Zfp69

Functionⁱ

Putative transcription factor that appears to regulate lipid metabolism.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	271 – 293	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	299 – 321	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	327 – 349	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	355 – 377	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	383 – 405	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	411 – 433	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	439 – 461	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	467 – 489	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	495 – 517	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lipid metabolic process Source: UniProtKB-KW
regulation of lipid metabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26232096
regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Lipid metabolism, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 69Curated Alternative name(s): Zinc finger protein 642
Gene namesⁱ	Name:Zfp69Imported Synonyms:Znf642
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:107794 Zfp69

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000444716	1 – 587	Zinc finger protein 69Add BLAST		587

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A2A761
PaxDbⁱ	A2A761
PeptideAtlas More...PeptideAtlasⁱ	A2A761
PRIDEⁱ	A2A761

PTM databases

iPTMnetⁱ	A2A761
PhosphoSitePlusⁱ	A2A761

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000064141 Expressed in 145 organ(s), highest expression level in follicle cell of tertiary follicle (mouse)
ExpressionAtlasⁱ	A2A761 baseline and differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000101887

STRINGⁱ

10090.ENSMUSP00000101887

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2A761
SMRⁱ	A2A761
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	76 – 147	KRABPROSITE-ProRule annotationAdd BLAST		72

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	271 – 293	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	299 – 321	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	327 – 349	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	355 – 377	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	383 – 405	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	411 – 433	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	439 – 461	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	467 – 489	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	495 – 517	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144215
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	A2A761
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	LITPATE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	A2A761
TreeFamⁱ	TF337055

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 7 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 9 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

A2A761-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPQQLLITPA TEATWVKLKE VSLWEDVTKM FGGEALLSHD ANGTQQESLA 
        60         70         80         90        100
DGTTPGTPAA GSHDGATPGT TATGSHDEAT PGTPAAGSHD GETPGIPAAG 
       110        120        130        140        150
SHDGETPGTP TAGSHDGVTP GTTAAGSQES LTFKDIAVDL SQEEWGQLAP 
       160        170        180        190        200
AYQDLYREVM LENYRNLVSV AGYQLSKPTV ISQLEKGEGP CMAESQGPED 
       210        220        230        240        250
PILDVKNKLE TKESTAEDDI SVKLDHGITR GRLIEDDIVC SPLKKASSYS 
       260        270        280        290        300
DTLESHRATC GKGTRRAIWT HKKKRQEGNK LENPESSNVI LEQKHRKHKP 
       310        320        330        340        350
ARKRNKYKLD SIDHPVSCMR ARRYPCNVCE KMFKQPIHLV EHMRTHTGEK 
       360        370        380        390        400
PFRCKECGRA FSQSASLNTH QRIHTGEKPF ACEECGKAFR HRSSLNQHHR 
       410        420        430        440        450
THTGEKPFTC DKCQKAFSQN ISLVQHLRTH SGEKPFSCSE CGKPFRQIRH 
       460        470        480        490        500
LSEHVRIHTG EKPYKCTSCC KTFSHRAYLT HHQRIHTGER PYKCKECGKA 
       510        520        530        540        550
FRQRIHLSNH RTVHTGVKAY ECNRCGKAYR HDSSFKKHQR HHTGEKPYEC 
       560        570        580 
TECGKSFSYN SSLSRHQKIH RRNTFRDDPG HENKRQL

Length:587

Mass (Da):65,725

Last modified:February 20, 2007 - v1

Checksum:ⁱ762F13B25B00426D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3UWJ2	G3UWJ2_MOUSE		Zinc finger protein 69 Zinc finger protein 69	Zfp69	110	Annotation score:

Polymorphismⁱ

New Zealand obese (NZO) mice carry a loss-of-function mutation due to the integration of the retrotransposon IAPLTR1 in intron 3 which generates a truncated mRNA lacking both the KRAB and the C2H2 domains. This strain is less diabetes prone (NZO).1 Publication

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL606904 Genomic DNA No translation available. AL731722 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18597.2
NCBI Reference Sequences More...RefSeqⁱ	NP_001005788.2, NM_001005788.3
UniGeneⁱ	Mm.331840

Genome annotation databases

Ensemblⁱ	ENSMUST00000106280; ENSMUSP00000101887; ENSMUSG00000064141 ENSMUST00000106281; ENSMUSP00000101888; ENSMUSG00000064141
GeneIDⁱ	381549
KEGGⁱ	mmu:381549
UCSC genome browser More...UCSCⁱ	uc008unv.2 mouse

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A2A761	Zinc finger protein 69		MOUSE		428	UniRef100_A2A761
UPI0000477DDB		MOUSE		396

Protein	Similar proteins		Species	Score	Length	Source
A2A761	Zinc finger protein 69		MOUSE		428	UniRef90_A2A761
Zinc finger protein 69 (Fragment)		MOUSE		110
UPI0000477DDB		MOUSE		396
UPI0000428A70		MOUSE		586

Protein	Similar proteins		Species	Score	Length	Source
A2A761	Zinc finger protein 69 homolog		BOVIN		524	UniRef50_A2A761
Zinc finger protein 69 homolog		HUMAN		526
Zinc finger protein 69		MOUSE		428
ZFP69 zinc finger protein		MUSPF		527
zinc finger protein ZFP69 isoform X1		Enhydra lutris kenyoni		527
+211

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL606904 Genomic DNA No translation available. AL731722 Genomic DNA No translation available.
CCDSⁱ	CCDS18597.2
RefSeqⁱ	NP_001005788.2, NM_001005788.3
UniGeneⁱ	Mm.331840

3D structure databases

ProteinModelPortalⁱ	A2A761
SMRⁱ	A2A761
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000101887

STRINGⁱ

10090.ENSMUSP00000101887

PTM databases

iPTMnetⁱ	A2A761
PhosphoSitePlusⁱ	A2A761

Proteomic databases

MaxQBⁱ	A2A761
PaxDbⁱ	A2A761
PeptideAtlasⁱ	A2A761
PRIDEⁱ	A2A761

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000106280; ENSMUSP00000101887; ENSMUSG00000064141 ENSMUST00000106281; ENSMUSP00000101888; ENSMUSG00000064141
GeneIDⁱ	381549
KEGGⁱ	mmu:381549
UCSCⁱ	uc008unv.2 mouse

Organism-specific databases

CTDⁱ	339559
MGIⁱ	MGI:107794 Zfp69

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00910000144215
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	A2A761
KOⁱ	K09228
OMAⁱ	LITPATE
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	A2A761
TreeFamⁱ	TF337055

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000064141 Expressed in 145 organ(s), highest expression level in follicle cell of tertiary follicle (mouse)
ExpressionAtlasⁱ	A2A761 baseline and differential

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 7 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 9 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZFP69_MOUSE
Accessionⁱ	A2A761Primary (citable) accession number: A2A761
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 18, 2018
	Last sequence update:	February 20, 2007
	Last modified:	October 10, 2018
	This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A2A761 (ZFP69_MOUSE)

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Zinc finger protein 69

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ