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UniProtKB - A1ZAN7 (A1ZAN7_DROME)

Entry version 133 (07 Oct 2020)
Sequence version 1 (06 Feb 2007)
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Protein
Submitted name:

Rho guanine nucleotide exchange factor 2, isoform E

Gene

RhoGEF2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorARBA annotation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		A1ZAN7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 2, isoform EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RhoGEF2Imported
Synonyms:Dmel\CG9635Imported, DRhoGEFImported, dRhoGEFImported, DRhoGEF2Imported, DrhoGEF2Imported, dRhoGEF2Imported, Gef2Imported, l(2)04291Imported, RG2Imported, Rho-GEF2Imported, RhoGEFImported, RhoGef2Imported, rhoGEF2Imported, rhogef2Imported, RhoGF2Imported, sharImported, Su(Rho1)2BImported, T2Imported
ORF Names:CG9635Imported, Dmel_CG9635Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0023172, RhoGEF2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation, MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		A1ZAN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0023172, Expressed in eye disc (Drosophila) and 38 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A1ZAN7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A1ZAN7, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A1ZAN7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini260 – 336PDZInterPro annotationAdd BLAST77
Domaini796 – 846Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini1184 – 1379DHInterPro annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 251DisorderedSequence analysisAdd BLAST251
Regioni343 – 367DisorderedSequence analysisAdd BLAST25
Regioni428 – 507DisorderedSequence analysisAdd BLAST80
Regioni879 – 929DisorderedSequence analysisAdd BLAST51
Regioni996 – 1049DisorderedSequence analysisAdd BLAST54
Regioni1061 – 1081DisorderedSequence analysisAdd BLAST21
Regioni1524 – 1544DisorderedSequence analysisAdd BLAST21
Regioni1590 – 1643DisorderedSequence analysisAdd BLAST54
Regioni1661 – 1692DisorderedSequence analysisAdd BLAST32
Regioni1836 – 1871DisorderedSequence analysisAdd BLAST36
Regioni1900 – 2075DisorderedSequence analysisAdd BLAST176
Regioni2164 – 2205DisorderedSequence analysisAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili382 – 402Sequence analysisAdd BLAST21
Coiled coili408 – 428Sequence analysisAdd BLAST21
Coiled coili1171 – 1198Sequence analysisAdd BLAST28
Coiled coili2109 – 2136Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17PolyampholyteSequence analysisAdd BLAST17
Compositional biasi30 – 68PolarSequence analysisAdd BLAST39
Compositional biasi105 – 126PolarSequence analysisAdd BLAST22
Compositional biasi127 – 143PolyampholyteSequence analysisAdd BLAST17
Compositional biasi177 – 251PolarSequence analysisAdd BLAST75
Compositional biasi442 – 461PolyampholyteSequence analysisAdd BLAST20
Compositional biasi879 – 894PolyampholyteSequence analysisAdd BLAST16
Compositional biasi912 – 929PolarSequence analysisAdd BLAST18
Compositional biasi1019 – 1040PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1061 – 1079PolarSequence analysisAdd BLAST19
Compositional biasi1524 – 1541PolarSequence analysisAdd BLAST18
Compositional biasi1918 – 1935PolarSequence analysisAdd BLAST18
Compositional biasi1948 – 1994PolyampholyteSequence analysisAdd BLAST47
Compositional biasi1995 – 2020PolarSequence analysisAdd BLAST26
Compositional biasi2021 – 2037PolyampholyteSequence analysisAdd BLAST17
Compositional biasi2040 – 2075PolarSequence analysisAdd BLAST36
Compositional biasi2166 – 2196PolarSequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000168706

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_227972_0_0_1

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029, C1, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001478, PDZ
IPR036034, PDZ_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR015212, RGS-like_dom
IPR036305, RGS_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00130, C1_1, 1 hit
PF00595, PDZ, 1 hit
PF17838, PH_16, 1 hit
PF09128, RGS-like, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109, C1, 1 hit
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065, SSF48065, 1 hit
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50010, DH_2, 1 hit
PS50106, PDZ, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A1ZAN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDPSIKKRL LDLYTDEHEY DEVQEIPEES SIQPPETSTS HTSTNGSSHS 
        60         70         80         90        100
GPGTATGPGA TSAGPSAGAP QSPVIVVDSV PELPAPKQKS VKNSKSKQKQ 
       110        120        130        140        150
KQLANKSKIP RSPSLASSLS SLASSLSGHR DRDKDRDKDR ENQNAVPPQT 
       160        170        180        190        200
PPLPPSYKQN QMNGDSTAAA GGGVSAPATP TTANNNNASH NNGSIMGGGV 
       210        220        230        240        250
QLNQSDNSNP VLQAPGERSS LNLTPLSRDL SGGHTQESTT PATTPSTPSL 
       260        270        280        290        300
ALPKNFQYLT LTVRKDSNGY GMKVSGDNPV FVESVKPGGA AEIAGLVAGD 
       310        320        330        340        350
MILRVNGHEV RLEKHPTVVG LIKASTTVEL AVKRSQKLTR PSSVSVVTPS 
       360        370        380        390        400
TPILSGRDRT ASITGPQPVD SIKRREMETY KIQTLQKMLE QEKLNLERLK 
       410        420        430        440        450
SDQNNPSYKL SEANIRKLRE QLHQVGAEAL GQTPNLGKNK HRRVGSSPDN 
       460        470        480        490        500
MHPRHPDRIT KTTSGSWEIV EKDGESSPPG TPPPPYLSSS HMTVLEDPNE 
       510        520        530        540        550
NNRGAAAAGP GVFIESHQFT PMAGASSPIP ISLHSSHMHA AQSNDTQKEI 
       560        570        580        590        600
ISMEDENSDL DEPFIDENGP FNNLTRLLEA ENVTFLAIFL NYVISNSDPA 
       610        620        630        640        650
PLLFYLITEL YKEGTSKDMR KWAYEIHSTF LVPRAPLSWY RQDESLAREV 
       660        670        680        690        700
DNVLQLEYDK VEILRTVFLR SRKRAKDLIS EQLREFQQKR TAGLGTIYGP 
       710        720        730        740        750
TDDKLAEAKT DKLREQIIDK YLMPNLHALI EDENGSPPED VRKVALCSAL 
       760        770        780        790        800
STVIYRIFNT RPPPSSIVER VHHFVSRDKS FKSRIMGKNR KMNVRGHPLV 
       810        820        830        840        850
LRQYYEVTHC NHCQTIIWGV SPQGYHCTDC KLNIHRQCSK VVDESCPGPL 
       860        870        880        890        900
PQAKRLAHND KISKFMGKIR PRTSDVIGNE KRSRQDEELD VELTPDRGQA 
       910        920        930        940        950
SIVRQPSDRR PDANISIRSN GNTSCNTSGL NTTDLQSSFH GSCANDSINP 
       960        970        980        990       1000
GGGAGCNMDL STSVASTTPS TSGSVAAGLS AFAELNALDT VDKEARRERY 
      1010       1020       1030       1040       1050
SQHPKHKSAP VSVNRSESYK ERLSNKRNRN SRRKTSDPSL SSRPNDEQLD 
      1060       1070       1080       1090       1100
LGLSNATYVG SSNSSLSSAG GSESPSTSME HFAAPGAAGG VQVPPMGLNQ 
      1110       1120       1130       1140       1150
NQHPHLLIQQ HAQQYCQQDS FQAGLAGAAG SSAASNSSFW NAGHPLPVAR 
      1160       1170       1180       1190       1200
WTLESEDEDD VNEADWSSMV AAEVLAALTD AEKKRQEIIN EIYQTERNHV 
      1210       1220       1230       1240       1250
RTLKLLDRLF FLPLYESGLL SQDHLLLLFP PALLSLREIH GAFEQSLKQR 
      1260       1270       1280       1290       1300
RIEHNHVVNT IGDLLADMFD GQSGVVLCEF AAQFCARQQI ALEALKEKRN 
      1310       1320       1330       1340       1350
KDEMLQKLLK KSESHKACRR LELKDLLPTV LQRLTKYPLL FENLYKVTVR 
      1360       1370       1380       1390       1400
LLPENTTEAE AIQRAVESSK RILVEVNQAV KTAEDAHKLQ NIQRKLDRSS 
      1410       1420       1430       1440       1450
YDKEEFKKLD LTQHHLIHDG NLTIKKNPSV QLHGLLFENM IVLLTKQDDK 
      1460       1470       1480       1490       1500
YYLKNLHTPL SITNKPVSPI MSIDADTLIR QEAADKNSFF LIKMKTSQML 
      1510       1520       1530       1540       1550
ELRAPSSSEC KTWFKHFSDV AARQSKNRSK NASSNHDTSI SDPALAAIPH 
      1560       1570       1580       1590       1600
SNTKESLELS TDTVQPLAAT ATLTTTPLAP MLPIATVTPA PATNNSNVSS 
      1610       1620       1630       1640       1650
LTGVQLRNPQ RDATASESDA DYVNTPKPRS SQNEVNRTMS IRSTGEPIQK 
      1660       1670       1680       1690       1700
YSANGTEAND VTLRHSQSTR ESVRPGSTGE ERNSTYGMVG GNSKRDSASI 
      1710       1720       1730       1740       1750
VCSNNSNNTR TLLMQSPLVD PTAIQVSISP AHTAEPVLTP GEKLRRLDAS 
      1760       1770       1780       1790       1800
IRNDLLEKQK IICDIFRLPV EHYDQIVDIA MMPEAPKDSA DIALAAYDQI 
      1810       1820       1830       1840       1850
QTLTKMLNEY MHVTPEQEVS AVSTAVCGHC HEKEKLRKKV APSSSFSSSP 
      1860       1870       1880       1890       1900
PPLPPPNRQH AQAQAQIPPS RLMPKLQTLD LDEVAIHEDD DGYCEIDELR 
      1910       1920       1930       1940       1950
LPAIPSKPHE RPTTPLAPFN TEPKTSQSVI DASKRQSTDA VPEGLLEQEP 
      1960       1970       1980       1990       2000
LEGDKTETKG EDNEVKTVPS DKLSESCNEE RQCVEADITK EVADPTTSKN 
      2010       2020       2030       2040       2050
EAAASVDELP SQSREIKTAE NASKSVADKK EDNEETIEEG VASTVDSSTQ 
      2060       2070       2080       2090       2100
TSPTESPKET DKLTGGSSST CGPNRIQHAS VLEPSVPCHA LSSIVTILNE 
      2110       2120       2130       2140       2150
QISMLLPKIN ERDMERERLR KENQHLRELL SALHDRQRVD EVKETPFDLK 
      2160       2170       2180       2190       2200
KLMHAEDVEF DDDIDAISNS SLTPTPTPIP TASPSASGQV ETAEAMRITS 

TEDEE
Length:2,205
Mass (Da):242,239
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FEDE92187295237
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A1ZAN6A1ZAN6_DROME
Rho guanine nucleotide exchange fac...
RhoGEF2 Dmel\CG9635, DRhoGEF, dRhoGEF, DRhoGEF2, DrhoGEF2
2,559Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7T7A0A0B4K7T7_DROME
Rho guanine nucleotide exchange fac...
RhoGEF2 Dmel\CG9635, DRhoGEF, dRhoGEF, DRhoGEF2, DrhoGEF2
2,557Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LFF8A0A0B4LFF8_DROME
Rho guanine nucleotide exchange fac...
RhoGEF2 Dmel\CG9635, DRhoGEF, dRhoGEF, DRhoGEF2, DrhoGEF2
2,456Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57915.2

NCBI Reference Sequences

More...RefSeqi		NP_995869.1, NM_206147.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0086969; FBpp0086123; FBgn0023172

Database of genes from NCBI RefSeq genomes

More...GeneIDi		36915

UCSC genome browser

More...UCSCi		CG9635-RE, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57915.2
RefSeqiNP_995869.1, NM_206147.4

3D structure databases

SMRiA1ZAN7
ModBaseiSearch...

Proteomic databases

PRIDEiA1ZAN7

Genome annotation databases

EnsemblMetazoaiFBtr0086969; FBpp0086123; FBgn0023172
GeneIDi36915
UCSCiCG9635-RE, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		36915
FlyBaseiFBgn0023172, RhoGEF2

Phylogenomic databases

GeneTreeiENSGT00940000168706
HOGENOMiCLU_227972_0_0_1

Enzyme and pathway databases

SignaLinkiA1ZAN7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		36915, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		36915

Gene expression databases

BgeeiFBgn0023172, Expressed in eye disc (Drosophila) and 38 other tissues
ExpressionAtlasiA1ZAN7, baseline and differential
GenevisibleiA1ZAN7, DM

Family and domain databases

CDDicd00029, C1, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001478, PDZ
IPR036034, PDZ_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR015212, RGS-like_dom
IPR036305, RGS_sf
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF00595, PDZ, 1 hit
PF17838, PH_16, 1 hit
PF09128, RGS-like, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50106, PDZ, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1ZAN7_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1ZAN7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 7, 2020
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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