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Entry version 91 (13 Feb 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Tetratricopeptide repeat protein 24

Gene

TTC24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 24
Short name:
TPR repeat protein 24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187862.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32348 TTC24

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A2A3L6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000187862

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670676

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTC24

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003077711 – 582Tetratricopeptide repeat protein 24Add BLAST582

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2A3L6

PRoteomics IDEntifications database

More...
PRIDEi
A2A3L6

ProteomicsDB human proteome resource

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ProteomicsDBi
285

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
A2A3L6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2A3L6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187862 Expressed in 58 organ(s), highest expression level in spleen

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029799

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A2A3L6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357219

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A2A3L6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2A3L6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati36 – 69TPR 1Add BLAST34
Repeati79 – 112TPR 2Add BLAST34
Repeati117 – 150TPR 3Add BLAST34
Repeati154 – 187TPR 4Add BLAST34
Repeati236 – 271TPR 5Add BLAST36
Repeati273 – 306TPR 6Add BLAST34
Repeati313 – 346TPR 7Add BLAST34
Repeati353 – 386TPR 8Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 28Poly-Lys7

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1124 Eukaryota
COG0457 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111346

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000090249

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG094909

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2A3L6

Identification of Orthologs from Complete Genome Data

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OMAi
CMLKSGR

Database of Orthologous Groups

More...
OrthoDBi
492447at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2A3L6

TreeFam database of animal gene trees

More...
TreeFami
TF328344

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR024812 TPR_24
IPR019734 TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR10098:SF112 PTHR10098:SF112, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13176 TPR_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2A3L6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSPNPEDVP RRPEPEPSSS NKKKKKRKWL RQEASIQALT RAGHGALQAG
60 70 80 90 100
QNHEALNNFQ RAFLLASKAP QTRDTPVLQA CAFNLGAAYV ETGDPARGLE
110 120 130 140 150
LLLRAHPEEK AQGRRHGDQC FNVALAYHAL GELPQALAWY HRALGHYQPQ
160 170 180 190 200
GDQGEAWAKM GACYQALGQP ELAAHCLQEA SQAYAQERQL RAAALALGAA
210 220 230 240 250
AGCMLKSGRH RVGEVVQVLE KSRRLAERST ERRLLGHLYN DLGLGYSQLQ
260 270 280 290 300
LFPLAVEAFL QALPLCWVPG EQATVLRNLG MAHNALGNYQ EAREFHQKAA
310 320 330 340 350
DLHGSVGQRW EQGRSFGSLA FALSQLGDHK AARDNYLHAL QAARDSGDMK
360 370 380 390 400
GQWQACEGLG AAAARLGQYD QALKYYKEAL AQCQKEPDSV RERLVAKLAD
410 420 430 440 450
TVRTRLAQVG LVQTHTLTSA PGRLQAPGGA SQAEGTPAKA GSSTAGVQHR
460 470 480 490 500
SSSGWEDEEF EEGHQKKKEE RSANVPVRAG PGRPELCFLP GTVNHSHHLA
510 520 530 540 550
SSCPTFTKHT PCRGTVLGKA SIYSPGPRAH LPFVGPGPPR AEYPSILVPN
560 570 580
GPQANRSSRW PRESLSRSRQ RRPMESGICT IV
Length:582
Mass (Da):63,396
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8614C5FC0D1BB185
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036643231E → G. Corresponds to variant dbSNP:rs6682716Ensembl.1
Natural variantiVAR_036644532P → A. Corresponds to variant dbSNP:rs17392348Ensembl.1
Natural variantiVAR_036645550N → S. Corresponds to variant dbSNP:rs12090808Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL365181 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53379.1

NCBI Reference Sequences

More...
RefSeqi
NP_001099139.2, NM_001105669.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.447851

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368236; ENSP00000357219; ENSG00000187862
ENST00000368237; ENSP00000357220; ENSG00000187862

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
164118

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:164118

UCSC genome browser

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UCSCi
uc021pbf.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365181 Genomic DNA No translation available.
CCDSiCCDS53379.1
RefSeqiNP_001099139.2, NM_001105669.3
UniGeneiHs.447851

3D structure databases

ProteinModelPortaliA2A3L6
SMRiA2A3L6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2A3L6, 1 interactor
STRINGi9606.ENSP00000357219

PTM databases

iPTMnetiA2A3L6
PhosphoSitePlusiA2A3L6

Polymorphism and mutation databases

BioMutaiTTC24

Proteomic databases

PaxDbiA2A3L6
PRIDEiA2A3L6
ProteomicsDBi285

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368236; ENSP00000357219; ENSG00000187862
ENST00000368237; ENSP00000357220; ENSG00000187862
GeneIDi164118
KEGGihsa:164118
UCSCiuc021pbf.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
164118
EuPathDBiHostDB:ENSG00000187862.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTC24
HGNCiHGNC:32348 TTC24
HPAiHPA029799
neXtProtiNX_A2A3L6
OpenTargetsiENSG00000187862
PharmGKBiPA142670676

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00730000111346
HOGENOMiHOG000090249
HOVERGENiHBG094909
InParanoidiA2A3L6
OMAiCMLKSGR
OrthoDBi492447at2759
PhylomeDBiA2A3L6
TreeFamiTF328344

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
164118

Protein Ontology

More...
PROi
PR:A2A3L6

Gene expression databases

BgeeiENSG00000187862 Expressed in 58 organ(s), highest expression level in spleen

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR024812 TPR_24
IPR019734 TPR_repeat
PANTHERiPTHR10098:SF112 PTHR10098:SF112, 1 hit
PfamiView protein in Pfam
PF13176 TPR_7, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 7 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC24_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A3L6
Secondary accession number(s): Q5T3H7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: February 13, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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