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Entry version 82 (13 Feb 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Ankyrin repeat domain-containing protein 18B

Gene

ANKRD18B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 18B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000230453.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23644 ANKRD18B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A2A2Z9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
441459

Open Targets

More...
OpenTargetsi
ENSG00000230453

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD18B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172451 – 1011Ankyrin repeat domain-containing protein 18BAdd BLAST1011

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2A2Z9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2A2Z9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2A2Z9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2A2Z9

PRoteomics IDEntifications database

More...
PRIDEi
A2A2Z9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
240

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2A2Z9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2A2Z9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000230453 Expressed in 92 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2A2Z9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2A2Z9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046346
HPA049923
HPA051288

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A2A2Z9, 1 interactor

Molecular INTeraction database

More...
MINTi
A2A2Z9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000290943

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2A2Z9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2A2Z9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati67 – 96ANK 1Add BLAST30
Repeati100 – 129ANK 2Add BLAST30
Repeati133 – 162ANK 3Add BLAST30
Repeati166 – 195ANK 4Add BLAST30
Repeati199 – 228ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili277 – 319Sequence analysisAdd BLAST43
Coiled coili385 – 639Sequence analysisAdd BLAST255
Coiled coili692 – 722Sequence analysisAdd BLAST31
Coiled coili752 – 908Sequence analysisAdd BLAST157

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163510

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033931

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG095812

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2A2Z9

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSITEMN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2A2Z9

TreeFam database of animal gene trees

More...
TreeFami
TF333496

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
IPR021885 DUF3496

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
PF12001 DUF3496, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A2A2Z9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKLLSFGRR LGQALLSSMD QEYAGRGYHI RDWELRKIHR AAIKGDAAEV
60 70 80 90 100
EHCLTRRFRD LDVRDRKDRT VLHLACAHGR VQVVTLLLDR KCQINICDRL
110 120 130 140 150
NRTPLMKAVH CQEEACAIIL LKRGANPNIK DIYGNTALHY AVYNEGTSLA
160 170 180 190 200
ERLLSHHANI EALNKEGNTP LLFAINSRRQ HMVEFLLKNQ ANIHAVDNFK
210 220 230 240 250
RTALILAVQH NLSSIVTLLL QQNIHISSQD MFGQTAEDYA FCCDLRSIQQ
260 270 280 290 300
QILEHKNKML KNHLRNDNQE TAAMKPENLK KRKKRKKLKK RKEGAKAEHN
310 320 330 340 350
LKVASEEKQE RLERSENKQP QDSQSYGKKK DEMFGNFMLK RDIAMLKEEL
360 370 380 390 400
YAIKNDSLRK EKKYIQEIKS ITEINANFEK SVRLNEEMIT KKVAQYSQQL
410 420 430 440 450
NDLKAENARL NSKLEKEKHN KERLEAEVES LHSNLATAIN EYNEILERKD
460 470 480 490 500
LELVLWRADD VSRHETMGSN ISQLTDKNEL LTEQVHKARV KFNTLKGKLR
510 520 530 540 550
ETRDALREKT LALESVQLDL KQAQHRIKEM KQMHPNGEAK ESQSIGKQNS
560 570 580 590 600
SEERIRQREL ENLLLERQLE DARKEGDNKE IVINIHRDCL ENGKEDLLEE
610 620 630 640 650
RNKELMNEYN YLKEKLLQYE KEKAEREVIV REFQEELVDH LKKFSMSESP
660 670 680 690 700
LEGTSHCHIN LDETWTSKKK LFQVEIQPEE KHEEFRKVFE LISLLNYTAD
710 720 730 740 750
QIRKKNRELE EEATGYKKCL EMTINMLNAF ANEDFSCHGD LNTDQLKMDI
760 770 780 790 800
LFKKLKQKFD DLMAEKEAVS SKCVNLAKDN EVLHQELLSM GKVQEKCEKL
810 820 830 840 850
EKDKKMLEEK VLNLKTHMEK DMVELGKVQE YKSELDERAM QAIEKLEEIH
860 870 880 890 900
LQKQAEYEKQ LEQLNKDNTA SLKKKELTLK DVECKFSKMK TAYEDVTTEL
910 920 930 940 950
EEYKEAFAVA LKANSSMSEK ITKSDKKIAV ISTKLFMEKE RMEYFLSTLP
960 970 980 990 1000
MRPDPELPCV ENLNSIELNR KYIPKMAIRI PTSNPQTSNN CKNSLTELLL
1010
RWALAPIYFL L
Length:1,011
Mass (Da):118,231
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DC98BDDD988B735
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A300A2A300_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD18B
401Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GNB3R4GNB3_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD18B
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3H1S4R3H1_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD18B
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL139008 Genomic DNA No translation available.

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.493710

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290943; ENSP00000290943; ENSG00000230453

UCSC genome browser

More...
UCSCi
uc064spz.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139008 Genomic DNA No translation available.
UniGeneiHs.493710

3D structure databases

ProteinModelPortaliA2A2Z9
SMRiA2A2Z9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2A2Z9, 1 interactor
MINTiA2A2Z9
STRINGi9606.ENSP00000290943

PTM databases

iPTMnetiA2A2Z9
PhosphoSitePlusiA2A2Z9

Polymorphism and mutation databases

BioMutaiANKRD18B

Proteomic databases

EPDiA2A2Z9
jPOSTiA2A2Z9
MaxQBiA2A2Z9
PaxDbiA2A2Z9
PRIDEiA2A2Z9
ProteomicsDBi240

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290943; ENSP00000290943; ENSG00000230453
UCSCiuc064spz.1 human

Organism-specific databases

DisGeNETi441459
EuPathDBiHostDB:ENSG00000230453.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANKRD18B
HGNCiHGNC:23644 ANKRD18B
HPAiHPA046346
HPA049923
HPA051288
neXtProtiNX_A2A2Z9
OpenTargetsiENSG00000230453

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000163510
HOGENOMiHOG000033931
HOVERGENiHBG095812
InParanoidiA2A2Z9
OMAiKSITEMN
PhylomeDBiA2A2Z9
TreeFamiTF333496

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2A2Z9

Gene expression databases

BgeeiENSG00000230453 Expressed in 92 organ(s), highest expression level in testis
ExpressionAtlasiA2A2Z9 baseline and differential
GenevisibleiA2A2Z9 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
IPR021885 DUF3496
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
PF12001 DUF3496, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAN18B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A2Z9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: February 13, 2019
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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