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Entry version 92 (05 Jun 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

KAT8 regulatory NSL complex subunit 1

Gene

Kansl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
KAT8 regulatory NSL complex subunit 1Imported
Submitted name:
MCG141096, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kansl1Imported
Synonyms:1700081L11RikImported
ORF Names:mCG_141096Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923969 Kansl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000018412 Expressed in 261 organ(s), highest expression level in dorsal pancreas

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini879 – 1029PEHEInterPro annotationAdd BLAST151

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni145 – 211DisorderedSequence analysisAdd BLAST67
Regioni226 – 257DisorderedSequence analysisAdd BLAST32
Regioni399 – 423DisorderedSequence analysisAdd BLAST25
Regioni762 – 850DisorderedSequence analysisAdd BLAST89
Regioni932 – 994DisorderedSequence analysisAdd BLAST63
Regioni1050 – 1099DisorderedSequence analysisAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili291 – 311Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi158 – 193PolarSequence analysisAdd BLAST36
Compositional biasi768 – 797PolyampholyteSequence analysisAdd BLAST30
Compositional biasi816 – 847PolarSequence analysisAdd BLAST32
Compositional biasi932 – 988PolarSequence analysisAdd BLAST57

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063688

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231028

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPSCVMC

Database of Orthologous Groups

More...
OrthoDBi
191128at2759

TreeFam database of animal gene trees

More...
TreeFami
TF336511

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026180 NSL1
IPR029332 PEHE_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22443 PTHR22443, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15275 PEHE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01300 PEHE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2A5Y4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAMAPALTD AAAEAHHIRF KLAPPSSTLS PGSAENNGNA NILISANGTK
60 70 80 90 100
RKAIAAEDPS LDFRNNPTKE DLGKLQPLVA SYLCSDVTSV PAKESLKLQG
110 120 130 140 150
VFSKQTVLKS HPLLSQSYEL RAELLGRQPV LEFSLENLRT MNTSGQTALP
160 170 180 190 200
QAPVNGLAKK LTKSSTHSDH DNSSSLNGGK RSLTSSSLQG GEVGGPDSGN
210 220 230 240 250
LKGGMTNCTL PHRSLDIQHT TLYSNNSTAN KSSVNSMDQP ALQGSSRLSP
260 270 280 290 300
STDSSSNLTN VKLEVKKSPL SSILFSALDS DTRITALLRR QADIEIRARR
310 320 330 340 350
LQKRLQVVQA KQVERHLQHQ LGGFLETTLS KLPNLESLRS RSQLMLTRKA
360 370 380 390 400
EAALRKAASE SATSEGLSNF LKSDSISEEL ERFTASGIAN LRCSEQAFDS
410 420 430 440 450
DVTDSSSGGE SDIEEEELTR ADPEQCHVPL KRRSEWRWAA DRAAIVSRWN
460 470 480 490 500
WLQAHVSDLE YRIRQQTDIY KQIRANKGLI VLGEAPFPDH TTDLLSLSSE
510 520 530 540 550
VKTDHGRDKL IESVSQPSEN HGILVSNITE SLSTKSCGAP RPVNGVVNSL
560 570 580 590 600
QPVLADQVPG DSSDAEEQLH KKQRLNLVSS SDGTCVAART RPVLTCKKRR
610 620 630 640 650
LVRPSSIVPL SKKVHRNVRS GCDVNPSCAL CGSGSVNTMP PEIHYEAPLL
660 670 680 690 700
ERLSQLDSCV HPVLAFPDDV PTSLHFQSML KSQWQNKPFD KIKPTKKFSL
710 720 730 740 750
KHRATMPCSL SDPVRKDRHK LVNSFLTTAK LCHQQTRPDR THRQHLDGVG
760 770 780 790 800
AVPMVERVTA PKAERLLHLP PPVHDPTHSK MRLRDHSSER SEVLKHHTDM
810 820 830 840 850
SSPSYLTATH HPPHSPLVRQ LSTSSDTSTP TSSGSQVAAS TSQPVRRRRG
860 870 880 890 900
ESSFDINNIV IPMSVAATTR VEKLQYKEIL TPSWREVDVQ SLKGSPDEEN
910 920 930 940 950
EEIEDLSDAA FAALHAKCEE MERARWLWTT SVPPQRRGSR SYRSSDGRTT
960 970 980 990 1000
PQLGSANPST PQPASPDVSS SHSLSEFSHG QSPRSPISPE LHSAPLTPVA
1010 1020 1030 1040 1050
RDSLRHLASE DTRCSTPELG LDEQSVQPWE RRTFPLAYSP QAECEEQLDA
1060 1070 1080 1090
QDTAARCTRR TSGSKTGREA EVAPTSPPVV PLKSRHLAAT VTAQRPAHR
Length:1,099
Mass (Da):120,402
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i593CBF52E27BFC18
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80TG1KANL1_MOUSE
KAT8 regulatory NSL complex subunit...
Kansl1 Kiaa1267, Nsl1
1,036Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AQV9B1AQV9_MOUSE
KAT8 regulatory NSL complex subunit...
Kansl1 1700081L11Rik
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL593843 Genomic DNA No translation available.
AL603709 Genomic DNA No translation available.
CH466558 Genomic DNA Translation: EDL34218.1

NCBI Reference Sequences

More...
RefSeqi
XP_006534508.1, XM_006534445.3
XP_006534509.1, XM_006534446.3
XP_006534510.1, XM_006534447.3
XP_006534511.1, XM_006534448.3
XP_006534512.1, XM_006534449.3
XP_006534513.1, XM_006534450.3
XP_011247608.1, XM_011249306.2
XP_011247609.1, XM_011249307.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000106971; ENSMUSP00000102584; ENSMUSG00000018412
ENSMUST00000106972; ENSMUSP00000102585; ENSMUSG00000018412

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
76719

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL593843 Genomic DNA No translation available.
AL603709 Genomic DNA No translation available.
CH466558 Genomic DNA Translation: EDL34218.1
RefSeqiXP_006534508.1, XM_006534445.3
XP_006534509.1, XM_006534446.3
XP_006534510.1, XM_006534447.3
XP_006534511.1, XM_006534448.3
XP_006534512.1, XM_006534449.3
XP_006534513.1, XM_006534450.3
XP_011247608.1, XM_011249306.2
XP_011247609.1, XM_011249307.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106971; ENSMUSP00000102584; ENSMUSG00000018412
ENSMUST00000106972; ENSMUSP00000102585; ENSMUSG00000018412
GeneIDi76719

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284058
MGIiMGI:1923969 Kansl1

Phylogenomic databases

GeneTreeiENSGT00530000063688
HOGENOMiHOG000231028
OMAiNPSCVMC
OrthoDBi191128at2759
TreeFamiTF336511

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Kansl1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000018412 Expressed in 261 organ(s), highest expression level in dorsal pancreas

Family and domain databases

InterProiView protein in InterPro
IPR026180 NSL1
IPR029332 PEHE_dom
PANTHERiPTHR22443 PTHR22443, 1 hit
PfamiView protein in Pfam
PF15275 PEHE, 1 hit
SMARTiView protein in SMART
SM01300 PEHE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2A5Y4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A5Y4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 5, 2019
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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