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Entry version 100 (16 Oct 2019)
Sequence version 1 (06 Feb 2007)
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Protein

Polynucleotide 5'-hydroxyl-kinase NOL9

Gene

CG8414

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polynucleotide 5'-kinase involved in rRNA processing.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi639 – 646ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processrRNA processing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polynucleotide 5'-hydroxyl-kinase NOL9 (EC:2.7.1.-)
Alternative name(s):
Nucleolar protein 9 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CG8414
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0034073 CG8414

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004037801 – 995Polynucleotide 5'-hydroxyl-kinase NOL9Add BLAST995

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1ZA92

PRoteomics IDEntifications database

More...
PRIDEi
A1ZA92

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034073 Expressed in 40 organ(s), highest expression level in egg chamber

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1ZA92 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
62499, 23 interactors

Protein interaction database and analysis system

More...
IntActi
A1ZA92, 9 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086393

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Clp1 family. NOL9/GRC3 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2750 Eukaryota
COG1341 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153668

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1ZA92

KEGG Orthology (KO)

More...
KOi
K06947

Identification of Orthologs from Complete Genome Data

More...
OMAi
SIQQIYH

Database of Orthologous Groups

More...
OrthoDBi
294689at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1ZA92

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032319 CLP1_P
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16575 CLP1_P, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1ZA92-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLDEHILKEM KLSFQLTEQR ELASGRRKPE KPQHPPAVPK KKVISKVASN
60 70 80 90 100
PAKISETMIQ KAQMESPKKS KKNKTAGAKR PLSNNVSNPD SSPSQKRLKK
110 120 130 140 150
DNTLPKKNPV NKSSNVAAKK SAATSKSAKL PIPKVHSINE LAPKKTKVKT
160 170 180 190 200
PNKTKEASLS KKHKVNGNKS SMKVVQNGKV VEIIGTAAET SDIEMNSLDD
210 220 230 240 250
WSEEDDYLIE SDSENDVVEE IDETFLKDPK IFKVKCKGPE YKLSDILPPF
260 270 280 290 300
EHDEYQPLLL DGDGSGTVRK IKVFKSAQEE TDSDEDDIDY EPEDSDDFGS
310 320 330 340 350
EEFDSEESDS EDTSSADYDS DGDFYSEYSD MEDVSDSDSE EFGSDIFDTD
360 370 380 390 400
DLDSTYEPPD IEGFFDHPPV GMQREPLIIE EIFDDPPVEK KQERIEQSSV
410 420 430 440 450
MDIVVKNLSS VPPKKESEVA IETEENDEVS LPEVVTPEKE NYLQPSDVPF
460 470 480 490 500
YRNPQANPTE LSVFENSLKS NHVLAVIKED LEVYGTLVLT LLCGQISVNG
510 520 530 540 550
YRARRQEAIT IYSPKGLNWV SISPTKTKKP VKDEVNWEEL NKNFTRAQLD
560 570 580 590 600
RIKTSFQRQT NAIVLLHRNT SAQQLVDTFG KHMAQNVFPL VNSSNRPFGQ
610 620 630 640 650
SETLLHCLIQ SSDQSRTLQV PQVWNKLQMH ATSRIIVAGG KGVGKSSLLR
660 670 680 690 700
YLINRNLGQF PSMLLIDLDI GQPEIFVPQT ISCTVIDEPL LGPGFLYNRQ
710 720 730 740 750
PEHAIVVGHT NIVLCAEQYA RAVIQLVQNI QNDAKYSNIP WLINTMGYNK
760 770 780 790 800
GFGIELMALL VDRIRPTDLV QIASPIPINN FDSVLDRNSL SQIKPIIYSA
810 820 830 840 850
EEFKINEIPK YTLHKLISAV PAREKGTWSL SAKDMRYSNL LARLSSCLTG
860 870 880 890 900
NAKSLTDCQP LGVSLESLKI LHPTSKNYSR EELIRGMEAN VVYLCHHGAG
910 920 930 940 950
LPQCLGIGVV RAIDYERKEL YLVPAMPLQK MSLVDCLILG GEQSLPQGFL
960 970 980 990
RDQGQGVSSS VPFVFILDDS KSSKSIQQIY HRAPAFLGVP ANQRN
Length:995
Mass (Da):111,208
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36D1904310B27714
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti551R → G in AAL48084 (PubMed:12537569).Curated1
Sequence conflicti806N → D in AAL48084 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58067.2
AY070613 mRNA Translation: AAL48084.1

NCBI Reference Sequences

More...
RefSeqi
NP_611084.2, NM_137240.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087255; FBpp0086393; FBgn0034073

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36774

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8414

UCSC genome browser

More...
UCSCi
CG8414-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58067.2
AY070613 mRNA Translation: AAL48084.1
RefSeqiNP_611084.2, NM_137240.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi62499, 23 interactors
IntActiA1ZA92, 9 interactors
STRINGi7227.FBpp0086393

Proteomic databases

PaxDbiA1ZA92
PRIDEiA1ZA92

Genome annotation databases

EnsemblMetazoaiFBtr0087255; FBpp0086393; FBgn0034073
GeneIDi36774
KEGGidme:Dmel_CG8414
UCSCiCG8414-RA d. melanogaster

Organism-specific databases

FlyBaseiFBgn0034073 CG8414

Phylogenomic databases

eggNOGiKOG2750 Eukaryota
COG1341 LUCA
GeneTreeiENSGT00940000153668
InParanoidiA1ZA92
KOiK06947
OMAiSIQQIYH
OrthoDBi294689at2759
PhylomeDBiA1ZA92

Enzyme and pathway databases

ReactomeiR-DME-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36774

Protein Ontology

More...
PROi
PR:A1ZA92

Gene expression databases

BgeeiFBgn0034073 Expressed in 40 organ(s), highest expression level in egg chamber
GenevisibleiA1ZA92 DM

Family and domain databases

InterProiView protein in InterPro
IPR032319 CLP1_P
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF16575 CLP1_P, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOL9_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1ZA92
Secondary accession number(s): Q8SZP4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: February 6, 2007
Last modified: October 16, 2019
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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