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Protein

G patch domain-containing protein 8

Gene

Gpatch8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri136 – 160C2H2-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain-containing protein 8
Gene namesi
Name:Gpatch8
Synonyms:Gpatc8, Kiaa0553
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1918667 Gpatch8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003797991 – 1505G patch domain-containing protein 8Add BLAST1505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei479N6-acetyllysineCombined sources1
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei648PhosphoserineBy similarity1
Modified residuei733PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1
Modified residuei753PhosphoserineBy similarity1
Modified residuei915PhosphoserineCombined sources1
Modified residuei918PhosphoserineCombined sources1
Modified residuei985PhosphoserineBy similarity1
Modified residuei1013PhosphoserineBy similarity1
Modified residuei1018PhosphoserineBy similarity1
Modified residuei1037PhosphoserineBy similarity1
Modified residuei1039PhosphoserineBy similarity1
Modified residuei1085PhosphoserineBy similarity1
Cross-linki1109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1179PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiA2A6A1
MaxQBiA2A6A1
PaxDbiA2A6A1
PeptideAtlasiA2A6A1
PRIDEiA2A6A1

PTM databases

iPTMnetiA2A6A1
PhosphoSitePlusiA2A6A1

Expressioni

Gene expression databases

BgeeiENSMUSG00000034621 Expressed in 271 organ(s), highest expression level in cochlea
GenevisibleiA2A6A1 MM

Interactioni

Protein-protein interaction databases

BioGridi231931, 1 interactor
STRINGi10090.ENSMUSP00000120649

Structurei

3D structure databases

SMRiA2A6A1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 86G-patchPROSITE-ProRule annotationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili89 – 124Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi660 – 715Lys-richAdd BLAST56
Compositional biasi740 – 744Poly-Arg5
Compositional biasi767 – 770Poly-Gly4
Compositional biasi799 – 1013Ser-richAdd BLAST215
Compositional biasi833 – 852Glu-richAdd BLAST20
Compositional biasi1387 – 1393Poly-Ala7
Compositional biasi1475 – 1481Poly-Ala7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri136 – 160C2H2-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGVP Eukaryota
ENOG410ZHVS LUCA
GeneTreeiENSGT00530000063305
HOGENOMiHOG000231046
InParanoidiA2A6A1
OMAiSPKPKGC
OrthoDBiEOG091G01DY
PhylomeDBiA2A6A1
TreeFamiTF332138

Family and domain databases

InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2A6A1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADRFSRFNE DRDFQGNHFD QYEEGHLEIE QASLDKPIES DNIGHRLLQK
60 70 80 90 100
HGWKLGQGLG KSLQGRTDPI PIVVKYDVMG MGRMEMELDY AEDATERRRV
110 120 130 140 150
LEVEKEDTEE LRQKYKDYVD KEKAIAKALE DLRANFYCEL CDKQYQKHQE
160 170 180 190 200
FDNHINSYDH AHKQRLKDLK QREFARNVSS RSRKDEKKQE KALRRLHELA
210 220 230 240 250
EQRKQAECAP GSGPMFRPTT VAVDEDGGEE DKDESSTNSG ASAVSSCGFG
260 270 280 290 300
ADFSTDKGGS FTSVQITNTT GLSQAPGLAS QGISFGIKNN LGPPLQKLGV
310 320 330 340 350
SFSFAKKAPV KLESIASVFK DHAEEGSSED GTKADEKSSD QGVQKVGDTD
360 370 380 390 400
GTGNLDGKKE DEDPQDGGSL ASTLSKLKRM KREEGTGATE PEYYHYIPPA
410 420 430 440 450
HCKVKPNFPF LLFMRASEQM EGDHSAHSKS APENRKSSSP KPQGCSKTAA
460 470 480 490 500
SPGAERTVSE ASELQKEAAV AGPSEPGGKT ETKKGSGGGE DEQSVESRET
510 520 530 540 550
SESPMCESNP KDISQATPAT KAGQGPKHPT GPFFPVLSKD ESTALQWPSE
560 570 580 590 600
LLIFTKAEPS ISYSCNPLYF DFKLSRNKDA KAKGTEKPKD VAGSSKDHLQ
610 620 630 640 650
SLDPREPNKS QEEEQDVVLS SEGRVDEPAS GAACSSLNKQ EPGGSHMSET
660 670 680 690 700
EDTGRSHPSK KEPSGKSHRH KKKKKHKKSS KHKRKHKADT EEKSSKAESG
710 720 730 740 750
EKSKKRKKRK RKKNKSSAAA DSERGPKSEP PGSGSPAPPR RRRRAQDDSQ
760 770 780 790 800
RRSLPAEEGN SGKKDDGGGG SSCQDHSGRK HKGEPPTSSC QRRANTKHSS
810 820 830 840 850
RSSHRSQPSS GDEDSDDASS HRLHQKSPSQ YSEEEEEEEE EEEEEDEDSG
860 870 880 890 900
SEHSRSRSRS GHRHSSHRSS RRSYSSSSDA SSDQSCYSRQ HSYSDDSYSD
910 920 930 940 950
YSDRSRRHSK RSHDSDDSDY TSSKHRSKRH KYSSSDDDYS LSCSQSRSRS
960 970 980 990 1000
RSHTRERSRS RGRSRSSSCS RSRSKRRSRS TTAHSWQRSR SYSRDRSRST
1010 1020 1030 1040 1050
RSPSQRSGSR KGSWGHESPE ERRSGRRDFI RSKIYRSQSP HYFQSGRGEG
1060 1070 1080 1090 1100
PGKKEDGRGD DSKGAGLPSQ NSNTGTGRGS ESDCSPEDKN SVTARLLLEK
1110 1120 1130 1140 1150
IQSRKVERKP NVCEEVLATP NKAGLKYKNP PQGYFGPKLP PSLGNKPVLP
1160 1170 1180 1190 1200
MIGKLPATRK SNKKCEESGL ERGEEQEHSE PEEGSPRSSD APFGHQFSEE
1210 1220 1230 1240 1250
AAGPLSDPPP EEPKSEEATA DHSVAPLGTP AHTDCYPGDP AISHNYLPDP
1260 1270 1280 1290 1300
SDGDTLESLD SGSQPGPVES SLLPIAPDLE HFPNYAPPSG EPSIESTDGT
1310 1320 1330 1340 1350
EDASLAPLES QPITFTPEEM EKYSKLQQAA QQHIQQQLLA KQVKAFPAST
1360 1370 1380 1390 1400
ALAPATPALQ PIHIQQPATA SATSITTVQH AILQHHAAAA AAAIGIHPHP
1410 1420 1430 1440 1450
HPQPLAQVHH IPQPHLTPIS LSHLTHSIIP GHPATFLASH PIHIIPASAI
1460 1470 1480 1490 1500
HPGPFTFHPV PHAALYPTLL APRPAAAAAT ALHLHPLLHP IFSGQDLQHP

PSHGT
Length:1,505
Mass (Da):164,987
Last modified:February 20, 2007 - v1
Checksum:i0BCC873DA8AE6DDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti954T → I in BAC65589 (PubMed:12693553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596258 Genomic DNA No translation available.
AK122307 mRNA Translation: BAC65589.1
CCDSiCCDS48944.1
RefSeqiNP_001152964.1, NM_001159492.1
UniGeneiMm.260282

Genome annotation databases

EnsembliENSMUST00000143842; ENSMUSP00000120649; ENSMUSG00000034621
GeneIDi237943
KEGGimmu:237943
UCSCiuc007lsb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596258 Genomic DNA No translation available.
AK122307 mRNA Translation: BAC65589.1
CCDSiCCDS48944.1
RefSeqiNP_001152964.1, NM_001159492.1
UniGeneiMm.260282

3D structure databases

SMRiA2A6A1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231931, 1 interactor
STRINGi10090.ENSMUSP00000120649

PTM databases

iPTMnetiA2A6A1
PhosphoSitePlusiA2A6A1

Proteomic databases

EPDiA2A6A1
MaxQBiA2A6A1
PaxDbiA2A6A1
PeptideAtlasiA2A6A1
PRIDEiA2A6A1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000143842; ENSMUSP00000120649; ENSMUSG00000034621
GeneIDi237943
KEGGimmu:237943
UCSCiuc007lsb.2 mouse

Organism-specific databases

CTDi23131
MGIiMGI:1918667 Gpatch8
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGVP Eukaryota
ENOG410ZHVS LUCA
GeneTreeiENSGT00530000063305
HOGENOMiHOG000231046
InParanoidiA2A6A1
OMAiSPKPKGC
OrthoDBiEOG091G01DY
PhylomeDBiA2A6A1
TreeFamiTF332138

Miscellaneous databases

ChiTaRSiGpatch8 mouse
PROiPR:A2A6A1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034621 Expressed in 271 organ(s), highest expression level in cochlea
GenevisibleiA2A6A1 MM

Family and domain databases

InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPTC8_MOUSE
AccessioniPrimary (citable) accession number: A2A6A1
Secondary accession number(s): Q80TY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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