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Protein

Arylacetamide deacetylase-like 3

Gene

Aadacl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei194By similarity1
Active sitei348By similarity1
Active sitei378By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERimouse-adcl3 Arylacetamide_deacetylase

Names & Taxonomyi

Protein namesi
Recommended name:
Arylacetamide deacetylase-like 3 (EC:3.1.1.-)
Gene namesi
Name:Aadacl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2685281 Aadacl3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003892531 – 408Arylacetamide deacetylase-like 3Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA2A7Z8
PRIDEiA2A7Z8

PTM databases

iPTMnetiA2A7Z8
PhosphoSitePlusiA2A7Z8

Expressioni

Gene expression databases

BgeeiENSMUSG00000078507 Expressed in 3 organ(s), highest expression level in zone of skin

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101375

Structurei

3D structure databases

ProteinModelPortaliA2A7Z8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi120 – 122Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity3

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1515 Eukaryota
COG0657 LUCA
GeneTreeiENSGT00550000074556
HOGENOMiHOG000231073
HOVERGENiHBG058974
InParanoidiA2A7Z8
KOiK14351
OMAiRICSMPQ
OrthoDBiEOG091G082E
PhylomeDBiA2A7Z8
TreeFamiTF314978

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR017157 Arylacetamide_deacetylase
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 2 hits
PIRSFiPIRSF037251 Arylacetamide_deacetylase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

A2A7Z8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVLALTLLV GSVAVFSLGS LLWVVGKHFW TEHIPEGITH PWRLRILSCL
60 70 80 90 100
FHLTMTWGMI FEKLGLCYAP QFASFLHDLK PLKRDPDVVV KDLHFGTIPV
110 120 130 140 150
KLYKPKKPSS IPRLGIIFFH GGGTIIGSLR THNSICLRLS KECDSVVVSV
160 170 180 190 200
GYRKSPMYKY PVMKDDCVVA TTHFLESLDV YGVDPARVVT CGDSVGGTAA
210 220 230 240 250
TVTSQMLVHR PDLPRIKAQI LIYPLLQLID FGSPSYQQNR NIPLLSWDLA
260 270 280 290 300
FYCFCCHLDV NISWKSVVKN GMHLPPDVWE KYRKWLGAEN IPERFKNRGY
310 320 330 340 350
KSIPWGPVNN DAYQEIKRSL NYTCSPLISE DSIVSQLPET CIVSCEYDLL
360 370 380 390 400
RDHSLLYKKR LEDLGVPVTW HHMEDGFHGV LSALDYGLLS FPCASRIMDL

IIQFIRKF
Length:408
Mass (Da):46,340
Last modified:February 20, 2007 - v1
Checksum:i948C83A1E308C4B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607073 Genomic DNA No translation available.
CCDSiCCDS38954.1
RefSeqiNP_001078972.1, NM_001085503.2
UniGeneiMm.457844

Genome annotation databases

EnsembliENSMUST00000105749; ENSMUSP00000101375; ENSMUSG00000078507
GeneIDi230883
KEGGimmu:230883
UCSCiuc008vrg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607073 Genomic DNA No translation available.
CCDSiCCDS38954.1
RefSeqiNP_001078972.1, NM_001085503.2
UniGeneiMm.457844

3D structure databases

ProteinModelPortaliA2A7Z8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101375

Protein family/group databases

ESTHERimouse-adcl3 Arylacetamide_deacetylase

PTM databases

iPTMnetiA2A7Z8
PhosphoSitePlusiA2A7Z8

Proteomic databases

PaxDbiA2A7Z8
PRIDEiA2A7Z8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105749; ENSMUSP00000101375; ENSMUSG00000078507
GeneIDi230883
KEGGimmu:230883
UCSCiuc008vrg.1 mouse

Organism-specific databases

CTDi126767
MGIiMGI:2685281 Aadacl3

Phylogenomic databases

eggNOGiKOG1515 Eukaryota
COG0657 LUCA
GeneTreeiENSGT00550000074556
HOGENOMiHOG000231073
HOVERGENiHBG058974
InParanoidiA2A7Z8
KOiK14351
OMAiRICSMPQ
OrthoDBiEOG091G082E
PhylomeDBiA2A7Z8
TreeFamiTF314978

Miscellaneous databases

PROiPR:A2A7Z8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078507 Expressed in 3 organ(s), highest expression level in zone of skin

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR017157 Arylacetamide_deacetylase
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 2 hits
PIRSFiPIRSF037251 Arylacetamide_deacetylase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADCL3_MOUSE
AccessioniPrimary (citable) accession number: A2A7Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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