UniProtKB - A2A472 (A2A472_MOUSE)
Protein
Submitted name:
TOX high mobility group box family member 2
Gene
Tox2
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 288 – 356 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- chromatin DNA binding Source: GO_Central
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II transcription factor binding Source: MGI
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: TOX high mobility group box family member 2Imported |
Gene namesi | Name:Tox2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3611233, Tox2 |
Subcellular locationi
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000074607, Expressed in cumulus cell and 228 other tissues |
ExpressionAtlasi | A2A472, baseline and differential |
Interactioni
GO - Molecular functioni
- RNA polymerase II transcription factor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000096710 |
Miscellaneous databases
RNActi | A2A472, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 288 – 356 | HMG boxInterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 226 – 291 | DisorderedSequence analysisAdd BLAST | 66 | |
Regioni | 360 – 386 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 424 – 547 | DisorderedSequence analysisAdd BLAST | 124 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 233 – 251 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 252 – 273 | PolyampholyteSequence analysisAdd BLAST | 22 | |
Compositional biasi | 428 – 445 | Pro-richSequence analysisAdd BLAST | 18 | |
Compositional biasi | 498 – 523 | PolarSequence analysisAdd BLAST | 26 |
Phylogenomic databases
eggNOGi | KOG0381, Eukaryota |
GeneTreei | ENSGT00940000158764 |
HOGENOMi | CLU_030650_2_0_1 |
InParanoidi | A2A472 |
TreeFami | TF106481 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
A2A472-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGGGAGPPA NRGPRVVGRL IKLLFLAFFS LSVLIMQQHL TEAVAGAFSR
60 70 80 90 100
CLGFRGMRLR LLTRHWCIAG ASLQKFDGDS AYVGMSDGNP ELLSTSQTYN
110 120 130 140 150
SQGESNEDYE IPPITPPNLP EPSLLHLGDH EAGYHSLCHG LAPNGLLPAY
160 170 180 190 200
SYQAMDLPAI MVSNMLAQDG HLLSGQLPTI QEMVHSEVAA YDSGRPGPLL
210 220 230 240 250
GRPAMLASHM SALSQSQLIS QMGIRSGIAH GSPSPPGSKS ATPSPSSSTQ
260 270 280 290 300
EEESDAHFKI SGEKRPSVDP GKKAKNPKKK KKKDPNEPQK PVSAYALFFR
310 320 330 340 350
DTQAAIKGQN PSATFGDVSK IVASMWDSLG EEQKQAYKRK TEAAKKEYLK
360 370 380 390 400
ALAAYRASLV SKSPPDQGEA KNTQANPPAK MLPPKQPMYA MPGLASFLTP
410 420 430 440 450
SDLQAFRSGA SPASLARTLG SKALLPGLST SPPPPSFPLS PSLHQQLPLP
460 470 480 490 500
PHAQGTLLSP PLSMSPAPQP PVLPASMALQ VQLAMSPSPP GPQDFPHISD
510 520 530 540
FSSGSGSRSP GPSNPSSSGD WDGSYPSGER GLGTCSLLPR DKSLYLT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q0B9 | E9Q0B9_MOUSE | TOX high mobility group box family ... | Tox2 | 522 | Annotation score: | ||
A2A473 | A2A473_MOUSE | TOX high mobility group box family ... | Tox2 | 505 | Annotation score: | ||
A2A474 | A2A474_MOUSE | TOX high mobility group box family ... | Tox2 | 124 | Annotation score: | ||
F6XVL5 | F6XVL5_MOUSE | TOX high mobility group box family ... | Tox2 | 169 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL589874 Genomic DNA No translation available. AL589876 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000099110; ENSMUSP00000096710; ENSMUSG00000074607 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL589874 Genomic DNA No translation available. AL589876 Genomic DNA No translation available. |
3D structure databases
SMRi | A2A472 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000096710 |
Proteomic databases
MaxQBi | A2A472 |
PeptideAtlasi | A2A472 |
PRIDEi | A2A472 |
Protocols and materials databases
Antibodypediai | 27319, 125 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000099110; ENSMUSP00000096710; ENSMUSG00000074607 |
Organism-specific databases
MGIi | MGI:3611233, Tox2 |
Phylogenomic databases
eggNOGi | KOG0381, Eukaryota |
GeneTreei | ENSGT00940000158764 |
HOGENOMi | CLU_030650_2_0_1 |
InParanoidi | A2A472 |
TreeFami | TF106481 |
Miscellaneous databases
RNActi | A2A472, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000074607, Expressed in cumulus cell and 228 other tissues |
ExpressionAtlasi | A2A472, baseline and differential |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A2A472_MOUSE | |
Accessioni | A2A472Primary (citable) accession number: A2A472 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |