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UniProtKB - A2A8L1 (CHD5_MOUSE)

Entry version 123 (23 Feb 2022)
Sequence version 1 (20 Feb 2007)
Previous versions | rss
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Protein

Chromodomain-helicase-DNA-binding protein 5

Gene

Chd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri345 – 392PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri418 – 465PHD-type 2PROSITE-ProRule annotationAdd BLAST48
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi727 – 734ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processDifferentiation, Neurogenesis, Spermatogenesis, Transcription, Transcription regulation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 5 (EC:3.6.4.12)
Short name:
CHD-5
Alternative name(s):
ATP-dependent helicase CHD5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Chd5
Synonyms:Kiaa0444
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:3036258, Chd5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000005045

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant males are infertile. Mating occurs, but the males are sterile, displaying abnormal spermatogenesis. Disruption of the gene has no effect on the fertility of females. Infertility is due to sperm morphological abnormalities and complete immotility that are observed in all mice. A variable sperm counts, with a complete absence is some individuals is also observed. Spermatogenesis is normal from spermatogonia through meiotic division of spermatocytes. However, at stage IX, step 9, abnormal nuclear morphology of differentiating spermatids appears. It is associated with increased histone retention and decreased histone H4 hyperacetylation, an important step in spermatid chromatid condensation. Finally, spermiation is also affected.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi346D → A: No effect on interaction with histone H3 unmethylated at 'Lys-4'. No significant effect on the ability to repress target genes expression. No effect on regulation of cell proliferation. 1 Publication1
Mutagenesisi355G → A: Loss of the ability to negatively regulate cell proliferation. 1 Publication1
Mutagenesisi361D → A: Loss of interaction with histone H3 unmethylated at 'Lys-4'. Loss of the ability to repress target genes expression. Loss of the ability to negatively regulate cell proliferation. 1 Publication1
Mutagenesisi415D → A: Loss of interaction with histone H3 unmethylated at 'Lys-4'. Loss of the ability to negatively regulate cell proliferation. 1 Publication1
Mutagenesisi432C → W: Loss of the ability to negatively regulate cell proliferation. 1 Publication1
Mutagenesisi434D → A: Loss of interaction with histone H3 unmethylated at 'Lys-4'. Loss of the ability to repress target genes expression. Loss of the ability to negatively regulate cell proliferation. 1 Publication1

Keywords - Diseasei

Tumor suppressor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004293261 – 1946Chromodomain-helicase-DNA-binding protein 5Add BLAST1946

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1392N5-methylglutamineBy similarity1
Modified residuei1556PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated at Gln-1392 by N6AMT1.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A2A8L1

MaxQB - The MaxQuant DataBase

More...MaxQBi		A2A8L1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2A8L1

PeptideAtlas

More...PeptideAtlasi		A2A8L1

PRoteomics IDEntifications database

More...PRIDEi		A2A8L1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		281603

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A2A8L1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A2A8L1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed by neurons in brain, retina and adrenal gland (at protein level). Also detected in testis.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at 15.5 dpc, expression increases after birth and to adulthood. Expression increases in late-stage neuronal progenitor during their terminal differentiation.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000005045, Expressed in primary visual cortex and 163 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2A8L1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A2A8L1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May be part of a nucleosome remodeling and histone deacetylation, NuRD-like, complex composed at least of GATAD2B, HDAC1, HDAC2 and MTA3.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		234678, 11 interactors

Protein interaction database and analysis system

More...IntActi		A2A8L1, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000030775

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A2A8L1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2A8L1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini499 – 556Chromo 1PROSITE-ProRule annotationAdd BLAST58
Domaini594 – 655Chromo 2PROSITE-ProRule annotationAdd BLAST62
Domaini714 – 898Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST185
Domaini1030 – 1195Helicase C-terminalPROSITE-ProRule annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 140DisorderedSequence analysisAdd BLAST140
Regioni236 – 272DisorderedSequence analysisAdd BLAST37
Regioni285 – 340DisorderedSequence analysisAdd BLAST56
Regioni345 – 655Histone-bindingBy similarityAdd BLAST311
Regioni551 – 573DisorderedSequence analysisAdd BLAST23
Regioni1210 – 1254DisorderedSequence analysisAdd BLAST45
Regioni1353 – 1413DisorderedSequence analysisAdd BLAST61
Regioni1525 – 1566DisorderedSequence analysisAdd BLAST42
Regioni1579 – 1696DisorderedSequence analysisAdd BLAST118
Regioni1926 – 1946DisorderedSequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi849 – 852DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 36Acidic residuesSequence analysisAdd BLAST22
Compositional biasi99 – 114Basic residuesSequence analysisAdd BLAST16
Compositional biasi115 – 132Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi244 – 259Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1212 – 1232Polar residuesSequence analysisAdd BLAST21
Compositional biasi1388 – 1410Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1602 – 1696Basic and acidic residuesSequence analysisAdd BLAST95

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PHD domains mediate specific binding to histone H3 unmethylated at 'Lys-4' and may preferentially recruit the protein to transcriptionally inactive genes.1 Publication
The chromo domains mediate specific binding to histone H3 trimethylated at 'Lys-27' (H3K27me3) and may be required in neuron differentiation for proper gene regulation.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri345 – 392PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri418 – 465PHD-type 2PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0383, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159249

Database of Orthologous Groups

More...OrthoDBi		709631at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2A8L1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 2 hits
3.40.50.10810, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028727, CHD5
IPR012957, CHD_C2
IPR009462, CHD_II_SANT-like
IPR012958, CHD_N
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR009463, DUF1087
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR45623:SF6, PTHR45623:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08074, CHDCT2, 1 hit
PF08073, CHDNT, 1 hit
PF00385, Chromo, 1 hit
PF06461, DUF1086, 1 hit
PF06465, DUF1087, 1 hit
PF00271, Helicase_C, 1 hit
PF00628, PHD, 2 hits
PF00176, SNF2-rel_dom, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM01146, DUF1086, 1 hit
SM01147, DUF1087, 1 hit
SM00490, HELICc, 1 hit
SM00249, PHD, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50013, CHROMO_2, 2 hits
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2A8L1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGPLGTEEE LPRLFAEEME NEEEMSEEED GGLEGFEDFF PAEPVSLPKK 
        60         70         80         90        100
KPKKLKESKS SKGKRKKKEG SNDEMSDNEE DLEEKSESEG SDYSPTKKKK 
       110        120        130        140        150
KKLKEKKEKK EKKEKRKKRG EDEDDNDDGG LKEPKSSGQL MAEWGLDDVD 
       160        170        180        190        200
YLFSEDDYHT LTNYKAFSQF LRPLIAKKNP KIPMSKMMTV LGAKWREFSA 
       210        220        230        240        250
NNPFKGSSAA AAAAAVAAAV ETVTIAPPLA ISPQQVPQTL PIRKAKTKEG 
       260        270        280        290        300
KGPGVRKKNK GAKDSKKKGR GKRVAGLKFR FGGISKRKKG SSSEEDERED 
       310        320        330        340        350
SDLDNASIHS SSVRSECSAA LGKKNKRRRK KKRIDDGDGY ETDHQDYCEV 
       360        370        380        390        400
CQQGGEIILC DTCPRAYHLV CLDPELEKAP EGKWSCPHCE KEGIQWEPKD 
       410        420        430        440        450
DDEEEEEGGC EEEEDDHMEF CRVCKDGGEL LCCDACPSSY HLHCLNPPLP 
       460        470        480        490        500
EIPNGEWLCP RCTCPPLKGK VQRILHWRWT EPPAPFVVGL PGPEVEPGMP 
       510        520        530        540        550
PPRPLEGIPE REFFVKWAGL SYWHCSWVKE LQLELYHTVM YRNYQRKNDM 
       560        570        580        590        600
DEPPPFDYGS GDEDGKSEKR KNKDPLYAKM EERFYRYGIK PEWMMVHRIL 
       610        620        630        640        650
NHSFDKKGDI HYLIKWKDLP YDQCTWEIDE IDIPYYDNLK QAYWGHRELM 
       660        670        680        690        700
LGEDARLPKR LVKKGKKLKD DKQEKPPDTP IVDPTVKFDK QPWYIDATGG 
       710        720        730        740        750
TLHPYQLEGL NWLRFSWAQG TDTILADEMG LGKTVQTIVF LYSLYKEGHS 
       760        770        780        790        800
KGPYLVSAPL STIINWEREF EMWAPDFYVV TYTGDKESRS VIRENEFSFE 
       810        820        830        840        850
DNAIRGGKKV FRMKKEVQIK FHVLLTSYEL ITIDQAILGS IEWACLVVDE 
       860        870        880        890        900
AHRLKNNQSK FFRVLNSYKI DYKLLLTGTP LQNNLEELFH LLNFLTPERF 
       910        920        930        940        950
NNLEGFLEEF ADISKEDQIK KLHDLLGPHM LRRLKADVFK NMPAKTELIV 
       960        970        980        990       1000
RVELSQMQKK YYKFILTRNF EALNSKGGGN QVSLLNIMMD LKKCCNHPYL 
      1010       1020       1030       1040       1050
FPVAAVEAPV LPNGSYDGSS LVKSSGKLML LQKMLKKLRD EGHRVLIFSQ 
      1060       1070       1080       1090       1100
MTKMLDLLED FLEYEGYKYE RIDGGITGGL RQEAIDRFNA PGAQQFCFLL 
      1110       1120       1130       1140       1150
STRAGGLGIN LATADTVIIY DSDWNPHNDI QAFSRAHRIG QNKKVMIYRF 
      1160       1170       1180       1190       1200
VTRASVEERI TQVAKRKMML THLVVRPGLG SKSGSMTKQE LDDILKFGTE 
      1210       1220       1230       1240       1250
ELFKDDVEGM MSQGQRPTTP IPDIQSTKGG SLTAGAKKKH GSTPPGDNKD 
      1260       1270       1280       1290       1300
VEDSSVIHYD DAAISKLLDR NQDATDDTEL QNMNEYLSSF KVAQYVVREE 
      1310       1320       1330       1340       1350
DGVEEVEREV IKQEENVDPD YWEKLLRHHY EQQQEDLARN LGKGKRIRKQ 
      1360       1370       1380       1390       1400
VNYNDASQED QEWQDELSDN QSEYSIGSED EDEDFEERPE GQSGRRQSRR 
      1410       1420       1430       1440       1450
QLKSDRDKPL PPLLARVGGN IEVLGFNARQ RKAFLNAIMR WGMPPQDAFN 
      1460       1470       1480       1490       1500
SHWLVRDLRG KSEKEFRAYV SLFMRHLCEP GADGAETFAD GVPREGLSRQ 
      1510       1520       1530       1540       1550
HVLTRIGVMS LVRKKVQEFE HVNGKYSTPD LVPEGAEGKK PGEVISSDPN 
      1560       1570       1580       1590       1600
TPVPASPAQL PPAPLGLTDK MEAQLGYTDE KESGMQKPKK SLEIQTLPTA 
      1610       1620       1630       1640       1650
LDRVEGEDKH QSSDSKDRAR EERTEEVEKA QGSPEQPLKE EVLPDKEPIP 
      1660       1670       1680       1690       1700
DKPELSLGHS GDFRPDDPKT EEKEPGETQQ NGDREEDEEG KKEDKNGKFK 
      1710       1720       1730       1740       1750
FMFNIADGGF TELHTLWQNE ERAAVSSGKI YEIWHRRHDY WLLAGIVTHG 
      1760       1770       1780       1790       1800
YARWQDIQND PRYMILNEPF KSEIHKGNYL EMKNKFLARR FKLLEQALVI 
      1810       1820       1830       1840       1850
EEQLRRAAYL NMTQDPNHPA MALNARLAEV ECLAESHQHL SKESLAGNKP 
      1860       1870       1880       1890       1900
ANAVLHKVLN QLEELLSDMK ADVTRLPSML SRIPPVAARL QMSERSILSR 
      1910       1920       1930       1940 
LTNRAGDPTI QQTSSRRRDF PLFQRSFPAE PSHLPNPRGR EKLQPF
Length:1,946
Mass (Da):222,515
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B94AB11A9C9BB03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PYL1E9PYL1_MOUSE
DNA helicase
Chd5
1,952Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PYU4E9PYU4_MOUSE
DNA helicase
Chd5
1,915Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL611985 Genomic DNA No translation available.
AK129145 mRNA Translation: BAC97955.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS89866.1

NCBI Reference Sequences

More...RefSeqi		XP_006538995.1, XM_006538932.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000005175; ENSMUSP00000005175; ENSMUSG00000005045

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL611985 Genomic DNA No translation available.
AK129145 mRNA Translation: BAC97955.1
CCDSiCCDS89866.1
RefSeqiXP_006538995.1, XM_006538932.2

3D structure databases

SMRiA2A8L1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi234678, 11 interactors
IntActiA2A8L1, 1 interactor
STRINGi10090.ENSMUSP00000030775

PTM databases

iPTMnetiA2A8L1
PhosphoSitePlusiA2A8L1

Proteomic databases

jPOSTiA2A8L1
MaxQBiA2A8L1
PaxDbiA2A8L1
PeptideAtlasiA2A8L1
PRIDEiA2A8L1
ProteomicsDBi281603

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27125, 139 antibodies from 29 providers

Genome annotation databases

EnsembliENSMUST00000005175; ENSMUSP00000005175; ENSMUSG00000005045

Organism-specific databases

MGIiMGI:3036258, Chd5
VEuPathDBiHostDB:ENSMUSG00000005045

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG0383, Eukaryota
GeneTreeiENSGT00940000159249
OrthoDBi709631at2759
PhylomeDBiA2A8L1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		269610, 5 hits in 65 CRISPR screens

Protein Ontology

More...PROi		PR:A2A8L1
RNActiA2A8L1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000005045, Expressed in primary visual cortex and 163 other tissues
ExpressionAtlasiA2A8L1, baseline and differential
GenevisibleiA2A8L1, MM

Family and domain databases

Gene3Di3.30.40.10, 2 hits
3.40.50.10810, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR028727, CHD5
IPR012957, CHD_C2
IPR009462, CHD_II_SANT-like
IPR012958, CHD_N
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR009463, DUF1087
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45623:SF6, PTHR45623:SF6, 1 hit
PfamiView protein in Pfam
PF08074, CHDCT2, 1 hit
PF08073, CHDNT, 1 hit
PF00385, Chromo, 1 hit
PF06461, DUF1086, 1 hit
PF06465, DUF1087, 1 hit
PF00271, Helicase_C, 1 hit
PF00628, PHD, 2 hits
PF00176, SNF2-rel_dom, 1 hit
SMARTiView protein in SMART
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM01146, DUF1086, 1 hit
SM01147, DUF1087, 1 hit
SM00490, HELICc, 1 hit
SM00249, PHD, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50013, CHROMO_2, 2 hits
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHD5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A8L1
Secondary accession number(s): Q6ZQB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 11, 2014
Last sequence update: February 20, 2007
Last modified: February 23, 2022
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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