Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 114 (16 Oct 2019)
Sequence version 1 (06 Feb 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Patronin

Gene

Patronin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mitotic spindle assembly (PubMed:17412918, PubMed:26246606). Regulates microtubule (MT) severing (PubMed:17412918). Antagonizes the activity of the kinesin-13 depolymerase Klp10A thereby switching off the depolymerization of the MTs at their pole-associated minus ends, which turns off poleward flux and induces anaphase B spindle elongation (PubMed:20946984, PubMed:24100293). Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell (PubMed:26659188).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Patronin
Alternative name(s):
Short spindle protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Patronin
Synonyms:l(2)k07433, ssp4
ORF Names:CG33130
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0263197 Patronin

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003728611 – 1630PatroninAdd BLAST1630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei322Phosphothreonine1 Publication1
Modified residuei422Phosphoserine1 Publication1
Modified residuei431Phosphoserine1 Publication1
Modified residuei441Phosphoserine1 Publication1
Modified residuei460Phosphoserine2 Publications1
Modified residuei463Phosphoserine1 Publication1
Modified residuei466Phosphoserine1 Publication1
Modified residuei492Phosphothreonine1 Publication1
Modified residuei494Phosphoserine1 Publication1
Modified residuei496Phosphoserine1 Publication1
Modified residuei513Phosphoserine1 Publication1
Modified residuei530Phosphoserine1 Publication1
Modified residuei1034Phosphoserine1 Publication1
Modified residuei1035Phosphoserine1 Publication1
Modified residuei1036Phosphoserine1 Publication1
Modified residuei1067Phosphoserine1 Publication1
Modified residuei1219Phosphoserine1 Publication1
Modified residuei1228Phosphoserine1 Publication1
Modified residuei1398Phosphoserine1 Publication1
Modified residuei1399Phosphoserine1 Publication1
Modified residuei1400Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A1ZAU8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1ZAU8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0263197 Expressed in 27 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1ZAU8 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1ZAU8 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the minus end of the microtubules.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
62669, 19 interactors

Protein interaction database and analysis system

More...
IntActi
A1ZAU8, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0304550

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini156 – 288Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST133
Domaini1489 – 1623CKKPROSITE-ProRule annotationAdd BLAST135

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili601 – 639Sequence analysisAdd BLAST39
Coiled coili1277 – 1343Sequence analysisAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi360 – 394Gln-richAdd BLAST35
Compositional biasi671 – 1027Gln-richAdd BLAST357

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CKK domain binds microtubules.PROSITE-ProRule annotation

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAMSAP1 family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182975

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1ZAU8

KEGG Orthology (KO)

More...
KOi
K17493

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.360, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032940 CAMSAP
IPR031372 CAMSAP_CC1
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR038209 CKK_dom_sf
IPR014797 CKK_domain
IPR011033 PRC_barrel-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21595 PTHR21595, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17095 CAMSAP_CC1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF08683 CAMSAP_CKK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01051 CAMSAP_CKK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF50346 SSF50346, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS51508 CKK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform C (identifier: A1ZAU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVETQEIRQ ARQRASVKWL LSKAFNNRVP DNLKEPFYRD HENQERLKPQ
60 70 80 90 100
IIVELGNATL YCQTLANLYS DPNYQSMNHW SIIQTLARKG VPVAESADMP
110 120 130 140 150
ITETVLIQTN PLRINAHMSV IESLMVLYAK EISSGDRVMA AIRRISGNNY
160 170 180 190 200
QAPTGQSYEQ ALLGWISHAC AALKKRIIKE VDAGLPDDNG SRLQTPDIPP
210 220 230 240 250
VRDFQDLCDG ICLALLISYY CPKVVPWTSV RINYLPAVED SIHNILLVCN
260 270 280 290 300
FSQKHLPYTV MHMTPEDVTY MRGSMKLNLV VLLTDLFNLF EIHPAKCVCY
310 320 330 340 350
PGMDGQVPHS NSFGGGLNRR STPPNEYQTV QSNNFDGNHA EAFVVHKSRG
360 370 380 390 400
ITTLASMHSQ QQQQLHQQQQ HQQQYHQQPL QQHPSQSQLQ IQQQEPLVPA
410 420 430 440 450
RLRQAKEKTN VESKADERGR RSRRNSSSED SQLTIENFGG SQDQLNTLGR
460 470 480 490 500
YERDRERKLS NTSVGSYPVE PAVAVRSSIA DARGTLQLGY DTDSGSEKQD
510 520 530 540 550
RETEKYSMRR QVSVDNVPTV SSHNLSNAGS PLPVARHKQH SSDKDYSSNS
560 570 580 590 600
GMTPDAYNDS RSTSGYDPES TPVRKSSTSS MPASPAAWQL DVGDDDMRSL
610 620 630 640 650
ENASKLSTIR MKLEEKRRRI EQDKRKIEMA LLRHQEKEDL ESCPDVMKWE
660 670 680 690 700
TMSNESKRTP DMDPVDLDKY QQSIAIMNMN LQDIQQDIHR LATQQSQMQA
710 720 730 740 750
QHLQAQQLMQ AQQIANMLNQ AYNAPVSAYS SRPPSRDPYQ QQLHHQQQQP
760 770 780 790 800
MPMPQPMQYV NEHGQYMSPP QPAHYMPQQA QQPQSIYSDN GAAYNHSNHS
810 820 830 840 850
PYGGTPQYRS SVVYDDYGQP TNHFYLHESS PQPQAHQHPQ RRTWAHSAAA
860 870 880 890 900
AAYEQQQQIQ PSLVDVNAWQ TQQHQKQKQT WMNRPPSSAG APSPGSFMLH
910 920 930 940 950
QNGGGGGGGG GGGELQHLFQ VQASPQHGQR QVSGSNGVQR QQSLTNLRDN
960 970 980 990 1000
RSPKAPQNMG MPMGMPMQQE DMMAPQSICF IGDEEDVDEL ERNIIESMQS
1010 1020 1030 1040 1050
THISDFVHQQ QQQHQHQQQL QQQQRLQGHS GRGSSSEDYD SGEMISNKLN
1060 1070 1080 1090 1100
ITSGNLTYRI PSPSRPSIQA NSFQDPRAMA AASGGEDQPP EKGFYISFDD
1110 1120 1130 1140 1150
EQPKRPKPPL RAKRSPKKES PPGSRDSVDN QATLKRESLS HLHNNNNIGF
1160 1170 1180 1190 1200
GNDDVNSKPV TRHSIHGLNN SNSVKSPGNA TYNKYTDEPP IQLRQLAVSG
1210 1220 1230 1240 1250
AMSPTSNERH HLDDVSNQSP QQTQQPMSPT RLQQSSNNAE AAKNKALVIG
1260 1270 1280 1290 1300
ADSTNLDPES VDEMERRKEK IMLLSLQRRQ QQEEAKARKE IEASQKREKE
1310 1320 1330 1340 1350
REKEEERARK KEEQMARRAA ILEQHRLKKA IEEAEREGKT LDRPDLHVKL
1360 1370 1380 1390 1400
QSHSSTSTTP RLRQQRTTRP RPKTIHVDDA SVDISEASSI SSRGKKGSSS
1410 1420 1430 1440 1450
NLTGYGQLSS NSMKRDYYRG SQDSLTVKES PDDYPSTSST PIGRRGSYKT
1460 1470 1480 1490 1500
SREPAGVERG RTLSRISVAK GSTLNFRGRK SNSLMNLCGP KLYKQPAAKS
1510 1520 1530 1540 1550
NRGIILNAVE YCVFPGVVNR EAKQKVLEKI ARSEAKHFLV LFRDAGCQFR
1560 1570 1580 1590 1600
ALYSYQPETD QVTKLYGTGP SQVEEVMFDK FFKYNSGGKC FSQVHTKHLT
1610 1620 1630
VTIDAFTIHN SLWQGKRVQL PSKKDMALVI
Note: No experimental confirmation available.
Length:1,630
Mass (Da):183,622
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8182F1FCEBF51DF
GO
Isoform A (identifier: A1ZAU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-418: R → RGDFVAAGRPSNWEQSRRPSFA
     671-719: Missing.
     1404-1488: Missing.

Note: No experimental confirmation available.
Show »
Length:1,517
Mass (Da):170,944
Checksum:iB1862656CCCF92EB
GO
Isoform B (identifier: A1ZAU8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-418: R → RGDFVAAGRPSNWEQSRRPSFA
     671-719: Missing.
     1404-1488: GYGQLSSNSM...RKSNSLMNLC → DSGLGRATPPRRAPSPGMGMGAS

Note: No experimental confirmation available.
Show »
Length:1,540
Mass (Da):173,153
Checksum:i31694E0CD0C269FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JH90E1JH90_DROME
Patronin, isoform F
Patronin BcDNA:LD17191, CG18459, CG18460, CG18462, CG30102
1,671Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7YZJ1B7YZJ1_DROME
Patronin, isoform D
Patronin BcDNA:LD17191, CG18459, CG18460, CG18462, CG30102
1,663Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7YZJ2B7YZJ2_DROME
Patronin, isoform E
Patronin BcDNA:LD17191, CG18459, CG18460, CG18462, CG30102
1,599Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JH91E1JH91_DROME
Patronin, isoform O
Patronin BcDNA:LD17191, CG18459, CG18460, CG18462, CG30102
1,683Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KEY4A0A0B4KEY4_DROME
Patronin, isoform I
Patronin BcDNA:LD17191, CG18459, CG18460, CG18462, CG30102
1,689Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KEY6A0A0B4KEY6_DROME
Patronin, isoform N
Patronin BcDNA:LD17191, CG18459, CG18460, CG18462, CG30102
1,439Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KFU3A0A0B4KFU3_DROME
Patronin, isoform M
Patronin BcDNA:LD17191, CG18459, CG18460, CG18462, CG30102
1,504Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KG58A0A0B4KG58_DROME
Patronin, isoform L
Patronin BcDNA:LD17191, CG18459, CG18460, CG18462, CG30102
1,538Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KFA4A0A0B4KFA4_DROME
Patronin, isoform K
Patronin BcDNA:LD17191, CG18459, CG18460, CG18462, CG30102
1,680Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KET5A0A0B4KET5_DROME
Patronin, isoform J
Patronin BcDNA:LD17191, CG18459, CG18460, CG18462, CG30102
1,674Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM49943 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti805T → A in AAO39638 (Ref. 3) Curated1
Sequence conflicti1170N → S in AAO39638 (Ref. 3) Curated1
Sequence conflicti1177P → H in AAO39638 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037213418R → RGDFVAAGRPSNWEQSRRPS FA in isoform A and isoform B. 2 Publications1
Alternative sequenceiVSP_037214671 – 719Missing in isoform A and isoform B. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_0372151404 – 1488Missing in isoform A. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_0372161404 – 1488GYGQL…LMNLC → DSGLGRATPPRRAPSPGMGM GAS in isoform B. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAO41362.1
AE013599 Genomic DNA Translation: AAS64821.1
AE013599 Genomic DNA Translation: AAS64822.1
BT003634 mRNA Translation: AAO39638.1
AY118574 mRNA Translation: AAM49943.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_788398.1, NM_176218.3 [A1ZAU8-2]
NP_995875.1, NM_206153.3 [A1ZAU8-1]
NP_995876.1, NM_206154.3 [A1ZAU8-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086948; FBpp0086104; FBgn0263197 [A1ZAU8-2]
FBtr0086949; FBpp0086105; FBgn0263197 [A1ZAU8-3]
FBtr0086950; FBpp0086106; FBgn0263197 [A1ZAU8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG33130

UCSC genome browser

More...
UCSCi
CG33130-RA d. melanogaster
CG33130-RB d. melanogaster
CG33130-RC d. melanogaster [A1ZAU8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAO41362.1
AE013599 Genomic DNA Translation: AAS64821.1
AE013599 Genomic DNA Translation: AAS64822.1
BT003634 mRNA Translation: AAO39638.1
AY118574 mRNA Translation: AAM49943.1 Different initiation.
RefSeqiNP_788398.1, NM_176218.3 [A1ZAU8-2]
NP_995875.1, NM_206153.3 [A1ZAU8-1]
NP_995876.1, NM_206154.3 [A1ZAU8-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi62669, 19 interactors
IntActiA1ZAU8, 4 interactors
STRINGi7227.FBpp0304550

PTM databases

iPTMnetiA1ZAU8

Proteomic databases

PRIDEiA1ZAU8

Genome annotation databases

EnsemblMetazoaiFBtr0086948; FBpp0086104; FBgn0263197 [A1ZAU8-2]
FBtr0086949; FBpp0086105; FBgn0263197 [A1ZAU8-3]
FBtr0086950; FBpp0086106; FBgn0263197 [A1ZAU8-1]
GeneIDi36978
KEGGidme:Dmel_CG33130
UCSCiCG33130-RA d. melanogaster
CG33130-RB d. melanogaster
CG33130-RC d. melanogaster [A1ZAU8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36978
FlyBaseiFBgn0263197 Patronin

Phylogenomic databases

GeneTreeiENSGT00950000182975
InParanoidiA1ZAU8
KOiK17493

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36978

Protein Ontology

More...
PROi
PR:A1ZAU8

Gene expression databases

BgeeiFBgn0263197 Expressed in 27 organ(s), highest expression level in head
ExpressionAtlasiA1ZAU8 differential
GenevisibleiA1ZAU8 DM

Family and domain databases

Gene3Di3.10.20.360, 1 hit
InterProiView protein in InterPro
IPR032940 CAMSAP
IPR031372 CAMSAP_CC1
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR038209 CKK_dom_sf
IPR014797 CKK_domain
IPR011033 PRC_barrel-like_sf
PANTHERiPTHR21595 PTHR21595, 2 hits
PfamiView protein in Pfam
PF17095 CAMSAP_CC1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF08683 CAMSAP_CKK, 1 hit
SMARTiView protein in SMART
SM01051 CAMSAP_CKK, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF50346 SSF50346, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51508 CKK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTRO_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1ZAU8
Secondary accession number(s): A1ZAU9
, A1ZAV0, Q86NU5, Q8MSU7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 6, 2007
Last modified: October 16, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again