UniProtKB - A2A761 (ZFP69_MOUSE)
Protein
Zinc finger protein 69
Gene
Zfp69
Organism
Mus musculus (Mouse)
Status
Functioni
Putative transcription factor that appears to regulate lipid metabolism.2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 271 – 293 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- lipid metabolic process Source: UniProtKB-KW
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of lipid metabolic process Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Lipid metabolism, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 69CuratedAlternative name(s): Zinc finger protein 642 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107794, Zfp69 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nuclear chromatin Source: GO_Central
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000444716 | 1 – 587 | Zinc finger protein 69Add BLAST | 587 |
Proteomic databases
MaxQBi | A2A761 |
PaxDbi | A2A761 |
PeptideAtlasi | A2A761 |
PTM databases
iPTMneti | A2A761 |
PhosphoSitePlusi | A2A761 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000064141, Expressed in follicle cell of tertiary follicle (mouse) and 167 other tissues |
ExpressionAtlasi | A2A761, baseline and differential |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000101887 |
Miscellaneous databases
RNActi | A2A761, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 76 – 147 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 271 – 293 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162278 |
HOGENOMi | CLU_002678_0_13_1 |
InParanoidi | A2A761 |
OMAi | IHVRCVH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A2A761 |
TreeFami | TF337055 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A2A761-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPQQLLITPA TEATWVKLKE VSLWEDVTKM FGGEALLSHD ANGTQQESLA
60 70 80 90 100
DGTTPGTPAA GSHDGATPGT TATGSHDEAT PGTPAAGSHD GETPGIPAAG
110 120 130 140 150
SHDGETPGTP TAGSHDGVTP GTTAAGSQES LTFKDIAVDL SQEEWGQLAP
160 170 180 190 200
AYQDLYREVM LENYRNLVSV AGYQLSKPTV ISQLEKGEGP CMAESQGPED
210 220 230 240 250
PILDVKNKLE TKESTAEDDI SVKLDHGITR GRLIEDDIVC SPLKKASSYS
260 270 280 290 300
DTLESHRATC GKGTRRAIWT HKKKRQEGNK LENPESSNVI LEQKHRKHKP
310 320 330 340 350
ARKRNKYKLD SIDHPVSCMR ARRYPCNVCE KMFKQPIHLV EHMRTHTGEK
360 370 380 390 400
PFRCKECGRA FSQSASLNTH QRIHTGEKPF ACEECGKAFR HRSSLNQHHR
410 420 430 440 450
THTGEKPFTC DKCQKAFSQN ISLVQHLRTH SGEKPFSCSE CGKPFRQIRH
460 470 480 490 500
LSEHVRIHTG EKPYKCTSCC KTFSHRAYLT HHQRIHTGER PYKCKECGKA
510 520 530 540 550
FRQRIHLSNH RTVHTGVKAY ECNRCGKAYR HDSSFKKHQR HHTGEKPYEC
560 570 580
TECGKSFSYN SSLSRHQKIH RRNTFRDDPG HENKRQL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3UWJ2 | G3UWJ2_MOUSE | Zinc finger protein 69 | Zfp69 | 110 | Annotation score: |
Polymorphismi
New Zealand obese (NZO) mice carry a loss-of-function mutation due to the integration of the retrotransposon IAPLTR1 in intron 3 which generates a truncated mRNA lacking both the KRAB and the C2H2 domains. This strain is less diabetes prone (NZO).1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL606904 Genomic DNA No translation available. AL731722 Genomic DNA No translation available. |
CCDSi | CCDS18597.2 |
RefSeqi | NP_001005788.2, NM_001005788.3 |
Genome annotation databases
Ensembli | ENSMUST00000106280; ENSMUSP00000101887; ENSMUSG00000064141 ENSMUST00000106281; ENSMUSP00000101888; ENSMUSG00000064141 |
GeneIDi | 381549 |
KEGGi | mmu:381549 |
UCSCi | uc008unv.2, mouse |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL606904 Genomic DNA No translation available. AL731722 Genomic DNA No translation available. |
CCDSi | CCDS18597.2 |
RefSeqi | NP_001005788.2, NM_001005788.3 |
3D structure databases
SMRi | A2A761 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000101887 |
PTM databases
iPTMneti | A2A761 |
PhosphoSitePlusi | A2A761 |
Proteomic databases
MaxQBi | A2A761 |
PaxDbi | A2A761 |
PeptideAtlasi | A2A761 |
Protocols and materials databases
Antibodypediai | 32097, 36 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000106280; ENSMUSP00000101887; ENSMUSG00000064141 ENSMUST00000106281; ENSMUSP00000101888; ENSMUSG00000064141 |
GeneIDi | 381549 |
KEGGi | mmu:381549 |
UCSCi | uc008unv.2, mouse |
Organism-specific databases
CTDi | 339559 |
MGIi | MGI:107794, Zfp69 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162278 |
HOGENOMi | CLU_002678_0_13_1 |
InParanoidi | A2A761 |
OMAi | IHVRCVH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A2A761 |
TreeFami | TF337055 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 381549, 2 hits in 17 CRISPR screens |
ChiTaRSi | Zfp69, mouse |
PROi | PR:A2A761 |
RNActi | A2A761, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000064141, Expressed in follicle cell of tertiary follicle (mouse) and 167 other tissues |
ExpressionAtlasi | A2A761, baseline and differential |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFP69_MOUSE | |
Accessioni | A2A761Primary (citable) accession number: A2A761 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 18, 2018 |
Last sequence update: | February 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families