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UniProtKB - A2A369 (A2A369_HUMAN)
Protein
Submitted name:
Dedicator of cytokinesis protein 8
Gene
DOCK8
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
GO - Biological processi
- small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | Guanine-nucleotide releasing factorARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Dedicator of cytokinesis protein 8 |
Gene namesi | Name:DOCK8 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19191, DOCK8 |
VEuPathDBi | HostDB:ENSG00000107099 |
PTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
MaxQBi | A2A369 |
PeptideAtlasi | A2A369 |
PRIDEi | A2A369 |
ProteomicsDBi | 254 |
Expressioni
Gene expression databases
Bgeei | ENSG00000107099, Expressed in leukocyte and 205 other tissues |
ExpressionAtlasi | A2A369, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the DOCK family.PROSITE-ProRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155876 |
Family and domain databases
Gene3Di | 1.20.58.740, 1 hit 1.25.40.410, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR027007, C2_DOCK-type_domain IPR035892, C2_domain_sf IPR026791, DOCK IPR043161, DOCK_C_lobe_A IPR043162, DOCK_C_lobe_C IPR027357, DOCKER_dom |
PANTHERi | PTHR23317, PTHR23317, 1 hit |
Pfami | View protein in Pfam PF06920, DHR-2, 1 hit PF14429, DOCK-C2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51650, C2_DOCK, 1 hit PS51651, DOCKER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
A2A369-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTHLNSLDVQ LAQELGDFTD DDLDVVFTPK ECRTLQPSLP EEGVELDPHV
60 70 80 90 100
RDCVQTYIRE WLIVNRKNQG SPEICGFKKT GSRKDFHKTL PKQTFESETL
110 120 130 140 150
ECSEPAAQAG PRHLNVLCDV SGKGPVTACD FDLRSLQPDK RLENLLQQVS
160 170 180 190 200
AEDFEKQNEE ARRTNRQAEL FALYPSVDEE DAVEIRPVPE CPKEHLGNRI
210 220 230 240 250
LVKLLTLKFE IEIEPLFASI ALYDVKERKK ISENFHCDLN SDQFKGFLRA
260 270 280 290 300
HTPSVAASSQ ARSAVFSVTY PSSDIYLVVK IEKVLQQGEI GDCAEPYTVI
310 320 330 340 350
KESDGGKSKE KIEKLKLQAE SFCQRLGKYR MPFAWAPISL SSFFNVSTLE
360 370 380 390 400
REVTDVDSVV GRSSVGERRT LAQSRRLSER ALSLEENGVG SNFKTSTLSV
410 420 430 440 450
SSFFKQEGDR LSDEDLFKFL ADYKRSSSLQ RRVKSIPGLL RLEISTAPEI
460 470 480 490 500
INCCLTPEML PVKPFPENRT RPHKEILEFP TREVYVPHTV YRNLLYVYPQ
510 520 530 540 550
RLNFVNKLAS ARNITIKIQF MCGEDASNAM PVIFGKSSGP EFLQEVYTAV
560 570 580 590 600
TYHNKSPDFY EEVKIKLPAK LTVNHHLLFT FYHISCQQKQ GASVETLLGY
610 620 630 640 650
SWLPILLNER LQTGSYCLPV ALEKLPPNYS MHSAEKVPLQ NPPIKWAEGH
660 670 680 690 700
KGVFNIEVQA VSSVHTQDNH LEKFFTLCHS LESQVTFPIR VLDQKISEMA
710 720 730 740 750
LEHELKLSII CLNSSRLEPL VLFLHLVLDK LFQLSVQPMV IAGQTANFSQ
760 770 780 790 800
FAFESVVAIA NSLHNSKDLS KDQHGRNCLL ASYVHYVFRL PEVQRDVPKS
810 820 830 840 850
GAPTALLDPR SYHTYGRTSA AAVSSKLLQA RVMSSSNPDL AGTHSAADEE
860 870 880 890 900
VKNIMSSKHF HEELALQMVV STGMVRETVF KYAWFFFELL VKSMAQHVHN
910 920 930 940 950
MDKRDSFRRT RFSDRFMDDI TTIVNVVTSE IAALLVKPQK ENEQAEKMNI
960 970 980 990 1000
SLAFFLYDLL SLMDRGFVFN LIRHYCSQLS AKLSNLPTLI SMRLEFLRIL
1010 1020 1030 1040 1050
CSHEHYLNLN LFFMNADTAP TSPCPSISSQ NSSSCSSFQD QKIASMFDLT
1060 1070 1080 1090 1100
SEYRQQHFLT GLLFTELAAA LDAEGEGISK VQRKAVSAIH SLLSSHDLDP
1110 1120 1130 1140 1150
RCVKPEVKVK IAALYLPLVG IILDALPQLC DFTVADTRRY RTSGSDEEQE
1160 1170 1180 1190 1200
GAGAINQNVA LAIAGNNFNL KTSGIVLSSL PYKQYNMLNA DTTRNLMICF
1210 1220 1230 1240 1250
LWIMKNADQS LIRKWIADLP STQLNRILDL LFICVLCFEY KGKQSSDKVS
1260 1270 1280 1290 1300
TQVLQKSRDV KARLEEALLR GEGARGEMMR RRAPGNDRFP GLNENLRWKK
1310 1320 1330 1340 1350
EQTHWRQANE KLDKTKAELD QEALISGNLA TEAHLIILDM QENIIQASSA
1360 1370 1380 1390 1400
LDCKDSLLGG VLRVLVNSLN CDQSTTYLTH CFATLRALIA KFGDLLFEEE
1410 1420 1430 1440 1450
VEQCFDLCHQ VLHHCSSSMD VTRSQACATL YLLMRFSFGA TSNFARVKMQ
1460 1470 1480 1490 1500
VTMSLASLVG RAPDFNEEHL RRSLRTILAY SEEDTAMQMT PFPTQVEELL
1510 1520 1530 1540 1550
CNLNSILYDT VKMREFQEDP EMLMDLMYRI AKSYQASPDL RLTWLQNMAE
1560 1570 1580 1590 1600
KHTKKKCYTE AAMCLVHAAA LVAEYLSMLE DHSYLPVGSV SFQNISSNVL
1610 1620 1630 1640 1650
EESVVSEDTL SPDEDGVCAG QYFTESGLVG LLEQAAELFS TGGLYETVNE
1660 1670 1680 1690 1700
VYKLVIPILE AHREFRKLTL THSKLQRAFD SIVNKDHKRM FGTYFRVGFF
1710 1720 1730 1740 1750
GSKFGDLDEQ EFVYKEPAIT KLPEISHRLE AFYGQCFGAE FVEVIKDSTP
1760 1770 1780 1790 1800
VDKTKLDPNK AYIQITFVEP YFDEYEMKDR VTYFEKNFNL RRFMYTTPFT
1810 1820 1830 1840 1850
LEGRPRGELH EQYRRNTVLT TMHAFPYIKT RISVIQKEEF VLTPIEVAIE
1860 1870 1880 1890 1900
DMKKKTLQLA VAINQEPPDA KMLQMVLQGS VGATVNQGPL EVAQVFLAEI
1910 1920 1930
PADPKLYRHH NKLRLCFKEF IMRSTASSAT TGQRPF
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8NF50 | DOCK8_HUMAN | Dedicator of cytokinesis protein 8 | DOCK8 | 2,099 | Annotation score: | ||
A0A804HK14 | A0A804HK14_HUMAN | Dedicator of cytokinesis protein 8 | DOCK8 | 187 | Annotation score: | ||
C9J7A3 | C9J7A3_HUMAN | Dedicator of cytokinesis protein 8 | DOCK8 | 107 | Annotation score: | ||
E9PDJ4 | E9PDJ4_HUMAN | Dedicator of cytokinesis protein 8 | DOCK8 | 503 | Annotation score: | ||
F8WC95 | F8WC95_HUMAN | Dedicator of cytokinesis protein 8 | DOCK8 | 66 | Annotation score: | ||
E9PHZ4 | E9PHZ4_HUMAN | Dedicator of cytokinesis protein 8 | DOCK8 | 50 | Annotation score: | ||
A0A8I5KQK5 | A0A8I5KQK5_HUMAN | Dedicator of cytokinesis protein 8 | DOCK8 | 64 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL158832 Genomic DNA No translation available. AL161725 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000382329.2; ENSP00000371766.2; ENSG00000107099.18 |
UCSCi | uc064rup.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL158832 Genomic DNA No translation available. AL161725 Genomic DNA No translation available. |
3D structure databases
SMRi | A2A369 |
ModBasei | Search... |
Proteomic databases
MaxQBi | A2A369 |
PeptideAtlasi | A2A369 |
PRIDEi | A2A369 |
ProteomicsDBi | 254 |
Protocols and materials databases
Antibodypediai | 758, 292 antibodies from 27 providers |
Genome annotation databases
Ensembli | ENST00000382329.2; ENSP00000371766.2; ENSG00000107099.18 |
UCSCi | uc064rup.1, human |
Organism-specific databases
HGNCi | HGNC:19191, DOCK8 |
OpenTargetsi | ENSG00000107099 |
VEuPathDBi | HostDB:ENSG00000107099 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155876 |
Miscellaneous databases
ChiTaRSi | DOCK8, human |
Gene expression databases
Bgeei | ENSG00000107099, Expressed in leukocyte and 205 other tissues |
ExpressionAtlasi | A2A369, baseline and differential |
Family and domain databases
Gene3Di | 1.20.58.740, 1 hit 1.25.40.410, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR027007, C2_DOCK-type_domain IPR035892, C2_domain_sf IPR026791, DOCK IPR043161, DOCK_C_lobe_A IPR043162, DOCK_C_lobe_C IPR027357, DOCKER_dom |
PANTHERi | PTHR23317, PTHR23317, 1 hit |
Pfami | View protein in Pfam PF06920, DHR-2, 1 hit PF14429, DOCK-C2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51650, C2_DOCK, 1 hit PS51651, DOCKER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2A369_HUMAN | |
Accessioni | A2A369Primary (citable) accession number: A2A369 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | May 25, 2022 | |
Last modified: | May 25, 2022 | |
This is version 111 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |