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Entry version 143 (07 Oct 2020)
Sequence version 1 (06 Feb 2007)
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Protein

Atypical protein kinase C

Gene

aPKC

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase which is required for apico-basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l2gl which restricts l2gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishment of correct oocyte polarity. Essential for apical localization of l2gl and par-6 in neuroblasts and for exclusion of mira from the apical cortex. Phosphorylates baz which is required for targeting of baz to the postsynaptic region where it is involved in actin organization, and for apical exclusion of baz which is necessary for establishment of the apical/lateral border in epithelial cells. Phosphorylates yrt which prevents its premature apical localization and is necessary for correct epithelial cell polarization. Required for the establishment of mitotic spindle orientation during symmetric division of epithelial cells and for apical exclusion of raps/Pins. Involved in symmetric adherens junction positioning during embryogenesis. Required for polarization of the spermatid cyst which is necessary for sperm differentiation. Required for stimulation of the Toll signaling pathway which activates Dif and dl and plays a role in innate immunity. Plays a role in memory enhancement.15 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei293ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei388Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri145 – 195Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi270 – 278ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1912408, Pre-NOTCH Transcription and Translation
R-DME-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-DME-5218921, VEGFR2 mediated cell proliferation
R-DME-9634635, Estrogen-stimulated signaling through PRKCZ

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
A1Z9X0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Atypical protein kinase CImported (EC:2.7.11.13)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aPKCImported
ORF Names:CG30475
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261854, aPKC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Zygotes survive to mid-larval stages where they exhibit defects in neuroblast and epithelial cell polarity. Mutant neuroblasts lack apical localization of l2gl and par-6, and fail to exclude mira from the apical cortex. Oocytes do not differentiate and display failure of BicD and ORB to translocate from the anterior to the posterior crescent, accumulation of Dhc64C in the two posterior-most presumptive pre-oocytes instead of in a single cell as normal, and defective posterior assembly of the microtubule organizing center. Adherens junctions form atypical planar-polarized puncta at gastrulation. Reduced yrt phosphorylation.4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004304881 – 606Atypical protein kinase CAdd BLAST606

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1Z9X0

PRoteomics IDEntifications database

More...
PRIDEi
A1Z9X0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1Z9X0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the testis. In spermatid cysts, localizes near the tips of spermatid flagellar axonemes (at protein level). Detectable in freshly laid eggs before onset of zygotic transcription so is deposited in the egg during oogenesis. At the cellular blastoderm stage, present in all cells except the pole cells. During gastrulation, strongly expressed in tissues undergoing morphogenetic movements such as invaginating mesoderm, proctodeum and cephalic furrow. Strongly expressed in neuroblasts.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261854, Expressed in wing disc (Drosophila) and 43 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1Z9X0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1Z9X0, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with baz; the interaction is required for apical localization of aPKC in neuroblasts and epithelial cells.

Interacts with Dap160; the interaction promotes aPKC apical localization and kinase activity.

Interacts with and phosphorylates l2gl and yrt.

Interacts with crb and ref2P.

Forms a complex with baz, fz and Patj.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
70851, 52 interactors

Protein interaction database and analysis system

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IntActi
A1Z9X0, 10 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0302921

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A1Z9X0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 113PB1PROSITE-ProRule annotationAdd BLAST84
Domaini264 – 532Protein kinasePROSITE-ProRule annotationAdd BLAST269
Domaini533 – 604AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi244 – 247Poly-ProSequence analysis4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 195Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0695, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000169305

KEGG Orthology (KO)

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KOi
K06069

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCVHKKC

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 1 hit
cd06404, PB1_aPKC, 1 hit
cd05588, STKc_aPKC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR034659, Atypical_PKC
IPR020454, DAG/PE-bd
IPR011009, Kinase-like_dom_sf
IPR034877, PB1_aPKC
IPR000270, PB1_dom
IPR002219, PE/DAG-bd
IPR012233, PKC
IPR017892, Pkinase_C
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 1 hit
PF00564, PB1, 1 hit
PF00069, Pkinase, 1 hit
PF00433, Pkinase_C, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000554, PKC_zeta, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00008, DAGPEDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00666, PB1, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS51745, PB1, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform A1 Publication (identifier: A1Z9X0-1) [UniParc]FASTAAdd to basket
Also known as: CImported

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKMPSQILN DGSSVSLNSA SMNMANTPNS ITVKTAYNGQ IIITTINKNI
60 70 80 90 100
SYEELCYEIR NICRFPLDQP FTIKWVDEEN DPCTISTKME LDEAIRLYEM
110 120 130 140 150
NFDSQLVIHV FPNVPQAPGL SCDGEDRSIY RRGARRWRKL YRVNGHIFQA
160 170 180 190 200
KRFNRRAFCA YCQDRIWGLG RQGFKCIQCK LLVHKKCHKL VQKHCTDQPE
210 220 230 240 250
PLVKERAEES SDPIPVPLPP LPYEAMSGGA EACETHDHAH IVAPPPPEDP
260 270 280 290 300
LEPGTQRQYS LNDFELIRVI GRGSYAKVLM VELRRTRRIY AMKVIKKALV
310 320 330 340 350
TDDEDIDWVQ TEKHVFETAS NHPFLVGLHS CFQTPSRLFF VIEFVRGGDL
360 370 380 390 400
MYHMQRQRRL PEEHARFYAA EISLALNFLH EKGIIYRDLK LDNVLLDHEG
410 420 430 440 450
HIKLTDYGMC KEGIRPGDTT STFCGTPNYI APEILRGEDY GFSVDWWALG
460 470 480 490 500
VLLYEMLAGR SPFDLAGASE NPDQNTEDYL FQVILEKTIR IPRSLSVRAA
510 520 530 540 550
SVLKGFLNKN PADRLGCHRE SAFMDIVSHP FFKNMDWELL ERKQVTPPFK
560 570 580 590 600
PRLDSDRDLA NFPPEFTGEA VQLTPDDDHV IDNIDQSEFE GFEYVNPLLM

SLEDCV
Length:606
Mass (Da):69,556
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C2E3046DBA61AEA
GO
Isoform B1 Publication (identifier: A1Z9X0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     83-110: CTISTKMELDEAIRLYEMNFDSQLVIHV → MIIWSGFCEAAQIYSTQTATFMSGGASL
     540-578: LERKQVTPPF...EAVQLTPDDD → IAQKEVQPPY...EPAVLTPDDP

Show »
Length:526
Mass (Da):60,050
Checksum:iB6A700C4AC381D26
GO
Isoform D1 Publication (identifier: A1Z9X0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     540-578: LERKQVTPPF...EAVQLTPDDD → IAQKEVQPPY...EPAVLTPDDP

Show »
Length:608
Mass (Da):69,661
Checksum:iAAABA092F151DE9E
GO
Isoform E1 Publication (identifier: A1Z9X0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     83-110: CTISTKMELDEAIRLYEMNFDSQLVIHV → MIIWSGFCEAAQIYSTQTATFMSGGASL

Show »
Length:524
Mass (Da):59,945
Checksum:iBC786D2F181E0FB6
GO
Isoform F1 Publication (identifier: A1Z9X0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
     104-110: SQLVIHV → MGKLACL

Show »
Length:503
Mass (Da):57,708
Checksum:iCF64515DE64A35A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KEQ8A0A0B4KEQ8_DROME
Protein kinase C
aPKC a-PKC, alphaPKCzeta, aPkc, apkc, aPKC zeta
620Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KG15A0A0B4KG15_DROME
Protein kinase C
aPKC a-PKC, alphaPKCzeta, aPkc, apkc, aPKC zeta
958Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JD78A0A0B4JD78_DROME
Protein kinase C
aPKC a-PKC, alphaPKCzeta, aPkc, apkc, aPKC zeta
951Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KEV2A0A0B4KEV2_DROME
Protein kinase C
aPKC a-PKC, alphaPKCzeta, aPkc, apkc, aPKC zeta
634Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KFQ6A0A0B4KFQ6_DROME
Protein kinase C
aPKC a-PKC, alphaPKCzeta, aPkc, apkc, aPKC zeta
519Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JD26A0A0B4JD26_DROME
Atypical protein kinase C, isoform ...
aPKC a-PKC, alphaPKCzeta, aPkc, apkc, aPKC zeta
511Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16S → T in AAG01528 (PubMed:10995441).Curated1
Sequence conflicti18N → S in AAG01528 (PubMed:10995441).Curated1
Sequence conflicti101N → K in AAM48431 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0567641 – 103Missing in isoform F. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_0567651 – 82Missing in isoform B and isoform E. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_05676683 – 110CTIST…LVIHV → MIIWSGFCEAAQIYSTQTAT FMSGGASL in isoform B and isoform E. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_056767104 – 110SQLVIHV → MGKLACL in isoform F. 1 Publication7
Alternative sequenceiVSP_056768540 – 578LERKQ…TPDDD → IAQKEVQPPYIPNIDTGDPY VTSNFDVQFTQEPAVLTPDD P in isoform B and isoform D. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF288482 mRNA Translation: AAG01528.1
AE013599 Genomic DNA Translation: AAF58177.2
AE013599 Genomic DNA Translation: ABI31090.1
AE013599 Genomic DNA Translation: ABI31091.1
AE013599 Genomic DNA Translation: ABI31092.1
AE013599 Genomic DNA Translation: ABI31093.1
AE013599 Genomic DNA Translation: ABI31094.1
AY118402 mRNA Translation: AAM48431.1
BT056247 mRNA Translation: ACL68694.1

NCBI Reference Sequences

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RefSeqi
NP_001036541.1, NM_001043076.3 [A1Z9X0-1]
NP_001036542.1, NM_001043077.3 [A1Z9X0-5]
NP_001036543.1, NM_001043078.2 [A1Z9X0-4]
NP_001036544.1, NM_001043079.2 [A1Z9X0-2]
NP_001036545.1, NM_001043080.3 [A1Z9X0-3]
NP_524892.2, NM_080153.5 [A1Z9X0-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0303429; FBpp0292486; FBgn0261854 [A1Z9X0-2]
FBtr0303430; FBpp0292487; FBgn0261854 [A1Z9X0-1]
FBtr0303431; FBpp0292488; FBgn0261854 [A1Z9X0-3]
FBtr0303432; FBpp0292489; FBgn0261854 [A1Z9X0-4]
FBtr0303433; FBpp0292490; FBgn0261854 [A1Z9X0-5]
FBtr0303434; FBpp0292491; FBgn0261854 [A1Z9X0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
47594

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG42783

UCSC genome browser

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UCSCi
CG10261-RA, d. melanogaster [A1Z9X0-1]
CG10261-RB, d. melanogaster
CG10261-RD, d. melanogaster
CG10261-RE, d. melanogaster
CG10261-RF, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288482 mRNA Translation: AAG01528.1
AE013599 Genomic DNA Translation: AAF58177.2
AE013599 Genomic DNA Translation: ABI31090.1
AE013599 Genomic DNA Translation: ABI31091.1
AE013599 Genomic DNA Translation: ABI31092.1
AE013599 Genomic DNA Translation: ABI31093.1
AE013599 Genomic DNA Translation: ABI31094.1
AY118402 mRNA Translation: AAM48431.1
BT056247 mRNA Translation: ACL68694.1
RefSeqiNP_001036541.1, NM_001043076.3 [A1Z9X0-1]
NP_001036542.1, NM_001043077.3 [A1Z9X0-5]
NP_001036543.1, NM_001043078.2 [A1Z9X0-4]
NP_001036544.1, NM_001043079.2 [A1Z9X0-2]
NP_001036545.1, NM_001043080.3 [A1Z9X0-3]
NP_524892.2, NM_080153.5 [A1Z9X0-1]

3D structure databases

SMRiA1Z9X0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi70851, 52 interactors
IntActiA1Z9X0, 10 interactors
STRINGi7227.FBpp0302921

PTM databases

iPTMnetiA1Z9X0

Proteomic databases

PaxDbiA1Z9X0
PRIDEiA1Z9X0

Genome annotation databases

EnsemblMetazoaiFBtr0303429; FBpp0292486; FBgn0261854 [A1Z9X0-2]
FBtr0303430; FBpp0292487; FBgn0261854 [A1Z9X0-1]
FBtr0303431; FBpp0292488; FBgn0261854 [A1Z9X0-3]
FBtr0303432; FBpp0292489; FBgn0261854 [A1Z9X0-4]
FBtr0303433; FBpp0292490; FBgn0261854 [A1Z9X0-5]
FBtr0303434; FBpp0292491; FBgn0261854 [A1Z9X0-1]
GeneIDi47594
KEGGidme:Dmel_CG42783
UCSCiCG10261-RA, d. melanogaster [A1Z9X0-1]
CG10261-RB, d. melanogaster
CG10261-RD, d. melanogaster
CG10261-RE, d. melanogaster
CG10261-RF, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
47594
FlyBaseiFBgn0261854, aPKC

Phylogenomic databases

eggNOGiKOG0695, Eukaryota
GeneTreeiENSGT00940000169305
KOiK06069
OMAiLCVHKKC

Enzyme and pathway databases

ReactomeiR-DME-1912408, Pre-NOTCH Transcription and Translation
R-DME-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-DME-5218921, VEGFR2 mediated cell proliferation
R-DME-9634635, Estrogen-stimulated signaling through PRKCZ
SignaLinkiA1Z9X0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
47594, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
47594

Protein Ontology

More...
PROi
PR:A1Z9X0

Gene expression databases

BgeeiFBgn0261854, Expressed in wing disc (Drosophila) and 43 other tissues
ExpressionAtlasiA1Z9X0, baseline and differential
GenevisibleiA1Z9X0, DM

Family and domain databases

CDDicd00029, C1, 1 hit
cd06404, PB1_aPKC, 1 hit
cd05588, STKc_aPKC, 1 hit
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR034659, Atypical_PKC
IPR020454, DAG/PE-bd
IPR011009, Kinase-like_dom_sf
IPR034877, PB1_aPKC
IPR000270, PB1_dom
IPR002219, PE/DAG-bd
IPR012233, PKC
IPR017892, Pkinase_C
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF00564, PB1, 1 hit
PF00069, Pkinase, 1 hit
PF00433, Pkinase_C, 1 hit
PIRSFiPIRSF000554, PKC_zeta, 1 hit
PRINTSiPR00008, DAGPEDOMAIN
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00666, PB1, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS51745, PB1, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPKC_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z9X0
Secondary accession number(s): Q0E971
, Q0E972, Q0E973, Q0E974, Q8MT38, Q9GSZ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 2014
Last sequence update: February 6, 2007
Last modified: October 7, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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