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UniProtKB - A2A5R6 (A2A5R6_MOUSE)

Entry version 84 (16 Oct 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

NFX1-type zinc finger-containing protein 1

Gene

Znfx1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NFX1-type zinc finger-containing protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Znfx1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2138982 Znfx1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500264242019 – 1045Sequence analysisAdd BLAST1027

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		A2A5R6

PeptideAtlas

More...PeptideAtlasi		A2A5R6

PRoteomics IDEntifications database

More...PRIDEi		A2A5R6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000039501 Expressed in 259 organ(s), highest expression level in zygote

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2A5R6 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2A5R6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini427 – 453NF-X1-typeInterPro annotationAdd BLAST27
Domaini456 – 475NF-X1-typeInterPro annotationAdd BLAST20
Domaini511 – 529NF-X1-typeInterPro annotationAdd BLAST19
Domaini599 – 616NF-X1-typeInterPro annotationAdd BLAST18
Domaini674 – 692NF-X1-typeInterPro annotationAdd BLAST19

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili78 – 98Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1807 Eukaryota
COG1112 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155154

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231024

Database of Orthologous Groups

More...OrthoDBi		271662at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2A5R6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR027417 P-loop_NTPase
IPR000967 Znf_NFX1

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13086 AAA_11, 1 hit
PF13087 AAA_12, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00438 ZnF_NFX, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A2A5R6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVIFTLAS VCALLAQTQR GQKKKMKRRV KVELRKLNTM TKAEANGIQD 
        60         70         80         90        100
VWQLDLSSRW QLYRLWLQMY QADTRRRILS YERQYRTWAE RMAELRLQED 
       110        120        130        140        150
LHILKDAEVV GMTTTGAAKY RQILQQVEPR IVIVEEAAEV LEAHTIATLS 
       160        170        180        190        200
KACQHLILIG DHQQLRPSAN VYDLAKNFNL EVSLFERLVK VNIPFVRLNY 
       210        220        230        240        250
QHRMRPEIAR LLTPHIYQDL ENHPSVLKYE QIKGVSSNLF FVEHNFPEQE 
       260        270        280        290        300
IQEGKSHQNQ HEAHFVVELC QYLLCQEYLP SQITILTTYT GQLFCLRKLM 
       310        320        330        340        350
PVKTFAGIKV HVVDKYQGEE NDIILLSLVR SNQEGKVGFL QIPNRICVAL 
       360        370        380        390        400
SRAKKGMYCI GNMQMLAKVP LWSRIIHTLR ENNQIGPSLR LCCQNHPETH 
       410        420        430        440        450
TLVSKASDFQ KVPEGGCSRP CEFRLACGHV CTRACHPYDS SHKEFQCMKP 
       460        470        480        490        500
CQKVLCQDGH RCPNVCFQEC QPCQVKVPKI ILKCGHKQMV PCSMSESEFC 
       510        520        530        540        550
CQEPCSKILR CGHRCSHLCG EDCVRLCSER VTVELKCGHS QLVKCGNVED 
       560        570        580        590        600
IKYGLPVKCT TKCDTTLDCG HPCPGSCHSC FEGRFHERCQ QPCKRLLICS 
       610        620        630        640        650
HKCQEPCTGE CPPCQRTCQN RCVHSQCKKK CGELCSPCVE PCVWRCQHYQ 
       660        670        680        690        700
CTKLCSEPCN RPPCYVPCTK LLACGHPCIG LCGEPCPKKC RVCQPDEVTQ 
       710        720        730        740        750
IFFGFEDEPD ARFVQLEDCS HIFEVQALDR FMNEQKDDEV AIKLKVCPIC 
       760        770        780        790        800
QVPIRKNLRY GTSIKQRLEE IEIVKEKIQG SAGEISTSQE QLKALLKSKT 
       810        820        830        840        850
LFHQLRPEEF LILQEKLAQK NLSVKDLGLV ENSIRFYDHL ANLEGSLEKV 
       860        870        880        890        900
HCGEQQSVRT RLEQVHEWLA KKRLSFSSQE LSDLQSEIQR LTYLVNLLMR 
       910        920        930        940        950
CKMAEKVKGS IAEEVSSIRN ILEKTSKFTQ EDEQLVQKKM DALKTTLPCS 
       960        970        980        990       1000
GLGISDEERV QIVTAMGVPR GHWFKCPNGH IYVITECGGA MQRSTCPECQ 
      1010       1020       1030       1040 
EVIGGENHTL ERSNHLASEM DGAQHPAWSN TANNFMNFEE IHRMM
Length:1,045
Mass (Da):119,496
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0815275957E5DAF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8R151ZNFX1_MOUSE
NFX1-type zinc finger-containing pr...
Znfx1
1,909Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A5R4A2A5R4_MOUSE
NFX1-type zinc finger-containing pr...
Znfx1
840Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A5R5A2A5R5_MOUSE
NFX1-type zinc finger-containing pr...
Znfx1
869Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL591711 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001278091.1, NM_001291162.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000067584; ENSMUSP00000072867; ENSMUSG00000039501

Database of genes from NCBI RefSeq genomes

More...GeneIDi		98999

UCSC genome browser

More...UCSCi		uc056zqy.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591711 Genomic DNA No translation available.
RefSeqiNP_001278091.1, NM_001291162.1

3D structure databases

SMRiA2A5R6
ModBaseiSearch...

Proteomic databases

MaxQBiA2A5R6
PeptideAtlasiA2A5R6
PRIDEiA2A5R6

Genome annotation databases

EnsembliENSMUST00000067584; ENSMUSP00000072867; ENSMUSG00000039501
GeneIDi98999
UCSCiuc056zqy.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57169
MGIiMGI:2138982 Znfx1

Phylogenomic databases

eggNOGiKOG1807 Eukaryota
COG1112 LUCA
GeneTreeiENSGT00940000155154
HOGENOMiHOG000231024
OrthoDBi271662at2759
PhylomeDBiA2A5R6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Znfx1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000039501 Expressed in 259 organ(s), highest expression level in zygote
ExpressionAtlasiA2A5R6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR027417 P-loop_NTPase
IPR000967 Znf_NFX1
PfamiView protein in Pfam
PF13086 AAA_11, 1 hit
PF13087 AAA_12, 1 hit
SMARTiView protein in SMART
SM00438 ZnF_NFX, 5 hits
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2A5R6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A5R6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 16, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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