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UniProtKB - A2A699 (F1712_MOUSE)

Entry version 93 (10 Feb 2021)
Sequence version 1 (20 Feb 2007)
Previous versions | rss
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Protein

Protein FAM171A2

Gene

Fam171a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM171A2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fam171a2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2448496, Fam171a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 315ExtracellularSequence analysisAdd BLAST286
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 822CytoplasmicSequence analysisAdd BLAST486

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032877230 – 822Protein FAM171A2Add BLAST793

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei369PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1
Modified residuei785PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A2A699

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A2A699

MaxQB - The MaxQuant DataBase

More...MaxQBi		A2A699

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2A699

PeptideAtlas

More...PeptideAtlasi		A2A699

PRoteomics IDEntifications database

More...PRIDEi		A2A699

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2627, 4 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		A2A699, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A2A699

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A2A699

SwissPalm database of S-palmitoylation events

More...SwissPalmi		A2A699

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000034685, Expressed in cortical plate and 175 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A2A699, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		229868, 3 interactors

Protein interaction database and analysis system

More...IntActi		A2A699, 3 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000038486

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A2A699, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi710 – 718Poly-Pro9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM171 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTDH, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183184

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019729_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2A699

Identification of Orthologs from Complete Genome Data

More...OMAi		RPLMVFH

Database of Orthologous Groups

More...OrthoDBi		615320at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2A699

TreeFam database of animal gene trees

More...TreeFami		TF331338

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018890, Uncharacterised_FAM171

The PANTHER Classification System

More...PANTHERi		PTHR31626, PTHR31626, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10577, UPF0560, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2A699-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPPSGPGVL ARLLPLLGLL LGGASRAPGK SPPEPPSPQE ILIKVQVYVS 
        60         70         80         90        100
GELVPLARAS VDVFGNRTLL AAGTTDSEGV ATLPLSYRLG TWVLVTAARP 
       110        120        130        140        150
GFLTNSVPWR VDKLPLYASV SLYLLPERPA TLILYEDLVH ILLGSPGARS 
       160        170        180        190        200
QPWVQFQRRA ARLPVSSTYS QLWASLTPAS TQQEMRAFPA FLGTEASSSG 
       210        220        230        240        250
NGSWLELIPL AAVSVHLLTG NGTEVPLSGP IHLSLPVPSE PRALAVGTSI 
       260        270        280        290        300
PAWRFDPKSG LWVRNGTGVI RKEGRQLYWT FVSPQLGYWV AAMASPTSGL 
       310        320        330        340        350
VTITSGIQDI GTYHTIFLLT ILAALALLVL ILLCLLIYYC RRRCLKPRQQ 
       360        370        380        390        400
HRKLQLSGPS DNKRDQATSM SQLHLICGGP LEPTSSGDPE APPPGSLHSA 
       410        420        430        440        450
FSSSRDLASS RDDFFRAKPR SASRPAAEPP GARTVEGAGL KSARSVEGPG 
       460        470        480        490        500
GLEPSLDEYR RGPAGAAAFL HEPPSPPPSF DHYLGHKGAA ESKTPDFLLS 
       510        520        530        540        550
QSVDQLARPP SLSQPGQLIF CGSIDHLKDN VYRNVMPTLV IPAHYVRLGG 
       560        570        580        590        600
EAGAAGVGDE ATPPEGSAAG PARPFPQPDP QRPLMQGHAG AGGDSGGGEG 
       610        620        630        640        650
WGGGRSAPVS GSVTIPVLFN ESTMAQLNGE LQALTEKKLL ELGVKPHPRA 
       660        670        680        690        700
WFVSLDGRSN SQVRHSYIDL QAGSGGRSTD ASLDSGVDVH EARPARRRLP 
       710        720        730        740        750
REERERAQLP APPPPAPPRL ALSEDTEPSS SESRTGLCSP EDNSLTPLLD 
       760        770        780        790        800
EVVAPEGRAA TVPRGRGRSR GDSSRSSASE LRRDSLTSPE DELGAEVGDE 
       810        820 
AGDKKSPWQR REERPLMVFN VK
Length:822
Mass (Da):87,487
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA4A1CA28B3E4516
GO
Isoform 2 (identifier: A2A699-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.

Show »
Length:638
Mass (Da):67,807
Checksum:i369EEDE6EA6CD54E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0327831 – 184Missing in isoform 2. 1 PublicationAdd BLAST184

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL596258 Genomic DNA No translation available.
BC025575 mRNA Translation: AAH25575.1
BC064455 mRNA Translation: AAH64455.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS36344.1 [A2A699-1]

NCBI Reference Sequences

More...RefSeqi		NP_954670.2, NM_199200.2 [A2A699-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000049057; ENSMUSP00000038486; ENSMUSG00000034685 [A2A699-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		217219

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:217219

UCSC genome browser

More...UCSCi		uc007lrw.2, mouse [A2A699-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596258 Genomic DNA No translation available.
BC025575 mRNA Translation: AAH25575.1
BC064455 mRNA Translation: AAH64455.1
CCDSiCCDS36344.1 [A2A699-1]
RefSeqiNP_954670.2, NM_199200.2 [A2A699-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi229868, 3 interactors
IntActiA2A699, 3 interactors
STRINGi10090.ENSMUSP00000038486

PTM databases

GlyConnecti2627, 4 N-Linked glycans (2 sites)
GlyGeniA2A699, 4 sites
iPTMnetiA2A699
PhosphoSitePlusiA2A699
SwissPalmiA2A699

Proteomic databases

EPDiA2A699
jPOSTiA2A699
MaxQBiA2A699
PaxDbiA2A699
PeptideAtlasiA2A699
PRIDEiA2A699

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		8250, 27 antibodies

Genome annotation databases

EnsembliENSMUST00000049057; ENSMUSP00000038486; ENSMUSG00000034685 [A2A699-1]
GeneIDi217219
KEGGimmu:217219
UCSCiuc007lrw.2, mouse [A2A699-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		284069
MGIiMGI:2448496, Fam171a2

Phylogenomic databases

eggNOGiENOG502QTDH, Eukaryota
GeneTreeiENSGT00950000183184
HOGENOMiCLU_019729_0_0_1
InParanoidiA2A699
OMAiRPLMVFH
OrthoDBi615320at2759
PhylomeDBiA2A699
TreeFamiTF331338

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		217219, 2 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Fam171a2, mouse

Protein Ontology

More...PROi		PR:A2A699
RNActiA2A699, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000034685, Expressed in cortical plate and 175 other tissues
GenevisibleiA2A699, MM

Family and domain databases

InterProiView protein in InterPro
IPR018890, Uncharacterised_FAM171
PANTHERiPTHR31626, PTHR31626, 1 hit
PfamiView protein in Pfam
PF10577, UPF0560, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1712_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A699
Secondary accession number(s): B7ZC48, Q05CH6, Q6P2L1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 20, 2007
Last modified: February 10, 2021
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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