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Protein

SH3 domain-containing protein Dlish

Gene

Dlish

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the apical cell cortex localization, total cellular level and full activity of dachs.1 Publication

GO - Molecular functioni

  • cadherin binding Source: FlyBase

GO - Biological processi

  • establishment of epithelial cell planar polarity Source: FlyBase
  • establishment of planar polarity Source: FlyBase
  • negative regulation of hippo signaling Source: FlyBase
  • protein localization involved in establishment of planar polarity Source: FlyBase

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-containing protein DlishCurated
Alternative name(s):
Dachs ligand with SH3 domains1 Publication
Gene namesi
Name:Dlish1 Publication
ORF Names:CG10933Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034264 Dlish

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in reduced spacing between the anterior and posterior crossveins of the wing, reduced levels of subapical cortical dachs, increased levels of dachs throughout the cytoplasm, increased total cellular levels of dachs and suppression of the overgrowth and dachs up-regulation seen in ft mutants.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004388531 – 355SH3 domain-containing protein DlishAdd BLAST355

Post-translational modificationi

Palmitoylated by app.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiA1ZAY1
PRIDEiA1ZAY1

PTM databases

SwissPalmiA1ZAY1

Expressioni

Gene expression databases

BgeeiFBgn0034264
ExpressionAtlasiA1ZAY1 baseline and differential

Interactioni

Subunit structurei

Interacts with dachs (via C-terminus); the interaction is direct. Interacts (via N-terminus including SH3 domain 1) with palmitoyltransferase app; this leads to palmitoylation of Dlish by app. Also interacts with dco, ft, ft-regulated E3 ubiquitin ligase Fbxl7, F-box protein slmb and SCF E3 ubiquitin-protein ligase complex component Cul1.1 Publication

GO - Molecular functioni

  • cadherin binding Source: FlyBase

Protein-protein interaction databases

IntActiA1ZAY1, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliA1ZAY1
SMRiA1ZAY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 117SH3 1PROSITE-ProRule annotationAdd BLAST61
Domaini183 – 243SH3 2PROSITE-ProRule annotationAdd BLAST61
Domaini287 – 352SH3 3PROSITE-ProRule annotationAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi248 – 277Gln-richPROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IIV7 Eukaryota
ENOG410XSY1 LUCA
GeneTreeiENSGT00390000000504
OMAiCPEQPID
OrthoDBiEOG091G0HCZ
PhylomeDBiA1ZAY1

Family and domain databases

InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 3 hits
SUPFAMiSSF50044 SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 3 hits

Sequencei

Sequence statusi: Complete.

A1ZAY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLCPVRMR RDKKKATNAS IERDLPAVGV LGMGRITGSS SIETLVRVGI
60 70 80 90 100
EKEHGLSPDS KMVVLHDFTP CVDDELEVKR GQLVNILYRE NDWVYVIGQD
110 120 130 140 150
SRQEGFIPFS YCAPCNTQLA DLAVKKKLPR EQCPEQPIEE NIPLLGTDNK
160 170 180 190 200
LDVLCDETLN PGSANSIENT LLVEPECTPF VKEPSGRCIV LYTFIARDEN
210 220 230 240 250
DLSVERGEFV TVLNREDPDW FWIMRSDGQE GFVPASFIYP ADSVRVLQQQ
260 270 280 290 300
KATLNAMETI LQQGQQGQQS QQQQQPQLGL GTDDLRYHGT ELVMLYDYKA
310 320 330 340 350
QAPDDLYLSV RRGDWIYADL TNQTVDGWLW AYAPKTRKYG FIPKAYARPP

AMTSL
Length:355
Mass (Da):40,131
Last modified:February 6, 2007 - v1
Checksum:iC500D56CD93F467B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57808.2
BT099964 mRNA Translation: ACX47665.1
RefSeqiNP_611251.2, NM_137407.3
UniGeneiDm.26280

Genome annotation databases

EnsemblMetazoaiFBtr0086860; FBpp0086020; FBgn0034264
GeneIDi37014
KEGGidme:Dmel_CG10933
UCSCiCG10933-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiDLISH_DROME
AccessioniPrimary (citable) accession number: A1ZAY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: February 6, 2007
Last modified: July 18, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

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