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UniProtKB - A2A6A1 (GPTC8_MOUSE)
Protein
G patch domain-containing protein 8
Gene
Gpatch8
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 136 – 160 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: G patch domain-containing protein 8 |
Gene namesi | Name:Gpatch8 Synonyms:Gpatc8, Kiaa0553 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1918667, Gpatch8 |
VEuPathDBi | HostDB:ENSMUSG00000034621 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000379799 | 1 – 1505 | G patch domain-containing protein 8Add BLAST | 1505 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 311 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 479 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 573 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 648 | PhosphoserineBy similarity | 1 | |
Modified residuei | 733 | PhosphoserineBy similarity | 1 | |
Modified residuei | 735 | PhosphoserineBy similarity | 1 | |
Modified residuei | 753 | PhosphoserineBy similarity | 1 | |
Modified residuei | 915 | PhosphoserineCombined sources | 1 | |
Modified residuei | 918 | PhosphoserineCombined sources | 1 | |
Modified residuei | 985 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1013 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1018 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1037 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1039 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1085 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1109 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1179 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | A2A6A1 |
jPOSTi | A2A6A1 |
MaxQBi | A2A6A1 |
PaxDbi | A2A6A1 |
PeptideAtlasi | A2A6A1 |
PRIDEi | A2A6A1 |
ProteomicsDBi | 271081 |
PTM databases
iPTMneti | A2A6A1 |
PhosphoSitePlusi | A2A6A1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034621, Expressed in cochlea and 294 other tissues |
Genevisiblei | A2A6A1, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 231931, 7 interactors |
STRINGi | 10090.ENSMUSP00000120649 |
Miscellaneous databases
RNActi | A2A6A1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 86 | G-patchPROSITE-ProRule annotationAdd BLAST | 47 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 244 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 322 – 393 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 419 – 537 | DisorderedSequence analysisAdd BLAST | 119 | |
Regioni | 575 – 1304 | DisorderedSequence analysisAdd BLAST | 730 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 89 – 124 | Sequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 166 – 204 | Basic and acidic residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 322 – 343 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 352 – 366 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 432 – 455 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 484 – 498 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 499 – 521 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 575 – 621 | Basic and acidic residuesSequence analysisAdd BLAST | 47 | |
Compositional biasi | 645 – 661 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 662 – 684 | Basic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 685 – 701 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 740 – 764 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 788 – 806 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 807 – 831 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 832 – 849 | Acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 871 – 895 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 896 – 936 | Basic and acidic residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 952 – 983 | Basic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1013 – 1034 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1048 – 1062 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1065 – 1089 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1159 – 1185 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1290 – 1304 | Polar residuesSequence analysisAdd BLAST | 15 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 136 – 160 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2184, Eukaryota |
GeneTreei | ENSGT00940000159523 |
HOGENOMi | CLU_006418_0_0_1 |
InParanoidi | A2A6A1 |
OMAi | AEPEYYH |
OrthoDBi | 332880at2759 |
PhylomeDBi | A2A6A1 |
TreeFami | TF332138 |
Family and domain databases
InterProi | View protein in InterPro IPR000467, G_patch_dom IPR022755, Znf_C2H2_jaz IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01585, G-patch, 1 hit PF12171, zf-C2H2_jaz, 1 hit |
SMARTi | View protein in SMART SM00443, G_patch, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50174, G_PATCH, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A2A6A1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADRFSRFNE DRDFQGNHFD QYEEGHLEIE QASLDKPIES DNIGHRLLQK
60 70 80 90 100
HGWKLGQGLG KSLQGRTDPI PIVVKYDVMG MGRMEMELDY AEDATERRRV
110 120 130 140 150
LEVEKEDTEE LRQKYKDYVD KEKAIAKALE DLRANFYCEL CDKQYQKHQE
160 170 180 190 200
FDNHINSYDH AHKQRLKDLK QREFARNVSS RSRKDEKKQE KALRRLHELA
210 220 230 240 250
EQRKQAECAP GSGPMFRPTT VAVDEDGGEE DKDESSTNSG ASAVSSCGFG
260 270 280 290 300
ADFSTDKGGS FTSVQITNTT GLSQAPGLAS QGISFGIKNN LGPPLQKLGV
310 320 330 340 350
SFSFAKKAPV KLESIASVFK DHAEEGSSED GTKADEKSSD QGVQKVGDTD
360 370 380 390 400
GTGNLDGKKE DEDPQDGGSL ASTLSKLKRM KREEGTGATE PEYYHYIPPA
410 420 430 440 450
HCKVKPNFPF LLFMRASEQM EGDHSAHSKS APENRKSSSP KPQGCSKTAA
460 470 480 490 500
SPGAERTVSE ASELQKEAAV AGPSEPGGKT ETKKGSGGGE DEQSVESRET
510 520 530 540 550
SESPMCESNP KDISQATPAT KAGQGPKHPT GPFFPVLSKD ESTALQWPSE
560 570 580 590 600
LLIFTKAEPS ISYSCNPLYF DFKLSRNKDA KAKGTEKPKD VAGSSKDHLQ
610 620 630 640 650
SLDPREPNKS QEEEQDVVLS SEGRVDEPAS GAACSSLNKQ EPGGSHMSET
660 670 680 690 700
EDTGRSHPSK KEPSGKSHRH KKKKKHKKSS KHKRKHKADT EEKSSKAESG
710 720 730 740 750
EKSKKRKKRK RKKNKSSAAA DSERGPKSEP PGSGSPAPPR RRRRAQDDSQ
760 770 780 790 800
RRSLPAEEGN SGKKDDGGGG SSCQDHSGRK HKGEPPTSSC QRRANTKHSS
810 820 830 840 850
RSSHRSQPSS GDEDSDDASS HRLHQKSPSQ YSEEEEEEEE EEEEEDEDSG
860 870 880 890 900
SEHSRSRSRS GHRHSSHRSS RRSYSSSSDA SSDQSCYSRQ HSYSDDSYSD
910 920 930 940 950
YSDRSRRHSK RSHDSDDSDY TSSKHRSKRH KYSSSDDDYS LSCSQSRSRS
960 970 980 990 1000
RSHTRERSRS RGRSRSSSCS RSRSKRRSRS TTAHSWQRSR SYSRDRSRST
1010 1020 1030 1040 1050
RSPSQRSGSR KGSWGHESPE ERRSGRRDFI RSKIYRSQSP HYFQSGRGEG
1060 1070 1080 1090 1100
PGKKEDGRGD DSKGAGLPSQ NSNTGTGRGS ESDCSPEDKN SVTARLLLEK
1110 1120 1130 1140 1150
IQSRKVERKP NVCEEVLATP NKAGLKYKNP PQGYFGPKLP PSLGNKPVLP
1160 1170 1180 1190 1200
MIGKLPATRK SNKKCEESGL ERGEEQEHSE PEEGSPRSSD APFGHQFSEE
1210 1220 1230 1240 1250
AAGPLSDPPP EEPKSEEATA DHSVAPLGTP AHTDCYPGDP AISHNYLPDP
1260 1270 1280 1290 1300
SDGDTLESLD SGSQPGPVES SLLPIAPDLE HFPNYAPPSG EPSIESTDGT
1310 1320 1330 1340 1350
EDASLAPLES QPITFTPEEM EKYSKLQQAA QQHIQQQLLA KQVKAFPAST
1360 1370 1380 1390 1400
ALAPATPALQ PIHIQQPATA SATSITTVQH AILQHHAAAA AAAIGIHPHP
1410 1420 1430 1440 1450
HPQPLAQVHH IPQPHLTPIS LSHLTHSIIP GHPATFLASH PIHIIPASAI
1460 1470 1480 1490 1500
HPGPFTFHPV PHAALYPTLL APRPAAAAAT ALHLHPLLHP IFSGQDLQHP
PSHGT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 954 | T → I in BAC65589 (PubMed:12693553).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596258 Genomic DNA No translation available. AK122307 mRNA Translation: BAC65589.1 |
CCDSi | CCDS48944.1 |
RefSeqi | NP_001152964.1, NM_001159492.1 |
Genome annotation databases
Ensembli | ENSMUST00000143842; ENSMUSP00000120649; ENSMUSG00000034621 |
GeneIDi | 237943 |
KEGGi | mmu:237943 |
UCSCi | uc007lsb.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596258 Genomic DNA No translation available. AK122307 mRNA Translation: BAC65589.1 |
CCDSi | CCDS48944.1 |
RefSeqi | NP_001152964.1, NM_001159492.1 |
3D structure databases
SMRi | A2A6A1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 231931, 7 interactors |
STRINGi | 10090.ENSMUSP00000120649 |
PTM databases
iPTMneti | A2A6A1 |
PhosphoSitePlusi | A2A6A1 |
Proteomic databases
EPDi | A2A6A1 |
jPOSTi | A2A6A1 |
MaxQBi | A2A6A1 |
PaxDbi | A2A6A1 |
PeptideAtlasi | A2A6A1 |
PRIDEi | A2A6A1 |
ProteomicsDBi | 271081 |
Protocols and materials databases
Antibodypediai | 52434, 34 antibodies from 14 providers |
Genome annotation databases
Ensembli | ENSMUST00000143842; ENSMUSP00000120649; ENSMUSG00000034621 |
GeneIDi | 237943 |
KEGGi | mmu:237943 |
UCSCi | uc007lsb.2, mouse |
Organism-specific databases
CTDi | 23131 |
MGIi | MGI:1918667, Gpatch8 |
VEuPathDBi | HostDB:ENSMUSG00000034621 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG2184, Eukaryota |
GeneTreei | ENSGT00940000159523 |
HOGENOMi | CLU_006418_0_0_1 |
InParanoidi | A2A6A1 |
OMAi | AEPEYYH |
OrthoDBi | 332880at2759 |
PhylomeDBi | A2A6A1 |
TreeFami | TF332138 |
Miscellaneous databases
BioGRID-ORCSi | 237943, 7 hits in 64 CRISPR screens |
ChiTaRSi | Gpatch8, mouse |
PROi | PR:A2A6A1 |
RNActi | A2A6A1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034621, Expressed in cochlea and 294 other tissues |
Genevisiblei | A2A6A1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000467, G_patch_dom IPR022755, Znf_C2H2_jaz IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01585, G-patch, 1 hit PF12171, zf-C2H2_jaz, 1 hit |
SMARTi | View protein in SMART SM00443, G_patch, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50174, G_PATCH, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GPTC8_MOUSE | |
Accessioni | A2A6A1Primary (citable) accession number: A2A6A1 Secondary accession number(s): Q80TY1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 23, 2022 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot