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Entry version 90 (11 Dec 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Putative PIP5K1A and PSMD4-like protein

Gene

PIPSL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein uncertaini <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has negligible PIP5 kinase activity. Binds to ubiquitinated proteins.

Miscellaneous

PIPSL gene appeared in hominoids by L1-mediated retrotransposition in a hominoid ancestor of a readthrough, intergenically spliced transcript between the PIP5K1A and PSMD4 genes.

Caution

Could be the product of a pseudogene. Although transcribed, the gene is poorly translated probably due to a deletion in the regulatory region. PubMed:17623810 could not detect the protein by Western blot.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative PIP5K1A and PSMD4-like protein
Short name:
PIP5K1A-PSMD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIPSL
Synonyms:PSMD4P2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23733 PIPSL

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A2A3N6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A2A3N6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HGNC:23733

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003470571 – 862Putative PIP5K1A and PSMD4-like proteinAdd BLAST862

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2A3N6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2A3N6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A2A3N6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2A3N6

PRoteomics IDEntifications database

More...
PRIDEi
A2A3N6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
288

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2A3N6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific.1 Publication

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029366
HPA038807
HPA039252

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A2A3N6, 6 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A2A3N6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2A3N6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 396PIPKPROSITE-ProRule annotationAdd BLAST369
Domaini490 – 673VWFAPROSITE-ProRule annotationAdd BLAST184
Domaini696 – 715UIM 1CuratedAdd BLAST20
Domaini766 – 783UIM 2CuratedAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi723 – 731Poly-Ala9

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2A3N6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2A3N6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.800.10, 1 hit
3.30.810.10, 2 hits
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23086 PTHR23086, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01504 PIP5K, 1 hit
PF13519 VWA_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00330 PIPKc, 1 hit
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51455 PIPK, 1 hit
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2A3N6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASEVPYASG MPIKKIGHRS VDSSGGTTSS ALKGAIQLGI THTVGSLSTK
60 70 80 90 100
PESDVLMQDF HMVESIFFPS EGSNLTPAHH YNAFRFKTYA PVAFRYFWEL
110 120 130 140 150
FGIRPDDYLY SLCSEPLIEL CSSGASGSLF YVSSDDEFIV KTVRHKEAEF
160 170 180 190 200
LQKLLPGYYI NLNQNPRTLL PKFYGLYCVQ TGGKNIRIVV MNNLLPRSVK
210 220 230 240 250
MHIKYDLKGS TYRRRASQKE REKPLPTFKD LDFLQDIPDG LFLDADVHNA
260 270 280 290 300
LCKTLQRDCL VLQSFKIMDY SLLMSIHNID HAQREPLSSE TQYSVDTRRP
310 320 330 340 350
APQKALYSTA MESIQGEARR GGTMETDDHM GGIPARNSKG ERLLLYIGII
360 370 380 390 400
DILQSYRFVK KLEHSWKALI HDGDTVSVHR PGFYAEWFQR FMCNTVFKKI
410 420 430 440 450
PLKPSPSKKL RSGSSFSQRA GSSGNSCITY QPLVSGEHKA QVTTKAEVEP
460 470 480 490 500
GVHLGCPDVL PQTPPLEEIS EGSPTPDPSF SPLVEETLQM LTTSVDNSEY
510 520 530 540 550
MGNGDFLPTR LQAQQDAVNT VCHSKTRSNP ENNVGLITLD NDCEVLTTLT
560 570 580 590 600
PDTGRILSKL HTVQPKGKIT FCMGIHVAHL ALKHRQGNNH KIRIIAFVGN
610 620 630 640 650
PVEDNEKNLV KLAKCLKKEK VNVDIINFGE EEVNTEKLTA FVNTLNGKDG
660 670 680 690 700
TGSHLVTVPP GPSLADALIS FPILAGEGGA MMGLGASDFE FGVDPSADPE
710 720 730 740 750
LALVLRVFME EQRQRQEEEA RQAAAASAAE AGIATTGTED SDDALLKMTI
760 770 780 790 800
SQQEFGHTGL PDLSSMTEEE KIVCAMQMSL QGAEFGLAES ADIDASSAMD
810 820 830 840 850
TSEPAKEEDD YDVMQDPEFL QSVLENLPGV DPNNEAIRNA VGSLASQATK
860
DSKKDKKEED KK
Length:862
Mass (Da):95,048
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F1F11EC0AB0D704
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL365510 Genomic DNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365510 Genomic DNA No translation available.

3D structure databases

SMRiA2A3N6
ModBaseiSearch...

Protein-protein interaction databases

IntActiA2A3N6, 6 interactors

PTM databases

iPTMnetiA2A3N6

Polymorphism and mutation databases

BioMutaiHGNC:23733

Proteomic databases

EPDiA2A3N6
jPOSTiA2A3N6
MassIVEiA2A3N6
MaxQBiA2A3N6
PRIDEiA2A3N6
ProteomicsDBi288

Organism-specific databases

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PIPSL
HGNCiHGNC:23733 PIPSL
HPAiHPA029366
HPA038807
HPA039252
neXtProtiNX_A2A3N6

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

InParanoidiA2A3N6
PhylomeDBiA2A3N6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PIPSL human
PharosiA2A3N6 Tdark

Protein Ontology

More...
PROi
PR:A2A3N6
RNActiA2A3N6 protein

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
PF13519 VWA_2, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIPSL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A3N6
Secondary accession number(s): Q6NUK8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 20, 2007
Last modified: December 11, 2019
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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