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Protein
Submitted name:

Next to BRCA1 gene 1 protein

Gene

Nbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Next to BRCA1 gene 1 proteinImported
Gene namesi
Name:Nbr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:108498 Nbr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiA2A4N5
PRIDEiA2A4N5

Expressioni

Gene expression databases

BgeeiENSMUSG00000017119 Expressed in 301 organ(s), highest expression level in ciliary body
ExpressionAtlasiA2A4N5 baseline and differential
GenevisibleiA2A4N5 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA2A4N5
SMRiA2A4N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86PB1InterPro annotationAdd BLAST83
Domaini212 – 258ZZ-typeInterPro annotationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili296 – 330Sequence analysisAdd BLAST35
Coiled coili720 – 740Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4351 Eukaryota
KOG4582 Eukaryota
ENOG4111TKN LUCA
GeneTreeiENSGT00390000016335
HOVERGENiHBG052578

Family and domain databases

CDDicd14947 NBR1_like, 1 hit
cd06396 PB1_NBR1, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR032350 N_BRCA1_central
IPR033513 NBR1
IPR000270 PB1_dom
IPR034852 PB1_NBR1
IPR000433 Znf_ZZ
PANTHERiPTHR20930:SF2 PTHR20930:SF2, 1 hit
PfamiView protein in Pfam
PF16158 N_BRCA1_IG, 1 hit
PF00564 PB1, 1 hit
PF00569 ZZ, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00291 ZnF_ZZ, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A2A4N5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD
60 70 80 90 100
EENEEISINS QGEYEEALKM ANIKQGNQLQ MQVHEGYHVV DEALPKNVVE
110 120 130 140 150
NQAAARTGKK PLAHYSSLVR VLGSDMKTTE EPAPEQCSSA PCDTDQPQDK
160 170 180 190 200
PPDWFTSYLE MFREQVVKET VEKLEQRLQE KLVLQKPLLS SSPTEVSMPI
210 220 230 240 250
SEETLFLPEN QFSWHIACSH CQKRIVGVRY QCSLCPSYNI CEDCEAGPYT
260 270 280 290 300
HDTNHVLLKL RRPVVISSEP FFYSKYSAPR LPAALEQVRL QKQVDKNFVK
310 320 330 340 350
AEKQRLRAEK KQRKAEVKEL KKQLKLHRKI HLWNSIHGLQ SPKSPLGRPE
360 370 380 390 400
SLLQSNTLML PLQPCAPVMP TLSAAFVDEN LPDGTHLQPG TKFIKHWRMK
410 420 430 440 450
NTGNVKWNTD TKLKFMWGNL TLASTEKKDV LVPCLKAGHV GVVSVEFIAP
460 470 480 490 500
TLEGTYTSHW RLSHKGQQFG PRVWCSIIVD PFPSSESPDN VEGDRISSSK
510 520 530 540 550
ADDFSCEQEE AFLLAEEEIP LGEVTKQTEG TGASASQKTR RAASERELYI
560 570 580 590 600
PSVDLLTAQD LLSFELLDIN IVQELERVPH NTPVDMTPCM SPLPHDSPLI
610 620 630 640 650
EKPGLGQIQE ESEGAGFKAP PDSTVSAKRK AETPASVEET EEDLSGTQFV
660 670 680 690 700
CETVIRSLTL DAAPDHNPPC RQRSPQRELQ LYSTEGQQPL VLPGFCRKDS
710 720 730 740 750
SLKFALPEEG PRGDEREEIV HIVEEEVVEE EEEVQDEEVQ SQSSASSEDY
760 770 780 790 800
IIILPECFDT SRPLGDSMYS SALSQPGLER GAEGEPGIES GLEPTEARER
810 820 830 840 850
LPERESQPQE QSISDILTTS QPLDTVPLVP EVAGLPAALS RSAPCGQCES
860 870 880 890 900
SGVDSPGVDS PATMHEVPPA PDDIRGEPRG STGLANSRQR SCDHSSPSFL

KIRPQP
Length:906
Mass (Da):100,861
Last modified:February 20, 2007 - v1
Checksum:i16A21DAD9E4DDF89
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P97432NBR1_MOUSE
Next to BRCA1 gene 1 protein
Nbr1 M17s2
988Annotation score:
A2A4N8A2A4N8_MOUSE
Next to BRCA1 gene 1 protein
Nbr1
951Annotation score:
A2A4N7A2A4N7_MOUSE
Next to BRCA1 gene 1 protein
Nbr1
963Annotation score:
Q05BC8Q05BC8_MOUSE
Nbr1 protein
Nbr1
888Annotation score:
K3W4P1K3W4P1_MOUSE
Next to BRCA1 gene 1 protein
Nbr1
988Annotation score:
F6S397F6S397_MOUSE
Next to BRCA1 gene 1 protein
Nbr1
712Annotation score:
G3UZH6G3UZH6_MOUSE
Next to BRCA1 gene 1 protein
Nbr1
41Annotation score:
A2A4R0A2A4R0_MOUSE
Next to BRCA1 gene 1 protein
Nbr1
43Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590994 Genomic DNA No translation available.
AL590996 Genomic DNA No translation available.
RefSeqiNP_001239152.1, NM_001252223.1
UniGeneiMm.489817
Mm.784

Genome annotation databases

EnsembliENSMUST00000107208; ENSMUSP00000102826; ENSMUSG00000017119
GeneIDi17966
UCSCiuc007lpj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590994 Genomic DNA No translation available.
AL590996 Genomic DNA No translation available.
RefSeqiNP_001239152.1, NM_001252223.1
UniGeneiMm.489817
Mm.784

3D structure databases

ProteinModelPortaliA2A4N5
SMRiA2A4N5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA2A4N5
PRIDEiA2A4N5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107208; ENSMUSP00000102826; ENSMUSG00000017119
GeneIDi17966
UCSCiuc007lpj.2 mouse

Organism-specific databases

CTDi4077
MGIiMGI:108498 Nbr1

Phylogenomic databases

eggNOGiKOG4351 Eukaryota
KOG4582 Eukaryota
ENOG4111TKN LUCA
GeneTreeiENSGT00390000016335
HOVERGENiHBG052578

Miscellaneous databases

ChiTaRSiNbr1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017119 Expressed in 301 organ(s), highest expression level in ciliary body
ExpressionAtlasiA2A4N5 baseline and differential
GenevisibleiA2A4N5 MM

Family and domain databases

CDDicd14947 NBR1_like, 1 hit
cd06396 PB1_NBR1, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR032350 N_BRCA1_central
IPR033513 NBR1
IPR000270 PB1_dom
IPR034852 PB1_NBR1
IPR000433 Znf_ZZ
PANTHERiPTHR20930:SF2 PTHR20930:SF2, 1 hit
PfamiView protein in Pfam
PF16158 N_BRCA1_IG, 1 hit
PF00564 PB1, 1 hit
PF00569 ZZ, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00291 ZnF_ZZ, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2A4N5_MOUSE
AccessioniPrimary (citable) accession number: A2A4N5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 12, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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