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Protein
Submitted name:

Protocadherin-15

Gene

PCDH15

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin-15Imported
Gene namesi
Name:PCDH15Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000150275.17
HGNCiHGNC:14674 PCDH15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150275

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500264215327 – 719Sequence analysisAdd BLAST693

Proteomic databases

PeptideAtlasiA2A3E5
PRIDEiA2A3E5

Expressioni

Gene expression databases

BgeeiENSG00000150275 Expressed in 67 organ(s), highest expression level in corpus callosum
ExpressionAtlasiA2A3E5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA2A3E5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 145CAInterPro annotationAdd BLAST82
Domaini174 – 263CAInterPro annotationAdd BLAST90
Domaini304 – 393CAInterPro annotationAdd BLAST90

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148958
HOGENOMiHOG000230918
HOVERGENiHBG053521

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR030718 Protocadherin-15
PANTHERiPTHR24028:SF11 PTHR24028:SF11, 3 hits
PfamiView protein in Pfam
PF00028 Cadherin, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 3 hits
SUPFAMiSSF49313 SSF49313, 2 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 29 potential isoforms that are computationally mapped.Show allAlign All

A2A3E5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRQFYLWTC LASGIILGSL FEICLGQYDD DCKLARGGPP ATIVAIDEES
60 70 80 90 100
RNGTILVDNM LIKGTAGGPD PTIELSLKDN VDYWVLMDPV KQMLFLNSTG
110 120 130 140 150
RVLDRDPPMN IHSIVVQVQC INKKVGTIIY HEVRIVVRDR NDNSPTFKHE
160 170 180 190 200
SYYATVNELT PVGTTIFTGF SGDNGATDID DGPNGQIEYV IQYNPDDPTS
210 220 230 240 250
NDTFEIPLML TGNIVLRKRL NYEDKTRYFV IIQANDRAQN LNERRTTTTT
260 270 280 290 300
LTVDVLDGDD LGPMFLPCVL VPNTRDCRPL TYQAAIPELR TPEELNPIIV
310 320 330 340 350
TPPIQAIDQD RNIQPPSDRP GILYSILVGT PEDYPRFFHM HPRTAELSLL
360 370 380 390 400
EPVNRDFHQK FDLVIKAEQD NGHPLPAFAG LHIEILDENN QSPYFTMPSY
410 420 430 440 450
QGYILESAPV GATISDSLNL TSPLRIVALD KDIEDEEPKK IKKPKVEIRE
460 470 480 490 500
PSEEEEVVVT IEKPPAAEPT YTTWKRARIF PMIFKKVRGL ADKRGIVDLE
510 520 530 540 550
GEEWQRRLEE EDKDYLKLTL DQEEATESTV ESEEESSSDY TEYSEEESEF
560 570 580 590 600
SESETTEEES ESETPSEEEE SSTPESEESE STESEGEKAR KNIVLARRRP
610 620 630 640 650
MVEEVKEVKG RKEEPQEEQK EPKMEEEEHS EEEESGPAPV EESTDPEAQD
660 670 680 690 700
IPEEGSAESA SVEGGVESEE ESESGSSSSS SESQSGGPWG YQVPAYDRSK
710
NANQKKSPGA NSEGYNTAL
Length:719
Mass (Da):80,741
Last modified:February 5, 2008 - v1
Checksum:i64801E4DC8E9C15E
GO

Computationally mapped potential isoform sequencesi

There are 29 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96QU1PCD15_HUMAN
Protocadherin-15
PCDH15 USH1F
1,955Annotation score:
A2A3D8A2A3D8_HUMAN
Protocadherin-15
PCDH15
1,962Annotation score:
A0A087WTR6A0A087WTR6_HUMAN
Protocadherin-15
PCDH15
1,539Annotation score:
A0A087WZN9A0A087WZN9_HUMAN
Protocadherin-15
PCDH15
1,790Annotation score:
A2A3E3A2A3E3_HUMAN
Protocadherin-15
PCDH15
1,540Annotation score:
A0A087WZW3A0A087WZW3_HUMAN
Protocadherin-15
PCDH15
1,789Annotation score:
A2A3E7A2A3E7_HUMAN
Protocadherin-15
PCDH15
1,957Annotation score:
A2A3E8A2A3E8_HUMAN
Protocadherin-15
PCDH15
1,932Annotation score:
A2A3E6A2A3E6_HUMAN
Protocadherin-15
PCDH15
1,952Annotation score:
A9Z1W1A9Z1W1_HUMAN
Protocadherin-15
PCDH15
1,677Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013737 Genomic DNA No translation available.
AC016817 Genomic DNA No translation available.
AC024073 Genomic DNA No translation available.
AC027671 Genomic DNA No translation available.
AL353784 Genomic DNA No translation available.
AL360214 Genomic DNA No translation available.
AL365496 Genomic DNA No translation available.
AL391356 Genomic DNA No translation available.
KF455239 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000395440; ENSP00000378827; ENSG00000150275
UCSCiuc057tib.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013737 Genomic DNA No translation available.
AC016817 Genomic DNA No translation available.
AC024073 Genomic DNA No translation available.
AC027671 Genomic DNA No translation available.
AL353784 Genomic DNA No translation available.
AL360214 Genomic DNA No translation available.
AL365496 Genomic DNA No translation available.
AL391356 Genomic DNA No translation available.
KF455239 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA2A3E5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA2A3E5
PRIDEiA2A3E5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395440; ENSP00000378827; ENSG00000150275
UCSCiuc057tib.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000150275.17
HGNCiHGNC:14674 PCDH15
OpenTargetsiENSG00000150275
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148958
HOGENOMiHOG000230918
HOVERGENiHBG053521

Miscellaneous databases

ChiTaRSiPCDH15 human

Gene expression databases

BgeeiENSG00000150275 Expressed in 67 organ(s), highest expression level in corpus callosum
ExpressionAtlasiA2A3E5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR030718 Protocadherin-15
PANTHERiPTHR24028:SF11 PTHR24028:SF11, 3 hits
PfamiView protein in Pfam
PF00028 Cadherin, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 3 hits
SUPFAMiSSF49313 SSF49313, 2 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2A3E5_HUMAN
AccessioniPrimary (citable) accession number: A2A3E5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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