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Entry version 145 (07 Oct 2020)
Sequence version 1 (06 Feb 2007)
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Protein
Submitted name:

Rho guanine nucleotide exchange factor 2, isoform D

Gene

RhoGEF2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-193648, NRAGE signals death through JNK
R-DME-194840, Rho GTPase cycle
R-DME-416482, G alpha (12/13) signalling events
R-DME-416572, Sema4D induced cell migration and growth-cone collapse

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 2, isoform DImported
Submitted name:
Rho guanine nucleotide exchange factor 2, isoform FImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RhoGEF2Imported
Synonyms:Dmel\CG9635Imported, DRhoGEFImported, dRhoGEFImported, DRhoGEF2Imported, DrhoGEF2Imported, dRhoGEF2Imported, Gef2Imported, l(2)04291Imported, RG2Imported, Rho-GEF2Imported, RhoGEFImported, RhoGef2Imported, rhoGEF2Imported, rhogef2Imported, RhoGF2Imported, sharImported, Su(Rho1)2BImported, T2Imported
ORF Names:CG9635Imported, Dmel_CG9635Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0023172, RhoGEF2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation, MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A1ZAN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0023172, Expressed in eye disc (Drosophila) and 38 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086124

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1ZAN6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini260 – 336PDZInterPro annotationAdd BLAST77
Domaini1150 – 1200Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini1538 – 1733DHInterPro annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 251DisorderedSequence analysisAdd BLAST251
Regioni343 – 367DisorderedSequence analysisAdd BLAST25
Regioni505 – 524DisorderedSequence analysisAdd BLAST20
Regioni533 – 670DisorderedSequence analysisAdd BLAST138
Regioni768 – 861DisorderedSequence analysisAdd BLAST94
Regioni1233 – 1283DisorderedSequence analysisAdd BLAST51
Regioni1350 – 1403DisorderedSequence analysisAdd BLAST54
Regioni1415 – 1435DisorderedSequence analysisAdd BLAST21
Regioni1878 – 1898DisorderedSequence analysisAdd BLAST21
Regioni1944 – 1997DisorderedSequence analysisAdd BLAST54
Regioni2015 – 2046DisorderedSequence analysisAdd BLAST32
Regioni2190 – 2225DisorderedSequence analysisAdd BLAST36
Regioni2254 – 2429DisorderedSequence analysisAdd BLAST176
Regioni2518 – 2559DisorderedSequence analysisAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili382 – 402Sequence analysisAdd BLAST21
Coiled coili408 – 428Sequence analysisAdd BLAST21
Coiled coili1525 – 1552Sequence analysisAdd BLAST28
Coiled coili2463 – 2490Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17PolyampholyteSequence analysisAdd BLAST17
Compositional biasi30 – 68PolarSequence analysisAdd BLAST39
Compositional biasi105 – 126PolarSequence analysisAdd BLAST22
Compositional biasi127 – 143PolyampholyteSequence analysisAdd BLAST17
Compositional biasi177 – 251PolarSequence analysisAdd BLAST75
Compositional biasi533 – 562PolarSequence analysisAdd BLAST30
Compositional biasi630 – 657PolarSequence analysisAdd BLAST28
Compositional biasi768 – 788PolarSequence analysisAdd BLAST21
Compositional biasi796 – 815PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1233 – 1248PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1266 – 1283PolarSequence analysisAdd BLAST18
Compositional biasi1373 – 1394PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1415 – 1433PolarSequence analysisAdd BLAST19
Compositional biasi1878 – 1895PolarSequence analysisAdd BLAST18
Compositional biasi2272 – 2289PolarSequence analysisAdd BLAST18
Compositional biasi2302 – 2348PolyampholyteSequence analysisAdd BLAST47
Compositional biasi2349 – 2374PolarSequence analysisAdd BLAST26
Compositional biasi2375 – 2391PolyampholyteSequence analysisAdd BLAST17
Compositional biasi2394 – 2429PolarSequence analysisAdd BLAST36
Compositional biasi2520 – 2550PolarSequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3520, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168706

Database of Orthologous Groups

More...
OrthoDBi
319635at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001478, PDZ
IPR036034, PDZ_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR015212, RGS-like_dom
IPR036305, RGS_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 1 hit
PF00595, PDZ, 1 hit
PF17838, PH_16, 1 hit
PF09128, RGS-like, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit
PS50106, PDZ, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A1ZAN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDPSIKKRL LDLYTDEHEY DEVQEIPEES SIQPPETSTS HTSTNGSSHS
60 70 80 90 100
GPGTATGPGA TSAGPSAGAP QSPVIVVDSV PELPAPKQKS VKNSKSKQKQ
110 120 130 140 150
KQLANKSKIP RSPSLASSLS SLASSLSGHR DRDKDRDKDR ENQNAVPPQT
160 170 180 190 200
PPLPPSYKQN QMNGDSTAAA GGGVSAPATP TTANNNNASH NNGSIMGGGV
210 220 230 240 250
QLNQSDNSNP VLQAPGERSS LNLTPLSRDL SGGHTQESTT PATTPSTPSL
260 270 280 290 300
ALPKNFQYLT LTVRKDSNGY GMKVSGDNPV FVESVKPGGA AEIAGLVAGD
310 320 330 340 350
MILRVNGHEV RLEKHPTVVG LIKASTTVEL AVKRSQKLTR PSSVSVVTPS
360 370 380 390 400
TPILSGRDRT ASITGPQPVD SIKRREMETY KIQTLQKMLE QEKLNLERLK
410 420 430 440 450
SDQNNPSYKL SEANIRKLRE QLHQVGAEDA PTVKLQAAAG NKNTALLTPN
460 470 480 490 500
QIQHLSASAT HSNQQFHHLH HHHNLHNNNY PPQQQPASTS PAFLSLLPRS
510 520 530 540 550
LSSLSLGTRK NKTEKDLTTS SPFGLTTDFL QQQRMSHQAE SMSQSMHQHT
560 570 580 590 600
STPTSQQFFH PHQQQHRFKE TGPTSKGKNK FLISRSLIEE DVPPPLPQRN
610 620 630 640 650
PPRQLNLDLK NGNASPGGSH LVAPVSDLDR ATSPQLNRSQ QQQLPSSTDN
660 670 680 690 700
SPSNAKSKRS KIKTKALSDP KMSTQMFLQM ESASAAGAAG GSIEVDGGPP
710 720 730 740 750
PLPPRLPGMM TEDMSRGSCQ NLAQPNSVGT AFNYPLVSTT TAVQNDNLNI
760 770 780 790 800
AFPLSQRPNI VQQLQQYQQQ QQHQMSGGQA TGALGQTPNL GKNKHRRVGS
810 820 830 840 850
SPDNMHPRHP DRITKTTSGS WEIVEKDGES SPPGTPPPPY LSSSHMTVLE
860 870 880 890 900
DPNENNRGAA AAGPGVFIES HQFTPMAGAS SPIPISLHSS HMHAAQSNDT
910 920 930 940 950
QKEIISMEDE NSDLDEPFID ENGPFNNLTR LLEAENVTFL AIFLNYVISN
960 970 980 990 1000
SDPAPLLFYL ITELYKEGTS KDMRKWAYEI HSTFLVPRAP LSWYRQDESL
1010 1020 1030 1040 1050
AREVDNVLQL EYDKVEILRT VFLRSRKRAK DLISEQLREF QQKRTAGLGT
1060 1070 1080 1090 1100
IYGPTDDKLA EAKTDKLREQ IIDKYLMPNL HALIEDENGS PPEDVRKVAL
1110 1120 1130 1140 1150
CSALSTVIYR IFNTRPPPSS IVERVHHFVS RDKSFKSRIM GKNRKMNVRG
1160 1170 1180 1190 1200
HPLVLRQYYE VTHCNHCQTI IWGVSPQGYH CTDCKLNIHR QCSKVVDESC
1210 1220 1230 1240 1250
PGPLPQAKRL AHNDKISKFM GKIRPRTSDV IGNEKRSRQD EELDVELTPD
1260 1270 1280 1290 1300
RGQASIVRQP SDRRPDANIS IRSNGNTSCN TSGLNTTDLQ SSFHGSCAND
1310 1320 1330 1340 1350
SINPGGGAGC NMDLSTSVAS TTPSTSGSVA AGLSAFAELN ALDTVDKEAR
1360 1370 1380 1390 1400
RERYSQHPKH KSAPVSVNRS ESYKERLSNK RNRNSRRKTS DPSLSSRPND
1410 1420 1430 1440 1450
EQLDLGLSNA TYVGSSNSSL SSAGGSESPS TSMEHFAAPG AAGGVQVPPM
1460 1470 1480 1490 1500
GLNQNQHPHL LIQQHAQQYC QQDSFQAGLA GAAGSSAASN SSFWNAGHPL
1510 1520 1530 1540 1550
PVARWTLESE DEDDVNEADW SSMVAAEVLA ALTDAEKKRQ EIINEIYQTE
1560 1570 1580 1590 1600
RNHVRTLKLL DRLFFLPLYE SGLLSQDHLL LLFPPALLSL REIHGAFEQS
1610 1620 1630 1640 1650
LKQRRIEHNH VVNTIGDLLA DMFDGQSGVV LCEFAAQFCA RQQIALEALK
1660 1670 1680 1690 1700
EKRNKDEMLQ KLLKKSESHK ACRRLELKDL LPTVLQRLTK YPLLFENLYK
1710 1720 1730 1740 1750
VTVRLLPENT TEAEAIQRAV ESSKRILVEV NQAVKTAEDA HKLQNIQRKL
1760 1770 1780 1790 1800
DRSSYDKEEF KKLDLTQHHL IHDGNLTIKK NPSVQLHGLL FENMIVLLTK
1810 1820 1830 1840 1850
QDDKYYLKNL HTPLSITNKP VSPIMSIDAD TLIRQEAADK NSFFLIKMKT
1860 1870 1880 1890 1900
SQMLELRAPS SSECKTWFKH FSDVAARQSK NRSKNASSNH DTSISDPALA
1910 1920 1930 1940 1950
AIPHSNTKES LELSTDTVQP LAATATLTTT PLAPMLPIAT VTPAPATNNS
1960 1970 1980 1990 2000
NVSSLTGVQL RNPQRDATAS ESDADYVNTP KPRSSQNEVN RTMSIRSTGE
2010 2020 2030 2040 2050
PIQKYSANGT EANDVTLRHS QSTRESVRPG STGEERNSTY GMVGGNSKRD
2060 2070 2080 2090 2100
SASIVCSNNS NNTRTLLMQS PLVDPTAIQV SISPAHTAEP VLTPGEKLRR
2110 2120 2130 2140 2150
LDASIRNDLL EKQKIICDIF RLPVEHYDQI VDIAMMPEAP KDSADIALAA
2160 2170 2180 2190 2200
YDQIQTLTKM LNEYMHVTPE QEVSAVSTAV CGHCHEKEKL RKKVAPSSSF
2210 2220 2230 2240 2250
SSSPPPLPPP NRQHAQAQAQ IPPSRLMPKL QTLDLDEVAI HEDDDGYCEI
2260 2270 2280 2290 2300
DELRLPAIPS KPHERPTTPL APFNTEPKTS QSVIDASKRQ STDAVPEGLL
2310 2320 2330 2340 2350
EQEPLEGDKT ETKGEDNEVK TVPSDKLSES CNEERQCVEA DITKEVADPT
2360 2370 2380 2390 2400
TSKNEAAASV DELPSQSREI KTAENASKSV ADKKEDNEET IEEGVASTVD
2410 2420 2430 2440 2450
SSTQTSPTES PKETDKLTGG SSSTCGPNRI QHASVLEPSV PCHALSSIVT
2460 2470 2480 2490 2500
ILNEQISMLL PKINERDMER ERLRKENQHL RELLSALHDR QRVDEVKETP
2510 2520 2530 2540 2550
FDLKKLMHAE DVEFDDDIDA ISNSSLTPTP TPIPTASPSA SGQVETAEAM

RITSTEDEE
Length:2,559
Mass (Da):280,808
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07725DE04982605C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A1ZAN7A1ZAN7_DROME
Rho guanine nucleotide exchange fac...
RhoGEF2 Dmel\CG9635, DRhoGEF, dRhoGEF, DRhoGEF2, DrhoGEF2
2,205Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7T7A0A0B4K7T7_DROME
Rho guanine nucleotide exchange fac...
RhoGEF2 Dmel\CG9635, DRhoGEF, dRhoGEF, DRhoGEF2, DrhoGEF2
2,557Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LFF8A0A0B4LFF8_DROME
Rho guanine nucleotide exchange fac...
RhoGEF2 Dmel\CG9635, DRhoGEF, dRhoGEF, DRhoGEF2, DrhoGEF2
2,456Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM68489.1
AE013599 Genomic DNA Translation: AAM68490.2

NCBI Reference Sequences

More...
RefSeqi
NP_477317.1, NM_057969.6
NP_995868.1, NM_206146.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086970; FBpp0086124; FBgn0023172
FBtr0086971; FBpp0086125; FBgn0023172

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36915

UCSC genome browser

More...
UCSCi
CG9635-RD, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM68489.1
AE013599 Genomic DNA Translation: AAM68490.2
RefSeqiNP_477317.1, NM_057969.6
NP_995868.1, NM_206146.4

3D structure databases

SMRiA1ZAN6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0086124

Proteomic databases

PRIDEiA1ZAN6

Genome annotation databases

EnsemblMetazoaiFBtr0086970; FBpp0086124; FBgn0023172
FBtr0086971; FBpp0086125; FBgn0023172
GeneIDi36915
UCSCiCG9635-RD, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36915
FlyBaseiFBgn0023172, RhoGEF2

Phylogenomic databases

eggNOGiKOG3520, Eukaryota
GeneTreeiENSGT00940000168706
OrthoDBi319635at2759

Enzyme and pathway databases

ReactomeiR-DME-193648, NRAGE signals death through JNK
R-DME-194840, Rho GTPase cycle
R-DME-416482, G alpha (12/13) signalling events
R-DME-416572, Sema4D induced cell migration and growth-cone collapse

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
36915, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
36915

Gene expression databases

BgeeiFBgn0023172, Expressed in eye disc (Drosophila) and 38 other tissues

Family and domain databases

CDDicd00029, C1, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001478, PDZ
IPR036034, PDZ_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR015212, RGS-like_dom
IPR036305, RGS_sf
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF00595, PDZ, 1 hit
PF17838, PH_16, 1 hit
PF09128, RGS-like, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50106, PDZ, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1ZAN6_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1ZAN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 7, 2020
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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