Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 97 (13 Feb 2019)
Sequence version 3 (01 Sep 2009)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Probable ribonuclease ZC3H12D

Gene

ZC3H12D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561).Curated3 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri248 – 279C3H1-typePROSITE-ProRule annotationAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMagnesium, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ribonuclease ZC3H12D (EC:3.1.-.-)
Alternative name(s):
MCP-induced protein 41 Publication
Transformed follicular lymphoma
Zinc finger CCCH domain-containing protein 12D
p341 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3H12D
Synonyms:C6orf95, MCPIP41 Publication, TFL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000178199.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21175 ZC3H12D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611106 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A2A288

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi95D → N: Inhibits interleukin IL6 mRNA instability. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
340152

Open Targets

More...
OpenTargetsi
ENSG00000178199

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134867170

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZC3H12D

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003489311 – 527Probable ribonuclease ZC3H12DAdd BLAST527

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2A288

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2A288

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2A288

PRoteomics IDEntifications database

More...
PRIDEi
A2A288

ProteomicsDB human proteome resource

More...
ProteomicsDBi
178
179 [A2A288-3]
180 [A2A288-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2A288

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2A288

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By prolonged exposure to bacterial lipopolysaccharides (LPS) in acute monocytic leukemia cell line THP-1 cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178199 Expressed in 155 organ(s), highest expression level in tonsil

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2A288 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2A288 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036897

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ZC3H12A (PubMed:26134560).1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131004, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
A2A288

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000374592

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2A288

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2A288

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni259 – 356Necessary for interaction with ZC3H12A1 PublicationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi357 – 441Pro-richSequence analysisAdd BLAST85

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZC3H12 family.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri248 – 279C3H1-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3777 Eukaryota
ENOG410ZNK1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161388

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000171065

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108759

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2A288

KEGG Orthology (KO)

More...
KOi
K18668

Identification of Orthologs from Complete Genome Data

More...
OMAi
RPPDDPW

Database of Orthologous Groups

More...
OrthoDBi
771251at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2A288

TreeFam database of animal gene trees

More...
TreeFami
TF315783

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040546 Rege-1_UBA-like
IPR021869 RNase_Zc3h12_NYN
IPR000571 Znf_CCCH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11977 RNase_Zc3h12a, 1 hit
PF18039 UBA_6, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103 ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: A2A288-1) [UniParc]FASTAAdd to basket
Also known as: P58TFL, TFL1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEHPSKMEFF QKLGYDREDV LRVLGKLGEG ALVNDVLQEL IRTGSRPGAL
60 70 80 90 100
EHPAAPRLVP RGSCGVPDSA QRGPGTALEE DFRTLASSLR PIVIDGSNVA
110 120 130 140 150
MSHGNKETFS CRGIKLAVDW FRDRGHTYIK VFVPSWRKDP PRADTPIREQ
160 170 180 190 200
HVLAELERQA VLVYTPSRKV HGKRLVCYDD RYIVKVAYEQ DGVIVSNDNY
210 220 230 240 250
RDLQSENPEW KWFIEQRLLM FSFVNDRFMP PDDPLGRHGP SLSNFLSRKP
260 270 280 290 300
KPPEPSWQHC PYGKKCTYGI KCKFYHPERP HHAQLAVADE LRAKTGARPG
310 320 330 340 350
AGAEEQRPPR APGGSAGARA APREPFAHSL PPARGSPDLA ALRGSFSRLA
360 370 380 390 400
FSDDLGPLGP PLPVPACSLT PRLGGPDWVS AGGRVPGPLS LPSPESQFSP
410 420 430 440 450
GDLPPPPGLQ LQPRGEHRPR DLHGDLLSPR RPPDDPWARP PRSDRFPGRS
460 470 480 490 500
VWAEPAWGDG ATGGLSVYAT EDDEGDARAR ARIALYSVFP RDQVDRVMAA
510 520
FPELSDLARL ILLVQRCQSA GAPLGKP
Length:527
Mass (Da):58,078
Last modified:September 1, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE330D92548D49DD7
GO
Isoform 2 (identifier: A2A288-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-527: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:227
Mass (Da):25,951
Checksum:i5267FCB7B992C467
GO
Isoform 3 (identifier: A2A288-4) [UniParc]FASTAAdd to basket
Also known as: P36TFL, TFL2

The sequence of this isoform differs from the canonical sequence as follows:
     300-321: GAGAEEQRPPRAPGGSAGARAA → VLPGRPPASARPAAPAAGRTPP
     322-527: Missing.

Show »
Length:321
Mass (Da):36,199
Checksum:i268B27A7F6375628
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBA4B7ZBA4_HUMAN
Probable ribonuclease ZC3H12D
ZC3H12D
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4Y6H0Y4Y6_HUMAN
Probable ribonuclease ZC3H12D
ZC3H12D
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135S → F in BAH28269 (PubMed:19531561).Curated1
Sequence conflicti140P → S in BAH28269 (PubMed:19531561).Curated1
Sequence conflicti140P → S in BAC87196 (PubMed:14702039).Curated1
Sequence conflicti299P → L in BAH28269 (PubMed:19531561).Curated1
Sequence conflicti299P → L in BAC87196 (PubMed:14702039).Curated1
Sequence conflicti405P → S in AAI57833 (PubMed:15489334).Curated1
Sequence conflicti499A → T in AAI57833 (PubMed:15489334).Curated1
Isoform 3 (identifier: A2A288-4)
Sequence conflicti300V → G in BAH28269 (PubMed:19531561).Curated1
Sequence conflicti300V → G in BAC87196 (PubMed:14702039).Curated1
Sequence conflicti301L → V in BAH28269 (PubMed:19531561).Curated1
Sequence conflicti301L → V in BAC87196 (PubMed:14702039).Curated1
Sequence conflicti302P → R in BAH28269 (PubMed:19531561).Curated1
Sequence conflicti302P → R in BAC87196 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04619953P → L2 PublicationsCorresponds to variant dbSNP:rs7747948Ensembl.1
Natural variantiVAR_046200106K → R in some sporadic lung cancer sample; appears to cause loss of tumor suppressor activity. 1 PublicationCorresponds to variant dbSNP:rs61997220Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052853228 – 527Missing in isoform 2. 1 PublicationAdd BLAST300
Alternative sequenceiVSP_040794300 – 321GAGAE…GARAA → VLPGRPPASARPAAPAAGRT PP in isoform 3. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_040795322 – 527Missing in isoform 3. 2 PublicationsAdd BLAST206

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB458221 mRNA Translation: BAH28268.1
AB458222 mRNA Translation: BAH28269.1
AK127932 mRNA Translation: BAC87196.1
AL031133 Genomic DNA No translation available.
BC127762 mRNA Translation: AAI27763.1
BC157832 mRNA Translation: AAI57833.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47500.2 [A2A288-1]

NCBI Reference Sequences

More...
RefSeqi
NP_997243.2, NM_207360.2 [A2A288-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.632618

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409806; ENSP00000386616; ENSG00000178199 [A2A288-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
340152

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:340152

UCSC genome browser

More...
UCSCi
uc010kid.4 human [A2A288-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB458221 mRNA Translation: BAH28268.1
AB458222 mRNA Translation: BAH28269.1
AK127932 mRNA Translation: BAC87196.1
AL031133 Genomic DNA No translation available.
BC127762 mRNA Translation: AAI27763.1
BC157832 mRNA Translation: AAI57833.1
CCDSiCCDS47500.2 [A2A288-1]
RefSeqiNP_997243.2, NM_207360.2 [A2A288-1]
UniGeneiHs.632618

3D structure databases

ProteinModelPortaliA2A288
SMRiA2A288
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131004, 1 interactor
CORUMiA2A288
STRINGi9606.ENSP00000374592

PTM databases

iPTMnetiA2A288
PhosphoSitePlusiA2A288

Polymorphism and mutation databases

BioMutaiZC3H12D

Proteomic databases

jPOSTiA2A288
MaxQBiA2A288
PaxDbiA2A288
PRIDEiA2A288
ProteomicsDBi178
179 [A2A288-3]
180 [A2A288-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409806; ENSP00000386616; ENSG00000178199 [A2A288-1]
GeneIDi340152
KEGGihsa:340152
UCSCiuc010kid.4 human [A2A288-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340152
DisGeNETi340152
EuPathDBiHostDB:ENSG00000178199.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZC3H12D
HGNCiHGNC:21175 ZC3H12D
HPAiHPA036897
MIMi611106 gene
neXtProtiNX_A2A288
OpenTargetsiENSG00000178199
PharmGKBiPA134867170

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3777 Eukaryota
ENOG410ZNK1 LUCA
GeneTreeiENSGT00940000161388
HOGENOMiHOG000171065
HOVERGENiHBG108759
InParanoidiA2A288
KOiK18668
OMAiRPPDDPW
OrthoDBi771251at2759
PhylomeDBiA2A288
TreeFamiTF315783

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
340152

Protein Ontology

More...
PROi
PR:A2A288

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000178199 Expressed in 155 organ(s), highest expression level in tonsil
ExpressionAtlasiA2A288 baseline and differential
GenevisibleiA2A288 HS

Family and domain databases

InterProiView protein in InterPro
IPR040546 Rege-1_UBA-like
IPR021869 RNase_Zc3h12_NYN
IPR000571 Znf_CCCH
PfamiView protein in Pfam
PF11977 RNase_Zc3h12a, 1 hit
PF18039 UBA_6, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZC12D_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2A288
Secondary accession number(s): A1L178
, B2RXF4, B7WNU7, B9ZZP9, B9ZZQ0, Q6ZRW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 1, 2009
Last modified: February 13, 2019
This is version 97 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again