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Entry version 102 (16 Oct 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Zinc finger protein 335

Gene

Znf335

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri248 – 271C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri466 – 488C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri563 – 585C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 673C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri679 – 702C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1019 – 1041C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1047 – 1069C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1075 – 1097C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1103 – 1126C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 335
Alternative name(s):
NRC-interacting factor 1
Short name:
NIF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Znf335
Synonyms:Zfp335
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2682313 Zfp335

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Loss leads to embryonic lethality as early as 7.5 dpc. Brain-specific conditional knockout produces a brain with an essentially absent cortex lacking all cortical neurons.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004192591 – 1337Zinc finger protein 335Add BLAST1337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei976PhosphoserineBy similarity1
Modified residuei1007PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1022Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1149PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2A5K6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2A5K6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2A5K6

PeptideAtlas

More...
PeptideAtlasi
A2A5K6

PRoteomics IDEntifications database

More...
PRIDEi
A2A5K6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2A5K6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2A5K6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at low levels in cerebral cortex, hippocampus and cerebellum (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In brain, expression peaks at 13-15 dpc, during cortical neurogenesis. At 8.5 dpc, expressed in forebrain and midbrain. At 14.5 dpc, expressed in ventricular zone, subventricular zone and cortical plate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039834 Expressed in 216 organ(s), highest expression level in mesenteric lymph node

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2A5K6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2A5K6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NCOA6; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity).

Interacts with CNOT6 (By similarity).

Interacts with CNOT9; the interaction is direct (By similarity).

Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity).

Interacts with members of histone H3'Lys4'(H3K4) methyltransferase complexes ASCL2, CXXC1, KMT2A/MLL1, SETD1A (By similarity).

Interacts with RBBP5 and WDR5.

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000038298

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2A5K6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1174 – 1325Gln-richAdd BLAST152

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri248 – 271C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri466 – 488C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri563 – 585C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 673C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri679 – 702C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1019 – 1041C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1047 – 1069C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1075 – 1097C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1103 – 1126C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158508

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231007

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2A5K6

Identification of Orthologs from Complete Genome Data

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OMAi
ICMESFH

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332472

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2A5K6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEENEVESSS DAAPRPGQPE EPSESGLGVC TSEAVSADSS DAATVPGLTE
60 70 80 90 100
ADDSGVGQSS DGGNHSVEEV SESISTDPLP HGCLPDSSSV SRGPVAEMPG
110 120 130 140 150
GPPALVHSSV LPDPSMLVSD CTASSSDLGS AIDKIIESTI GPDLIQSCIT
160 170 180 190 200
VTSGEEGGAE TTQYLILQGP DDGAPMASSM STSTLANSLA AIEALADGPT
210 220 230 240 250
STSACLEPPE EPQGDPSSVA QQPPAPVTEE LDLQSLEAMM EVVVVQQFKC
260 270 280 290 300
KMCQYRSSTK ATLLRHMRER HFRPALAAAA AATGKRGRVR KWGTSTKTTE
310 320 330 340 350
EDRPEEEEED DDIVDAGAID DLEEDSDYNP AEDEPRGRQL RLQRPTPSTP
360 370 380 390 400
RPRRRPGRPR KLPRLETSDL HDGVGQPLVS SQSTQSPPEL QDLEAPSSSG
410 420 430 440 450
LRALGKVGRG LVESGVSQSD AENAAPSCQD EADAPPRRRG RPSRRFLGKK
460 470 480 490 500
YRKYYYKSPK PLLRPYLCRI CGSRFLSHED LRFHVNSHEA GDPQLFRCLQ
510 520 530 540 550
CSYRSRRWSS LKEHMFNHVG SKPYKCDECS YTSVYRKDVI RHAAVHSQDR
560 570 580 590 600
KKRPDPTPKL SSFPCPVCGR VYPMQKRLTQ HMKTHSTEKP HMCDKCGKSF
610 620 630 640 650
KKRYTFKMHL LTHIQAVANR RFKCEFCEFV CEDKKALLNH QLSHVSDKPF
660 670 680 690 700
KCSFCPYRTF REDFLLSHVA VKHTGAKPFA CEYCHFSTRH KKNLRLHVRC
710 720 730 740 750
RHANSFEEWG RRHPEEPPSR RRPFFSLQQI EELKQQHSTA PGPPLSSPGP
760 770 780 790 800
EAPQEPAPFQ SPETPPLLCP DALGGTTIIY QQGAEESTAV ATQTALDLLL
810 820 830 840 850
NMSAQRELGA TALQVAVVKS EGIEAELTST GGQPSPEDTT PRVVTLHMAE
860 870 880 890 900
SGSSVAAESQ LGPSDLQQIA LPSGPFGGAS YSVITAPPVE GRTSASGPPY
910 920 930 940 950
REEPPGEAAQ AVVVSDTLKE AGTHYIMAAD GTQLHHIELT ADGSISFPSP
960 970 980 990 1000
DTLAPGTKWP LLQCGGPPRD GSEVLSPTKT HHMGGSQGSS TPPPAASHTL
1010 1020 1030 1040 1050
GLVVPQSPPS AAASSTKKFS CKVCSEAFPS RAEMESHKRA HAGPAAFKCP
1060 1070 1080 1090 1100
DCPFSARQWP EVRAHMAQHS SLRPHQCNQC SFASKNKKDL RRHMLTHTNE
1110 1120 1130 1140 1150
KPFSCHVCGQ RFNRNGHLKF HIQRLHSIDG RKTGTSTARA PAQTIILNSE
1160 1170 1180 1190 1200
EETLATLHTA FQSSHGVLGT ERLQQALSQE HIIVAQEQTV TNQEEATYIQ
1210 1220 1230 1240 1250
EITADGQTVQ HLVTSDNQVQ YIISQDGVQH LLPQEYVVVP DGHHIQVQEG
1260 1270 1280 1290 1300
QITHIQYEQG TPFLQESQIQ YVPVSPSQQL VTQAQLEAAA HSAVTAVADA
1310 1320 1330
AMAQAQGLFG TEEAVPEQIH QLQHQGIEYD VITLSDD
Length:1,337
Mass (Da):145,603
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48E6D13B3C16F2BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P5F4Q6P5F4_MOUSE
Zfp335 protein
Zfp335
598Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2J0S4R2J0_MOUSE
Zinc finger protein 335
Zfp335
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti309E → EE in BAE34126 (PubMed:16141072).Curated1
Sequence conflicti309E → EE in AAI57955 (PubMed:15489334).Curated1
Sequence conflicti309E → EE in AAI51014 (PubMed:15489334).Curated1
Sequence conflicti400G → D in BAE34126 (PubMed:16141072).Curated1
Sequence conflicti400G → D in AAI57955 (PubMed:15489334).Curated1
Sequence conflicti400G → D in AAI51014 (PubMed:15489334).Curated1
Sequence conflicti490A → V in BAE34126 (PubMed:16141072).Curated1
Sequence conflicti526C → G in BAE34126 (PubMed:16141072).Curated1
Sequence conflicti712R → C in BAE34126 (PubMed:16141072).Curated1
Sequence conflicti856A → E in BAE34126 (PubMed:16141072).Curated1
Sequence conflicti856A → E in AAI57955 (PubMed:15489334).Curated1
Sequence conflicti856A → E in AAI51014 (PubMed:15489334).Curated1
Sequence conflicti949S → G in BAE34126 (PubMed:16141072).Curated1
Sequence conflicti1135T → I in BAE34126 (PubMed:16141072).Curated1
Sequence conflicti1135T → I in AAI57955 (PubMed:15489334).Curated1
Sequence conflicti1135T → I in AAI51014 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK157577 mRNA Translation: BAE34126.1
AL591495 Genomic DNA No translation available.
BC151013 mRNA Translation: AAI51014.1
BC157954 mRNA Translation: AAI57955.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS38331.1

NCBI Reference Sequences

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RefSeqi
NP_950192.2, NM_199027.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000041361; ENSMUSP00000038298; ENSMUSG00000039834

Database of genes from NCBI RefSeq genomes

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GeneIDi
329559

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:329559

UCSC genome browser

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UCSCi
uc008nwr.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157577 mRNA Translation: BAE34126.1
AL591495 Genomic DNA No translation available.
BC151013 mRNA Translation: AAI51014.1
BC157954 mRNA Translation: AAI57955.1
CCDSiCCDS38331.1
RefSeqiNP_950192.2, NM_199027.2

3D structure databases

SMRiA2A5K6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038298

PTM databases

iPTMnetiA2A5K6
PhosphoSitePlusiA2A5K6

Proteomic databases

EPDiA2A5K6
MaxQBiA2A5K6
PaxDbiA2A5K6
PeptideAtlasiA2A5K6
PRIDEiA2A5K6

Genome annotation databases

EnsembliENSMUST00000041361; ENSMUSP00000038298; ENSMUSG00000039834
GeneIDi329559
KEGGimmu:329559
UCSCiuc008nwr.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
329559
MGIiMGI:2682313 Zfp335

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000158508
HOGENOMiHOG000231007
InParanoidiA2A5K6
OMAiICMESFH
OrthoDBi1318335at2759
TreeFamiTF332472

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Zfp335 mouse

Protein Ontology

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PROi
PR:A2A5K6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039834 Expressed in 216 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiA2A5K6 baseline and differential
GenevisibleiA2A5K6 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN335_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A5K6
Secondary accession number(s): B2RXR9, Q3TZT1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: February 20, 2007
Last modified: October 16, 2019
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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