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Protein

Microtubule-associated protein

Gene

Mapt

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated proteinUniRule annotation
Gene namesi
Name:MaptImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97180 Mapt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation, MicrotubuleUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiA2A5Y6
PeptideAtlasiA2A5Y6
PRIDEiA2A5Y6

Expressioni

Gene expression databases

BgeeiENSMUSG00000018411 Expressed in 261 organ(s), highest expression level in forebrain
ExpressionAtlasiA2A5Y6 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA2A5Y6
SMRiA2A5Y6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2418 Eukaryota
ENOG4111J07 LUCA
GeneTreeiENSGT00530000063491
HOGENOMiHOG000231029
HOVERGENiHBG000991
OMAiPPEFTFH
OrthoDBiEOG091G0AHK
PhylomeDBiA2A5Y6

Family and domain databases

InterProiView protein in InterPro
IPR001084 MAP_tubulin-bd_rpt
IPR002955 Tau
PfamiView protein in Pfam
PF00418 Tubulin-binding, 4 hits
PRINTSiPR01261 TAUPROTEIN
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 2 hits
PS51491 TAU_MAP_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A2A5Y6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPRQEFDT MEDHAGDYTL LQDQEGDMDH GLKESPPQPP ADDGAEEPGS
60 70 80 90 100
ETSDAKSTPT AEDVTAPLVD ERAPDKQAAA QPHTEIPEGI TAEEAGIGDT
110 120 130 140 150
PNQEDQAAGH VTQEPEKVEI FSQSLLVEPG RREGQAPDLG TSDWTRQQVS
160 170 180 190 200
SMSGAPLLPQ GLREATCQPS GTRPEDIEKS HPASELLRRG PPQKEGWGQD
210 220 230 240 250
RLGSEEEVDE DLTVDESSQD SPPSQASLTP GRAAPQAGSG SVCGETASVP
260 270 280 290 300
GLPTEGSVPL PADFFSKVSA ETQASQPEGP GTGPMEEGHE AAPEFTFHVE
310 320 330 340 350
IKASTPKEQD LEGATVVGVP GEEQKAQTQG PSVGKGTKEA SLQEPPGKQP
360 370 380 390 400
AAGLPGRPVS RVPQLKARVA SKDRTGNDEK KAKTSTPSCA KAPSHRPCLS
410 420 430 440 450
PTRPTLGSSD PLIKPSSPAV CPEPATSPKH VSSVTPRNGS PGTKQMKLKG
460 470 480 490 500
ADGKTGAKIA TPRGAASPAQ KGTSNATRIP AKTTPSPKTP PGSGEPPKSG
510 520 530 540 550
ERSGYSSPGS PGTPGSRSRT PSLPTPPTRE PKKVAVVRTP PKSPSASKSR
560 570 580 590 600
LQTAPVPMPD LKNVRSKIGS TENLKHQPGG GKVQIINKKL DLSNVQSKCG
610 620 630 640 650
SKDNIKHVPG GGSVQIVYKP VDLSKVTSKC GSLGNIHHKP GGGQVEVKSE
660 670 680 690 700
KLDFKDRVQS KIGSLDNITH VPGGGNKKIE THKLTFRENA KAKTDHGAEI
710 720 730 740
VYKSPVVSGD TSPRHLSNVS STGSIDMVDS PQLATLADEV SASLAKQGL
Length:749
Mass (Da):78,086
Last modified:February 20, 2007 - v1
Checksum:iFAE2174381807E38
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P10637TAU_MOUSE
Microtubule-associated protein tau
Mapt Mtapt, Tau
733Annotation score:
B1AQW2B1AQW2_MOUSE
Microtubule-associated protein
Mapt
390Annotation score:
A0A0A0MQC7A0A0A0MQC7_MOUSE
Microtubule-associated protein
Mapt
733Annotation score:
B1AQW5B1AQW5_MOUSE
Microtubule-associated protein tau
Mapt
123Annotation score:
B1AQW6B1AQW6_MOUSE
Microtubule-associated protein tau
Mapt
84Annotation score:
B1AQW4B1AQW4_MOUSE
Microtubule-associated protein tau
Mapt
154Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL593843 Genomic DNA No translation available.
AL596383 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000106989; ENSMUSP00000102602; ENSMUSG00000018411

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL593843 Genomic DNA No translation available.
AL596383 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA2A5Y6
SMRiA2A5Y6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA2A5Y6
PeptideAtlasiA2A5Y6
PRIDEiA2A5Y6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106989; ENSMUSP00000102602; ENSMUSG00000018411

Organism-specific databases

MGIiMGI:97180 Mapt

Phylogenomic databases

eggNOGiKOG2418 Eukaryota
ENOG4111J07 LUCA
GeneTreeiENSGT00530000063491
HOGENOMiHOG000231029
HOVERGENiHBG000991
OMAiPPEFTFH
OrthoDBiEOG091G0AHK
PhylomeDBiA2A5Y6

Miscellaneous databases

ChiTaRSiMapt mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018411 Expressed in 261 organ(s), highest expression level in forebrain
ExpressionAtlasiA2A5Y6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001084 MAP_tubulin-bd_rpt
IPR002955 Tau
PfamiView protein in Pfam
PF00418 Tubulin-binding, 4 hits
PRINTSiPR01261 TAUPROTEIN
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 2 hits
PS51491 TAU_MAP_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA2A5Y6_MOUSE
AccessioniPrimary (citable) accession number: A2A5Y6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 12, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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