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Protein

Peptidase inhibitor R3HDML

Gene

R3hdml

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Putative serine protease inhibitor.By similarity

Caution

Despite its name, it does not contain a R3H domain.Curated

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase inhibitor R3HDML
Alternative name(s):
Cysteine-rich secretory protein R3HDML
Gene namesi
Name:R3hdml
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3650937 R3hdml

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000028763724 – 56By similarityAdd BLAST33
ChainiPRO_000028763857 – 253Peptidase inhibitor R3HDMLAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiA2A5I3
PaxDbiA2A5I3
PRIDEiA2A5I3

Expressioni

Gene expression databases

BgeeiENSMUSG00000078949 Expressed in 7 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105043

Structurei

3D structure databases

ProteinModelPortaliA2A5I3
SMRiA2A5I3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 207SCPAdd BLAST141

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000111978
HOVERGENiHBG079090
InParanoidiA2A5I3
OMAiHIRASVH
OrthoDBiEOG091G048D
PhylomeDBiA2A5I3
TreeFamiTF316148

Family and domain databases

Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR014044 CAP_domain
IPR035940 CAP_sf
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2A5I3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLSSIVGL TGLLLWMGHT VGALRMPNTT LVQGRPKNTA VWPLSGLGVP
60 70 80 90 100
RHRRKRHISA RDMSALLDYH NHIRASVHPP AANMEYMVWD EQLARSAEAW
110 120 130 140 150
ATQCIWTHGP SQLMKYVGQN LSIHSGRFRS VVDLVRSWSE EKRHYSFPAP
160 170 180 190 200
KDCTPHCPWL CSGPVCSHYT QMVWASSSRL GCAINTCSSI NVWGNTWQQA
210 220 230 240 250
VYLVCNYAIK GNWIGEAPYK AGKPCSACPP SYQGNCNSNM CFSGLKSNRL

PWV
Length:253
Mass (Da):28,269
Last modified:February 20, 2007 - v1
Checksum:iECD1E2A41F341243
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591488 Genomic DNA No translation available.
CCDSiCCDS38316.1
RefSeqiNP_001092801.1, NM_001099331.2
XP_006498585.1, XM_006498522.3
UniGeneiMm.442535

Genome annotation databases

EnsembliENSMUST00000109416; ENSMUSP00000105043; ENSMUSG00000078949
GeneIDi100043899
KEGGimmu:100043899
UCSCiuc008nsw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591488 Genomic DNA No translation available.
CCDSiCCDS38316.1
RefSeqiNP_001092801.1, NM_001099331.2
XP_006498585.1, XM_006498522.3
UniGeneiMm.442535

3D structure databases

ProteinModelPortaliA2A5I3
SMRiA2A5I3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105043

Proteomic databases

MaxQBiA2A5I3
PaxDbiA2A5I3
PRIDEiA2A5I3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109416; ENSMUSP00000105043; ENSMUSG00000078949
GeneIDi100043899
KEGGimmu:100043899
UCSCiuc008nsw.2 mouse

Organism-specific databases

CTDi140902
MGIiMGI:3650937 R3hdml

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000111978
HOVERGENiHBG079090
InParanoidiA2A5I3
OMAiHIRASVH
OrthoDBiEOG091G048D
PhylomeDBiA2A5I3
TreeFamiTF316148

Miscellaneous databases

PROiPR:A2A5I3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078949 Expressed in 7 organ(s), highest expression level in liver

Family and domain databases

Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR014044 CAP_domain
IPR035940 CAP_sf
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRSPL_MOUSE
AccessioniPrimary (citable) accession number: A2A5I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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