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UniProtKB - A1ZAN7 (A1ZAN7_DROME)
Protein
Submitted name:
Rho guanine nucleotide exchange factor 2, isoform E
Gene
RhoGEF2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: FlyBase
GO - Biological processi
- actin cytoskeleton reorganization Source: FlyBase
- actin filament organization Source: FlyBase
- actin-mediated cell contraction Source: FlyBase
- anterior midgut invagination Source: FlyBase
- cell elongation involved in imaginal disc-derived wing morphogenesis Source: FlyBase
- cellularization Source: FlyBase
- germ-band extension Source: FlyBase
- intracellular signal transduction Source: InterPro
- morphogenesis of embryonic epithelium Source: FlyBase
- pole cell development Source: FlyBase
- positive regulation of Rho protein signal transduction Source: FlyBase
- posterior midgut invagination Source: FlyBase
- pseudocleavage involved in syncytial blastoderm formation Source: FlyBase
- regulation of axonogenesis Source: FlyBase
- regulation of cell shape Source: FlyBase
- regulation of embryonic cell shape Source: FlyBase
- regulation of myosin II filament organization Source: FlyBase
- spiracle morphogenesis, open tracheal system Source: FlyBase
- ventral furrow formation Source: FlyBase
Keywordsi
Molecular function | Guanine-nucleotide releasing factorARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Rho guanine nucleotide exchange factor 2, isoform EImported |
Gene namesi | Name:RhoGEF2Imported Synonyms:Dmel\CG9635Imported, DRhoGEFImported, dRhoGEFImported, DRhoGEF2Imported, DrhoGEF2Imported, dRhoGEF2Imported, Gef2Imported, l(2)04291Imported, RG2Imported, Rho-GEF2Imported, RhoGEFImported, RhoGef2Imported, rhoGEF2Imported, rhogef2Imported, RhoGF2Imported, sharImported, Su(Rho1)2BImported, T2Imported ORF Names:CG9635Imported, Dmel_CG9635Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0023172, RhoGEF2 |
VEuPathDBi | VectorBase:FBgn0023172 |
Subcellular locationi
Cytoskeleton
- actin cap Source: FlyBase
- actomyosin contractile ring Source: FlyBase
Plasma Membrane
- apical plasma membrane Source: FlyBase
- lateral plasma membrane Source: FlyBase
Other locations
- apical cortex Source: FlyBase
- apical part of cell Source: FlyBase
- basal part of cell Source: FlyBase
Keywords - Cellular componenti
CytoplasmARBA annotation, MembraneARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0023172, Expressed in eye disc (Drosophila) and 38 other tissues |
ExpressionAtlasi | A1ZAN7, baseline and differential |
Genevisiblei | A1ZAN7, DM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 260 – 336 | PDZInterPro annotationAdd BLAST | 77 | |
Domaini | 796 – 846 | Phorbol-ester/DAG-typeInterPro annotationAdd BLAST | 51 | |
Domaini | 1184 – 1379 | DHInterPro annotationAdd BLAST | 196 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 251 | DisorderedSequence analysisAdd BLAST | 251 | |
Regioni | 343 – 367 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 428 – 507 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 879 – 929 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 996 – 1049 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 1061 – 1081 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1524 – 1544 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1590 – 1643 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 1661 – 1692 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1836 – 1871 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 1900 – 2075 | DisorderedSequence analysisAdd BLAST | 176 | |
Regioni | 2164 – 2205 | DisorderedSequence analysisAdd BLAST | 42 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 382 – 402 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 408 – 428 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1171 – 1198 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 2109 – 2136 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 30 – 68 | Polar residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 105 – 126 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 127 – 143 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 177 – 251 | Polar residuesSequence analysisAdd BLAST | 75 | |
Compositional biasi | 442 – 461 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 879 – 894 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 912 – 929 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1019 – 1040 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1061 – 1079 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1524 – 1541 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1918 – 1935 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1948 – 1994 | Basic and acidic residuesSequence analysisAdd BLAST | 47 | |
Compositional biasi | 1995 – 2020 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 2021 – 2037 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 2040 – 2075 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 2166 – 2196 | Polar residuesSequence analysisAdd BLAST | 31 |
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000168706 |
HOGENOMi | CLU_227972_0_0_1 |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.10.167.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001478, PDZ IPR036034, PDZ_sf IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR015212, RGS-like_dom IPR036305, RGS_sf IPR044926, RGS_subdomain_2 |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00595, PDZ, 1 hit PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00228, PDZ, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50106, PDZ, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A1ZAN7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDPSIKKRL LDLYTDEHEY DEVQEIPEES SIQPPETSTS HTSTNGSSHS
60 70 80 90 100
GPGTATGPGA TSAGPSAGAP QSPVIVVDSV PELPAPKQKS VKNSKSKQKQ
110 120 130 140 150
KQLANKSKIP RSPSLASSLS SLASSLSGHR DRDKDRDKDR ENQNAVPPQT
160 170 180 190 200
PPLPPSYKQN QMNGDSTAAA GGGVSAPATP TTANNNNASH NNGSIMGGGV
210 220 230 240 250
QLNQSDNSNP VLQAPGERSS LNLTPLSRDL SGGHTQESTT PATTPSTPSL
260 270 280 290 300
ALPKNFQYLT LTVRKDSNGY GMKVSGDNPV FVESVKPGGA AEIAGLVAGD
310 320 330 340 350
MILRVNGHEV RLEKHPTVVG LIKASTTVEL AVKRSQKLTR PSSVSVVTPS
360 370 380 390 400
TPILSGRDRT ASITGPQPVD SIKRREMETY KIQTLQKMLE QEKLNLERLK
410 420 430 440 450
SDQNNPSYKL SEANIRKLRE QLHQVGAEAL GQTPNLGKNK HRRVGSSPDN
460 470 480 490 500
MHPRHPDRIT KTTSGSWEIV EKDGESSPPG TPPPPYLSSS HMTVLEDPNE
510 520 530 540 550
NNRGAAAAGP GVFIESHQFT PMAGASSPIP ISLHSSHMHA AQSNDTQKEI
560 570 580 590 600
ISMEDENSDL DEPFIDENGP FNNLTRLLEA ENVTFLAIFL NYVISNSDPA
610 620 630 640 650
PLLFYLITEL YKEGTSKDMR KWAYEIHSTF LVPRAPLSWY RQDESLAREV
660 670 680 690 700
DNVLQLEYDK VEILRTVFLR SRKRAKDLIS EQLREFQQKR TAGLGTIYGP
710 720 730 740 750
TDDKLAEAKT DKLREQIIDK YLMPNLHALI EDENGSPPED VRKVALCSAL
760 770 780 790 800
STVIYRIFNT RPPPSSIVER VHHFVSRDKS FKSRIMGKNR KMNVRGHPLV
810 820 830 840 850
LRQYYEVTHC NHCQTIIWGV SPQGYHCTDC KLNIHRQCSK VVDESCPGPL
860 870 880 890 900
PQAKRLAHND KISKFMGKIR PRTSDVIGNE KRSRQDEELD VELTPDRGQA
910 920 930 940 950
SIVRQPSDRR PDANISIRSN GNTSCNTSGL NTTDLQSSFH GSCANDSINP
960 970 980 990 1000
GGGAGCNMDL STSVASTTPS TSGSVAAGLS AFAELNALDT VDKEARRERY
1010 1020 1030 1040 1050
SQHPKHKSAP VSVNRSESYK ERLSNKRNRN SRRKTSDPSL SSRPNDEQLD
1060 1070 1080 1090 1100
LGLSNATYVG SSNSSLSSAG GSESPSTSME HFAAPGAAGG VQVPPMGLNQ
1110 1120 1130 1140 1150
NQHPHLLIQQ HAQQYCQQDS FQAGLAGAAG SSAASNSSFW NAGHPLPVAR
1160 1170 1180 1190 1200
WTLESEDEDD VNEADWSSMV AAEVLAALTD AEKKRQEIIN EIYQTERNHV
1210 1220 1230 1240 1250
RTLKLLDRLF FLPLYESGLL SQDHLLLLFP PALLSLREIH GAFEQSLKQR
1260 1270 1280 1290 1300
RIEHNHVVNT IGDLLADMFD GQSGVVLCEF AAQFCARQQI ALEALKEKRN
1310 1320 1330 1340 1350
KDEMLQKLLK KSESHKACRR LELKDLLPTV LQRLTKYPLL FENLYKVTVR
1360 1370 1380 1390 1400
LLPENTTEAE AIQRAVESSK RILVEVNQAV KTAEDAHKLQ NIQRKLDRSS
1410 1420 1430 1440 1450
YDKEEFKKLD LTQHHLIHDG NLTIKKNPSV QLHGLLFENM IVLLTKQDDK
1460 1470 1480 1490 1500
YYLKNLHTPL SITNKPVSPI MSIDADTLIR QEAADKNSFF LIKMKTSQML
1510 1520 1530 1540 1550
ELRAPSSSEC KTWFKHFSDV AARQSKNRSK NASSNHDTSI SDPALAAIPH
1560 1570 1580 1590 1600
SNTKESLELS TDTVQPLAAT ATLTTTPLAP MLPIATVTPA PATNNSNVSS
1610 1620 1630 1640 1650
LTGVQLRNPQ RDATASESDA DYVNTPKPRS SQNEVNRTMS IRSTGEPIQK
1660 1670 1680 1690 1700
YSANGTEAND VTLRHSQSTR ESVRPGSTGE ERNSTYGMVG GNSKRDSASI
1710 1720 1730 1740 1750
VCSNNSNNTR TLLMQSPLVD PTAIQVSISP AHTAEPVLTP GEKLRRLDAS
1760 1770 1780 1790 1800
IRNDLLEKQK IICDIFRLPV EHYDQIVDIA MMPEAPKDSA DIALAAYDQI
1810 1820 1830 1840 1850
QTLTKMLNEY MHVTPEQEVS AVSTAVCGHC HEKEKLRKKV APSSSFSSSP
1860 1870 1880 1890 1900
PPLPPPNRQH AQAQAQIPPS RLMPKLQTLD LDEVAIHEDD DGYCEIDELR
1910 1920 1930 1940 1950
LPAIPSKPHE RPTTPLAPFN TEPKTSQSVI DASKRQSTDA VPEGLLEQEP
1960 1970 1980 1990 2000
LEGDKTETKG EDNEVKTVPS DKLSESCNEE RQCVEADITK EVADPTTSKN
2010 2020 2030 2040 2050
EAAASVDELP SQSREIKTAE NASKSVADKK EDNEETIEEG VASTVDSSTQ
2060 2070 2080 2090 2100
TSPTESPKET DKLTGGSSST CGPNRIQHAS VLEPSVPCHA LSSIVTILNE
2110 2120 2130 2140 2150
QISMLLPKIN ERDMERERLR KENQHLRELL SALHDRQRVD EVKETPFDLK
2160 2170 2180 2190 2200
KLMHAEDVEF DDDIDAISNS SLTPTPTPIP TASPSASGQV ETAEAMRITS
TEDEE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA1ZAN6 | A1ZAN6_DROME | Rho guanine nucleotide exchange fac... | RhoGEF2 Dmel\CG9635, DRhoGEF, dRhoGEF, DRhoGEF2, DrhoGEF2 | 2,559 | Annotation score: | ||
A0A0B4K7T7 | A0A0B4K7T7_DROME | Rho guanine nucleotide exchange fac... | RhoGEF2 Dmel\CG9635, DRhoGEF, dRhoGEF, DRhoGEF2, DrhoGEF2 | 2,557 | Annotation score: | ||
A0A0B4LFF8 | A0A0B4LFF8_DROME | Rho guanine nucleotide exchange fac... | RhoGEF2 Dmel\CG9635, DRhoGEF, dRhoGEF, DRhoGEF2, DrhoGEF2 | 2,456 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57915.2 |
RefSeqi | NP_995869.1, NM_206147.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0086969; FBpp0086123; FBgn0023172 |
GeneIDi | 36915 |
UCSCi | CG9635-RE, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57915.2 |
RefSeqi | NP_995869.1, NM_206147.4 |
3D structure databases
SMRi | A1ZAN7 |
ModBasei | Search... |
Proteomic databases
PRIDEi | A1ZAN7 |
Genome annotation databases
EnsemblMetazoai | FBtr0086969; FBpp0086123; FBgn0023172 |
GeneIDi | 36915 |
UCSCi | CG9635-RE, d. melanogaster |
Organism-specific databases
CTDi | 36915 |
FlyBasei | FBgn0023172, RhoGEF2 |
VEuPathDBi | VectorBase:FBgn0023172 |
Phylogenomic databases
GeneTreei | ENSGT00940000168706 |
HOGENOMi | CLU_227972_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 36915, 0 hits in 3 CRISPR screens |
GenomeRNAii | 36915 |
Gene expression databases
Bgeei | FBgn0023172, Expressed in eye disc (Drosophila) and 38 other tissues |
ExpressionAtlasi | A1ZAN7, baseline and differential |
Genevisiblei | A1ZAN7, DM |
Family and domain databases
CDDi | cd00029, C1, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.10.167.10, 1 hit 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001478, PDZ IPR036034, PDZ_sf IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR015212, RGS-like_dom IPR036305, RGS_sf IPR044926, RGS_subdomain_2 |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00595, PDZ, 1 hit PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00228, PDZ, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50106, PDZ, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A1ZAN7_DROME | |
Accessioni | A1ZAN7Primary (citable) accession number: A1ZAN7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | January 19, 2022 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |