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Protein
Submitted name:

potassium Voltage-gated channel, subfamily H (Eag-related), member 4

Gene

Kcnh4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • phosphorelay sensor kinase activity Source: InterPro
  • voltage-gated potassium channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Submitted name:
potassium Voltage-gated channel, subfamily H (Eag-related), member 4Imported
Gene namesi
Name:Kcnh4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2156184 Kcnh4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei323 – 345HelicalSequence analysisAdd BLAST23
Transmembranei357 – 383HelicalSequence analysisAdd BLAST27
Transmembranei425 – 447HelicalSequence analysisAdd BLAST23
Transmembranei454 – 478HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000035355 Expressed in 14 organ(s), highest expression level in brain

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102984

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 90PASInterPro annotationAdd BLAST77
Domaini93 – 145PACInterPro annotationAdd BLAST53
Domaini556 – 620Cyclic nucleotide-bindingInterPro annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili874 – 908Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
GeneTreeiENSGT00900000140833
HOGENOMiHOG000230794
HOVERGENiHBG052232
KOiK04907
OMAiRELRHIM
OrthoDBiEOG091G0OXR
TreeFamiTF313130

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00130 PAS, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR003950 K_chnl_volt-dep_ELK
IPR001610 PAC
IPR000014 PAS
IPR000700 PAS-assoc_C
IPR035965 PAS-like_dom_sf
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF13426 PAS_9, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
PR01465 ELKCHANNEL
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00086 PAC, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
SSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50113 PAC, 1 hit
PS50112 PAS, 1 hit

Sequencei

Sequence statusi: Complete.

A2A5F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVMKGLLAP QNTFLDTIAT RFDGTHSNFL LANAQGPRGF PIVYCSDGFC
60 70 80 90 100
ELTGYGRTEV MQKTCSCRFL YGPETSEPAL QRLQKALEGH QEHRTEICFY
110 120 130 140 150
RKDGSAFWCL LDMMPIKNEM GEVVLFLFSF KDISQSGGPG LGSPGIHGDN
160 170 180 190 200
NHENSLGRRG TSSRLRSTKR QNRTVLHRLT GHFGRRGQSS VKANSNLFEP
210 220 230 240 250
KPSVPEYKVA SVGGSRCLLL HYSIPKAVWD GLILLATFYV AVTVPYNVCF
260 270 280 290 300
AGDDDTPITS RHTLVSDIAV EMLFILDIIL NFRTTYVSQS GQVISAPRSI
310 320 330 340 350
GLHYLATWFF VDLIAALPFD LLYVFNITVT SLVHLLKTVR LLRLLRLLQK
360 370 380 390 400
LERYSQCSAV VLTLLMSVFA LLAHWMACVW YVIGRREMEA NDPLLWDIGW
410 420 430 440 450
LHELGKRLEE PYVNGSAGGP SRRSAYIAAL YFTLSSLTSV GFGNVCANTD
460 470 480 490 500
AEKIFSICTM LIGALMHAVV FGNVTAIIQR MYSRRSLYHS RMKDLKDFIR
510 520 530 540 550
VHRLPRPLKQ RMLEYFQTTW AVNSGIDANE LLRDFPDELR ADIAMHLNRE
560 570 580 590 600
ILQLPLFGAA SRGCLRALSL HIKTSFCAPG EYLLRRGDAL QAHYYVCSGS
610 620 630 640 650
LEVLRDNMVL AILGKGDLIG ADIPELGQEP GSGAGPSCVL KTSADVKALT
660 670 680 690 700
YCGLQQLSSR GLAEVLRLYP EYAAAFRAGL PRDLTFNLRQ GSENNGLGRF
710 720 730 740 750
SRSPRLSQAR SDTLGSSSDK TLPSITETEG GTEPGAGSKP RRPHLLPNLS
760 770 780 790 800
PARPRGSLVS LLGEELPPFS ALVSSPSLSP TPSPALAGRG QSPSPHGPPR
810 820 830 840 850
GSAAWKPPQL LIPPLGTFGP PDLSPRIVDG IEDSSNTAEA PTFRFSKRPE
860 870 880 890 900
PTRTRSQAPP SGPRLSRELA TEAAEEVKEK VCRLNQEISR LNQEVSQLSR
910 920 930 940 950
ELRQVMGLLQ ARLGPPSHTA GPAWLPDLPC PHQRLPCISP HMSGPPPGLQ
960 970 980 990 1000
NTTLAVVHCP ASVGTVEIGA TPSELRPSTI PPYPSEPDPL GPSPAPEAPP
1010
LTPSLLKHSF QSGSDTFH
Length:1,018
Mass (Da):111,481
Last modified:February 5, 2008 - v1
Checksum:iC4FF6748C0DAF45C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591466 Genomic DNA No translation available.
AL591469 Genomic DNA No translation available.
BC150990 mRNA Translation: AAI50991.1
BC150994 mRNA Translation: AAI50995.1
RefSeqiNP_001074663.1, NM_001081194.2
UniGeneiMm.297539

Genome annotation databases

EnsembliENSMUST00000107361; ENSMUSP00000102984; ENSMUSG00000035355
ENSMUST00000107363; ENSMUSP00000102986; ENSMUSG00000035355
GeneIDi380728
KEGGimmu:380728
UCSCiuc007lmf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591466 Genomic DNA No translation available.
AL591469 Genomic DNA No translation available.
BC150990 mRNA Translation: AAI50991.1
BC150994 mRNA Translation: AAI50995.1
RefSeqiNP_001074663.1, NM_001081194.2
UniGeneiMm.297539

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102984

Protocols and materials databases

DNASUi380728
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107361; ENSMUSP00000102984; ENSMUSG00000035355
ENSMUST00000107363; ENSMUSP00000102986; ENSMUSG00000035355
GeneIDi380728
KEGGimmu:380728
UCSCiuc007lmf.2 mouse

Organism-specific databases

CTDi23415
MGIiMGI:2156184 Kcnh4

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
GeneTreeiENSGT00900000140833
HOGENOMiHOG000230794
HOVERGENiHBG052232
KOiK04907
OMAiRELRHIM
OrthoDBiEOG091G0OXR
TreeFamiTF313130

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035355 Expressed in 14 organ(s), highest expression level in brain

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00130 PAS, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR003950 K_chnl_volt-dep_ELK
IPR001610 PAC
IPR000014 PAS
IPR000700 PAS-assoc_C
IPR035965 PAS-like_dom_sf
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF13426 PAS_9, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
PR01465 ELKCHANNEL
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00086 PAC, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
SSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50113 PAC, 1 hit
PS50112 PAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2A5F7_MOUSE
AccessioniPrimary (citable) accession number: A2A5F7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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