UniProtKB - A1Z9S1 (BL1S1_DROME)
Protein
Biogenesis of lysosome-related organelles complex 1 subunit 1
Gene
Blos1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses (PubMed:20015953, PubMed:28317021). In response to high synaptic activity at neuromuscular junctions, stabilizes Pldn protein levels and, together with Pldn, plays a role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes (PubMed:28317021).2 Publications
GO - Biological processi
- autophagosome-lysosome fusion Source: FlyBase
- endosomal transport Source: GO_Central
- eye pigment granule organization Source: FlyBase
- neuromuscular synaptic transmission Source: FlyBase
- olfactory learning Source: FlyBase
- synapse organization Source: FlyBase
- synaptic vesicle recycling via endosome Source: FlyBase
- synaptic vesicle transport Source: FlyBase
Enzyme and pathway databases
Reactomei | R-DME-432720, Lysosome Vesicle Biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Biogenesis of lysosome-related organelles complex 1 subunit 1Short name: BLOC-1 subunit 1 |
Gene namesi | |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0050077, Blos1 |
Subcellular locationi
Cytosol
- BLOC-1 complex Source: FlyBase
Mitochondrion
- mitochondrion Source: GO_Central
Other locations
- presynapse Source: GOC
Pathology & Biotechi
Disruption phenotypei
Show reduced eye pigmentation.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000420192 | 1 – 147 | Biogenesis of lysosome-related organelles complex 1 subunit 1Add BLAST | 147 |
Proteomic databases
PaxDbi | A1Z9S1 |
Expressioni
Gene expression databases
Bgeei | FBgn0050077, Expressed in antenna and 37 other tissues |
ExpressionAtlasi | A1Z9S1, baseline and differential |
Genevisiblei | A1Z9S1, DM |
Interactioni
Subunit structurei
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of Blos1, Blos2, Blos3, Blos4, Dysb, Muted, Pldn and Snapin.
Interacts with Pldn.
1 PublicationProtein-protein interaction databases
BioGRIDi | 73022, 63 interactors |
IntActi | A1Z9S1, 40 interactors |
STRINGi | 7227.FBpp0290948 |
Family & Domainsi
Sequence similaritiesi
Belongs to the BLOC1S1 family.Curated
Phylogenomic databases
eggNOGi | KOG3390, Eukaryota |
GeneTreei | ENSGT00390000002689 |
HOGENOMi | CLU_115602_3_0_1 |
InParanoidi | A1Z9S1 |
OMAi | HSATNFA |
OrthoDBi | 1603359at2759 |
PhylomeDBi | A1Z9S1 |
Family and domain databases
InterProi | View protein in InterPro IPR009395, BLOC1S1 |
PANTHERi | PTHR13073, PTHR13073, 1 hit |
Pfami | View protein in Pfam PF06320, GCN5L1, 1 hit |
i Sequence
Sequence statusi: Complete.
A1Z9S1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTSMVKEHH KEQAKRKQEQ EVRRKEAIEA SNELTQSLVD TLNVGVAQAY
60 70 80 90 100
LNQKRLDAEA KQLHLGATNF AKQTHQWLQL IDQFSTALKD LGDVENWARS
110 120 130 140
IEGDMHTINQ TLELAYKASR ATQTSSGAGT SLEASTSASA SANPSAT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAM68556.2 |
RefSeqi | NP_725401.2, NM_166060.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0301734; FBpp0290948; FBgn0050077 |
GeneIDi | 246439 |
KEGGi | dme:Dmel_CG30077 |
UCSCi | CG30077-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAM68556.2 |
RefSeqi | NP_725401.2, NM_166060.3 |
3D structure databases
SMRi | A1Z9S1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 73022, 63 interactors |
IntActi | A1Z9S1, 40 interactors |
STRINGi | 7227.FBpp0290948 |
Proteomic databases
PaxDbi | A1Z9S1 |
Genome annotation databases
EnsemblMetazoai | FBtr0301734; FBpp0290948; FBgn0050077 |
GeneIDi | 246439 |
KEGGi | dme:Dmel_CG30077 |
UCSCi | CG30077-RA, d. melanogaster |
Organism-specific databases
CTDi | 246439 |
FlyBasei | FBgn0050077, Blos1 |
Phylogenomic databases
eggNOGi | KOG3390, Eukaryota |
GeneTreei | ENSGT00390000002689 |
HOGENOMi | CLU_115602_3_0_1 |
InParanoidi | A1Z9S1 |
OMAi | HSATNFA |
OrthoDBi | 1603359at2759 |
PhylomeDBi | A1Z9S1 |
Enzyme and pathway databases
Reactomei | R-DME-432720, Lysosome Vesicle Biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 246439, 1 hit in 1 CRISPR screen |
GenomeRNAii | 246439 |
PROi | PR:A1Z9S1 |
Gene expression databases
Bgeei | FBgn0050077, Expressed in antenna and 37 other tissues |
ExpressionAtlasi | A1Z9S1, baseline and differential |
Genevisiblei | A1Z9S1, DM |
Family and domain databases
InterProi | View protein in InterPro IPR009395, BLOC1S1 |
PANTHERi | PTHR13073, PTHR13073, 1 hit |
Pfami | View protein in Pfam PF06320, GCN5L1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BL1S1_DROME | |
Accessioni | A1Z9S1Primary (citable) accession number: A1Z9S1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2012 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 10, 2021 | |
This is version 102 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families