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Entry version 94 (08 May 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Signal peptide peptidase-like 2C

Gene

Sppl2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei395By similarity1
Active sitei457By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal peptide peptidase-like 2CBy similarityImported (EC:3.4.23.-)
Short name:
SPP-like 2CBy similarity
Short name:
SPPL2cBy similarity
Alternative name(s):
Intramembrane protease 5By similarity
Short name:
IMP-5By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sppl2cBy similarityImported
Synonyms:Imp5By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3045264 Sppl2c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 192LumenalBy similarityAdd BLAST164
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 260CytoplasmicSequence analysisAdd BLAST47
Transmembranei261 – 283HelicalSequence analysisAdd BLAST23
Topological domaini284LumenalSequence analysis1
Transmembranei285 – 307HelicalSequence analysisAdd BLAST23
Topological domaini308 – 328CytoplasmicSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 354LumenalSequence analysis5
Transmembranei355 – 373HelicalSequence analysisAdd BLAST19
Topological domaini374 – 384CytoplasmicSequence analysisAdd BLAST11
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 448LumenalBy similarityAdd BLAST43
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 482CytoplasmicSequence analysisAdd BLAST13
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
Topological domaini504LumenalSequence analysis1
Transmembranei505 – 525HelicalSequence analysisAdd BLAST21
Topological domaini526 – 690CytoplasmicBy similarityAdd BLAST165

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28By similarityAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031479829 – 690Signal peptide peptidase-like 2CAdd BLAST662

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2A6C4

PRoteomics IDEntifications database

More...
PRIDEi
A2A6C4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2A6C4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2A6C4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000049506 Expressed in 5 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000102613

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini87 – 166PAAdd BLAST80

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi508 – 510PAL3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase A22B family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2442 Eukaryota
ENOG410ZP52 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163306

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231496

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2A6C4

KEGG Orthology (KO)

More...
KOi
K14212

Identification of Orthologs from Complete Genome Data

More...
OMAi
DILSHTH

Database of Orthologous Groups

More...
OrthoDBi
535101at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2A6C4

TreeFam database of animal gene trees

More...
TreeFami
TF319186

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007369 Peptidase_A22B_SPP
IPR006639 Preselin/SPP
IPR033150 SPPL2C

The PANTHER Classification System

More...
PANTHERi
PTHR12174 PTHR12174, 1 hit
PTHR12174:SF38 PTHR12174:SF38, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04258 Peptidase_A22B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00730 PSN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2A6C4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACLGSLHPL GSLLLLFLLL LLSPEARGEY GLVRVVSKNW SKDYCVLYSS
60 70 80 90 100
DYVNLPRDLH HAPLLSLHDG TKTPWCPDED SFHQAQDSSP RQRPLHQTTT
110 120 130 140 150
MVTRGNCSFY AKGWLAQDQG AQGLLIVSRA RNQQCSDTIS KPQDPSKPWP
160 170 180 190 200
ALTIPVAVLR YTDMLDIVSH TYGDTDVRVA MFAPLEPVTD YNMAIIFILA
210 220 230 240 250
VGTVAAGGYW AGLMEANKLQ RRQAQRGGGL GGHNQQQTVA AERSQRAWED
260 270 280 290 300
DDFEDAPMDF TPAMTGAVVT MSCSIMILLY FFYDCFVYVM IGIFSLGAST
310 320 330 340 350
GLYSCLAPIL CHLPLWRYQW VLPGQRVSVT WPLLLLAGLC AMVTVLWVIH
360 370 380 390 400
RNEDHWAWLL QDTLGVAYCL FVLRRVRLPT FKNCTLFLLA LLAFDVFFVF
410 420 430 440 450
ITPLFTKTGE SIMVEVASGP ADSSSHERLP MVLKVPRLSF SALTLCNQPF
460 470 480 490 500
SILGFGDIVV PGFLVAYCHR FDMQVQSRQV YYMACTVAYA VGLLVTFVAM
510 520 530 540 550
ILMQMGQPAL LYLVSSTLLT SLAVATCRQE FTLFWTGQGR AKIPAEPVAQ
560 570 580 590 600
PCIASAVGSK MKLEDAKDSR TTNRFEQAVD GESGDLESST GDDMAEMVTL
610 620 630 640 650
SEDEATSPEG HSESSEGWSD TNLDPNELPS GSPMALEAML IPLIQPIPHP
660 670 680 690
SELGHIRTQS RVHDSSLPWM GLHKRKGLKV KKSMSAQAPL
Length:690
Mass (Da):76,266
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70AF4E127EE09E7B
GO
Isoform 2 (identifier: A2A6C4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     575-581: FEQAVDG → MPEEDFV
     582-690: Missing.

Note: No experimental confirmation available.
Show »
Length:581
Mass (Da):64,626
Checksum:i0A5089139EEA1E46
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC36625 differs from that shown. Reason: Frameshift at position 521.Curated
The sequence BAC36625 differs from that shown. Reason: Erroneous termination at position 616. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti299S → G in BAC36625 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030363575 – 581FEQAVDG → MPEEDFV in isoform 2. 1 Publication7
Alternative sequenceiVSP_030364582 – 690Missing in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK077122 mRNA Translation: BAC36625.1 Sequence problems.
AL596383 Genomic DNA No translation available.
BC100418 mRNA Translation: AAI00419.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36351.1 [A2A6C4-2]
CCDS36352.1 [A2A6C4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001076004.1, NM_001082535.1 [A2A6C4-2]
NP_950184.2, NM_199019.2 [A2A6C4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000059448; ENSMUSP00000091453; ENSMUSG00000049506 [A2A6C4-2]
ENSMUST00000107000; ENSMUSP00000102613; ENSMUSG00000049506 [A2A6C4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
237958

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:237958

UCSC genome browser

More...
UCSCi
uc007lwd.1 mouse [A2A6C4-2]
uc011yfz.1 mouse [A2A6C4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077122 mRNA Translation: BAC36625.1 Sequence problems.
AL596383 Genomic DNA No translation available.
BC100418 mRNA Translation: AAI00419.1
CCDSiCCDS36351.1 [A2A6C4-2]
CCDS36352.1 [A2A6C4-1]
RefSeqiNP_001076004.1, NM_001082535.1 [A2A6C4-2]
NP_950184.2, NM_199019.2 [A2A6C4-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102613

PTM databases

iPTMnetiA2A6C4
PhosphoSitePlusiA2A6C4

Proteomic databases

PaxDbiA2A6C4
PRIDEiA2A6C4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059448; ENSMUSP00000091453; ENSMUSG00000049506 [A2A6C4-2]
ENSMUST00000107000; ENSMUSP00000102613; ENSMUSG00000049506 [A2A6C4-1]
GeneIDi237958
KEGGimmu:237958
UCSCiuc007lwd.1 mouse [A2A6C4-2]
uc011yfz.1 mouse [A2A6C4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
162540
MGIiMGI:3045264 Sppl2c

Phylogenomic databases

eggNOGiKOG2442 Eukaryota
ENOG410ZP52 LUCA
GeneTreeiENSGT00940000163306
HOGENOMiHOG000231496
InParanoidiA2A6C4
KOiK14212
OMAiDILSHTH
OrthoDBi535101at2759
PhylomeDBiA2A6C4
TreeFamiTF319186

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2A6C4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000049506 Expressed in 5 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR007369 Peptidase_A22B_SPP
IPR006639 Preselin/SPP
IPR033150 SPPL2C
PANTHERiPTHR12174 PTHR12174, 1 hit
PTHR12174:SF38 PTHR12174:SF38, 1 hit
PfamiView protein in Pfam
PF04258 Peptidase_A22B, 1 hit
SMARTiView protein in SMART
SM00730 PSN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPP2C_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A6C4
Secondary accession number(s): Q497R4, Q8BHP0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: May 8, 2019
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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