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Entry version 102 (31 Jul 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Protocadherin-15

Gene

PCDH15

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protocadherin-15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDH15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14674 PCDH15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1354 – 1377HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000150275

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32999

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500264239927 – 1932Sequence analysisAdd BLAST1906

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2A3E8

PRoteomics IDEntifications database

More...
PRIDEi
A2A3E8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
273

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150275 Expressed in 67 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2A3E8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2A3E8 HS

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2A3E8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 123CAInterPro annotationAdd BLAST82
Domaini152 – 241CAInterPro annotationAdd BLAST90
Domaini282 – 371CAInterPro annotationAdd BLAST90
Domaini404 – 485CAInterPro annotationAdd BLAST82
Domaini509 – 591CAInterPro annotationAdd BLAST83
Domaini616 – 693CAInterPro annotationAdd BLAST78
Domaini717 – 795CAInterPro annotationAdd BLAST79
Domaini819 – 902CAInterPro annotationAdd BLAST84
Domaini926 – 1012CAInterPro annotationAdd BLAST87
Domaini1033 – 1120CAInterPro annotationAdd BLAST88
Domaini1144 – 1228CAInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1578 – 1600DisorderedSequence analysisAdd BLAST23
Regioni1722 – 1743DisorderedSequence analysisAdd BLAST22
Regioni1905 – 1932DisorderedSequence analysisAdd BLAST28

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230919

Database of Orthologous Groups

More...
OrthoDBi
21247at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR041149 EC_dom
IPR030718 Protocadherin-15

The PANTHER Classification System

More...
PANTHERi
PTHR24028:SF11 PTHR24028:SF11, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 8 hits
PF18432 ECD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 29 potential isoforms that are computationally mapped.Show allAlign All

A2A3E8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRQFYLWTC LASGIILGSL FEICLGQYDD GTILVDNMLI KGTAGGPDPT
60 70 80 90 100
IELSLKDNVD YWVLMDPVKQ MLFLNSTGRV LDRDPPMNIH SIVVQVQCIN
110 120 130 140 150
KKVGTIIYHE VRIVVRDRND NSPTFKHESY YATVNELTPV GTTIFTGFSG
160 170 180 190 200
DNGATDIDDG PNGQIEYVIQ YNPDDPTSND TFEIPLMLTG NIVLRKRLNY
210 220 230 240 250
EDKTRYFVII QANDRAQNLN ERRTTTTTLT VDVLDGDDLG PMFLPCVLVP
260 270 280 290 300
NTRDCRPLTY QAAIPELRTP EELNPIIVTP PIQAIDQDRN IQPPSDRPGI
310 320 330 340 350
LYSILVGTPE DYPRFFHMHP RTAELSLLEP VNRDFHQKFD LVIKAEQDNG
360 370 380 390 400
HPLPAFAGLH IEILDENNQS PYFTMPSYQG YILESAPVGA TISDSLNLTS
410 420 430 440 450
PLRIVALDKD IEDTKDPELH LFLNDYTSVF TVTQTGITRY LTLLQPVDRE
460 470 480 490 500
EQQTYTFSIT AFDGVQESEP VIVNIQVMDA NDNTPTFPEI SYDVYVYTDM
510 520 530 540 550
RPGDSVIQLT AVDADEGSNG EITYEILVGA QGDFIINKTT GLITIAPGVE
560 570 580 590 600
MIVGRTYALT VQAADNAPPA ERRNSICTVY IEVLPPNNQS PPRFPQLMYS
610 620 630 640 650
LEISEAMRVG AVLLNLQATD REGDSITYAI ENGDPQRVFN LSETTGILTL
660 670 680 690 700
GKALDRESTD RYILIITASD GRPDGTSTAT VNIVVTDVND NAPVFDPYLP
710 720 730 740 750
RNLSVVEEEA NAFVGQVKAT DPDAGINGQV HYSLGNFNNL FRITSNGSIY
760 770 780 790 800
TAVKLNREVR DYYELVVVAT DGAVHPRHST LTLAIKVLDI DDNSPVFTNS
810 820 830 840 850
TYTVLVEENL PAGTTILQIE AKDVDLGANV SYRIRSPEVK HFFALHPFTG
860 870 880 890 900
ELSLLRSLDY EAFPDQEASI TFLVEAFDIY GTMPPGIATV TVIVKDMNDY
910 920 930 940 950
PPVFSKRIYK GMVAPDAVKG TPITTVYAED ADPPGLPASR VRYRVDDVQF
960 970 980 990 1000
PYPASIFEVE EDSGRVITRV NLNEEPTTIF KLVVVAFDDG EPVMSSSATV
1010 1020 1030 1040 1050
KILVLHPGEI PRFTQEEYRP PPVSELATKG TMVGVISAAA INQSIVYSIV
1060 1070 1080 1090 1100
SGNEEDTFGI NNITGVIYVN GPLDYETRTS YVLRVQADSL EVVLANLRVP
1110 1120 1130 1140 1150
SKSNTAKVYI EIQDENNHPP VFQKKFYIGG VSEDARMFTS VLRVKATDKD
1160 1170 1180 1190 1200
TGNYSVMAYR LIIPPIKEGK EGFVVETYTG LIKTAMLFHN MRRSYFKFQV
1210 1220 1230 1240 1250
IATDDYGKGL SGKADVLVSV VNQLDMQVIV SNVPPTLVEK KIEDLTEILD
1260 1270 1280 1290 1300
RYVQEQIPGA KVVVESIGAR RHGDAFSLED YTKCDLTVYA IDPQTNRAID
1310 1320 1330 1340 1350
RNELFKFLDG KLLDINKDFQ PYYGEGGRIL EIRTPEAVTS IKKRGESLGY
1360 1370 1380 1390 1400
TEGALLALAF IIILCCIPAI LVVLVSYRQR QAECTKTARI QAALPAAKPA
1410 1420 1430 1440 1450
VPAPAPVAAP PPPPPPPPGA HLYEELGDSS MHNLFLLYHF QQSRGNNSVS
1460 1470 1480 1490 1500
EDRKHQQVVM PFSSNTIEAH KSAHVDGSLK SNKLKSARKF TFLSDEDDLS
1510 1520 1530 1540 1550
AHNPLYKENI SQVSTNSDIS QRTDFVDPFS PKIQAKSKSL RGPREKIQRL
1560 1570 1580 1590 1600
WSQSVSLPRR LMRKVPNRPE IIDLQQWQGT RQKAENENTG ICTNKRGSSN
1610 1620 1630 1640 1650
PLLTTEEANL TEKEEIRQGE TLMIEGTEQL KSLSSDSSFC FPRPHFSFST
1660 1670 1680 1690 1700
LPTVSRTVEL KSEPNVISSP AECSLELSPS RPCVLHSSLS RRETPICMLP
1710 1720 1730 1740 1750
IETERNIFEN FAHPPNISPS ACPLPPPPPI SPPSPPPAPA PLAPPPDISP
1760 1770 1780 1790 1800
FSLFCPPPSP PSIPLPLPPP TFFPLSVSTS GPPTPPLLPP FPTPLPPPPP
1810 1820 1830 1840 1850
SIPCPPPPSA SFLSTECVCI TGVKCTTNLM PAEKIKSSMT QLSTTTVCKT
1860 1870 1880 1890 1900
DPQREPKGIL RHVKNLAELE KSVANMYSQI EKNYLRTNVS ELQTMCPSEV
1910 1920 1930
TNMEITSEQN KGSLNNIVEG TEKQSHSQST SL
Length:1,932
Mass (Da):213,670
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i499FDAD2022E67FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 29 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96QU1PCD15_HUMAN
Protocadherin-15
PCDH15 USH1F
1,955Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3D8A2A3D8_HUMAN
Protocadherin-15
PCDH15
1,962Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTR6A0A087WTR6_HUMAN
Protocadherin-15
PCDH15
1,539Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZN9A0A087WZN9_HUMAN
Protocadherin-15
PCDH15
1,790Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZW3A0A087WZW3_HUMAN
Protocadherin-15
PCDH15
1,789Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6C0A0A2R8Y6C0_HUMAN
Protocadherin-15
PCDH15
1,740Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZBT8B7ZBT8_HUMAN
Protocadherin-15
PCDH15
1,150Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3E3A2A3E3_HUMAN
Protocadherin-15
PCDH15
1,540Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3E7A2A3E7_HUMAN
Protocadherin-15
PCDH15
1,957Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3E6A2A3E6_HUMAN
Protocadherin-15
PCDH15
1,952Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC013737 Genomic DNA No translation available.
AC016817 Genomic DNA No translation available.
AC024073 Genomic DNA No translation available.
AC027671 Genomic DNA No translation available.
AL353784 Genomic DNA No translation available.
AL360214 Genomic DNA No translation available.
AL365496 Genomic DNA No translation available.
AL391356 Genomic DNA No translation available.
KF455239 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001136245.1, NM_001142773.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000395433; ENSP00000378821; ENSG00000150275

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65217

UCSC genome browser

More...
UCSCi
uc057tiq.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013737 Genomic DNA No translation available.
AC016817 Genomic DNA No translation available.
AC024073 Genomic DNA No translation available.
AC027671 Genomic DNA No translation available.
AL353784 Genomic DNA No translation available.
AL360214 Genomic DNA No translation available.
AL365496 Genomic DNA No translation available.
AL391356 Genomic DNA No translation available.
KF455239 Genomic DNA No translation available.
RefSeqiNP_001136245.1, NM_001142773.1

3D structure databases

SMRiA2A3E8
ModBaseiSearch...

Proteomic databases

MaxQBiA2A3E8
PRIDEiA2A3E8
ProteomicsDBi273

Genome annotation databases

EnsembliENST00000395433; ENSP00000378821; ENSG00000150275
GeneIDi65217
UCSCiuc057tiq.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65217
HGNCiHGNC:14674 PCDH15
OpenTargetsiENSG00000150275
PharmGKBiPA32999

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000156675
HOGENOMiHOG000230919
OrthoDBi21247at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PCDH15 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65217

Gene expression databases

BgeeiENSG00000150275 Expressed in 67 organ(s), highest expression level in corpus callosum
ExpressionAtlasiA2A3E8 baseline and differential
GenevisibleiA2A3E8 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR041149 EC_dom
IPR030718 Protocadherin-15
PANTHERiPTHR24028:SF11 PTHR24028:SF11, 3 hits
PfamiView protein in Pfam
PF00028 Cadherin, 8 hits
PF18432 ECD, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 11 hits
SUPFAMiSSF49313 SSF49313, 10 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2A3E8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A3E8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 31, 2019
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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