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Protein
Submitted name:

Protocadherin-15

Gene

PCDH15

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin-15Imported
Gene namesi
Name:PCDH15Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000150275.17
HGNCiHGNC:14674 PCDH15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150275

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500264260027 – 650Sequence analysisAdd BLAST624

Proteomic databases

PeptideAtlasiA2A3E1
PRIDEiA2A3E1

Expressioni

Gene expression databases

BgeeiENSG00000150275
ExpressionAtlasiA2A3E1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA2A3E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 145CAInterPro annotationAdd BLAST82
Domaini174 – 263CAInterPro annotationAdd BLAST90

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148958
HOGENOMiHOG000230918
HOVERGENiHBG053521

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR030718 Protocadherin-15
PANTHERiPTHR24028:SF11 PTHR24028:SF11, 3 hits
PfamiView protein in Pfam
PF00028 Cadherin, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 2 hits
SUPFAMiSSF49313 SSF49313, 1 hit
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

A2A3E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRQFYLWTC LASGIILGSL FEICLGQYDD DCKLARGGPP ATIVAIDEES
60 70 80 90 100
RNGTILVDNM LIKGTAGGPD PTIELSLKDN VDYWVLMDPV KQMLFLNSTG
110 120 130 140 150
RVLDRDPPMN IHSIVVQVQC INKKVGTIIY HEVRIVVRDR NDNSPTFKHE
160 170 180 190 200
SYYATVNELT PVGTTIFTGF SGDNGATDID DGPNGQIEYV IQYNPDDPTS
210 220 230 240 250
NDTFEIPLML TGNIVLRKRL NYEDKTRYFV IIQANDRAQN LNERRTTTTT
260 270 280 290 300
LTVDVLDGDD LGPMFLPCVL VPNTRDCRPL TYQAAIPELR TPEELNPIIV
310 320 330 340 350
TPPIQAIDQD RNIQPPSDRP GILYSILVGT PEDYPRFFHM HPRTAELSLL
360 370 380 390 400
EPVNRDFHQK FDLVIKEEPK KIKKPKVEIR EPSEEEEVVV TIEKPPAAEP
410 420 430 440 450
TYTTWKRARI FPMIFKKVRG LADKRGIVDL EGEEWQRRLE EEDKDYLKLT
460 470 480 490 500
LDQEEATEST VESEEESSSD YTEYSEEESE FSESETTEEE SESETPSEEE
510 520 530 540 550
ESSTPESEES ESTESEGEKA RKNIVLARRR PMVEEVKEVK GRKEEPQEEQ
560 570 580 590 600
KEPKMEEEEH SEEEESGPAP VEESTDPEAQ DIPEEGSAES ASVEGGVESE
610 620 630 640 650
EESESGSSSS SSESQSGGPW GYQVPAYDRS KNANQKKSPG ANSEGYNTAL
Length:650
Mass (Da):73,245
Last modified:February 5, 2008 - v1
Checksum:i56B235DD47FD1CBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013737 Genomic DNA No translation available.
AC016817 Genomic DNA No translation available.
AC024073 Genomic DNA No translation available.
AC027671 Genomic DNA No translation available.
AL353784 Genomic DNA No translation available.
AL360214 Genomic DNA No translation available.
AL365496 Genomic DNA No translation available.
AL391356 Genomic DNA No translation available.
KF455239 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000395442; ENSP00000378829; ENSG00000150275
UCSCiuc057tic.1 human

Similar proteinsi

Entry informationi

Entry nameiA2A3E1_HUMAN
AccessioniPrimary (citable) accession number: A2A3E1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 18, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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