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Entry version 121 (29 Sep 2021)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Bromodomain PHD finger transcription factor

Gene

Bptf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Bromodomain PHD finger transcription factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BptfImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444008, Bptf

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000040481

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2A654

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2A654

PeptideAtlas

More...
PeptideAtlasi
A2A654

PRoteomics IDEntifications database

More...
PRIDEi
A2A654

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
361911

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2A654

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040481, Expressed in cochlea and 312 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2A654, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-694, NuRF chromatin remodeling complex

Protein interaction database and analysis system

More...
IntActi
A2A654, 2 interactors

Molecular INTeraction database

More...
MINTi
A2A654

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000102374

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A2A654, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2A654

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini252 – 312DDTInterPro annotationAdd BLAST61
Domaini402 – 449PHD-typeInterPro annotationAdd BLAST48
Domaini2857 – 2908PHD-typeInterPro annotationAdd BLAST52
Domaini2934 – 3004BromoInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 239DisorderedSequence analysisAdd BLAST239
Regioni577 – 787DisorderedSequence analysisAdd BLAST211
Regioni1056 – 1145DisorderedSequence analysisAdd BLAST90
Regioni1203 – 1461DisorderedSequence analysisAdd BLAST259
Regioni1478 – 1560DisorderedSequence analysisAdd BLAST83
Regioni1604 – 1707DisorderedSequence analysisAdd BLAST104
Regioni1975 – 2004DisorderedSequence analysisAdd BLAST30
Regioni2233 – 2270DisorderedSequence analysisAdd BLAST38
Regioni2345 – 2528DisorderedSequence analysisAdd BLAST184
Regioni2701 – 2721DisorderedSequence analysisAdd BLAST21
Regioni2769 – 2849DisorderedSequence analysisAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili532 – 552Sequence analysisAdd BLAST21
Coiled coili990 – 1014Sequence analysisAdd BLAST25
Coiled coili2024 – 2051Sequence analysisAdd BLAST28
Coiled coili2608 – 2642Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 47Pro residuesSequence analysisAdd BLAST30
Compositional biasi139 – 199Acidic residuesSequence analysisAdd BLAST61
Compositional biasi203 – 217Polar residuesSequence analysisAdd BLAST15
Compositional biasi577 – 640Basic and acidic residuesSequence analysisAdd BLAST64
Compositional biasi648 – 664Polar residuesSequence analysisAdd BLAST17
Compositional biasi701 – 738Polar residuesSequence analysisAdd BLAST38
Compositional biasi740 – 769Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1065 – 1101Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi1116 – 1145Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1229 – 1267Polar residuesSequence analysisAdd BLAST39
Compositional biasi1299 – 1317Polar residuesSequence analysisAdd BLAST19
Compositional biasi1332 – 1349Polar residuesSequence analysisAdd BLAST18
Compositional biasi1368 – 1384Polar residuesSequence analysisAdd BLAST17
Compositional biasi1489 – 1532Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi1604 – 1651Polar residuesSequence analysisAdd BLAST48
Compositional biasi2345 – 2402Polar residuesSequence analysisAdd BLAST58
Compositional biasi2403 – 2421Pro residuesSequence analysisAdd BLAST19
Compositional biasi2422 – 2494Polar residuesSequence analysisAdd BLAST73
Compositional biasi2509 – 2528Polar residuesSequence analysisAdd BLAST20
Compositional biasi2701 – 2717Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi2784 – 2820Pro residuesSequence analysisAdd BLAST37
Compositional biasi2826 – 2849Basic and acidic residuesSequence analysisAdd BLAST24

Keywords - Domaini

BromodomainPROSITE-ProRule annotationARBA annotation, Coiled coilSequence analysisARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1473, Eukaryota
KOG1632, Eukaryota
KOG1827, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154830

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2A654

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDDRLQG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2A654

TreeFam database of animal gene trees

More...
TreeFami
TF316840

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038028, BPTF
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR018501, DDT_dom
IPR028941, WHIM2_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45975, PTHR45975, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439, Bromodomain, 1 hit
PF02791, DDT, 1 hit
PF00628, PHD, 2 hits
PF15613, WSD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00571, DDT, 1 hit
SM00249, PHD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS50827, DDT, 1 hit
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A2A654-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGRRGRPPK QPAAPAAERC APAPPPPPPP PPPPPPPPPP PPPASGPIGG
60 70 80 90 100
LRSRHRGSSR GRWAAAQAEV APKTRLSSPR GGGRRKQPPP PPPASGSSAS
110 120 130 140 150
GPGRGGRGGG GGRTGGGGGH LARTTPARRA VNKVVYDDHE SDDDDEEEDM
160 170 180 190 200
VSEEDEEEEE DGDAEETQDS EDEEEDDMEE DDDDSDYPEE MEDDDDDASY
210 220 230 240 250
CTESSFRSHS TYSSTPGRRK PRVHRPRSPI LEEKDIPPLE FPKSSEDLMV
260 270 280 290 300
PNEHIMNVIA IYEVVRNFGN VLRLSPFCFE DFCAALVSQE QCTLMAEMHV
310 320 330 340 350
ALLKAVLREE DTSNTTFGPA DLKDSVNSTL YFIDGMTWPE VLRVYCESDK
360 370 380 390 400
EYHHVLPYQE AEDYPYGPVE NKIKVLQFLV DQFLTTNIAR EELMSEGVIQ
410 420 430 440 450
YDDHCRVCHK LGDLLCCETC SAVYHLECVK PPLEEVPEDE WQCEVCVAHK
460 470 480 490 500
VPGVTDCVAE VQKNKPYVRH EPIGYDRSRR KYWFLNRRLI IEEDTDNENE
510 520 530 540 550
KKVWYYSTKV QLAELIDCLD KGYWEAELCR VLEDIREEMQ QHMDVTEDLT
560 570 580 590 600
NKARGSNKSF LAAANEEILD SLRIKRGEDI DCDQSPEDPE KDKHEGENNS
610 620 630 640 650
SKDAEKSREE AEDPSADKDA DSKGLEEEPG HGKPEEPTEV GDKGNSVPAN
660 670 680 690 700
LGDNTTNASP EETSPCDGRS PEGCLSETHD SSSMAEKKVA SELPPDVPED
710 720 730 740 750
SNRTCDSSNT SATTASSQPN LETCSSSELT SSQSDSAKAA DDPEIGERDS
760 770 780 790 800
HTPVSVHEEI GDFRLEKSNG EVSESPGAGK GTSGSTRIIT RLRNPESKLS
810 820 830 840 850
QLKSQQVAAA AHEANKLFKE GKEVLVVNSQ GEVSRLSTKK EVVMKGNINN
860 870 880 890 900
YFKLGQEGKY RVYHNQYSTN SFALNKHQHR EDHDKRRHLA HKFCLTPAGE
910 920 930 940 950
FKWNGSVHGS KVLTISTLRL TITQLESNIP SSFLHPNWAS HRANWIKAVQ
960 970 980 990 1000
MCSKPREFAL ALAILECAVK PVVMLPIWRE SLGHTRLHRM TSIEREEKEK
1010 1020 1030 1040 1050
VKKKEKKQEE EETMQQATWV KYTFPVKHQV TGYGGWSWIS KTHVYRFLPK
1060 1070 1080 1090 1100
LPGNTNVNYR KPLDGAKNNT DENKDESEKR KSPRSPKKMK TECDSEQGET
1110 1120 1130 1140 1150
RDADATAGAA AGAMELSKEP EKKDQDVKEL LDSDNDKSFK EEPMEIDDTI
1160 1170 1180 1190 1200
KTESHVSSLE STEVDVVNVS EGFHLRTSYK KKTKSSKLDG LLERRIRQFT
1210 1220 1230 1240 1250
LEEKQRLEKL KLESGVKGAG KPPMGALKSS SESPGSTKAS EGHQGDSLRQ
1260 1270 1280 1290 1300
EQSPSSSQAS TVDLGLGGSQ SDPLVLGISP PSLSTHKPDP KDQVLDDVSI
1310 1320 1330 1340 1350
QSPGPNCQRQ NSVESDLDAR ISEPAGKGLE LSQTKTEVTD SSSDDSKPTS
1360 1370 1380 1390 1400
ADDVGILICK SRKLHSQDDS STVVSSSKST LPASVPKSPR DRDARAFSKA
1410 1420 1430 1440 1450
VDFDGRLGGD SEYSSTLENS SDNMCIRDSA EEDMVVQNSS EATSKRFIAP
1460 1470 1480 1490 1500
EQGGESVEST KCQVVSKSTE NCEDKLQGKV TEANGKKLGQ HPPKPEERAV
1510 1520 1530 1540 1550
NRCTDQVSLR HSVDRKNSEP RESEKKGQKA NKFQINGKDS KAKGYLKGPG
1560 1570 1580 1590 1600
TKDGSDGKVV SSAVEPKVNN INKVIPGNTK SLAGKESAAK PFINGDIIME
1610 1620 1630 1640 1650
ELSEQNTSET NSYSLSSSDA KGNHQDGLHT LPSTKESAST QVITPRAPCP
1660 1670 1680 1690 1700
DRNSLSQVED METESPEVKR VIPSPVRTGE GSNLSKGFMD DNGLPSSKDE
1710 1720 1730 1740 1750
NVNGESQRKT VITEVTTMTS TVATESKTVI KVAKGDKQTV VSSTENCARS
1760 1770 1780 1790 1800
TVTTTTTTVT KLSTPSPDTG VDTISVKEQS KTVVTTTVTD SLTTAGSTLV
1810 1820 1830 1840 1850
TSMTVSKEYS TRDRVKLMKF SRPKKTRSGT ALPSYRKFVT KSSKKSIFVL
1860 1870 1880 1890 1900
PNDDLKKLAR KGGIREVPYF NYNAKPALDI WPYPSPRPTF GITWRYRLQT
1910 1920 1930 1940 1950
VKSLAGVSLM LRLLWASLRW DDMAAKAPPG GGSTRTETSE TEITTTEIIK
1960 1970 1980 1990 2000
RRDVGPYGIR SEYCIRKIIC PIGVPEAPKE TPTPQRKGLR SSALRPKRPE
2010 2020 2030 2040 2050
TPKQTGPVII ESWVAEEELE LWEIRAFAER VEKEKAQAAE QQTKKRLEQQ
2060 2070 2080 2090 2100
KPAVIAASTT SPANNTSSTV SPAQKVMVAP LSGSVTPGTK MVLATKVGSP
2110 2120 2130 2140 2150
ATVTFQQNKN FHQTFATWVK QGQSNSGMVQ VQQKVLGIIP STTGPSQQTF
2160 2170 2180 2190 2200
TSFQPRTATV TIRPNTSASA GTTTTSQVIT GPQIRPGMTV IRTPLQQPAL
2210 2220 2230 2240 2250
GKAIIRTPVV VQPGTPQQVV TQIIRGQPVS TAISAPSTAS SAPVQKGLTP
2260 2270 2280 2290 2300
GAAAGPLQPS APHSPRPQQG QVKLTMAQLT QLTQGHGGNQ GLTVVIQGQG
2310 2320 2330 2340 2350
QTTGQLQLIP QGMTVLPGPG QQLMQAAMPN GTVQRFLFTP LSTSATAASS
2360 2370 2380 2390 2400
SSNSSSTTTN ATAAGSGEQK QSKILPQTQV QPATTLAPTQ SSSVSPAEAQ
2410 2420 2430 2440 2450
PQPAQPAAQP QPQPQPPAQP EVQTQPAVSS HVPSETQPSQ AQTSKPLVAT
2460 2470 2480 2490 2500
QCQPQSSVQG QSPVRVQSPP LTRIRPSTPS QVTPGQQPQV QTTASQPIPI
2510 2520 2530 2540 2550
PPPTSLQAPS QGQPQSQPQV QSSTQTLSSG QTLNQVTVLS PSCPQPQPQV
2560 2570 2580 2590 2600
IAVPQLQQVQ VLSQIQSQVV AQIQAQQSGV PQQIKLQLPI QVQQNSAAQT
2610 2620 2630 2640 2650
QSVVTVQAAS VQEQLQRVQQ LRDQQQKKKQ QIETEREHTL QASNQSEIIQ
2660 2670 2680 2690 2700
KQVVMKHNAV IEHLKQKKTM TPAEREENQR MIVCNQVMKY ILDKIDKEEK
2710 2720 2730 2740 2750
QAAKKRKREE SVEQKRSKQN ASKLSALLFK HKEQLKAEIL RKRALLDKEL
2760 2770 2780 2790 2800
QIQVQEELKR DLKMKREREM AQAVQANAAS VPTPSVPAPV PAPAPAAPPA
2810 2820 2830 2840 2850
PPRSPPPSTH SLPPAGHPTA PLPVTSQKRK REEEKDSKSK KKKMISTTSK
2860 2870 2880 2890 2900
EAKKDTRLYC ICKTPYDESK FYIGCDRCQN WYHGRCVGIL QSEADLIDEY
2910 2920 2930 2940 2950
VCPQCQSTED AMTVLTPLTE KDYEGLKRVL RSLQAHKMAW PFLEPVDPND
2960 2970 2980 2990 3000
APDYYGVIKE PMDLATMEER IQKRYYEKLT EFVADMTKIF DNCRYYNPRD
3010 3020 3030
TPFYQCAEVL ESFFVQKLKG FKASRSHNNK LQSTAP
Length:3,036
Mass (Da):333,228
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB5E7A095A97E3AA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6A7E9Q6A7_MOUSE
Bromodomain PHD finger transcriptio...
Bptf
2,921Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A655A2A655_MOUSE
Bromodomain PHD finger transcriptio...
Bptf
2,973Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A653A2A653_MOUSE
Bromodomain PHD finger transcriptio...
Bptf
289Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LHY5A0A140LHY5_MOUSE
Bromodomain PHD finger transcriptio...
Bptf
329Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A652A2A652_MOUSE
Bromodomain PHD finger transcriptio...
Bptf
158Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000106763; ENSMUSP00000102374; ENSMUSG00000040481

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiA2A654
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-694, NuRF chromatin remodeling complex
IntActiA2A654, 2 interactors
MINTiA2A654
STRINGi10090.ENSMUSP00000102374

PTM databases

iPTMnetiA2A654

Proteomic databases

jPOSTiA2A654
MaxQBiA2A654
PeptideAtlasiA2A654
PRIDEiA2A654
ProteomicsDBi361911

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
19216, 98 antibodies

Genome annotation databases

EnsembliENSMUST00000106763; ENSMUSP00000102374; ENSMUSG00000040481

Organism-specific databases

MGIiMGI:2444008, Bptf
VEuPathDBiHostDB:ENSMUSG00000040481

Phylogenomic databases

eggNOGiKOG1473, Eukaryota
KOG1632, Eukaryota
KOG1827, Eukaryota
GeneTreeiENSGT00940000154830
InParanoidiA2A654
OMAiCDDRLQG
PhylomeDBiA2A654
TreeFamiTF316840

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Bptf, mouse
RNActiA2A654, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040481, Expressed in cochlea and 312 other tissues
ExpressionAtlasiA2A654, baseline and differential

Family and domain databases

Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR038028, BPTF
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR018501, DDT_dom
IPR028941, WHIM2_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45975, PTHR45975, 2 hits
PfamiView protein in Pfam
PF00439, Bromodomain, 1 hit
PF02791, DDT, 1 hit
PF00628, PHD, 2 hits
PF15613, WSD, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00571, DDT, 1 hit
SM00249, PHD, 2 hits
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS50827, DDT, 1 hit
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2A654_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A654
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 29, 2021
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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