UniProtKB - A1ZAV3 (A1ZAV3_DROME)
Protein
Submitted name:
Misexpression suppressor of ras 4, isoform A
Gene
MESR4
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cellular lipid metabolic process Source: FlyBase
- cellular response to hypoxia Source: FlyBase
- germarium-derived oocyte differentiation Source: FlyBase
- regulation of gene expression Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Misexpression suppressor of ras 4, isoform AImportedSubmitted name: Misexpression suppressor of ras 4, isoform BImported |
Gene namesi | Name:MESR4Imported Synonyms:Dmel\CG4903Imported, EP(2)0988Imported, EP0386Imported, EP0988Imported, EP988Imported, Mesr4Imported, mesr4Imported, MSR4Imported ORF Names:CG4903Imported, Dmel_CG4903Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0034240, MESR4 |
Subcellular locationi
Nucleus
- nucleus Source: FlyBase
Keywords - Cellular componenti
NucleusARBA annotationInteractioni
Protein-protein interaction databases
IntActi | A1ZAV3, 9 interactors |
STRINGi | 7227.FBpp0112003 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1293 – 1320 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 1321 – 1350 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 2108 – 2159 | PHD-typeInterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 151 | DisorderedSequence analysisAdd BLAST | 151 | |
Regioni | 191 – 362 | DisorderedSequence analysisAdd BLAST | 172 | |
Regioni | 403 – 518 | DisorderedSequence analysisAdd BLAST | 116 | |
Regioni | 709 – 737 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 762 – 781 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 804 – 852 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 905 – 1001 | DisorderedSequence analysisAdd BLAST | 97 | |
Regioni | 1374 – 1536 | DisorderedSequence analysisAdd BLAST | 163 | |
Regioni | 1587 – 1725 | DisorderedSequence analysisAdd BLAST | 139 | |
Regioni | 1757 – 2044 | DisorderedSequence analysisAdd BLAST | 288 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 853 – 876 | Sequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 42 – 64 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 104 – 124 | AcidicSequence analysisAdd BLAST | 21 | |
Compositional biasi | 128 – 151 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 191 – 251 | PolyampholyteSequence analysisAdd BLAST | 61 | |
Compositional biasi | 320 – 345 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 408 – 422 | AcidicSequence analysisAdd BLAST | 15 | |
Compositional biasi | 428 – 450 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 459 – 480 | PolarSequence analysisAdd BLAST | 22 | |
Compositional biasi | 709 – 724 | BasicSequence analysisAdd BLAST | 16 | |
Compositional biasi | 767 – 781 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 833 – 847 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 905 – 926 | PolarSequence analysisAdd BLAST | 22 | |
Compositional biasi | 984 – 998 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1399 – 1422 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1494 – 1536 | PolyampholyteSequence analysisAdd BLAST | 43 | |
Compositional biasi | 1595 – 1663 | PolarSequence analysisAdd BLAST | 69 | |
Compositional biasi | 1683 – 1708 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1767 – 1781 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1821 – 1843 | Pro-richSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1851 – 1879 | PolarSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1951 – 1970 | PolarSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota KOG1973, Eukaryota |
HOGENOMi | CLU_231757_0_0_1 |
OrthoDBi | 1434088at2759 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR019786, Zinc_finger_PHD-type_CS IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
SMARTi | View protein in SMART SM00249, PHD, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A1ZAV3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMEALDQQQA KLTSNRDDGE AGRGSETGSE EGTGAGAAAG EEDDIEELHY
60 70 80 90 100
VLDQAKEENE SHQHGQNNNA KGNEDGKPKK NDDVIDVTMA NGQGFKDTPE
110 120 130 140 150
EETTGTEETA ETEETAETEE AEQAEESLLN SRKSTDTPVD LGANCLTTGS
160 170 180 190 200
PSKDLVKQEL VEDKSEELKE PTSISLNEQF LDDIELKTEV EDKSDSLSET
210 220 230 240 250
HMEFLTDSEE QPSESLGANH ESEIDEKVDH FQPKESDSNE VEDKYFQSAN
260 270 280 290 300
EDSESEIEET VYTPPVINLE TDSESGDKEF ISIKDNESPV LEIEGGTEKS
310 320 330 340 350
QTSGDLYQAD VGEYASTAPP EVDETTSQTI GVPSLEGSDT LDSPSLTMDV
360 370 380 390 400
DLPCSEDGAP PNVIKIESDM EDEAHSDSVK LKEHTVEVVP LIKLNGAHKA
410 420 430 440 450
LKEEKLEDGE VEEVEDPGEE LEDPKEQSVI TNHTGNNTKE EDTTASQVSA
460 470 480 490 500
LPLILPVGTT RSRSISSRSS TVSSASQPHL VIDHPESEHN AKPPALKLSL
510 520 530 540 550
KRRRSKSSSV SQPEKQTKVE AGGFVSSLLL QRLQSNSNVI PPAISTESQQ
560 570 580 590 600
VLSCAKCNLQ FDFERFQELN KHQAQCSGIQ SANSSQLSQK QERFFRCSQC
610 620 630 640 650
CSVHQCWHFF LHMREVHRRY ICLYCNHVYP SVEKLSLHLE NKHDIDQSHF
660 670 680 690 700
AKDAWDQQQS KEDRARHLVC CTCQATFVQG SEFEDHDCSQ LMQPCALCNQ
710 720 730 740 750
KGGHIIGCKN NKRKPTKRRR KVRRPPEPPL PVSQEAVEQP VPVEAIPEQL
760 770 780 790 800
PQQLHLQSDI QNPFPAENIP APEPVEDPPA PPIPKLVVPK IMLRVPKEFQ
810 820 830 840 850
KSVDAALSST DTEDEELETA QPVEEAVSAP PEDLPFDAPP PPPPALSYDD
860 870 880 890 900
STSSKLNRVL AELERTKLDI ERTKADIITK KQSKIIMANA HLENVVPQVV
910 920 930 940 950
DPPQHLQPQQ EEQRRWSLTP PASPHNNHVN LPEPPPALIT EFQGQPDAVR
960 970 980 990 1000
RNSLGSDCMD MDDSLNAPEM EGSRDFTEAQ KETLEPAPPS QDTQTADEPL
1010 1020 1030 1040 1050
AIQPLPPADG IMVAGPDTHT VDLQLDRPLD RFSMVDFVRL CLKSVYSLCL
1060 1070 1080 1090 1100
YCNHARRIAV NVKQLVIHLI GQHRFTATVD SITAEELYAE TIVAKLKSFL
1110 1120 1130 1140 1150
PNLENEYMNA ASCCSLENGK YVEPFNERIY ECFTCRFVTS THKELYTHNR
1160 1170 1180 1190 1200
RLHIKSNITC VMCQTNFYSY SEILCHICPG EVAGSVYDLQ FRCCLCDMAP
1210 1220 1230 1240 1250
LPSAFRLMVH LRKQHQACDI CLEDCQSQSK LSSHVWKHKL LHLCYRCGIA
1260 1270 1280 1290 1300
YRNKQDISKH LFWKHGTESA GCKQCLQKRW RHVYHFCVPP AEFPCEQCGF
1310 1320 1330 1340 1350
VFSKAIYLEV HQRMHTGDFR YACTEEGCEE KFVSRKLLLK HASSHVAKEL
1360 1370 1380 1390 1400
PQAVSVEQTA DAAPTEKLED IKEELEEGED EKEGAHNQEK LLSESLTNNE
1410 1420 1430 1440 1450
TPKKEESDRI DNSIEPPLSK SENRKRRKKS KRNKESLEDL NLIAPNLSES
1460 1470 1480 1490 1500
DSSDDSDSDA PRSSHQEQPK LPMRSSVDDL DMPKVMLSPS SESDADELDG
1510 1520 1530 1540 1550
KSKLEDKEEK PLDGSTEEKA LDADDELEPK KEEDQVDVSI WKNLLQNQAV
1560 1570 1580 1590 1600
AIPEEQAVKD EEREDSLVNL PPAKLHVAWS DHDYCKLYRT PAPSPVKQKS
1610 1620 1630 1640 1650
ANKSSIKTPG ENASSDSDSS SSSSSSDSDS SSCSCGSNCS CSSSNSSSSS
1660 1670 1680 1690 1700
GNSDDSDSST ARGSPQKRSR KKSLKVKKSS ESLKIDQNGQ NEQNQVEDTT
1710 1720 1730 1740 1750
AVNENNNPVA PPSPKPPMYN ESDFDTAFSD TDEEFYDSHP QKLANELLTQ
1760 1770 1780 1790 1800
KREALMAEHA PMRPSNNYDI VENSRPSTPS LPEEASAFAD KREKVRNKKK
1810 1820 1830 1840 1850
KRERKSTCKS GKLQPVASTT PPPMDRIPGM PGMIAPLEPP TPILSHPESS
1860 1870 1880 1890 1900
LFPVTPLTHR QLQSSMTRMS EGSSCSDADG QLKRSKRQRR PNKFYGYTSD
1910 1920 1930 1940 1950
DENMSAVLAP PLQVGMQLIK PQPPPQLTWA KEDLPTPPKQ RNRNNNNSSH
1960 1970 1980 1990 2000
HHHSHSNGGM AGSSRKRSKQ RSLFGAGGSR PAKRHKPDPN DHLPPIPTLK
2010 2020 2030 2040 2050
IRPSLLPTTA PPSDSSESSS DDEEAEVNVT SVVPTPQPAP PPVLPTPLPV
2060 2070 2080 2090 2100
ALPVPPPPPP AATAFNQPIP PALLPNPGFA TLQYFKANNI RYPIRPPAGA
2110 2120 2130 2140 2150
RLAREGESVY CYCRCPYDEV SEMIACDGDN CLIEWFHFEC VGIMVAPQGK
2160 2170
WFCAECRPKY SEGIYQGAKP Q
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4LGV3 | A0A0B4LGV3_DROME | Misexpression suppressor of ras 4, ... | MESR4 Dmel\CG4903, EP(2)0988, EP0386, EP0988, EP988 | 2,151 | Annotation score: | ||
A0A0B4LFV9 | A0A0B4LFV9_DROME | Misexpression suppressor of ras 4, ... | MESR4 Dmel\CG4903, EP(2)0988, EP0386, EP0988, EP988 | 2,169 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57837.2 AE013599 Genomic DNA Translation: ABV53837.1 |
RefSeqi | NP_001097359.1, NM_001103889.2 NP_523775.2, NM_079051.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0086946; FBpp0086102; FBgn0034240 FBtr0113090; FBpp0112003; FBgn0034240 |
GeneIDi | 36986 |
KEGGi | dme:Dmel_CG4903 |
UCSCi | CG4903-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57837.2 AE013599 Genomic DNA Translation: ABV53837.1 |
RefSeqi | NP_001097359.1, NM_001103889.2 NP_523775.2, NM_079051.4 |
3D structure databases
SMRi | A1ZAV3 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A1ZAV3, 9 interactors |
STRINGi | 7227.FBpp0112003 |
Genome annotation databases
EnsemblMetazoai | FBtr0086946; FBpp0086102; FBgn0034240 FBtr0113090; FBpp0112003; FBgn0034240 |
GeneIDi | 36986 |
KEGGi | dme:Dmel_CG4903 |
UCSCi | CG4903-RA, d. melanogaster |
Organism-specific databases
CTDi | 36986 |
FlyBasei | FBgn0034240, MESR4 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota KOG1973, Eukaryota |
HOGENOMi | CLU_231757_0_0_1 |
OrthoDBi | 1434088at2759 |
Miscellaneous databases
BioGRID-ORCSi | 36986, 1 hit in 1 CRISPR screen |
GenomeRNAii | 36986 |
Gene expression databases
Bgeei | FBgn0034240, Expressed in embryo and 49 other tissues |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR019786, Zinc_finger_PHD-type_CS IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
SMARTi | View protein in SMART SM00249, PHD, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A1ZAV3_DROME | |
Accessioni | A1ZAV3Primary (citable) accession number: A1ZAV3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | April 7, 2021 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |