDEntifications database

More...PRIDEi		A2A8V8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		306628

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000028809, Expressed in forelimb bud and 328 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2A8V8, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A2A8V8, 1 interactor

Molecular INTeraction database

More...MINTi		A2A8V8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2A8V8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 126PWIInterPro annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni142 – 909DisorderedSequence analysisAdd BLAST768

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi142 – 167Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi168 – 206Basic residuesSequence analysisAdd BLAST39
Compositional biasi208 – 226Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi250 – 271Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi272 – 347Basic residuesSequence analysisAdd BLAST76
Compositional biasi348 – 367Polar residuesSequence analysisAdd BLAST20
Compositional biasi398 – 412Pro residuesSequence analysisAdd BLAST15
Compositional biasi413 – 436Polar residuesSequence analysisAdd BLAST24
Compositional biasi437 – 471Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi475 – 498Polar residuesSequence analysisAdd BLAST24
Compositional biasi511 – 527Basic residuesSequence analysisAdd BLAST17
Compositional biasi537 – 552Basic residuesSequence analysisAdd BLAST16
Compositional biasi553 – 598Pro residuesSequence analysisAdd BLAST46
Compositional biasi607 – 641Pro residuesSequence analysisAdd BLAST35
Compositional biasi645 – 678Polar residuesSequence analysisAdd BLAST34
Compositional biasi686 – 700Pro residuesSequence analysisAdd BLAST15
Compositional biasi702 – 726Polar residuesSequence analysisAdd BLAST25
Compositional biasi745 – 760Polar residuesSequence analysisAdd BLAST16
Compositional biasi815 – 839Basic residuesSequence analysisAdd BLAST25
Compositional biasi868 – 900Basic and acidic residuesSequence analysisAdd BLAST33

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111080

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015415_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002483, PWI_dom
IPR036483, PWI_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01480, PWI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00311, PWI, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101233, SSF101233, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51025, PWI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A2A8V8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAGFFRGTS AEQDNRFSNK QKKLLKQLKF AECLEKKVDM SKVNLEVIKP 
        60         70         80         90        100
WITKRVTEIL GFEDDVVIEF IFNQLEVKNP DSKMMQINLT GFLNGKNARE 
       110        120        130        140        150
FMGELWPLLL SAQENIAGIP SAFLELKKEE IKQRQIEQEK LASLKKQDED 
       160        170        180        190        200
KDKRDKEEKE SSREKRERSR SPRRRKSRSP SPRRRSSPVR RERKRSHSRS 
       210        220        230        240        250
PRHRTKSRSP SPAPEKKEKS PELPEPSVRM KDSSVQEATS TSDILKAPKP 
       260        270        280        290        300
EPVPEPKEPS PEKNSKKEKE KTRPRSRSRS KSRSRTRSRS PSHTRPRRRH 
       310        320        330        340        350
RSRSRSYSPR RRPSPRRRPS PRRRTPPRRM PPPPRHRRSR SPGRRRRRSS 
       360        370        380        390        400
ASLSGSSSSS SSSRSRSPPK KPPKRTSSPP RKTRRLSPSA SPPRRRHRPS 
       410        420        430        440        450
SPATPPPKTR HSPTPQQSNR TRKSRVSVSP GRTSGKVTKH KGTEKRESPS 
       460        470        480        490        500
PAPKPRKVEL SESEEDKGSK MAAADSVQQR RQYRRQNQQS SSDSGSSSTS 
       510        520        530        540        550
EDERPKRSHV KNGEVGRRRR HSPSRSASPS PRKRQKETSP RSRRRRSPSP 
       560        570        580        590        600
PPARRRRSPS PAPPPPPPPP PPRRRRSPTP PPRRRTPSPP PRRRSPSPRR 
       610        620        630        640        650
YSPPIQRRYS PSPPPKRRTA SPPPPPKRRA SPSPPPKRRV SHSPPPKQRS 
       660        670        680        690        700
PTVTKRRSPS LSSKHRKGSS PGRSTREARS PQPNKRHSPS PRPRAPQTSS 
       710        720        730        740        750
PPPVRRGASA SPQGRQSPSP STRPIRRVSR TPEPKKIKKA ASPSPQSVRR 
       760        770        780        790        800
VSSSRSVSGS PEPAAKKPPA PPSPVQSQSP STNWSPAVPA KKAKSPTPSL 
       810        820        830        840        850
SPARNSDQEG GGKKKKKKKD KKHKKDKKHK KHKKHKKEKA VTIATPATAA 
       860        870        880        890        900
PAAVSAATTT SAQEEPAAAP EPRKETESEA EDDNLDDLER HLREKALRSM 

RKAQVSPQS
Length:909
Mass (Da):102,660
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2650953332327B7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q52KI8SRRM1_MOUSE
Serine/arginine repetitive matrix p...
Srrm1 Pop101
946Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PUK6E9PUK6_MOUSE
Serine/arginine repetitive matrix p...
Srrm1
923Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A8V9A2A8V9_MOUSE
Serine/arginine repetitive matrix p...
Srrm1
918Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A983A2A983_MOUSE
Serine/arginine repetitive matrix p...
Srrm1
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QKA4E9QKA4_MOUSE
Serine/arginine repetitive matrix p...
Srrm1
897Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UK16F6UK16_MOUSE
Serine/arginine repetitive matrix p...
Srrm1
318Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BWM1F7BWM1_MOUSE
Serine/arginine repetitive matrix p...
Srrm1
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6T4M4F6T4M4_MOUSE
Serine/arginine repetitive matrix p...
Srrm1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_006539090.1, XM_006539027.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000105861.8; ENSMUSP00000101487.2; ENSMUSG00000028809.17

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_006539090.1, XM_006539027.1

3D structure databases

SMRiA2A8V8
ModBaseiSearch...

Protein-protein interaction databases

IntActiA2A8V8, 1 interactor
MINTiA2A8V8

Proteomic databases

jPOSTiA2A8V8
MaxQBiA2A8V8
PeptideAtlasiA2A8V8
PRIDEiA2A8V8
ProteomicsDBi306628

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30330, 121 antibodies from 22 providers

Genome annotation databases

EnsembliENSMUST00000105861.8; ENSMUSP00000101487.2; ENSMUSG00000028809.17

Organism-specific databases

MGIiMGI:1858303, Srrm1
VEuPathDBiHostDB:ENSMUSG00000028809

Phylogenomic databases

GeneTreeiENSGT00730000111080
HOGENOMiCLU_015415_0_0_1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51796, 27 hits in 75 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Srrm1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000028809, Expressed in forelimb bud and 328 other tissues
ExpressionAtlasiA2A8V8, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002483, PWI_dom
IPR036483, PWI_dom_sf
PfamiView protein in Pfam
PF01480, PWI, 1 hit
SMARTiView protein in SMART
SM00311, PWI, 1 hit
SUPFAMiSSF101233, SSF101233, 1 hit
PROSITEiView protein in PROSITE
PS51025, PWI, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2A8V8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A8V8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: May 25, 2022
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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