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UniProtKB - A2A891 (CMTA1_MOUSE)

Protein

Calmodulin-binding transcription activator 1

Gene

Camta1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi63 – 188CG-1PROSITE-ProRule annotationAdd BLAST126

GO - Molecular functioni

  • proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
  • sequence-specific DNA binding Source: MGI
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 1Imported
Gene namesi
Name:Camta1Imported
Synonyms:Kiaa0833Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140230 Camta1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003550431 – 1682Calmodulin-binding transcription activator 1Add BLAST1682

Proteomic databases

MaxQBiA2A891
PaxDbiA2A891
PRIDEiA2A891

PTM databases

iPTMnetiA2A891
PhosphoSitePlusiA2A891

Expressioni

Gene expression databases

BgeeiENSMUSG00000014592 Expressed in 237 organ(s), highest expression level in cerebellum
ExpressionAtlasiA2A891 baseline and differential
GenevisibleiA2A891 MM

Interactioni

Subunit structurei

May interact with calmodulin.By similarity

Protein-protein interaction databases

IntActiA2A891, 1 interactor
STRINGi10090.ENSMUSP00000054804

Structurei

3D structure databases

ProteinModelPortaliA2A891
SMRiA2A891
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini875 – 955IPT/TIGAdd BLAST81
Repeati1066 – 1095ANK 1Sequence analysisAdd BLAST30
Repeati1111 – 1141ANK 2Sequence analysisAdd BLAST31
Repeati1145 – 1174ANK 3Sequence analysisAdd BLAST30
Domaini1549 – 1585IQ 1PROSITE-ProRule annotationAdd BLAST37
Domaini1586 – 1608IQ 2PROSITE-ProRule annotationAdd BLAST23
Domaini1609 – 1631IQ 3PROSITE-ProRule annotationAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi112 – 119Nuclear localization signalPROSITE-ProRule annotationBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1006 – 1033Gly-richSequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the CAMTA family.Sequence analysis

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0520 Eukaryota
ENOG410XS5M LUCA
GeneTreeiENSGT00390000001446
HOVERGENiHBG080107
InParanoidiA2A891
KOiK21596
OMAiCSSEHYL
OrthoDBiEOG091G01MB
PhylomeDBiA2A891
TreeFamiTF323452

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039033 Camta1
IPR005559 CG-1_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR000048 IQ_motif_EF-hand-BS
PANTHERiPTHR23335:SF11 PTHR23335:SF11, 1 hit
PfamiView protein in Pfam
PF03859 CG-1, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM01076 CG-1, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS51437 CG_1, 1 hit
PS50096 IQ, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: A2A891-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK 
        60         70         80         90        100
IFLPKKLLEC LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT 
       110        120        130        140        150
RPQNGSMILY NRKKVKYRKD GYCWKKRKDG KTTREDHMKL KVQGVECLYG 
       160        170        180        190        200
CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL NVPAIEDCGK PCGPILCSIN 
       210        220        230        240        250
TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV EQLVQQILDS 
       260        270        280        290        300
HQTKPQPRTH NCLCTGSLGA GSSVHHKCNS AKHRIISPKV EPRAGGYGGH 
       310        320        330        340        350
SEVQHNDVSE GKHEPSHGRS TSREKRNGKV AKPALLHQNS TEVSSTNQVE 
       360        370        380        390        400
VPDTTQSSPV SISSGLNSDP DMVDSPVVTG VSSMAVASVM GGLSQSATVF 
       410        420        430        440        450
MSEVTNEAVY TMSPTAGPNH HLLSPDASQG LVLAVSSDGH KFAFPTTGSS 
       460        470        480        490        500
DSLSMLPANV SEELVLSTTL DGGRKIPETA MNFDPDCFLN NPKQGQTYGG 
       510        520        530        540        550
GGLKAEMVST NIRHSPPAER SFGFTSVLTK EIKTEDTSFE QQMAKEAAYS 
       560        570        580        590        600
SSAAAAASSS LTLTAAGSSL LPSGGGLSPS TTLEQMDFSA IDSNKDYASS 
       610        620        630        640        650
FSQTGHSPHI HQTPSPSFFL QDASKPLPLE QNTHSSLSES GAAFVMPTVK 
       660        670        680        690        700
TEASSQTSSC SGHVETRIES TSSLHLMQFQ ANFQAMAAEG EVTMETSQAA 
       710        720        730        740        750
EGNEVLLKSG ELQACGSEHY LQPETNGVIR SAGGVPLLPS NVVQGLYPVA 
       760        770        780        790        800
QPSLGNSSNM ELSLDHFDIS FSNQFSDLIN DFISVEGGSG TIYGHQLVSG 
       810        820        830        840        850
DSAALSQSED GARAPFTQAE MCIPCCSPQQ GSLQLSSAEG GPSTMAYMHV 
       860        870        880        890        900
AEVVSAASAQ GALGMLQQSG RVFMVTDYSP EWSYPEGGVK VLITGPWQEA 
       910        920        930        940        950
SNNYSCLFDQ ISVPASLIQP GVLRCYCPAH DTGLVTLQVA FNNQIISNSV 
       960        970        980        990       1000
VFEYKARALP TLPSSQHDWL SLDDNQFRMS ILERLEQMER RMAEMTGSQQ 
      1010       1020       1030       1040       1050
HKQASGGGGS GSGSGSGAGG GQAQCASGAG TLGSCFESRV VVVCEKMMSR 
      1060       1070       1080       1090       1100
ACWAKSKHLI HSKTFRGMTL LHLAAAQGYA TLIQTLIKWR TKHADSIDLE 
      1110       1120       1130       1140       1150
LEVDPLNVDH FSCTPLMWAC ALGHLEAAVV LYKWDRRAIS IPDSLGRLPL 
      1160       1170       1180       1190       1200
GIARSRGHVK LAECLEHLQR DEQAQLGQAS RIHCAPSEEP TTDSWMAQWQ 
      1210       1220       1230       1240       1250
REAMSPPEIP KGVTVIASTN PELRRPRSEP SNYYSTEGHK DYPAPKKHKL 
      1260       1270       1280       1290       1300
NPESFQARQE KLLCTALSLE QPNIRKQSPR SKQPSPETIS PSEGVREYSR 
      1310       1320       1330       1340       1350
EAAPPTPETA ASQASASQPV VKWSAKDLYI GVSTVQVTGN PKGTSVVKDA 
      1360       1370       1380       1390       1400
APSQVRPREP MSVLMLANRE VVNTEMGAYR DRTEHEDCPQ PMDDIQVNMM 
      1410       1420       1430       1440       1450
TLAEHIIEAT PDRIKQENFV PMESSALERT DPATISSTMS WLASYLADAD 
      1460       1470       1480       1490       1500
RLPSAAHIRS AYTEPLTPSS NASLSPAGSP VSEVAFEKPS LPSAADWSEF 
      1510       1520       1530       1540       1550
LSASTSEKVE SELAQLTLSD HEQRELYEAA RLVQTAFRKY KGRPLREQQE 
      1560       1570       1580       1590       1600
VAAAVIQRCY RKYKQLTWIA LKYALYKKMT QAAILIQSKF RSYYEQKRFQ 
      1610       1620       1630       1640       1650
QSRRAAVLIQ NFYRSYKKCG RRRPARRTAV IVQQKLRSSL LTKKQDQAAR 
      1660       1670       1680 
KIMRFLRRCR HSPLVDHRLY KRSERIEKGQ GT
Note: Gene prediction based on EST data.Curated
Length:1,682
Mass (Da):184,319
Last modified:February 5, 2008 - v1
Checksum:i3F96253C6CF119C6
GO
Isoform 2 (identifier: A2A891-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1566-1572: Missing.

Show »
Length:1,675
Mass (Da):183,493
Checksum:iC811D17DE9DB7D26
GO
Isoform 3 (identifier: A2A891-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-978: Missing.
     1222-1334: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:591
Mass (Da):66,116
Checksum:i18DEB1C54B8316DB
GO
Isoform 4 (identifier: A2A891-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-978: Missing.
     1222-1334: Missing.
     1566-1572: Missing.
     1662-1682: SPLVDHRLYKRSERIEKGQGT → RVKELKKAKELEDIQQHPLAM

Note: No experimental confirmation available.Curated
Show »
Length:584
Mass (Da):65,325
Checksum:iD71B213119E7D3BF
GO
Isoform 5 (identifier: A2A891-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1459-1472: Missing.
     1566-1572: Missing.
     1662-1682: SPLVDHRLYKRSERIEKGQGT → RVKELKKAKELEDIQQHPLAM

Note: No experimental confirmation available.Curated
Show »
Length:1,661
Mass (Da):182,052
Checksum:i42F3C95AD83F2CC1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YMK8Z4YMK8_MOUSE
Calmodulin-binding transcription ac...
Camta1
238Annotation score:
B0QZL6B0QZL6_MOUSE
Calmodulin-binding transcription ac...
Camta1
75Annotation score:
Q3TYE0Q3TYE0_MOUSE
Calmodulin-binding transcription ac...
Camta1
80Annotation score:

Sequence cautioni

The sequence CAM24788 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1394D → G in CAQ51627 (PubMed:19468303).Curated1
Sequence conflicti1394D → G in CAQ51628 (PubMed:19468303).Curated1
Sequence conflicti1394D → G in CAQ51883 (PubMed:19468303).Curated1
Sequence conflicti1394D → G in CAQ51884 (PubMed:19468303).Curated1
Sequence conflicti1482S → N in CAQ51627 (PubMed:19468303).Curated1
Sequence conflicti1482S → N in CAQ51628 (PubMed:19468303).Curated1
Sequence conflicti1482S → N in CAQ51883 (PubMed:19468303).Curated1
Sequence conflicti1482S → N in CAQ51884 (PubMed:19468303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0529871 – 978Missing in isoform 3 and isoform 4. CuratedAdd BLAST978
Alternative sequenceiVSP_0529881222 – 1334Missing in isoform 3 and isoform 4. CuratedAdd BLAST113
Alternative sequenceiVSP_0529891459 – 1472Missing in isoform 5. CuratedAdd BLAST14
Alternative sequenceiVSP_0529901566 – 1572Missing in isoform 2, isoform 4 and isoform 5. Curated7
Alternative sequenceiVSP_0529911662 – 1682SPLVD…KGQGT → RVKELKKAKELEDIQQHPLA M in isoform 4 and isoform 5. CuratedAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606986
, AL606967, AL607143, AL611931, AL732550 Genomic DNA Translation: CAM18834.1
AL606986
, AL606967, AL607143, AL611931, AL732550 Genomic DNA Translation: CAM18835.1
AL606967
, AL606986, AL607143, AL611931, AL732550 Genomic DNA Translation: CAM20269.1
AL606967
, AL606986, AL607143, AL611931, AL732550 Genomic DNA Translation: CAM20270.1
AL732550
, AL606967, AL606986, AL607143, AL611931 Genomic DNA Translation: CAM24365.1
AL732550
, AL606967, AL606986, AL607143, AL611931 Genomic DNA Translation: CAM24366.1
AL607143
, AL606967, AL606986, AL611931, AL732550 Genomic DNA Translation: CAM24783.1
AL607143
, AL606967, AL606986, AL611931, AL732550 Genomic DNA Translation: CAM24784.1
AL607143 Genomic DNA Translation: CAM24788.2 Sequence problems.
AL607143 Genomic DNA Translation: CAM24789.1
AL607143 Genomic DNA Translation: CAM24790.1
AL611931
, AL606967, AL606986, AL607143, AL732550 Genomic DNA Translation: CAM25054.1
AL611931
, AL606967, AL606986, AL607143, AL732550 Genomic DNA Translation: CAM25055.1
CU442759, CU207342, CU407306 Genomic DNA Translation: CAQ51627.1
CU442759, CU207342, CU407306 Genomic DNA Translation: CAQ51628.1
CU407306, CU207342, CU442759 Genomic DNA Translation: CAQ51883.1
CU407306, CU207342, CU442759 Genomic DNA Translation: CAQ51884.1
AK122383 mRNA Translation: BAC65665.1
CCDSiCCDS38981.1 [A2A891-1]
RefSeqiNP_001075026.1, NM_001081557.3 [A2A891-1]
UniGeneiMm.318846

Genome annotation databases

EnsembliENSMUST00000049790; ENSMUSP00000054804; ENSMUSG00000014592 [A2A891-1]
ENSMUST00000097774; ENSMUSP00000095381; ENSMUSG00000014592 [A2A891-2]
ENSMUST00000105668; ENSMUSP00000101293; ENSMUSG00000014592 [A2A891-3]
ENSMUST00000105670; ENSMUSP00000101295; ENSMUSG00000014592 [A2A891-4]
ENSMUST00000169423; ENSMUSP00000127916; ENSMUSG00000014592 [A2A891-1]
GeneIDi100072
KEGGimmu:100072
UCSCiuc008vyk.2 mouse [A2A891-4]
uc008vym.2 mouse [A2A891-3]
uc008vyn.2 mouse [A2A891-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606986
, AL606967, AL607143, AL611931, AL732550 Genomic DNA Translation: CAM18834.1
AL606986
, AL606967, AL607143, AL611931, AL732550 Genomic DNA Translation: CAM18835.1
AL606967
, AL606986, AL607143, AL611931, AL732550 Genomic DNA Translation: CAM20269.1
AL606967
, AL606986, AL607143, AL611931, AL732550 Genomic DNA Translation: CAM20270.1
AL732550
, AL606967, AL606986, AL607143, AL611931 Genomic DNA Translation: CAM24365.1
AL732550
, AL606967, AL606986, AL607143, AL611931 Genomic DNA Translation: CAM24366.1
AL607143
, AL606967, AL606986, AL611931, AL732550 Genomic DNA Translation: CAM24783.1
AL607143
, AL606967, AL606986, AL611931, AL732550 Genomic DNA Translation: CAM24784.1
AL607143 Genomic DNA Translation: CAM24788.2 Sequence problems.
AL607143 Genomic DNA Translation: CAM24789.1
AL607143 Genomic DNA Translation: CAM24790.1
AL611931
, AL606967, AL606986, AL607143, AL732550 Genomic DNA Translation: CAM25054.1
AL611931
, AL606967, AL606986, AL607143, AL732550 Genomic DNA Translation: CAM25055.1
CU442759, CU207342, CU407306 Genomic DNA Translation: CAQ51627.1
CU442759, CU207342, CU407306 Genomic DNA Translation: CAQ51628.1
CU407306, CU207342, CU442759 Genomic DNA Translation: CAQ51883.1
CU407306, CU207342, CU442759 Genomic DNA Translation: CAQ51884.1
AK122383 mRNA Translation: BAC65665.1
CCDSiCCDS38981.1 [A2A891-1]
RefSeqiNP_001075026.1, NM_001081557.3 [A2A891-1]
UniGeneiMm.318846

3D structure databases

ProteinModelPortaliA2A891
SMRiA2A891
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2A891, 1 interactor
STRINGi10090.ENSMUSP00000054804

PTM databases

iPTMnetiA2A891
PhosphoSitePlusiA2A891

Proteomic databases

MaxQBiA2A891
PaxDbiA2A891
PRIDEiA2A891

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049790; ENSMUSP00000054804; ENSMUSG00000014592 [A2A891-1]
ENSMUST00000097774; ENSMUSP00000095381; ENSMUSG00000014592 [A2A891-2]
ENSMUST00000105668; ENSMUSP00000101293; ENSMUSG00000014592 [A2A891-3]
ENSMUST00000105670; ENSMUSP00000101295; ENSMUSG00000014592 [A2A891-4]
ENSMUST00000169423; ENSMUSP00000127916; ENSMUSG00000014592 [A2A891-1]
GeneIDi100072
KEGGimmu:100072
UCSCiuc008vyk.2 mouse [A2A891-4]
uc008vym.2 mouse [A2A891-3]
uc008vyn.2 mouse [A2A891-1]

Organism-specific databases

CTDi23261
MGIiMGI:2140230 Camta1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0520 Eukaryota
ENOG410XS5M LUCA
GeneTreeiENSGT00390000001446
HOVERGENiHBG080107
InParanoidiA2A891
KOiK21596
OMAiCSSEHYL
OrthoDBiEOG091G01MB
PhylomeDBiA2A891
TreeFamiTF323452

Miscellaneous databases

PROiPR:A2A891
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014592 Expressed in 237 organ(s), highest expression level in cerebellum
ExpressionAtlasiA2A891 baseline and differential
GenevisibleiA2A891 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039033 Camta1
IPR005559 CG-1_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR000048 IQ_motif_EF-hand-BS
PANTHERiPTHR23335:SF11 PTHR23335:SF11, 1 hit
PfamiView protein in Pfam
PF03859 CG-1, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM01076 CG-1, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS51437 CG_1, 1 hit
PS50096 IQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCMTA1_MOUSE
AccessioniPrimary (citable) accession number: A2A891
Secondary accession number(s): A2A892
, A2A896, A2A897, A2A898, B2KGR3, B2KGR4, Q80TQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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