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Protein

Carboxylic ester hydrolase

Gene

Jhe

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: FlyBase
  • juvenile-hormone esterase activity Source: FlyBase

GO - Biological processi

  • behavioral response to ethanol Source: FlyBase
  • juvenile hormone catabolic process Source: FlyBase
  • male mating behavior Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BRENDAi3.1.1.59 1994

Protein family/group databases

ESTHERidrome-CG8425 Juvenile_hormone_esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:JheImported
ORF Names:CG8425Imported, Dmel_CG8425Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010052 Jhe

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4265

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17UniRule annotationAdd BLAST17
ChainiPRO_501501932318 – 579Carboxylic ester hydrolaseUniRule annotationAdd BLAST562

Expressioni

Gene expression databases

BgeeiFBgn0010052 Expressed in 11 organ(s), highest expression level in Malpighian tubule

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0086362

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 522COesteraseInterPro annotationAdd BLAST485

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00680000100015
KOiK01063
OMAiYHEFANA
OrthoDBiEOG091G05S3

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1ZA98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQQRMLQLL LLGQLLAGPG PFCAALATVD QLTVCPPSVG CLKGTNLQGY
60 70 80 90 100
QSERFEAFMG IPYALPPIGD LRFSNPKVMP KLLGMYDASA PKMDCIQKNY
110 120 130 140 150
LLPTPVVYGD EDCLYLNVYR PEIRKSALPV MVYIHGGGFF GGSAGPGVTG
160 170 180 190 200
PEYFMDSGEV ILVTMAYRLG PFGFLSTQDA VMSGNFGLKD QNLALRWVQR
210 220 230 240 250
NIRFFGGDPQ RVTIFGQSAG GVAAHMHLLS PRSHGLFHRV ISMSGTANVP
260 270 280 290 300
FAIAEQPLEQ ARLLAEFADV PDARNLSTVK LTKALRRINA TKLLNAGDGL
310 320 330 340 350
KYWDVDHMTN FRPVVEEGLE VDAFLNAHPM DMLAQGMPTS IPLLLGTVPG
360 370 380 390 400
EGAVRVVNIL GNETLRQSFN LRFDELLQEL LEFPASFSQD RREKMMDLLV
410 420 430 440 450
EVYFQGQHEV NELTVQGFMN LISDRGFKQP LYNTIHKNVC HTPNPVYLYS
460 470 480 490 500
FNYQGPLSYA SAYTSANVTG KYGVVHCDDL LYLFRSPLLF PDFQRNSTEA
510 520 530 540 550
KVIHSFVDYF VHFAKFGKPR NSESLTPCSI EVLQSRPDGI CDYHEFANAP
560 570
DAYQGFEVHV ASEFQTDRVN LWSHILNEK
Length:579
Mass (Da):64,509
Last modified:November 13, 2007 - v2
Checksum:i334E6C9685764CB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58061.3
AE013599 Genomic DNA Translation: ACZ94438.1
AE013599 Genomic DNA Translation: AHN56273.1
RefSeqiNP_001163166.1, NM_001169695.2
NP_001286476.1, NM_001299547.1
NP_523758.3, NM_079034.5

Genome annotation databases

EnsemblMetazoaiFBtr0087223; FBpp0086362; FBgn0010052
FBtr0301751; FBpp0290965; FBgn0010052
FBtr0340021; FBpp0309035; FBgn0010052
GeneIDi36780
KEGGidme:Dmel_CG8425
UCSCiCG8425-RA d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58061.3
AE013599 Genomic DNA Translation: ACZ94438.1
AE013599 Genomic DNA Translation: AHN56273.1
RefSeqiNP_001163166.1, NM_001169695.2
NP_001286476.1, NM_001299547.1
NP_523758.3, NM_079034.5

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0086362

Chemistry databases

ChEMBLiCHEMBL4265

Protein family/group databases

ESTHERidrome-CG8425 Juvenile_hormone_esterase

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087223; FBpp0086362; FBgn0010052
FBtr0301751; FBpp0290965; FBgn0010052
FBtr0340021; FBpp0309035; FBgn0010052
GeneIDi36780
KEGGidme:Dmel_CG8425
UCSCiCG8425-RA d. melanogaster

Organism-specific databases

CTDi36780
FlyBaseiFBgn0010052 Jhe

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00680000100015
KOiK01063
OMAiYHEFANA
OrthoDBiEOG091G05S3

Enzyme and pathway databases

BRENDAi3.1.1.59 1994

Miscellaneous databases

GenomeRNAii36780

Gene expression databases

BgeeiFBgn0010052 Expressed in 11 organ(s), highest expression level in Malpighian tubule

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA1ZA98_DROME
AccessioniPrimary (citable) accession number: A1ZA98
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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