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Entry version 118 (16 Oct 2019)
Sequence version 1 (06 Feb 2007)
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Protein
Submitted name:

FI05611p

Gene

knon

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FI05611pImported
Submitted name:
Knotted onionsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:knonImported
Synonyms:CG7813-RAImported, Dmel\CG7813Imported, ms(2)1400Imported
ORF Names:CG7813Imported, Dmel_CG7813Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0285943 knon

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A1ZAH1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034133 Expressed in 7 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A1ZAH1, 1 interactor

STRING: functional protein association networks

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STRINGi
7227.FBpp0086272

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A1ZAH1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni174 – 241DisorderedSequence analysisAdd BLAST68
Regioni273 – 352DisorderedSequence analysisAdd BLAST80
Regioni368 – 391DisorderedSequence analysisAdd BLAST24
Regioni413 – 526DisorderedSequence analysisAdd BLAST114
Regioni593 – 616DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili129 – 149Sequence analysisAdd BLAST21
Coiled coili631 – 669Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi195 – 220PolyampholyteSequence analysisAdd BLAST26
Compositional biasi290 – 327PolarSequence analysisAdd BLAST38
Compositional biasi329 – 352PolyampholyteSequence analysisAdd BLAST24
Compositional biasi413 – 463PolyampholyteSequence analysisAdd BLAST51
Compositional biasi469 – 486PolarSequence analysisAdd BLAST18
Compositional biasi491 – 510PolyampholyteSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3366 Eukaryota
ENOG4111IHJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003582

Identification of Orthologs from Complete Genome Data

More...
OMAi
MTMEEFC

Database of Orthologous Groups

More...
OrthoDBi
1299717at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.880, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008689 ATP_synth_F0_dsu_mt
IPR036228 ATP_synth_F0_dsu_sf_mt

The PANTHER Classification System

More...
PANTHERi
PTHR12700 PTHR12700, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05873 Mt_ATP-synt_D, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161065 SSF161065, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1ZAH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWEKLVNCIK SNGGNGGVKN VSCQVVELAD LMKQVPPNQM HKFKMFAKKH
60 70 80 90 100
EEYKDRVRKY PESMPTIDWE YYRQNVREEF VDWVKGYETK YDKLHSVFEN
110 120 130 140 150
RHAIVDHKRY FELVDEEKKV VTKCISEYKA ESDKRIQELT EKLEFVKAMR
160 170 180 190 200
PYSEMTMEEF CFARPHLAPD FINKPTFWPH TPEEQMPGPS DPEAAAALHH
210 220 230 240 250
EEEPEPPKKP APEKLPDKPS GEGKPPAAAA PKEPKEPVVD TSQLAEKATL
260 270 280 290 300
IAKDLMAKAI VLFNSLKEKM SGLAKNVQKK ADAAKAARSE TASKSATPTA
310 320 330 340 350
APTKSLDSIT ERESGPNICN QTIIRSEEAE ANPEVKARHT NLSIEADPCD
360 370 380 390 400
AQEERAREIA RTLERKRQLK EAEEWEKHKT KKDPCDAEKE TDPCKLMEEE
410 420 430 440 450
TVCKPDPCKA KEEEAVCKPD PCQQKEKEDD ICKPDPCKPK DEEGSCEDEE
460 470 480 490 500
DPCKKKPKCD GDYQFGGDNE GGSTKSKQQD QVFINISECS KELAKQEEKK
510 520 530 540 550
SGDSGKPKEK ASLSEIPQGS DQKPVLGMQI TESKDSKKDH KASIEGANEI
560 570 580 590 600
GPVYTDPNQL AELLVQKKEK PVIIEEAQKP EDDKPITIYP KLEISANPKG
610 620 630 640 650
DQVKQEAEGQ KSPKDMAKQV FTMASGAATL LTEATNTLED LKRKKEARLE
660 670 680 690 700
ALEQAYTSAQ RQAQGALAEA SKAVEAANNL AIRSAEQTGE VSSRDREALE
710 720 730
MAEKHAILAK MLAGRAVALK DEIARVLKDL KKKK
Length:734
Mass (Da):82,222
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47DA9C604CEB3787
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57991.1
BT044541 mRNA Translation: ACI03577.1

NCBI Reference Sequences

More...
RefSeqi
NP_611133.1, NM_137289.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087126; FBpp0086272; FBgn0285943

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36845

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7813

UCSC genome browser

More...
UCSCi
CG7813-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57991.1
BT044541 mRNA Translation: ACI03577.1
RefSeqiNP_611133.1, NM_137289.1

3D structure databases

SMRiA1ZAH1
ModBaseiSearch...

Protein-protein interaction databases

IntActiA1ZAH1, 1 interactor
STRINGi7227.FBpp0086272

Proteomic databases

PRIDEiA1ZAH1

Genome annotation databases

EnsemblMetazoaiFBtr0087126; FBpp0086272; FBgn0285943
GeneIDi36845
KEGGidme:Dmel_CG7813
UCSCiCG7813-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36845
FlyBaseiFBgn0285943 knon

Phylogenomic databases

eggNOGiKOG3366 Eukaryota
ENOG4111IHJ LUCA
GeneTreeiENSGT00390000003582
OMAiMTMEEFC
OrthoDBi1299717at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36845

Gene expression databases

BgeeiFBgn0034133 Expressed in 7 organ(s), highest expression level in testis

Family and domain databases

Gene3Di1.20.58.880, 1 hit
InterProiView protein in InterPro
IPR008689 ATP_synth_F0_dsu_mt
IPR036228 ATP_synth_F0_dsu_sf_mt
PANTHERiPTHR12700 PTHR12700, 1 hit
PfamiView protein in Pfam
PF05873 Mt_ATP-synt_D, 1 hit
SUPFAMiSSF161065 SSF161065, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1ZAH1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1ZAH1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 16, 2019
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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