UniProtKB - A2A274 (A2A274_HUMAN)
Protein
Submitted name:
Aconitate hydratase, mitochondrial
Gene
ACO2
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
[4Fe-4S] clusterARBA annotation
GO - Molecular functioni
- 3 iron, 4 sulfur cluster binding Source: Ensembl
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- aconitate hydratase activity Source: Ensembl
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- citrate metabolic process Source: Ensembl
- isocitrate metabolic process Source: Ensembl
- liver development Source: Ensembl
- response to isolation stress Source: Ensembl
- tricarboxylic acid cycle Source: Ensembl
Keywordsi
Ligand | 4Fe-4SARBA annotation, Iron, Iron-sulfur, Metal-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Aconitate hydratase, mitochondrialImported |
Gene namesi | Name:ACO2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:118, ACO2 |
VEuPathDBi | HostDB:ENSG00000100412.15 |
PTM / Processingi
Proteomic databases
EPDi | A2A274 |
MaxQBi | A2A274 |
PeptideAtlasi | A2A274 |
PRIDEi | A2A274 |
ProteomicsDBi | 171 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100412, Expressed in heart right ventricle and 243 other tissues |
ExpressionAtlasi | A2A274, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 67 – 279 | AconitaseInterPro annotationAdd BLAST | 213 | |
Domaini | 303 – 528 | AconitaseInterPro annotationAdd BLAST | 226 | |
Domaini | 608 – 736 | Aconitase_CInterPro annotationAdd BLAST | 129 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 553 – 585 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 570 – 585 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the aconitase/IPM isomerase family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000154892 |
OMAi | QFHASCY |
PhylomeDBi | A2A274 |
Family and domain databases
Gene3Di | 3.20.19.10, 1 hit 3.30.499.10, 2 hits 3.40.1060.10, 2 hits |
InterProi | View protein in InterPro IPR015931, Acnase/IPM_dHydase_lsu_aba_1/3 IPR001030, Acoase/IPM_deHydtase_lsu_aba IPR015928, Aconitase/3IPM_dehydase_swvl IPR018136, Aconitase_4Fe-4S_BS IPR036008, Aconitase_4Fe-4S_dom IPR015932, Aconitase_dom2 IPR000573, AconitaseA/IPMdHydase_ssu_swvl |
Pfami | View protein in Pfam PF00330, Aconitase, 2 hits PF00694, Aconitase_C, 1 hit |
PRINTSi | PR00415, ACONITASE |
SUPFAMi | SSF53732, SSF53732, 1 hit |
PROSITEi | View protein in PROSITE PS00450, ACONITASE_1, 1 hit PS01244, ACONITASE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
A2A274-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPYSLLVTR LQKALGVRQY HVASVLCQRA KVAMSHFEPN EYIHYDLLEK
60 70 80 90 100
NINIVRKRLN RPLTLSEKIV YGHLDDPASQ EIERGKSYLR LRPDRVAMQD
110 120 130 140 150
ATAQMAMLQF ISSGLSKVAV PSTIHCDHLI EAQVGGEKDL RRAKDINQEV
160 170 180 190 200
YNFLATAGAK YGVGFWKPGS GIIHQIILEN YAYPGVLLIG TDSHTPNGGG
210 220 230 240 250
LGGICIGVGG ADAVDVMAGI PWELKCPKVI GVKLTGSLSG WSSPKDVILK
260 270 280 290 300
VAGILTVKGG TGAIVEYHGP GVDSISCTGE EGGQATWPLP CAGPDGSPVG
310 320 330 340 350
SRSGMATICN MGAEIGATTS VFPYNHRMKK YLSKTGREDI ANLADEFKDH
360 370 380 390 400
LVPDPGCHYD QLIEINLSEL KPHINGPFTP DLAHPVAEVG KVAEKEGWPL
410 420 430 440 450
DIRVGLIGSC TNSSYEDMGR SAAVAKQALA HGLKCKSQFT ITPGSEQIRA
460 470 480 490 500
TIERDGYAQI LRDLGGIVLA NACGPCIGQW DRKDIKKGEK NTIVTSYNRN
510 520 530 540 550
FTGRNDANPE THAFVTSPEI VTALAIAGTL KFNPETDYLT GTDGKKFRLE
560 570 580 590 600
APDADELPKG EFDPGQDTYQ HPPKDSSGQH VDVSPTSQRL QLLEPFDKWD
610 620 630 640 650
GKDLEDLQIL IKVKGKCTTD HISAAGPWLK FRGHLDNISN NLLIGAINIE
660 670 680 690 700
NGKANSVRNA VTQEFGPVPD TARYYKKHGI RWVVIGDENY GEGSSREHAA
710 720 730 740 750
LEPRHLGGRA IITKSFARIH ETNLKKQGLL PLTFADPADY NKIHPVDKLT
760 770 780 790 800
IQGLKDFTPG KPLKCIIKHP NGTQETILLN HTFNETQIEW FRAGSALNRM
KELQQ
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ99798 | ACON_HUMAN | Aconitate hydratase, mitochondrial | ACO2 | 780 | Annotation score: | ||
A0A7I2V2Y4 | A0A7I2V2Y4_HUMAN | Aconitate hydratase, mitochondrial | ACO2 | 92 | Annotation score: | ||
A0A7I2V3C8 | A0A7I2V3C8_HUMAN | Aconitate hydratase, mitochondrial | ACO2 | 324 | Annotation score: | ||
A0A7I2V3F1 | A0A7I2V3F1_HUMAN | Aconitate hydratase, mitochondrial | ACO2 | 788 | Annotation score: | ||
A0A7I2V3U0 | A0A7I2V3U0_HUMAN | Aconitate hydratase, mitochondrial | ACO2 | 725 | Annotation score: | ||
A0A7I2V3U7 | A0A7I2V3U7_HUMAN | Aconitate hydratase, mitochondrial | ACO2 | 160 | Annotation score: | ||
A0A7I2V499 | A0A7I2V499_HUMAN | Aconitate hydratase, mitochondrial | ACO2 | 69 | Annotation score: | ||
A0A7I2V4I8 | A0A7I2V4I8_HUMAN | Aconitate hydratase, mitochondrial | ACO2 | 288 | Annotation score: | ||
A0A7I2V538 | A0A7I2V538_HUMAN | Aconitate hydratase, mitochondrial | ACO2 | 487 | Annotation score: | ||
A0A7I2V586 | A0A7I2V586_HUMAN | Aconitate hydratase, mitochondrial | ACO2 | 747 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL008582 Genomic DNA No translation available. AL023553 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000396512; ENSP00000379769; ENSG00000100412 ENST00000678269; ENSP00000504150; ENSG00000100412 |
UCSCi | uc062eqp.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL008582 Genomic DNA No translation available. AL023553 Genomic DNA No translation available. |
3D structure databases
SMRi | A2A274 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A2A274, 2 interactors |
Proteomic databases
EPDi | A2A274 |
MaxQBi | A2A274 |
PeptideAtlasi | A2A274 |
PRIDEi | A2A274 |
ProteomicsDBi | 171 |
Protocols and materials databases
Antibodypediai | 240, 498 antibodies |
Genome annotation databases
Ensembli | ENST00000396512; ENSP00000379769; ENSG00000100412 ENST00000678269; ENSP00000504150; ENSG00000100412 |
UCSCi | uc062eqp.1, human |
Organism-specific databases
HGNCi | HGNC:118, ACO2 |
OpenTargetsi | ENSG00000100412 |
VEuPathDBi | HostDB:ENSG00000100412.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154892 |
OMAi | QFHASCY |
PhylomeDBi | A2A274 |
Miscellaneous databases
ChiTaRSi | ACO2, human |
Gene expression databases
Bgeei | ENSG00000100412, Expressed in heart right ventricle and 243 other tissues |
ExpressionAtlasi | A2A274, baseline and differential |
Family and domain databases
Gene3Di | 3.20.19.10, 1 hit 3.30.499.10, 2 hits 3.40.1060.10, 2 hits |
InterProi | View protein in InterPro IPR015931, Acnase/IPM_dHydase_lsu_aba_1/3 IPR001030, Acoase/IPM_deHydtase_lsu_aba IPR015928, Aconitase/3IPM_dehydase_swvl IPR018136, Aconitase_4Fe-4S_BS IPR036008, Aconitase_4Fe-4S_dom IPR015932, Aconitase_dom2 IPR000573, AconitaseA/IPMdHydase_ssu_swvl |
Pfami | View protein in Pfam PF00330, Aconitase, 2 hits PF00694, Aconitase_C, 1 hit |
PRINTSi | PR00415, ACONITASE |
SUPFAMi | SSF53732, SSF53732, 1 hit |
PROSITEi | View protein in PROSITE PS00450, ACONITASE_1, 1 hit PS01244, ACONITASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A2A274_HUMAN | |
Accessioni | A2A274Primary (citable) accession number: A2A274 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | April 7, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |