UniProtKB - A2A891 (CMTA1_MOUSE)
Protein
Calmodulin-binding transcription activator 1
Gene
Camta1
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional activator.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 63 – 188 | CG-1PROSITE-ProRule annotationAdd BLAST | 126 |
GO - Molecular functioni
- double-stranded DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- neuromuscular process controlling balance Source: MGI
- positive regulation of calcineurin-NFAT signaling cascade Source: MGI
- positive regulation of protein dephosphorylation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Calmodulin-binding transcription activator 1Imported |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2140230, Camta1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000355043 | 1 – 1682 | Calmodulin-binding transcription activator 1Add BLAST | 1682 |
Proteomic databases
MaxQBi | A2A891 |
PaxDbi | A2A891 |
PRIDEi | A2A891 |
PTM databases
iPTMneti | A2A891 |
PhosphoSitePlusi | A2A891 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000014592, Expressed in cerebellum and 253 other tissues |
ExpressionAtlasi | A2A891, baseline and differential |
Genevisiblei | A2A891, MM |
Interactioni
Subunit structurei
May interact with calmodulin.
By similarityProtein-protein interaction databases
IntActi | A2A891, 1 interactor |
STRINGi | 10090.ENSMUSP00000054804 |
Miscellaneous databases
RNActi | A2A891, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 875 – 955 | IPT/TIGAdd BLAST | 81 | |
Repeati | 1066 – 1095 | ANK 1Sequence analysisAdd BLAST | 30 | |
Repeati | 1111 – 1141 | ANK 2Sequence analysisAdd BLAST | 31 | |
Repeati | 1145 – 1174 | ANK 3Sequence analysisAdd BLAST | 30 | |
Domaini | 1549 – 1585 | IQ 1PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1586 – 1608 | IQ 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Domaini | 1609 – 1631 | IQ 3PROSITE-ProRule annotationAdd BLAST | 23 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 112 – 119 | Nuclear localization signalPROSITE-ProRule annotationBy similarity | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1006 – 1033 | Gly-richSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the CAMTA family.Sequence analysis
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0520, Eukaryota |
GeneTreei | ENSGT00940000155203 |
HOGENOMi | CLU_003170_1_0_1 |
InParanoidi | A2A891 |
OMAi | CSPQQGG |
OrthoDBi | 315169at2759 |
PhylomeDBi | A2A891 |
TreeFami | TF323452 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR039033, Camta1 IPR005559, CG-1_dom IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR000048, IQ_motif_EF-hand-BS |
PANTHERi | PTHR23335:SF11, PTHR23335:SF11, 1 hit |
Pfami | View protein in Pfam PF03859, CG-1, 1 hit PF01833, TIG, 1 hit |
SMARTi | View protein in SMART SM01076, CG-1, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS51437, CG_1, 1 hit PS50096, IQ, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 11 Publication (identifier: A2A891-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK
60 70 80 90 100
IFLPKKLLEC LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT
110 120 130 140 150
RPQNGSMILY NRKKVKYRKD GYCWKKRKDG KTTREDHMKL KVQGVECLYG
160 170 180 190 200
CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL NVPAIEDCGK PCGPILCSIN
210 220 230 240 250
TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV EQLVQQILDS
260 270 280 290 300
HQTKPQPRTH NCLCTGSLGA GSSVHHKCNS AKHRIISPKV EPRAGGYGGH
310 320 330 340 350
SEVQHNDVSE GKHEPSHGRS TSREKRNGKV AKPALLHQNS TEVSSTNQVE
360 370 380 390 400
VPDTTQSSPV SISSGLNSDP DMVDSPVVTG VSSMAVASVM GGLSQSATVF
410 420 430 440 450
MSEVTNEAVY TMSPTAGPNH HLLSPDASQG LVLAVSSDGH KFAFPTTGSS
460 470 480 490 500
DSLSMLPANV SEELVLSTTL DGGRKIPETA MNFDPDCFLN NPKQGQTYGG
510 520 530 540 550
GGLKAEMVST NIRHSPPAER SFGFTSVLTK EIKTEDTSFE QQMAKEAAYS
560 570 580 590 600
SSAAAAASSS LTLTAAGSSL LPSGGGLSPS TTLEQMDFSA IDSNKDYASS
610 620 630 640 650
FSQTGHSPHI HQTPSPSFFL QDASKPLPLE QNTHSSLSES GAAFVMPTVK
660 670 680 690 700
TEASSQTSSC SGHVETRIES TSSLHLMQFQ ANFQAMAAEG EVTMETSQAA
710 720 730 740 750
EGNEVLLKSG ELQACGSEHY LQPETNGVIR SAGGVPLLPS NVVQGLYPVA
760 770 780 790 800
QPSLGNSSNM ELSLDHFDIS FSNQFSDLIN DFISVEGGSG TIYGHQLVSG
810 820 830 840 850
DSAALSQSED GARAPFTQAE MCIPCCSPQQ GSLQLSSAEG GPSTMAYMHV
860 870 880 890 900
AEVVSAASAQ GALGMLQQSG RVFMVTDYSP EWSYPEGGVK VLITGPWQEA
910 920 930 940 950
SNNYSCLFDQ ISVPASLIQP GVLRCYCPAH DTGLVTLQVA FNNQIISNSV
960 970 980 990 1000
VFEYKARALP TLPSSQHDWL SLDDNQFRMS ILERLEQMER RMAEMTGSQQ
1010 1020 1030 1040 1050
HKQASGGGGS GSGSGSGAGG GQAQCASGAG TLGSCFESRV VVVCEKMMSR
1060 1070 1080 1090 1100
ACWAKSKHLI HSKTFRGMTL LHLAAAQGYA TLIQTLIKWR TKHADSIDLE
1110 1120 1130 1140 1150
LEVDPLNVDH FSCTPLMWAC ALGHLEAAVV LYKWDRRAIS IPDSLGRLPL
1160 1170 1180 1190 1200
GIARSRGHVK LAECLEHLQR DEQAQLGQAS RIHCAPSEEP TTDSWMAQWQ
1210 1220 1230 1240 1250
REAMSPPEIP KGVTVIASTN PELRRPRSEP SNYYSTEGHK DYPAPKKHKL
1260 1270 1280 1290 1300
NPESFQARQE KLLCTALSLE QPNIRKQSPR SKQPSPETIS PSEGVREYSR
1310 1320 1330 1340 1350
EAAPPTPETA ASQASASQPV VKWSAKDLYI GVSTVQVTGN PKGTSVVKDA
1360 1370 1380 1390 1400
APSQVRPREP MSVLMLANRE VVNTEMGAYR DRTEHEDCPQ PMDDIQVNMM
1410 1420 1430 1440 1450
TLAEHIIEAT PDRIKQENFV PMESSALERT DPATISSTMS WLASYLADAD
1460 1470 1480 1490 1500
RLPSAAHIRS AYTEPLTPSS NASLSPAGSP VSEVAFEKPS LPSAADWSEF
1510 1520 1530 1540 1550
LSASTSEKVE SELAQLTLSD HEQRELYEAA RLVQTAFRKY KGRPLREQQE
1560 1570 1580 1590 1600
VAAAVIQRCY RKYKQLTWIA LKYALYKKMT QAAILIQSKF RSYYEQKRFQ
1610 1620 1630 1640 1650
QSRRAAVLIQ NFYRSYKKCG RRRPARRTAV IVQQKLRSSL LTKKQDQAAR
1660 1670 1680
KIMRFLRRCR HSPLVDHRLY KRSERIEKGQ GT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB0QZL6 | B0QZL6_MOUSE | Calmodulin-binding transcription ac... | Camta1 | 75 | Annotation score: | ||
Z4YMK8 | Z4YMK8_MOUSE | Calmodulin-binding transcription ac... | Camta1 | 238 | Annotation score: | ||
Q3TYE0 | Q3TYE0_MOUSE | Calmodulin-binding transcription ac... | Camta1 | 80 | Annotation score: |
Sequence cautioni
The sequence CAM24788 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1394 | D → G in CAQ51627 (PubMed:19468303).Curated | 1 | |
Sequence conflicti | 1394 | D → G in CAQ51628 (PubMed:19468303).Curated | 1 | |
Sequence conflicti | 1394 | D → G in CAQ51883 (PubMed:19468303).Curated | 1 | |
Sequence conflicti | 1394 | D → G in CAQ51884 (PubMed:19468303).Curated | 1 | |
Sequence conflicti | 1482 | S → N in CAQ51627 (PubMed:19468303).Curated | 1 | |
Sequence conflicti | 1482 | S → N in CAQ51628 (PubMed:19468303).Curated | 1 | |
Sequence conflicti | 1482 | S → N in CAQ51883 (PubMed:19468303).Curated | 1 | |
Sequence conflicti | 1482 | S → N in CAQ51884 (PubMed:19468303).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052987 | 1 – 978 | Missing in isoform 3 and isoform 4. CuratedAdd BLAST | 978 | |
Alternative sequenceiVSP_052988 | 1222 – 1334 | Missing in isoform 3 and isoform 4. CuratedAdd BLAST | 113 | |
Alternative sequenceiVSP_052989 | 1459 – 1472 | Missing in isoform 5. CuratedAdd BLAST | 14 | |
Alternative sequenceiVSP_052990 | 1566 – 1572 | Missing in isoform 2, isoform 4 and isoform 5. Curated | 7 | |
Alternative sequenceiVSP_052991 | 1662 – 1682 | SPLVD…KGQGT → RVKELKKAKELEDIQQHPLA M in isoform 4 and isoform 5. CuratedAdd BLAST | 21 |
Sequence databases
Genome annotation databases
Ensembli | ENSMUST00000049790; ENSMUSP00000054804; ENSMUSG00000014592 [A2A891-1] ENSMUST00000097774; ENSMUSP00000095381; ENSMUSG00000014592 [A2A891-2] ENSMUST00000105668; ENSMUSP00000101293; ENSMUSG00000014592 [A2A891-3] ENSMUST00000105670; ENSMUSP00000101295; ENSMUSG00000014592 [A2A891-4] ENSMUST00000169423; ENSMUSP00000127916; ENSMUSG00000014592 [A2A891-1] |
GeneIDi | 100072 |
KEGGi | mmu:100072 |
UCSCi | uc008vyk.2, mouse [A2A891-4] uc008vym.2, mouse [A2A891-3] uc008vyn.2, mouse [A2A891-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | A2A891 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A2A891, 1 interactor |
STRINGi | 10090.ENSMUSP00000054804 |
PTM databases
iPTMneti | A2A891 |
PhosphoSitePlusi | A2A891 |
Proteomic databases
MaxQBi | A2A891 |
PaxDbi | A2A891 |
PRIDEi | A2A891 |
Protocols and materials databases
Antibodypediai | 49059, 56 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000049790; ENSMUSP00000054804; ENSMUSG00000014592 [A2A891-1] ENSMUST00000097774; ENSMUSP00000095381; ENSMUSG00000014592 [A2A891-2] ENSMUST00000105668; ENSMUSP00000101293; ENSMUSG00000014592 [A2A891-3] ENSMUST00000105670; ENSMUSP00000101295; ENSMUSG00000014592 [A2A891-4] ENSMUST00000169423; ENSMUSP00000127916; ENSMUSG00000014592 [A2A891-1] |
GeneIDi | 100072 |
KEGGi | mmu:100072 |
UCSCi | uc008vyk.2, mouse [A2A891-4] uc008vym.2, mouse [A2A891-3] uc008vyn.2, mouse [A2A891-1] |
Organism-specific databases
CTDi | 23261 |
MGIi | MGI:2140230, Camta1 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG0520, Eukaryota |
GeneTreei | ENSGT00940000155203 |
HOGENOMi | CLU_003170_1_0_1 |
InParanoidi | A2A891 |
OMAi | CSPQQGG |
OrthoDBi | 315169at2759 |
PhylomeDBi | A2A891 |
TreeFami | TF323452 |
Miscellaneous databases
BioGRID-ORCSi | 100072, 1 hit in 18 CRISPR screens |
ChiTaRSi | Camta1, mouse |
PROi | PR:A2A891 |
RNActi | A2A891, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000014592, Expressed in cerebellum and 253 other tissues |
ExpressionAtlasi | A2A891, baseline and differential |
Genevisiblei | A2A891, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR039033, Camta1 IPR005559, CG-1_dom IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR000048, IQ_motif_EF-hand-BS |
PANTHERi | PTHR23335:SF11, PTHR23335:SF11, 1 hit |
Pfami | View protein in Pfam PF03859, CG-1, 1 hit PF01833, TIG, 1 hit |
SMARTi | View protein in SMART SM01076, CG-1, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS51437, CG_1, 1 hit PS50096, IQ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CMTA1_MOUSE | |
Accessioni | A2A891Primary (citable) accession number: A2A891 Secondary accession number(s): A2A892 Q80TQ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | December 2, 2020 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families