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Protein

Zinc finger protein 69

Gene

Zfp69

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Putative transcription factor that appears to regulate lipid metabolism.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 293C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processLipid metabolism, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 69Curated
Alternative name(s):
Zinc finger protein 642
Gene namesi
Name:Zfp69Imported
Synonyms:Znf642
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107794 Zfp69

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004447161 – 587Zinc finger protein 69Add BLAST587

Proteomic databases

MaxQBiA2A761
PaxDbiA2A761
PeptideAtlasiA2A761
PRIDEiA2A761

PTM databases

iPTMnetiA2A761
PhosphoSitePlusiA2A761

Expressioni

Gene expression databases

BgeeiENSMUSG00000064141 Expressed in 145 organ(s), highest expression level in follicle cell of tertiary follicle (mouse)
ExpressionAtlasiA2A761 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101887

Structurei

3D structure databases

ProteinModelPortaliA2A761
SMRiA2A761
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 147KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 293C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144215
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA2A761
KOiK09228
OMAiLITPATE
OrthoDBiEOG091G02KC
PhylomeDBiA2A761
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2A761-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQQLLITPA TEATWVKLKE VSLWEDVTKM FGGEALLSHD ANGTQQESLA
60 70 80 90 100
DGTTPGTPAA GSHDGATPGT TATGSHDEAT PGTPAAGSHD GETPGIPAAG
110 120 130 140 150
SHDGETPGTP TAGSHDGVTP GTTAAGSQES LTFKDIAVDL SQEEWGQLAP
160 170 180 190 200
AYQDLYREVM LENYRNLVSV AGYQLSKPTV ISQLEKGEGP CMAESQGPED
210 220 230 240 250
PILDVKNKLE TKESTAEDDI SVKLDHGITR GRLIEDDIVC SPLKKASSYS
260 270 280 290 300
DTLESHRATC GKGTRRAIWT HKKKRQEGNK LENPESSNVI LEQKHRKHKP
310 320 330 340 350
ARKRNKYKLD SIDHPVSCMR ARRYPCNVCE KMFKQPIHLV EHMRTHTGEK
360 370 380 390 400
PFRCKECGRA FSQSASLNTH QRIHTGEKPF ACEECGKAFR HRSSLNQHHR
410 420 430 440 450
THTGEKPFTC DKCQKAFSQN ISLVQHLRTH SGEKPFSCSE CGKPFRQIRH
460 470 480 490 500
LSEHVRIHTG EKPYKCTSCC KTFSHRAYLT HHQRIHTGER PYKCKECGKA
510 520 530 540 550
FRQRIHLSNH RTVHTGVKAY ECNRCGKAYR HDSSFKKHQR HHTGEKPYEC
560 570 580
TECGKSFSYN SSLSRHQKIH RRNTFRDDPG HENKRQL
Length:587
Mass (Da):65,725
Last modified:February 20, 2007 - v1
Checksum:i762F13B25B00426D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UWJ2G3UWJ2_MOUSE
Zinc finger protein 69
Zfp69
110Annotation score:

Polymorphismi

New Zealand obese (NZO) mice carry a loss-of-function mutation due to the integration of the retrotransposon IAPLTR1 in intron 3 which generates a truncated mRNA lacking both the KRAB and the C2H2 domains. This strain is less diabetes prone (NZO).1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606904 Genomic DNA No translation available.
AL731722 Genomic DNA No translation available.
CCDSiCCDS18597.2
RefSeqiNP_001005788.2, NM_001005788.3
UniGeneiMm.331840

Genome annotation databases

EnsembliENSMUST00000106280; ENSMUSP00000101887; ENSMUSG00000064141
ENSMUST00000106281; ENSMUSP00000101888; ENSMUSG00000064141
GeneIDi381549
KEGGimmu:381549
UCSCiuc008unv.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606904 Genomic DNA No translation available.
AL731722 Genomic DNA No translation available.
CCDSiCCDS18597.2
RefSeqiNP_001005788.2, NM_001005788.3
UniGeneiMm.331840

3D structure databases

ProteinModelPortaliA2A761
SMRiA2A761
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101887

PTM databases

iPTMnetiA2A761
PhosphoSitePlusiA2A761

Proteomic databases

MaxQBiA2A761
PaxDbiA2A761
PeptideAtlasiA2A761
PRIDEiA2A761

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106280; ENSMUSP00000101887; ENSMUSG00000064141
ENSMUST00000106281; ENSMUSP00000101888; ENSMUSG00000064141
GeneIDi381549
KEGGimmu:381549
UCSCiuc008unv.2 mouse

Organism-specific databases

CTDi339559
MGIiMGI:107794 Zfp69

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144215
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA2A761
KOiK09228
OMAiLITPATE
OrthoDBiEOG091G02KC
PhylomeDBiA2A761
TreeFamiTF337055

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064141 Expressed in 145 organ(s), highest expression level in follicle cell of tertiary follicle (mouse)
ExpressionAtlasiA2A761 baseline and differential

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP69_MOUSE
AccessioniPrimary (citable) accession number: A2A761
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 18, 2018
Last sequence update: February 20, 2007
Last modified: October 10, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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